FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17187

FusionGeneSummary for IGFBP3_IGFBP3

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBP3_IGFBP3
Fusion gene ID: 17187
HgeneTgene
Gene symbol

IGFBP3

IGFBP3

Gene ID

3486

3486

Gene nameinsulin like growth factor binding protein 3insulin like growth factor binding protein 3
SynonymsBP-53|IBP3BP-53|IBP3
Cytomap

7p12.3

7p12.3

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding proteininsulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding protein
Modification date2018052720180527
UniProtAcc

P17936

P17936

Ensembl transtripts involved in fusion geneENST00000381086, ENST00000275521, 
ENST00000381083, ENST00000465642, 
ENST00000381086, ENST00000275521, 
ENST00000381083, ENST00000465642, 
Fusion gene scores* DoF score6 X 6 X 2=725 X 5 X 1=25
# samples 76
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IGFBP3 [Title/Abstract] AND IGFBP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGFBP3

GO:0001933

negative regulation of protein phosphorylation

17591901

HgeneIGFBP3

GO:0006468

protein phosphorylation

17434920

HgeneIGFBP3

GO:0014912

negative regulation of smooth muscle cell migration

10766744

HgeneIGFBP3

GO:0045663

positive regulation of myoblast differentiation

12599210

HgeneIGFBP3

GO:0048662

negative regulation of smooth muscle cell proliferation

10766744

TgeneIGFBP3

GO:0001933

negative regulation of protein phosphorylation

17591901

TgeneIGFBP3

GO:0006468

protein phosphorylation

17434920

TgeneIGFBP3

GO:0014912

negative regulation of smooth muscle cell migration

10766744

TgeneIGFBP3

GO:0045663

positive regulation of myoblast differentiation

12599210

TgeneIGFBP3

GO:0048662

negative regulation of smooth muscle cell proliferation

10766744


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA554686IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000381086ENST00000381086IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000381086ENST00000275521IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000381086ENST00000381083IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000381086ENST00000465642IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000275521ENST00000381086IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000275521ENST00000275521IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000275521ENST00000381083IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000275521ENST00000465642IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000381083ENST00000381086IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000381083ENST00000275521IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000381083ENST00000381083IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000381083ENST00000465642IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000465642ENST00000381086IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000465642ENST00000275521IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000465642ENST00000381083IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-
intron-intronENST00000465642ENST00000465642IGFBP3chr7

45953389

-IGFBP3chr7

45960533

-

Top

FusionProtFeatures for IGFBP3_IGFBP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP3

P17936

IGFBP3

P17936

IGF-binding proteins prolong the half-life of the IGFsand have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors. Alsoexhibits IGF-independent antiproliferative and apoptotic effectsmediated by its receptor TMEM219/IGFBP-3R.{ECO:0000269|PubMed:20353938}. IGF-binding proteins prolong the half-life of the IGFsand have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors. Alsoexhibits IGF-independent antiproliferative and apoptotic effectsmediated by its receptor TMEM219/IGFBP-3R.{ECO:0000269|PubMed:20353938}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IGFBP3_IGFBP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IGFBP3_IGFBP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IGFBP3_IGFBP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIGFBP3P17936DB00523AlitretinoinInsulin-like growth factor-binding protein 3small moleculeapproved|investigational
HgeneIGFBP3P17936DB01277MecaserminInsulin-like growth factor-binding protein 3biotechapproved|investigational
TgeneIGFBP3P17936DB00523AlitretinoinInsulin-like growth factor-binding protein 3small moleculeapproved|investigational
TgeneIGFBP3P17936DB01277MecaserminInsulin-like growth factor-binding protein 3biotechapproved|investigational

Top

RelatedDiseases for IGFBP3_IGFBP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGFBP3C0033578Prostatic Neoplasms3CTD_human
HgeneIGFBP3C0000786Spontaneous abortion1CTD_human
HgeneIGFBP3C0003873Rheumatoid Arthritis1CTD_human
HgeneIGFBP3C0004352Autistic Disorder1CTD_human
HgeneIGFBP3C0005695Bladder Neoplasm1CTD_human
HgeneIGFBP3C0007138Carcinoma, Transitional Cell1CTD_human
HgeneIGFBP3C0009404Colorectal Neoplasms1CTD_human
HgeneIGFBP3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIGFBP3C0038356Stomach Neoplasms1CTD_human
HgeneIGFBP3C0151744Myocardial Ischemia1CTD_human
TgeneIGFBP3C0033578Prostatic Neoplasms3CTD_human
TgeneIGFBP3C0000786Spontaneous abortion1CTD_human
TgeneIGFBP3C0003873Rheumatoid Arthritis1CTD_human
TgeneIGFBP3C0004352Autistic Disorder1CTD_human
TgeneIGFBP3C0005695Bladder Neoplasm1CTD_human
TgeneIGFBP3C0007138Carcinoma, Transitional Cell1CTD_human
TgeneIGFBP3C0009404Colorectal Neoplasms1CTD_human
TgeneIGFBP3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIGFBP3C0038356Stomach Neoplasms1CTD_human
TgeneIGFBP3C0151744Myocardial Ischemia1CTD_human