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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17180

FusionGeneSummary for IGFBP2_CLCN3

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBP2_CLCN3
Fusion gene ID: 17180
HgeneTgene
Gene symbol

IGFBP2

CLCN3

Gene ID

3485

1182

Gene nameinsulin like growth factor binding protein 2chloride voltage-gated channel 3
SynonymsIBP2|IGF-BP53CLC3|ClC-3
Cytomap

2q35

4q33

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 2IGF-binding protein 2insulin-like growth factor binding protein 2, 36kDaH(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3
Modification date2018052320180523
UniProtAcc

P18065

P51790

Ensembl transtripts involved in fusion geneENST00000233809, ENST00000456764, 
ENST00000513761, ENST00000347613, 
ENST00000360642, ENST00000504131, 
ENST00000506924, 
Fusion gene scores* DoF score4 X 4 X 3=4836 X 4 X 19=2736
# samples 439
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(39/2736*10)=-2.81052220113629
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGFBP2 [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGFBP2

GO:0042104

positive regulation of activated T cell proliferation

15694994

TgeneCLCN3

GO:1902476

chloride transmembrane transport

11274166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N6-A4V9-01AIGFBP2chr2

217529159

+CLCN3chr4

170623929

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000233809ENST00000513761IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
5CDS-intronENST00000233809ENST00000347613IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
5CDS-intronENST00000233809ENST00000360642IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
5CDS-intronENST00000233809ENST00000504131IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
5CDS-intronENST00000233809ENST00000506924IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
intron-intronENST00000456764ENST00000513761IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
intron-intronENST00000456764ENST00000347613IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
intron-intronENST00000456764ENST00000360642IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
intron-intronENST00000456764ENST00000504131IGFBP2chr2

217529159

+CLCN3chr4

170623929

+
intron-intronENST00000456764ENST00000506924IGFBP2chr2

217529159

+CLCN3chr4

170623929

+

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FusionProtFeatures for IGFBP2_CLCN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP2

P18065

CLCN3

P51790

Inhibits IGF-mediated growth and developmental rates.IGF-binding proteins prolong the half-life of the IGFs and havebeen shown to either inhibit or stimulate the growth promotingeffects of the IGFs on cell culture. They alter the interaction ofIGFs with their cell surface receptors.{ECO:0000269|PubMed:19081843}. Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGFBP2_CLCN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGFBP2_CLCN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IGFBP2IGF1, INO80B, GSDMB, EGFR, DEFA1CLCN3CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGFBP2_CLCN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGFBP2_CLCN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGFBP2C0005586Bipolar Disorder3PSYGENET
HgeneIGFBP2C0023893Liver Cirrhosis, Experimental2CTD_human
HgeneIGFBP2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneIGFBP2C0011616Contact Dermatitis1CTD_human
HgeneIGFBP2C0021655Insulin Resistance1CTD_human
HgeneIGFBP2C0023890Liver Cirrhosis1CTD_human
HgeneIGFBP2C0028754Obesity1CTD_human
HgeneIGFBP2C0036095Salivary Gland Neoplasms1CTD_human
TgeneCLCN3C0017638Glioma1CTD_human
TgeneCLCN3C0038356Stomach Neoplasms1CTD_human
TgeneCLCN3C2931822Nasopharyngeal carcinoma1CTD_human