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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17179

FusionGeneSummary for IGF2_YY1

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2_YY1
Fusion gene ID: 17179
HgeneTgene
Gene symbol

IGF2

YY1

Gene ID

3481

7528

Gene nameinsulin like growth factor 2YY1 transcription factor
SynonymsC11orf43|GRDF|IGF-II|PP9974DELTA|GADEVS|INO80S|NF-E1|UCRBP|YIN-YANG-1
Cytomap

11p15.5

14q32.2

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptintranscriptional repressor protein YY1INO80 complex subunit SYY-1Yin and Yang 1 proteindelta transcription factor
Modification date2018052720180527
UniProtAcc

P01344

P25490

Ensembl transtripts involved in fusion geneENST00000381395, ENST00000381406, 
ENST00000416167, ENST00000300632, 
ENST00000434045, ENST00000381392, 
ENST00000381389, ENST00000418738, 
ENST00000262238, 
Fusion gene scores* DoF score10 X 5 X 8=4006 X 4 X 5=120
# samples 127
** MAII scorelog2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGF2 [Title/Abstract] AND YY1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGF2

GO:0008284

positive regulation of cell proliferation

28873464

HgeneIGF2

GO:0042104

positive regulation of activated T cell proliferation

15694994

HgeneIGF2

GO:0043410

positive regulation of MAPK cascade

11500939

HgeneIGF2

GO:0045840

positive regulation of mitotic nuclear division

11500939

HgeneIGF2

GO:0046628

positive regulation of insulin receptor signaling pathway

11500939

HgeneIGF2

GO:0051897

positive regulation of protein kinase B signaling

11500939

TgeneYY1

GO:0000122

negative regulation of transcription by RNA polymerase II

9857059|16260628

TgeneYY1

GO:0032688

negative regulation of interferon-beta production

16260628


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N5-A4RO-01AIGF2chr11

2150351

-YY1chr14

100728641

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000381395ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+
intron-3CDSENST00000381406ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+
intron-3CDSENST00000416167ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+
In-frameENST00000300632ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+
intron-3CDSENST00000434045ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+
intron-3CDSENST00000381392ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+
intron-3CDSENST00000381389ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+
intron-3CDSENST00000418738ENST00000262238IGF2chr11

2150351

-YY1chr14

100728641

+

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FusionProtFeatures for IGF2_YY1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2

P01344

YY1

P25490

Multifunctional transcription factor that exhibitspositive and negative control on a large number of cellular andviral genes by binding to sites overlapping the transcriptionstart site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; somegenes have been shown to contain a longer binding motif allowingenhanced binding; the initial CG dinucleotide can be methylatedgreatly reducing the binding affinity. The effect on transcriptionregulation is depending upon the context in which it binds anddiverse mechanisms of action include direct activation orrepression, indirect activation or repression via cofactorrecruitment, or activation or repression by disruption of bindingsites or conformational DNA changes. Its activity is regulated bytranscription factors and cytoplasmic proteins that have beenshown to abrogate or completely inhibit YY1-mediated activation orrepression. For example, it acts as a repressor in absence ofadenovirus E1A protein but as an activator in its presence. Actssynergistically with the SMAD1 and SMAD4 in bone morphogeneticprotein (BMP)-mediated cardiac-specific gene expression(PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiacactivating regions. May play an important role in development anddifferentiation. Proposed to recruit the PRC2/EED-EZH2 complex totarget genes that are transcriptional repressed. Involved in DNArepair. In vitro, binds to DNA recombination intermediatestructures (Holliday junctions). Plays a role in regulatingenhancer activation (PubMed:28575647).{ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:24326773,ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}. Proposed core component of the chromatin remodelingINO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair; proposed to target the INO80complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549,ECO:0000269|PubMed:18026119}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGF2_YY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_IGF2_ENST00000300632_chr11_2150351_-_YY1_ENST00000262238_chr14_100728641_+_188aa
MKKKILTMRQWLKNRSLERTHLLIIQNIXQERNFLLEEYLALTSQIPNNWQNLLEXSQEKLKKMMLQEQXLALIKAAQRCSGITRPXENI
CTPTVPESTSVQNVAKLLLRVQNXNDTNWFILERSPFSARSKAVGNAFHWTSICAHMCESIPETGPMCAPSMVVIRSLLSQLTXNLTSXH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_IGF2_ENST00000300632_chr11_2150351_-_YY1_ENST00000262238_chr14_100728641_+_566nt
ATGAAAAAAAAGATATTGACCATGAGACAGTGGTTGAAGAACAGATCATTGGAGAGAACTCACCTCCTGATTATTCAGAATATATGACAG
GAAAGAAACTTCCTCCTGGAGGAATACCTGGCATTGACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCCAAGAAAAA
TTAAAGAAGATGATGCTCCAAGAACAATAGCTTGCCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAAAACATC
TGCACACCCACGGTCCCAGAGTCCACGTCTGTGCAGAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCAACTGGTTC
ATACTGGAGAGAAGCCCTTTCAGTGCACGTTCGAAGGCTGTGGGAAACGCTTTTCACTGGACTTCAATTTGCGCACACATGTGCGAATCC
ATACCGGAGACAGGCCCTATGTGTGCCCCTTCGATGGTTGTAATAAGAAGTTTGCTCAGTCAACTAACCTGAAATCTCACATCTTAACAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_IGF2_ENST00000300632_chr11_2150351_-_YY1_ENST00000262238_chr14_100728641_+_10896nt
CCGCTAATGTACCATGCCCTGGTGCTGGAAAGTGCCTGAGCCAGCTGCCCCAGCGGCCTCAGCACTACCAAGTTGGCACAAAGCTCCCCA
AATTCGGAGGGGCTCAGGGAAACGAGTGGAGGGGATGAGGAGGTGAGGGGTAAACCCATCATTTCAGTTGGCATTTGAGCAGGTGCCATG
CTCAGCGGAGATGAGGCTCTCCCATCTGTAGGGGCCGTATTAACATGCACACTCTAAAAGTGCCCTTCGTTTCTCCAGCCTCAGCTTTGT
CCCTCTCCTCCTCCACGTCAACCTGGCCAGAGGGTCTGGACGCCACAGCCAGGGCACCCCCTGCTTTGGTGGTGACTGCTAATATTGGCC
AGGCCGGCGGATCATCGTCCAGGCAGTTTCGGCAGAGAGCCTTGGGCACCAGTGACTCCCCGGTCCTCTTTATCCACTGTCCAGGAGCTG
CGGGGACTGCGCAGGGACTAGAGTACAGGGGCCGAAGAGTCACCACCGAGCTTGTGTGGGAGGAGGTGGATTCCAGCCCCCAGCCCCAGG
GCTCTGAATCGCTGCCAGCTCAGCCCCCTGCCCAGCCTGCCCCACAGCCTGAGCCCCAGCAGGCCAGAGAGCCCAGTCCTGAGGTGAGCT
GCTGTGGCCTGTGGCCCAGGCGACCCCAGCGCTCCCAGAACTGAGGCTGGCAGCCAGCCCCAGCCTCAGCCCCAACTGCGAGGCAGAGAG
ACACCAATGGGAATCCCAATGGGGAAGTCGATGCTGGTGCTTCTCACCTTCTTGGCCTTCGCCTCGTGCTGCATTGCTGCTTACCGCCCC
AGTGAGACCCTGTGCGGCGGGGAGCTGGTGGACACCCTCCAGTTCGTCTGTGGGGACCGCGGCTTCTACTTCAGCAGGCCCGCAAGCCGT
GTGAGCCGTCGCAGCCGTGGCATCGTTGAGGAGTGCTGTTTCCGCAGCTGTGACCTGGCCCTCCTGGAGACGTACTGTGCTACCCCCGCC
AAGTCCGAGAGGGACGTGTCGACCCCTCCGACCGTGCTTCCGGACAACTTCCCCAGATACCCCGTGGGCAAGTTCTTCCAATATGACACC
TGGAAGCAGTCCACCCAGCGCCTGCGCAGGGGCCTGCCTGCCCTCCTGCGTGCCCGCCGGGGTCACGTGCTCGCCAAGGAGCTCGAGGCG
TTCAGGGAGGCCAAACGTCACCGTCCCCTGATTGCTCTACCCACCCAAGACCCCGCCCACGGGGGCGCCCCCCCAGAGATGGCCAGCAAT
CGGAAGTGAGCAAAACTGCCGCAAGTCTGCAGCCCGGCGCCACCATCCTGCAGCCTCCTCCTGACCACGGACGTTTCCATCAGGTTCCAT
CCCGAAAATCTCTCGGTTCCACGTCCCCCTGGGGCTTCTCCTGACCCAGTCCCCGTGCCCCGCCTCCCCGAAACAGGCTACTCTCCTCGG
CCCCCTCCATCGGGCTGAGGAAGCACAGCAGCATCTTCAAACATGTACAAAATCGATTGGCTTTAAACACCCTTCACATACCCTCCCCCC
AAATTATCCCCAATTATCCCCACACATAAAAAATCAAAACATTAAACTAACCCCCTTCCCCCCCCCCCACAACAACCCTCTTAAAACTAA
TTGGCTTTTTAGAAACACCCCACAAAAGCTCAGAAATTGGCTTTAAAAAAAACAACCACCAAAAAAAATCAATTGGCTAAAAAAAAAAAG
TATTAAAAACGAATTGGCTGAGAAACAATTGGCAAAATAAAGGAATTTGGCACTCCCCACCCCCCTCTTTCTCTTCTCCCTTGGACTTTG
AGTCAAATTGGCCTGGACTTGAGTCCCTGAACCAGCAAAGAGAAAAGAAGGACCCCAGAAATCACAGGTGGGCACGTCGCTGCTACCGCC
ATCTCCCTTCTCACGGGAATTTTCAGGGTAAACTGGCCATCCGAAAATAGCAACAACCCAGACTGGCTCCTCACTCCCTTTTCCATCACT
AAAAATCACAGAGCAGTCAGAGGGACCCAGTAAGACCAAAGGAGGGGAGGACAGAGCATGAAAACCAAAATCCATGCAAATGAAATGTAA
TTGGCACGACCCTCACCCCCAAATCTTACATCTCAATTCCCATCCTAAAAAGCACTCATACTTTATGCATCCCCGCAGCTACACACACAC
AACACACAGCACACGCATGAACACAGCACACACACGAGCACAGCACACACACAAACGCACAGCACACACAGCACACAGATGAGCACACAG
CACACACACAAACGCACAGCACACACACGCACACACATGCACACACAGCACACAAACGCACGGCACACACACGCACACACATGCACACAC
AGCACACACACAAACGCACAGCACACACAAACGCACAGCACACACGCACACACAGCACACACACGAGCACACAGCACACAAACGCACAGC
ACACGCACACACATGCACACACAGCACACACACTAGCACACAGCACACACACAAAGACACAGCACACACATGCACACACAGCACACACAC
GCGAACACAGCACACACGAACACAGCACACACAGCACACACACAAACACAGCACACACATGCACACAGCACACGCACACACAGCACACAC
ATGAACACAGCACACAGCACACACATGCACACACAGCACACACGCATGCACAGCACACATGAACACAGCACACACACAAACACACAGCAC
ACACATGCACACACAGCACACACACTCATGCGCAGCACATACATGAACACAGCTCACAGCACACAAACACGCAGCACACACGTTGCACAC
GCAAGCACCCACCTGCACACACACATGCGCACACACACGCACACCCCCACAAAATTGGATGAAAACAATAAGCATATCTAAGCAACTACG
ATATCTGTATGGATCAGGCCAAAGTCCCGCTAAGATTCTCCAATGTTTTCATGGTCTGAGCCCCGCTCCTGTTCCCATCTCCACTGCCCC
TCGGCCCTGTCTGTGCCCTGCCTCTCAGAGGAGGGGGCTCAGATGGTGCGGCCTGAGTGTGCGGCCGGCGGCATTTGGGATACACCCGTA
GGGTGGGCGGGGTGTGTCCCAGGCCTAATTCCATCTTTCCACCATGACAGAGATGCCCTTGTGAGGCTGGCCTCCTTGGCGCCTGTCCCC
ACGGCCCCCGCAGCGTGAGCCACGATGCTCCCCATACCCCACCCATTCCCGATACACCTTACTTACTGTGTGTTGGCCCAGCCAGAGTGA
GGAAGGAGTTTGGCCACATTGGAGATGGCGGTAGCTGAGCAGACATGCCCCCACGAGTAGCCTGACTCCCTGGTGTGCTCCTGGAAGGAA
GATCTTGGGGACCCCCCCACCGGAGCACACCTAGGGATCATCTTTGCCCGTCTCCTGGGGACCCCCCAAGAAATGTGGAGTCCTCGGGGG
CCGTGCACTGATGCGGGGAGTGTGGGAAGTCTGGCGGTTGGAGGGGTGGGTGGGGGGCAGTGGGGGCTGGGCGGGGGGAGTTCTGGGGTA
GGAAGTGGTCCCGGGAGATTTTGGATGGAAAAGTCAGGAGGATTGACAGCAGACTTGCAGAATTACATAGAGAAATTAGGAACCCCCAAA
TTTCATGTCAATTGATCTATTCCCCCTCTTTGTTTCTTGGGGCATTTTTCCTTTTTTTTTTTTTTTTGTTTTTTTTTTACCCCTCCTTAG
CTTTATGCGCTCAGAAACCAAATTAAACCCCCCCCCCATGTAACAGGGGGGCAGTGACAAAAGCAAGAACGCACGAAGCCAGCCTGGAGA
CCACCACGTCCTGCCCCCCGCCATTTATCGCCCTGATTGGATTTTGTTTTTCATCTGTCCCTGTTGCTTGGGTTGAGTTGAGGGTGGAGC
CTCCTGGGGGGCACTGGCCACTGAGCCCCCTTGGAGAAGTCAGAGGGGAGTGGAGAAGGCCACTGTCCGGCCTGGCTTCTGGGGACAGTG
GCTGGTCCCCAGAAGTCCTGAGGGCGGAGGGGGGGGTTGGGCAGGGTCTCCTCAGGTGTCAGGAGGGTGCTCGGAGGCCACAGGAGGGGG
CTCCTGGCTGGCCTGAGGCTGGCCGGAGGGGAAGGGGCTAGCAGGTGTGTAAACAGAGGGTTCCATCAGGCTGGGGCAGGGTGGCCGCCT
TCCGCACACTTGAGGAACCCTCCCCTCTCCCTCGGTGACATCTTGCCCGCCCCTCAGCACCCTGCCTTGTCTCCAGGAGGTCCGAAGCTC
TGTGGGACCTCTTGGGGGCAAGGTGGGGTGAGGCCGGGGAGTAGGGAGGTCAGGCGGGTCTGAGCCCACAGAGCAGGAGAGCTGCCAGGT
CTGCCCATCGACCAGGTTGCTTGGGCCCCGGAGCCCACGGGTCTGGTGATGCCATAGCAGCCACCACCGCGGCGCCTAGGGCTGCGGCAG
GGACTCGGCCTCTGGGAGGTTTACCTCGCCCCCACTTGTGCCCCCAGCTCAGCCCCCCTGCACGCAGCCCGACTAGCAGTCTAGAGGCCT
GAGGCTTCTGGGTCCTGGTGACGGGGCTGGCATGACCCCGGGGGTCGTCCATGCCAGTCCGCCTCAGTCGCAGAGGGTCCCTCGGCAAGC
GCCCTGTGAGTGGGCCATTCGGAACATTGGACAGAAGCCCAAAGAGCCAAATTGTCACAATTGTGGAACCCACATTGGCCTGAGATCCAA
AACGCTTCGAGGCACCCCAAATTACCTGCCCATTCGTCAGGACACCCACCCACCCAGTGTTATATTCTGCCTCGCCGGAGTGGGTGTTCC
CGGGGGCACTTGCCGACCAGCCCCTTGCGTCCCCAGGTTTGCAGCTCTCCCCTGGGCCACTAACCATCCTGGCCCGGGCTGCCTGTCTGA
CCTCCGTGCCTAGTCGTGGCTCTCCATCTTGTCTCCTCCCCGTGTCCCCAATGTCTTCAGTGGGGGGCCCCCTCTTGGGTCCCCTCCTCT
GCCATCACCTGAAGACCCCCACGCCAAACACTGAATGTCACCTGTGCCTGCCGCCTCGGTCCACCTTGCGGCCCGTGTTTGACTCAACTC
AACTCCTTTAACGCTAATATTTCCGGCAAAATCCCATGCTTGGGTTTTGTCTTTAACCTTGTAACGCTTGCAATCCCAATAAAGCATTAA
AAGTCATGATGAAAAAAAAGATATTGACCATGAGACAGTGGTTGAAGAACAGATCATTGGAGAGAACTCACCTCCTGATTATTCAGAATA
TATGACAGGAAAGAAACTTCCTCCTGGAGGAATACCTGGCATTGACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCC
AAGAAAAATTAAAGAAGATGATGCTCCAAGAACAATAGCTTGCCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAG
AAAACATCTGCACACCCACGGTCCCAGAGTCCACGTCTGTGCAGAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCA
ACTGGTTCATACTGGAGAGAAGCCCTTTCAGTGCACGTTCGAAGGCTGTGGGAAACGCTTTTCACTGGACTTCAATTTGCGCACACATGT
GCGAATCCATACCGGAGACAGGCCCTATGTGTGCCCCTTCGATGGTTGTAATAAGAAGTTTGCTCAGTCAACTAACCTGAAATCTCACAT
CTTAACACATGCTAAGGCCAAAAACAACCAGTGAAAAGAAGAGAGAAGACCCTTCTCGACCACGGGAAGCATCTTCCAGAAGTGTGATTG
GGAATAAATATGCCTCTCCTTTGTATATTATTTCTAGGAAGAATTTTAAAAATGAATCCTACACACCTAAGGGACATGTTTTGATAAAGT
AGTAAAAATTAAAAAAAAAAAACTTTACTAAGATGACATTGCTAAGATGCTCTATCTTGCTCTGTAATCTCGTTTCAAAAACACAGTGTT
TTTGTAAAGTGTGGTCCCAACAGGAGGACAATTCATGAACTTCGCATCAAAAGACAATTCTTTATACAACAGTGCTAAAAATGGGACTTC
TTTTCACATTCTTATAAATATGAAGCTCACCTGTTGCTTACAATTTTTTTAATTTTGTATTTTCCAAGTGTGCATATTGTACACTTTTTT
GGGGATATGCTTAGTAATGCTACGTGTGATTTTTCTGGAGGTTGATAACTTTGCTTGCAGTAGATTTTCTTTAAAAGAATGGGCAGTTAC
ATGCATACTTCAAAAGTATTTTCCTGTAAAAAAAAAAAAGTTATATAGGTTTTGTTTGCTATCTTAATTTTGGTTGTATTCTTTGATGTT
AACACATTTTGTATAATTGTATCGTATAGCTGTATTGAATCATGTAGTATCAAATATTAGATGTGATTTAATAGTGTTAATCAATTTAAA
CCCATTTTAGTCACTTTTTTTTTCCAAAAAAATACTGCCAGATGCTGATGTTCAGTGTAATTTCTTTGCCTGTTCAGTTACAGAAAGTGG
TGCTCAGTTGTAGAATGTATTGTACCTTTTAACACCTGATGTGTACATCCCATGTAACAGAAAGGGCAACAATAAAATAGCAATCCTAAA
GCAAGAATATGGCAGAACAAGATCTGTAAGCACAGTCTTATTTTCTTTTGTTGTCCAGAATACTTATAATTCTTGAGCCTCCCAGAAATT
GGAAGCTAAATAAAGCAACTCAAGTTTCCTTTATTTTGCACTCAATTACAGTGATTATTGATGAAAGCGATGCATGGATATTTTAATACT
TCCTACATGTCCTGACTTCTGAAAGAGAGTAGGTAACAGGCATCCCGAGTTCAGGAACTACCTCAGAACACCCCAGGCCAGGTTGGTCAT
AGGCTGTGATTTTAGCCCCCGGCAAGTGTGAGTGAAGCATCTGTACCACCGCGCAGGCTGAGCGCCTGCGCAGGGTAAGGTGCCACCTGG
CAGTGGGGCACACAGAGGGAAGACCAGGCCTGTCCATCAGCCGGCTGCCTTCAGAGGCAGCTCCAGCAGGACCTTGGCTTGTCTGACAGG
AAATGCTTGTGGTCGTTGGTTATTTGGTTTGAGAGCCCTTGTTCCTCCATCTAGTGGAGTCCTTATTAAATGCTAGCAATGTGGCAATTG
AGTGCCAGTAGCTTAATTTCATGTTTCTAAATGGACACTGGGTGCAAATCGGCAAGGTGATTAGATTATTAGAAAATTCTGCTCAATGAG
TACCTCTCACATTGTAACCTCTTAAATGTACGATTATAATGTTGGATCTTAGGTCAAATAACAGACTTGAGAATACTTTATAAACTGCCA
TGATACAGCAAAATCTCATTTATTCAAAGTGCAAACATACTGTGTGTCTTTCTGTTTTGTGTATGCTTGACTGCAAGATAAATGACAAAC
TAGCTAATATCCGAGATTTATTTACAAATGGCCAGGGACCCCATCAGGTGAAACACATAGCCCATTGTCTTAGAGCTTCTCCATCGGTCC
TGTACAGGAGGATTGGTGACCTACTAACAGTGACCCTGTGGCTCTGTGGAATTTTGAAGTGCCTTTTGTGAATCATGAATGAAACATTTA
ACTTGAGACCCTTTAAAAAATTCATCCAGAATCTGTTACCCCTTGGGTAGTTTGATGGAACTGAGTTAAGCAGAAGACCCCAGCTGTTTT
CTGGGTAAGCCAGGCTTTGCTGTATCTGGCAGTCAGGAGAGAGGTCAGCCCATGGTGGAGGTCTTCAGTGCCGAGGGCTCGGATGAGAAC
GTGTAGTTCTTTGACTTGGACCTGGGCAGCGTCTTCTATGGATGCCTGCCTTGTGAGCACCCACACCTTCCCTCCCCACTGTCGGGTTGA
GTAGCCCCAGCGTGGCTGTGTTAGGAGTCCTTTGCCCAACATTGTGCTGCACTGGAGCCTGGCCCTGGCACTGTCCTCAGGACCCTGCCC
AAGGGCCCACCGCAGAGCACACCTATGCTATGGGGAGCCCTGCTGGCAGCCCCGAGAGCCATGCCATGGCCTGCAGGAGCCAGGCTCCTG
TGTGGATGAAGTCCCTCTTCCTCTGTGCCTTGATCCCTTGGGGGTGCCTTTGGTCATCTCTTCTGTCCTTTCCTGTCTCTGAAATAGTCA
TCACTCCCCTTGACTCTCTCTGTTCACGTCTTCTCAGTCTGCAGAGTTAACTTCTGTAAGGAGTTTAATCTGGGGTTCCAAGAAAACAAG
TTCCTTGTTAACATAGCACTGACTTTGCAACAATAGAAAACTAACAAATGAGCAACAATATAAAGAGTAGAGGTAGTTCTCATTGGGTGT
AACTTCAACCCATTCTGCTTGTGGTTAGAATTTATAATTTTGCTAACGATGTAATTTACTAAGGTTTGAAATGGTATTCTAACAGTGAGT
CCATTGTCTTGAGGATTAATCTGATTTATAAGTAATACTGATAGACATATTTTCGTACATCTGAGCAGAAATAAATGCATGTTTCTAGCA
TATGTAATATAAAAACTCCAGAGGATAAGTTTACACTTAACAAGATGTTGTTTTCTATTTTTGAATTTCTTATTATTTCCCCCTTTTTGG
TAGTGGAGTTGAGAGGGGGAGCATACTATTTGTATAAAGAACTGTCACCCCAGAGTGACATTTATTTTCCAAGATGACCCTGAACTCATG
CTGTTGGTTTCATATGGTGTTTGTGTGCTTTGCCTAGATTCAAGGCCTGAGGATTTGAGGAAAATCGGGATTTTTTTTTTCCTATTTGGT
TTTCATGTAAAAGTTCTAAATGTCACTTATTTTGCTAAATAAGACCCTTTCACAGGATAGTGTGCGCAATACCTGTCCGTGTTTCCAAGC
AGAGTTCAAGTTCATGTCTTCACAAGTAGATGAGAGTCACTTCCAGTCGGGGGAAGCCCGCCTGAGCAGTGTTTTGAGAGTGCGTACATT
GGAGGACTGCCCCACGTCCGTTTGCACTCTGCCTTGCAAAACTTACTGTGGAGACGTGTCCCAGACTGGTCTCAGACCAGAGTTTGTGGC
ACAGGAAAACCTGGCCCCCTAAAAAGAAGTTTTGGAATTGGAAGCCTGATAATTTCGGGAGGCTGAGGCAGGAGAACGGCGTGAACCCGG
GAGGCGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCCCAAAAAAAAAAAAAAA
AAAAAAAAAAAGGAAACCTGACAATTCTACCCACCTCCCCCCACCCCCGACTATAGGCAAAGAGAGTTGATCACTTCCAGGGTCTCTGAC
TTCTGTGACCTGGAAATCAGCCTGGCTTGGGAAATTCATGTTGTTGATCTTTAATTATTTAATTATTCTTTAATAATCCTTCTATTTTCT
TGACATCTGACCCCCAGCAAGAGTAAGGATCCCAGAGGTCAAAACAGTGGTGAGAGCCAAGCTGCTCACAGACACCCACTTGATGCCACA
GCCATGCCATGAGGCTTCCTCCCAGCTGCTCTGCTGGCTTGCTGAAGCCAGCTCTGAGTCACAGGGTTGCCTTGGACCCTCGGCTGTAGG
GGGCACCTGTCTGGCTCCGGGCCCTTTGTCCTGGATACACTGACAGTAATGTGAGCGCAGCACTTCAGAGTTCAGGCCCAGCAGGTCCTG
GCAAGTGCATTCCACCCGAACTTTTAACCCAAGCGGTGGGGAAGGAAGCCAAAACTCCAAGCTGCACTTTCTTGGGGTTCTGGCCATGCA
CTTCTTAGCCTTCTCTCTGACTTTACAGGACAAAAGGTACCCCACGCCTTCAGAATCATGCTTACCTGCACGGCAGCATCTGACTGGATG
GCTGGCTAGGTCTCATCCACCCCAAATTACTGACCCTTGATTTATGTTGTTACTGCTCAGGTTATGCTCAGATGCCCTGGTTGCCTGAAG
ATGGTTTAAGTGCAGGCCCTTCAGACAAGTCACGTCAGGCAAGAGAGGGCTGGCCTCTGACCCACAAGAGGGCAGATTTGTGGCCAAGAG
GCTTCCTGGCATCCACCCCCAGGCCCAAGGGATCAGTGTGGTGCCAGAGAGGATCTTTAAGCTGGGACTGTACTGAGGCTTGATGGGAAG
TATGGGCAGCATGTACTTGACACGTTATCACCCAGTCCCCTTGTAAAATCTGGAATGGAGCGTTTAAGCTGAGCGTTAGCATCAGGTCAG
CAGGCAAAGCAAACCTCCCACAAACTGGGTGCCGTAAGGTGGGAGGTGACACATGGAGAGCTTCGTCCTGGCCGAGCAGGCACCCAGCCC
CATGTCCCCCGCCAGCATTCTGGATGTCAGAGGAGGGTGCGTGTGATGGCGTCACATTCATCTGAAGCACACTGATTGATTTTCCACAAG
GTGGCAAGTTTGATCAAATTGACCGCTTTTCATGAGACACCCAGATGCTGTAAAAAAAAAAAACAGCACTGGGATGTGTTGAGGAGGGGG
CAGTTTGCTGTGCTCTGTTCTGTCTGCTGCTCTCTCTGGGGGCCGCACAATGTCCGCACACATCACGGAGGGGAGAAAGGCATCAGTACC
AAACGGAACAACCTCTTTTTTCTACATTGTCCATACCCGGACATGTGAGGCTCTATTATCAACAGGTGGTGAGAAAAATTATGTTTTTAT
TCGCTTTCTGGTAACTTCTGTAGGCCCTGGCTCAAGGACTTAGCATTTCGTCTCATGTACATCTTTTTCTTAAGTGTTCTTTGCCATTTC
TGGAATTGTCCTTGGTTTTTCCTTAGCTCATAGGTCATAGATGCAGAAATATAGTATTTAAGGCATCCGCATCCAGCATCAGATGGCTTT
GCATCCAGAAAAACATTGATAACTCAGTTTGAAGCACCAAGCATGTGTAATATGGCTCTATACAATATAATAAATGCATAATGTTAAGCT


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FusionGenePPI for IGF2_YY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IGF2NOV, IGFBP7, IGFBP1, TF, IGFBP3, VTN, IDE, IGFBP6, IGFBP4, IGFBP5, BAG6, NMRK2, FAF1, PCSK4, RBPMSYY1FKBP1A, YAF2, MTA2, NOTCH1, SAP30, HDAC1, HDAC2, HDAC3, KAT2B, EP300, FKBP3, RYBP, SP1, SREBF1, MYC, ATF6, PPIA, CTCF, HDAC4, ATF2, ZNF232, HOXA11, MAX, CREBBP, HDAC5, TP53, MDM2, CDKN2A, SMAD4, SMAD1, SMAD2, SMAD3, PRMT1, ILF3, NPM1, TFAP2A, EZH2, INO80, TFCP2, PRKDC, ACTR8, HSPA4, ACTR5, ACTL6A, RUVBL1, RUVBL2, RELB, YY1, JUNB, JUND, RB1, NFE2L2, MECP2, TERF1, TERF2, INO80C, INO80E, NFRKB, TCF3, INO80B, UCHL5, INO80D, MCRS1, TFPT, HSPA5, BCL6, NEDD4, UHRF2, CREB1, ATF7, BAP1, HCFC1, NEDD4L, XRCC6, XRCC5, SMARCAD1, DDX5, DDX3X, SP3, PSMD9, SKP2, ELAVL1, EED, APP, ZNF830, NHP2L1, ZNF638, NCL, WDHD1, ZNF24, ARRB1, RING1, RNF2, PCGF2, LAMC2, GABPB1, GABPA, SLC39A7, CRKL, GRN, NFKB1, RAF1, TESK1, NR1H2, SPRY1, SHFM1, SMURF2, SUZ12, BMI1, TWIST1, PPP1R3B, TMEM150A, TRPV5, CEP164, BAX, FOXB1, FOXJ2, FOXL1, FOXN1, KMT2E, DNMT3L, AURKA, ID2, F9, TRIM25, AGO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGF2_YY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGF2_YY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGF2C0004903Beckwith-Wiedemann Syndrome2CTD_human
HgeneIGF2C0015934Fetal Growth Retardation2CTD_human;HPO
HgeneIGF2C0036341Schizophrenia2PSYGENET
HgeneIGF2C0206686Adrenocortical carcinoma2CTD_human;HPO
HgeneIGF2C2239176Liver carcinoma2CTD_human;HPO
HgeneIGF2C0000786Spontaneous abortion1CTD_human
HgeneIGF2C0002395Alzheimer's Disease1CTD_human
HgeneIGF2C0002871Anemia1CTD_human
HgeneIGF2C0004153Atherosclerosis1CTD_human
HgeneIGF2C0004352Autistic Disorder1CTD_human
HgeneIGF2C0005941Bone Diseases, Developmental1CTD_human
HgeneIGF2C0009241Cognition Disorders1CTD_human
HgeneIGF2C0009375Colonic Neoplasms1CTD_human
HgeneIGF2C0009404Colorectal Neoplasms1CTD_human
HgeneIGF2C0018273Growth Disorders1CTD_human
HgeneIGF2C0019284Diaphragmatic Hernia1CTD_human
HgeneIGF2C0020224Polyhydramnios1CTD_human
HgeneIGF2C0020615Hypoglycemia1CTD_human
HgeneIGF2C0023903Liver neoplasms1CTD_human
HgeneIGF2C0025261Memory Disorders1CTD_human
HgeneIGF2C0027708Nephroblastoma1CTD_human;HPO
HgeneIGF2C0027746Nerve Degeneration1CTD_human
HgeneIGF2C0028754Obesity1CTD_human
HgeneIGF2C0030567Parkinson Disease1CTD_human
HgeneIGF2C0032045Placenta Disorders1CTD_human
HgeneIGF2C0032927Precancerous Conditions1CTD_human
HgeneIGF2C0035412Rhabdomyosarcoma1CTD_human
HgeneIGF2C0175693Russell-Silver syndrome1CTD_human
HgeneIGF2C0206624Hepatoblastoma1CTD_human;HPO
HgeneIGF2C0678807prenatal alcohol exposure1PSYGENET
HgeneIGF2C0752347Lewy Body Disease1CTD_human
TgeneYY1C0007873Uterine Cervical Neoplasm1CTD_human
TgeneYY1C0019693HIV Infections1CTD_human
TgeneYY1C3714756Intellectual Disability1CTD_human