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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 17175

FusionGeneSummary for IGF2_MTHFD1

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2_MTHFD1
Fusion gene ID: 17175
HgeneTgene
Gene symbol

IGF2

MTHFD1

Gene ID

3481

4522

Gene nameinsulin like growth factor 2methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
SynonymsC11orf43|GRDF|IGF-II|PP9974CIMAH|MTHFC|MTHFD
Cytomap

11p15.5

14q23.3

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptinC-1-tetrahydrofolate synthase, cytoplasmic5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetaseC1-THF synthasecytoplasmic C-1-tetrahydrofolate synthasemethylenetetrahydrofolat
Modification date2018052720180523
UniProtAcc

P01344

P11586

Ensembl transtripts involved in fusion geneENST00000381395, ENST00000381406, 
ENST00000416167, ENST00000300632, 
ENST00000434045, ENST00000381392, 
ENST00000381389, ENST00000418738, 
ENST00000545908, ENST00000216605, 
ENST00000556284, 
Fusion gene scores* DoF score10 X 5 X 8=4007 X 7 X 4=196
# samples 127
** MAII scorelog2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGF2 [Title/Abstract] AND MTHFD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGF2

GO:0008284

positive regulation of cell proliferation

28873464

HgeneIGF2

GO:0042104

positive regulation of activated T cell proliferation

15694994

HgeneIGF2

GO:0043410

positive regulation of MAPK cascade

11500939

HgeneIGF2

GO:0045840

positive regulation of mitotic nuclear division

11500939

HgeneIGF2

GO:0046628

positive regulation of insulin receptor signaling pathway

11500939

HgeneIGF2

GO:0051897

positive regulation of protein kinase B signaling

11500939


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-NG-A4VU-01AIGF2chr11

2150351

-MTHFD1chr14

64891522

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000381395ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000381395ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-intronENST00000381395ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000381406ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000381406ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-intronENST00000381406ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000416167ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000416167ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-intronENST00000416167ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+
In-frameENST00000300632ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
In-frameENST00000300632ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
5CDS-intronENST00000300632ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000434045ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000434045ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-intronENST00000434045ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000381392ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000381392ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-intronENST00000381392ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000381389ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000381389ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-intronENST00000381389ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000418738ENST00000545908IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-3CDSENST00000418738ENST00000216605IGF2chr11

2150351

-MTHFD1chr14

64891522

+
intron-intronENST00000418738ENST00000556284IGF2chr11

2150351

-MTHFD1chr14

64891522

+

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FusionProtFeatures for IGF2_MTHFD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2

P01344

MTHFD1

P11586


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IGF2_MTHFD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_IGF2_ENST00000300632_chr11_2150351_-_MTHFD1_ENST00000545908_chr14_64891522_+_722aa
MIKNQMGEKLWVMWHTTRPKRGRASSLLFLAAXGPXQLQCSCRAQXRVPSVSWRNLSQESGXFSITTLTSRHLFQVTLIYHDLVNRSPLV
SWLEKLVCCLKRXNYMVKQRPKFCCQHXNAXSTGLMGNTWWXLEXLQHPWEKGKAQLQSGXCKPLVPISTRMSLRVCDSLLRAPPLEXKV
ALQEAATPRSFLWKSLISTSQVTSMPSLQLITSLLRPLMLGYFMNXPRQTRLSLIVWCHQXMEXEGSLTSKSEGXRDXALKRLTLPHXQM
KRXTDLQDWTLIQKPXLGKECWIPMIDSXGRSRLDRLQRRRVTHGRPSLISLWPVKLWLSWLSPLLXKTXERDWAKWWWHPVRKESPSVP
KIWGXVVHXQCLXRTQSSPISCRHWRALQCLSMLARLPTSHMAIPPSLQTGSHSSLLAQKGLXXRKQDLEQTLEWKSFLTSNAGIPASAP
TWWCLLPLSGLSRCTGAAPRSLLDCLFPRLTYRRTWSWLKKASVTXRNKLKMPECLEFQXXWPXMHSRRIQSLSWTSSAAFPENMGLLMP
XSALTGQKGARVPXPWLRPSREQHKHPAASSSFMTSSSQLRIKSGSLHRRSMEQMTLNYFPKLNTKLKSTRSRALGISPSAWLKHTCLCL
TTQSKKVSLQASFCPFATSAPALGLVFCTPXXERSPSIFKKLLXKSGQCLFRPTGSXEVXVSQEKSAPAQKIXNXXXEFPQKSFSALILI

>In-frame_IGF2_ENST00000300632_chr11_2150351_-_MTHFD1_ENST00000216605_chr14_64891522_+_693aa
MIKNQMGEKLWVMWHTTRPKRGRASSLLFLAAXGPXQLQCSCRAQXRVPSVSWRNLSQESGXFSITTLTSRHLFQVTLIYHDLVNRSPLV
SWLEKLVCCLKRXNYMVKQRPKFCCQHXNAXSTGLMGNTWWXLEXLQHPWEKGKAQLQSGXCKPLVPISTRMSLRVCDSLLRAPPLEXKV
ALQEAATPRSFLWKSLISTSQVTSMPSLQLITSLLRPLMLGYFMNXPRQTRLSLIVWCHQXMEXEGSLTSKSEGXRDXALKRLTLPHXQM
KRXTDLQDWTLIQKPXLGKECWIPMIDSXGRSRLDRLQRRRVTHGRPSLISLWPVKLWLSWLSPLLXKTXERDWAKWWWHPVRKESPSVP
KIWGXVVHXQCLXRTQSSPISCRHWRALQCLSMLARLPTSHMAIPPSLQTGSHSSLLAQKGLXXRKQDLEQTLEWKSFLTSNAGIPASAP
TWWCLLPLSGLSRCTGAAPRSLLDCLFPRLTYRRTWSWLKKASVTXRNKLKMPECLEFQXXWPXMHSRRIQSLSWTSSAAFPENMGLLMP
XSALTGQKGARVPXPWLRPSREQHKHPAASSSFMTSSSQLRIKSGSLHRRSMEQMTLNYFPKLNTKLKSTRSRALGISPSAWLKHTCLCL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_IGF2_ENST00000300632_chr11_2150351_-_MTHFD1_ENST00000545908_chr14_64891522_+_2168nt
ATGATAAAAAACCAAATGGGAGAAAAGTTGTGGGTGATGTGGCATACGACGAGGCCAAAGAGAGGGCGAGCTTCATCACTCCTGTTCCTG
GCGGCGTAGGGCCCATGACAGTTGCAATGCTCATGCAGAGCACAGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAAGCCAGGAAAGT
GGATGATTCAGTATAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATTGATATATCACGATCTTGTAAACCGAAGCCCATTGGTA
AGCTGGCTCGAGAAATTGGTCTGCTGTCTGAAGAGGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACTAGAACGCC
TGAAGCACCGGCCTGATGGGAAATACGTGGTGGTGACTGGAATAACTCCAACACCCCTGGGAGAAGGGAAAAGCACAACTACAATCGGGC
TAGTGCAAGCCCTTGGTGCCCATCTCTACCAGAATGTCTTTGCGTGTGTGCGACAGCCTTCTCAGGGCCCCACCTTTGGAATAAAAGGTG
GCGCTGCAGGAGGCGGCTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTCCACCTCACAGGTGACATCCATGCCATCACTGCAGCTA
ATAACCTCGTTGCTGCGGCCATTGATGCTCGGATATTTCATGAACTGACCCAGACAGACAAGGCTCTCTTTAATCGTTTGGTGCCATCAG
TAAATGGAGTGAGAAGGTTCTCTGACATCCAAATCCGAAGGTTAAAGAGACTAGGCATTGAAAAGACTGACCCTACCACACTGACAGATG
AAGAGATAAACAGATTTGCAAGATTGGACATTGATCCAGAAACCATAACTTGGCAAAGAGTGTTGGATACCAATGATAGATTCCTGAGGA
AGATCACGATTGGACAGGCTCCAACGGAGAAGGGTCACACACGGACGGCCCAGTTTGATATCTCTGTGGCCAGTGAAATTATGGCTGTCC
TGGCTCTCACCACTTCTCTAGAAGACATGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGAGAGCCCGTCAGTGCCG
AAGATCTGGGGGTGAGTGGTGCACTGACAGTGCTTATGAAGGACGCAATCAAGCCCAATCTCATGCAGACACTGGAGGGCACTCCAGTGT
TTGTCCATGCTGGCCCGTTTGCCAACATCGCACATGGCAATTCCTCCATCATTGCAGACCGGATCGCACTCAAGCTTGTTGGCCCAGAAG
GGTTTGTAGTGACGGAAGCAGGATTTGGAGCAGACATTGGAATGGAAAAGTTTTTTAACATCAAATGCCGGTATTCCGGCCTCTGCCCCC
ACGTGGTGGTGCTTGTTGCCACTGTCAGGGCTCTCAAGATGCACGGGGGCGGCCCCACGGTCACTGCTGGACTGCCTCTTCCCAAGGCTT
ACATACAGGAGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAACAAATTGAAAATGCCAGAATGTTTGGAATTCCAGTAG
TAGTGGCCGTGAATGCATTCAAGACGGATACAGAGTCTGAGCTGGACCTCATCAGCCGCCTTTCCAGAGAACATGGGGCTTTTGATGCCG
TGAAGTGCACTCACTGGGCAGAAGGGGGCAAGGGTGCCTTAGCCCTGGCTCAGGCCGTCCAGAGAGCAGCACAAGCACCCAGCAGCTTCC
AGCTCCTTTATGACCTCAAGCTCCCAGTTGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGATGACATTGAATTACTTC
CCGAAGCTCAACACAAAGCTGAAGTCTACACGAAGCAGGGCTTTGGGAATCTCCCCATCTGCATGGCTAAAACACACTTGTCTTTGTCTC
ACAACCCAGAGCAAAAAGGTGTCCCTACAGGCTTCATTCTGCCCATTCGCGACATCCGCGCCAGCGTTGGGGCTGGTTTTCTGTACCCCT
TAGTAGGAACGATCACCATCCATCTTCAAGAAGCTACTTTGAAAGTCTGGCCAGTGTCTATTCAGGCCCACTGGGAGTTAGGAAGTATAA
GTAAGCCAAGAGAAGTCAGCCCCTGCCCAGAAGATCTGAAACTAATAGTAGGAGTTTCCCCAGAAGTCATTTTCAGCCTTAATTCTCATC

>In-frame_IGF2_ENST00000300632_chr11_2150351_-_MTHFD1_ENST00000216605_chr14_64891522_+_2081nt
ATGATAAAAAACCAAATGGGAGAAAAGTTGTGGGTGATGTGGCATACGACGAGGCCAAAGAGAGGGCGAGCTTCATCACTCCTGTTCCTG
GCGGCGTAGGGCCCATGACAGTTGCAATGCTCATGCAGAGCACAGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAAGCCAGGAAAGT
GGATGATTCAGTATAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATTGATATATCACGATCTTGTAAACCGAAGCCCATTGGTA
AGCTGGCTCGAGAAATTGGTCTGCTGTCTGAAGAGGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACTAGAACGCC
TGAAGCACCGGCCTGATGGGAAATACGTGGTGGTGACTGGAATAACTCCAACACCCCTGGGAGAAGGGAAAAGCACAACTACAATCGGGC
TAGTGCAAGCCCTTGGTGCCCATCTCTACCAGAATGTCTTTGCGTGTGTGCGACAGCCTTCTCAGGGCCCCACCTTTGGAATAAAAGGTG
GCGCTGCAGGAGGCGGCTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTCCACCTCACAGGTGACATCCATGCCATCACTGCAGCTA
ATAACCTCGTTGCTGCGGCCATTGATGCTCGGATATTTCATGAACTGACCCAGACAGACAAGGCTCTCTTTAATCGTTTGGTGCCATCAG
TAAATGGAGTGAGAAGGTTCTCTGACATCCAAATCCGAAGGTTAAAGAGACTAGGCATTGAAAAGACTGACCCTACCACACTGACAGATG
AAGAGATAAACAGATTTGCAAGATTGGACATTGATCCAGAAACCATAACTTGGCAAAGAGTGTTGGATACCAATGATAGATTCCTGAGGA
AGATCACGATTGGACAGGCTCCAACGGAGAAGGGTCACACACGGACGGCCCAGTTTGATATCTCTGTGGCCAGTGAAATTATGGCTGTCC
TGGCTCTCACCACTTCTCTAGAAGACATGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGAGAGCCCGTCAGTGCCG
AAGATCTGGGGGTGAGTGGTGCACTGACAGTGCTTATGAAGGACGCAATCAAGCCCAATCTCATGCAGACACTGGAGGGCACTCCAGTGT
TTGTCCATGCTGGCCCGTTTGCCAACATCGCACATGGCAATTCCTCCATCATTGCAGACCGGATCGCACTCAAGCTTGTTGGCCCAGAAG
GGTTTGTAGTGACGGAAGCAGGATTTGGAGCAGACATTGGAATGGAAAAGTTTTTTAACATCAAATGCCGGTATTCCGGCCTCTGCCCCC
ACGTGGTGGTGCTTGTTGCCACTGTCAGGGCTCTCAAGATGCACGGGGGCGGCCCCACGGTCACTGCTGGACTGCCTCTTCCCAAGGCTT
ACATACAGGAGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAACAAATTGAAAATGCCAGAATGTTTGGAATTCCAGTAG
TAGTGGCCGTGAATGCATTCAAGACGGATACAGAGTCTGAGCTGGACCTCATCAGCCGCCTTTCCAGAGAACATGGGGCTTTTGATGCCG
TGAAGTGCACTCACTGGGCAGAAGGGGGCAAGGGTGCCTTAGCCCTGGCTCAGGCCGTCCAGAGAGCAGCACAAGCACCCAGCAGCTTCC
AGCTCCTTTATGACCTCAAGCTCCCAGTTGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGATGACATTGAATTACTTC
CCGAAGCTCAACACAAAGCTGAAGTCTACACGAAGCAGGGCTTTGGGAATCTCCCCATCTGCATGGCTAAAACACACTTGTCTTTGTCTC
ACAACCCAGAGCAAAAAGGTGTCCCTACAGGCTTCATTCTGCCCATTCGCGACATCCGCGCCAGCGTTGGGGCTGGTTTTCTGTACCCCT
TAGTAGGAACGATGAGCACAATGCCTGGACTCCCCACCCGGCCCTGTTTTTATGATATTGATTTGGACCCTGAAACAGAACAGGTGAATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_IGF2_ENST00000300632_chr11_2150351_-_MTHFD1_ENST00000545908_chr14_64891522_+_7375nt
CCGCTAATGTACCATGCCCTGGTGCTGGAAAGTGCCTGAGCCAGCTGCCCCAGCGGCCTCAGCACTACCAAGTTGGCACAAAGCTCCCCA
AATTCGGAGGGGCTCAGGGAAACGAGTGGAGGGGATGAGGAGGTGAGGGGTAAACCCATCATTTCAGTTGGCATTTGAGCAGGTGCCATG
CTCAGCGGAGATGAGGCTCTCCCATCTGTAGGGGCCGTATTAACATGCACACTCTAAAAGTGCCCTTCGTTTCTCCAGCCTCAGCTTTGT
CCCTCTCCTCCTCCACGTCAACCTGGCCAGAGGGTCTGGACGCCACAGCCAGGGCACCCCCTGCTTTGGTGGTGACTGCTAATATTGGCC
AGGCCGGCGGATCATCGTCCAGGCAGTTTCGGCAGAGAGCCTTGGGCACCAGTGACTCCCCGGTCCTCTTTATCCACTGTCCAGGAGCTG
CGGGGACTGCGCAGGGACTAGAGTACAGGGGCCGAAGAGTCACCACCGAGCTTGTGTGGGAGGAGGTGGATTCCAGCCCCCAGCCCCAGG
GCTCTGAATCGCTGCCAGCTCAGCCCCCTGCCCAGCCTGCCCCACAGCCTGAGCCCCAGCAGGCCAGAGAGCCCAGTCCTGAGGTGAGCT
GCTGTGGCCTGTGGCCCAGGCGACCCCAGCGCTCCCAGAACTGAGGCTGGCAGCCAGCCCCAGCCTCAGCCCCAACTGCGAGGCAGAGAG
ACACCAATGGGAATCCCAATGGGGAAGTCGATGCTGGTGCTTCTCACCTTCTTGGCCTTCGCCTCGTGCTGCATTGCTGCTTACCGCCCC
AGTGAGACCCTGTGCGGCGGGGAGCTGGTGGACACCCTCCAGTTCGTCTGTGGGGACCGCGGCTTCTACTTCAGCAGGCCCGCAAGCCGT
GTGAGCCGTCGCAGCCGTGGCATCGTTGAGGAGTGCTGTTTCCGCAGCTGTGACCTGGCCCTCCTGGAGACGTACTGTGCTACCCCCGCC
AAGTCCGAGAGGGACGTGTCGACCCCTCCGACCGTGCTTCCGGACAACTTCCCCAGATACCCCGTGGGCAAGTTCTTCCAATATGACACC
TGGAAGCAGTCCACCCAGCGCCTGCGCAGGGGCCTGCCTGCCCTCCTGCGTGCCCGCCGGGGTCACGTGCTCGCCAAGGAGCTCGAGGCG
TTCAGGGAGGCCAAACGTCACCGTCCCCTGATTGCTCTACCCACCCAAGACCCCGCCCACGGGGGCGCCCCCCCAGAGATGGCCAGCAAT
CGGAAGTGAGCAAAACTGCCGCAAGTCTGCAGCCCGGCGCCACCATCCTGCAGCCTCCTCCTGACCACGGACGTTTCCATCAGGTTCCAT
CCCGAAAATCTCTCGGTTCCACGTCCCCCTGGGGCTTCTCCTGACCCAGTCCCCGTGCCCCGCCTCCCCGAAACAGGCTACTCTCCTCGG
CCCCCTCCATCGGGCTGAGGAAGCACAGCAGCATCTTCAAACATGTACAAAATCGATTGGCTTTAAACACCCTTCACATACCCTCCCCCC
AAATTATCCCCAATTATCCCCACACATAAAAAATCAAAACATTAAACTAACCCCCTTCCCCCCCCCCCACAACAACCCTCTTAAAACTAA
TTGGCTTTTTAGAAACACCCCACAAAAGCTCAGAAATTGGCTTTAAAAAAAACAACCACCAAAAAAAATCAATTGGCTAAAAAAAAAAAG
TATTAAAAACGAATTGGCTGAGAAACAATTGGCAAAATAAAGGAATTTGGCACTCCCCACCCCCCTCTTTCTCTTCTCCCTTGGACTTTG
AGTCAAATTGGCCTGGACTTGAGTCCCTGAACCAGCAAAGAGAAAAGAAGGACCCCAGAAATCACAGGTGGGCACGTCGCTGCTACCGCC
ATCTCCCTTCTCACGGGAATTTTCAGGGTAAACTGGCCATCCGAAAATAGCAACAACCCAGACTGGCTCCTCACTCCCTTTTCCATCACT
AAAAATCACAGAGCAGTCAGAGGGACCCAGTAAGACCAAAGGAGGGGAGGACAGAGCATGAAAACCAAAATCCATGCAAATGAAATGTAA
TTGGCACGACCCTCACCCCCAAATCTTACATCTCAATTCCCATCCTAAAAAGCACTCATACTTTATGCATCCCCGCAGCTACACACACAC
AACACACAGCACACGCATGAACACAGCACACACACGAGCACAGCACACACACAAACGCACAGCACACACAGCACACAGATGAGCACACAG
CACACACACAAACGCACAGCACACACACGCACACACATGCACACACAGCACACAAACGCACGGCACACACACGCACACACATGCACACAC
AGCACACACACAAACGCACAGCACACACAAACGCACAGCACACACGCACACACAGCACACACACGAGCACACAGCACACAAACGCACAGC
ACACGCACACACATGCACACACAGCACACACACTAGCACACAGCACACACACAAAGACACAGCACACACATGCACACACAGCACACACAC
GCGAACACAGCACACACGAACACAGCACACACAGCACACACACAAACACAGCACACACATGCACACAGCACACGCACACACAGCACACAC
ATGAACACAGCACACAGCACACACATGCACACACAGCACACACGCATGCACAGCACACATGAACACAGCACACACACAAACACACAGCAC
ACACATGCACACACAGCACACACACTCATGCGCAGCACATACATGAACACAGCTCACAGCACACAAACACGCAGCACACACGTTGCACAC
GCAAGCACCCACCTGCACACACACATGCGCACACACACGCACACCCCCACAAAATTGGATGAAAACAATAAGCATATCTAAGCAACTACG
ATATCTGTATGGATCAGGCCAAAGTCCCGCTAAGATTCTCCAATGTTTTCATGGTCTGAGCCCCGCTCCTGTTCCCATCTCCACTGCCCC
TCGGCCCTGTCTGTGCCCTGCCTCTCAGAGGAGGGGGCTCAGATGGTGCGGCCTGAGTGTGCGGCCGGCGGCATTTGGGATACACCCGTA
GGGTGGGCGGGGTGTGTCCCAGGCCTAATTCCATCTTTCCACCATGACAGAGATGCCCTTGTGAGGCTGGCCTCCTTGGCGCCTGTCCCC
ACGGCCCCCGCAGCGTGAGCCACGATGCTCCCCATACCCCACCCATTCCCGATACACCTTACTTACTGTGTGTTGGCCCAGCCAGAGTGA
GGAAGGAGTTTGGCCACATTGGAGATGGCGGTAGCTGAGCAGACATGCCCCCACGAGTAGCCTGACTCCCTGGTGTGCTCCTGGAAGGAA
GATCTTGGGGACCCCCCCACCGGAGCACACCTAGGGATCATCTTTGCCCGTCTCCTGGGGACCCCCCAAGAAATGTGGAGTCCTCGGGGG
CCGTGCACTGATGCGGGGAGTGTGGGAAGTCTGGCGGTTGGAGGGGTGGGTGGGGGGCAGTGGGGGCTGGGCGGGGGGAGTTCTGGGGTA
GGAAGTGGTCCCGGGAGATTTTGGATGGAAAAGTCAGGAGGATTGACAGCAGACTTGCAGAATTACATAGAGAAATTAGGAACCCCCAAA
TTTCATGTCAATTGATCTATTCCCCCTCTTTGTTTCTTGGGGCATTTTTCCTTTTTTTTTTTTTTTTGTTTTTTTTTTACCCCTCCTTAG
CTTTATGCGCTCAGAAACCAAATTAAACCCCCCCCCCATGTAACAGGGGGGCAGTGACAAAAGCAAGAACGCACGAAGCCAGCCTGGAGA
CCACCACGTCCTGCCCCCCGCCATTTATCGCCCTGATTGGATTTTGTTTTTCATCTGTCCCTGTTGCTTGGGTTGAGTTGAGGGTGGAGC
CTCCTGGGGGGCACTGGCCACTGAGCCCCCTTGGAGAAGTCAGAGGGGAGTGGAGAAGGCCACTGTCCGGCCTGGCTTCTGGGGACAGTG
GCTGGTCCCCAGAAGTCCTGAGGGCGGAGGGGGGGGTTGGGCAGGGTCTCCTCAGGTGTCAGGAGGGTGCTCGGAGGCCACAGGAGGGGG
CTCCTGGCTGGCCTGAGGCTGGCCGGAGGGGAAGGGGCTAGCAGGTGTGTAAACAGAGGGTTCCATCAGGCTGGGGCAGGGTGGCCGCCT
TCCGCACACTTGAGGAACCCTCCCCTCTCCCTCGGTGACATCTTGCCCGCCCCTCAGCACCCTGCCTTGTCTCCAGGAGGTCCGAAGCTC
TGTGGGACCTCTTGGGGGCAAGGTGGGGTGAGGCCGGGGAGTAGGGAGGTCAGGCGGGTCTGAGCCCACAGAGCAGGAGAGCTGCCAGGT
CTGCCCATCGACCAGGTTGCTTGGGCCCCGGAGCCCACGGGTCTGGTGATGCCATAGCAGCCACCACCGCGGCGCCTAGGGCTGCGGCAG
GGACTCGGCCTCTGGGAGGTTTACCTCGCCCCCACTTGTGCCCCCAGCTCAGCCCCCCTGCACGCAGCCCGACTAGCAGTCTAGAGGCCT
GAGGCTTCTGGGTCCTGGTGACGGGGCTGGCATGACCCCGGGGGTCGTCCATGCCAGTCCGCCTCAGTCGCAGAGGGTCCCTCGGCAAGC
GCCCTGTGAGTGGGCCATTCGGAACATTGGACAGAAGCCCAAAGAGCCAAATTGTCACAATTGTGGAACCCACATTGGCCTGAGATCCAA
AACGCTTCGAGGCACCCCAAATTACCTGCCCATTCGTCAGGACACCCACCCACCCAGTGTTATATTCTGCCTCGCCGGAGTGGGTGTTCC
CGGGGGCACTTGCCGACCAGCCCCTTGCGTCCCCAGGTTTGCAGCTCTCCCCTGGGCCACTAACCATCCTGGCCCGGGCTGCCTGTCTGA
CCTCCGTGCCTAGTCGTGGCTCTCCATCTTGTCTCCTCCCCGTGTCCCCAATGTCTTCAGTGGGGGGCCCCCTCTTGGGTCCCCTCCTCT
GCCATCACCTGAAGACCCCCACGCCAAACACTGAATGTCACCTGTGCCTGCCGCCTCGGTCCACCTTGCGGCCCGTGTTTGACTCAACTC
AACTCCTTTAACGCTAATATTTCCGGCAAAATCCCATGCTTGGGTTTTGTCTTTAACCTTGTAACGCTTGCAATCCCAATAAAGCATTAA
AAGTCATGATGATAAAAAACCAAATGGGAGAAAAGTTGTGGGTGATGTGGCATACGACGAGGCCAAAGAGAGGGCGAGCTTCATCACTCC
TGTTCCTGGCGGCGTAGGGCCCATGACAGTTGCAATGCTCATGCAGAGCACAGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAAGCC
AGGAAAGTGGATGATTCAGTATAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATTGATATATCACGATCTTGTAAACCGAAGCC
CATTGGTAAGCTGGCTCGAGAAATTGGTCTGCTGTCTGAAGAGGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACT
AGAACGCCTGAAGCACCGGCCTGATGGGAAATACGTGGTGGTGACTGGAATAACTCCAACACCCCTGGGAGAAGGGAAAAGCACAACTAC
AATCGGGCTAGTGCAAGCCCTTGGTGCCCATCTCTACCAGAATGTCTTTGCGTGTGTGCGACAGCCTTCTCAGGGCCCCACCTTTGGAAT
AAAAGGTGGCGCTGCAGGAGGCGGCTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTCCACCTCACAGGTGACATCCATGCCATCAC
TGCAGCTAATAACCTCGTTGCTGCGGCCATTGATGCTCGGATATTTCATGAACTGACCCAGACAGACAAGGCTCTCTTTAATCGTTTGGT
GCCATCAGTAAATGGAGTGAGAAGGTTCTCTGACATCCAAATCCGAAGGTTAAAGAGACTAGGCATTGAAAAGACTGACCCTACCACACT
GACAGATGAAGAGATAAACAGATTTGCAAGATTGGACATTGATCCAGAAACCATAACTTGGCAAAGAGTGTTGGATACCAATGATAGATT
CCTGAGGAAGATCACGATTGGACAGGCTCCAACGGAGAAGGGTCACACACGGACGGCCCAGTTTGATATCTCTGTGGCCAGTGAAATTAT
GGCTGTCCTGGCTCTCACCACTTCTCTAGAAGACATGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGAGAGCCCGT
CAGTGCCGAAGATCTGGGGGTGAGTGGTGCACTGACAGTGCTTATGAAGGACGCAATCAAGCCCAATCTCATGCAGACACTGGAGGGCAC
TCCAGTGTTTGTCCATGCTGGCCCGTTTGCCAACATCGCACATGGCAATTCCTCCATCATTGCAGACCGGATCGCACTCAAGCTTGTTGG
CCCAGAAGGGTTTGTAGTGACGGAAGCAGGATTTGGAGCAGACATTGGAATGGAAAAGTTTTTTAACATCAAATGCCGGTATTCCGGCCT
CTGCCCCCACGTGGTGGTGCTTGTTGCCACTGTCAGGGCTCTCAAGATGCACGGGGGCGGCCCCACGGTCACTGCTGGACTGCCTCTTCC
CAAGGCTTACATACAGGAGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAACAAATTGAAAATGCCAGAATGTTTGGAAT
TCCAGTAGTAGTGGCCGTGAATGCATTCAAGACGGATACAGAGTCTGAGCTGGACCTCATCAGCCGCCTTTCCAGAGAACATGGGGCTTT
TGATGCCGTGAAGTGCACTCACTGGGCAGAAGGGGGCAAGGGTGCCTTAGCCCTGGCTCAGGCCGTCCAGAGAGCAGCACAAGCACCCAG
CAGCTTCCAGCTCCTTTATGACCTCAAGCTCCCAGTTGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGATGACATTGA
ATTACTTCCCGAAGCTCAACACAAAGCTGAAGTCTACACGAAGCAGGGCTTTGGGAATCTCCCCATCTGCATGGCTAAAACACACTTGTC
TTTGTCTCACAACCCAGAGCAAAAAGGTGTCCCTACAGGCTTCATTCTGCCCATTCGCGACATCCGCGCCAGCGTTGGGGCTGGTTTTCT
GTACCCCTTAGTAGGAACGATCACCATCCATCTTCAAGAAGCTACTTTGAAAGTCTGGCCAGTGTCTATTCAGGCCCACTGGGAGTTAGG
AAGTATAAGTAAGCCAAGAGAAGTCAGCCCCTGCCCAGAAGATCTGAAACTAATAGTAGGAGTTTCCCCAGAAGTCATTTTCAGCCTTAA

>In-frame_IGF2_ENST00000300632_chr11_2150351_-_MTHFD1_ENST00000216605_chr14_64891522_+_7468nt
CCGCTAATGTACCATGCCCTGGTGCTGGAAAGTGCCTGAGCCAGCTGCCCCAGCGGCCTCAGCACTACCAAGTTGGCACAAAGCTCCCCA
AATTCGGAGGGGCTCAGGGAAACGAGTGGAGGGGATGAGGAGGTGAGGGGTAAACCCATCATTTCAGTTGGCATTTGAGCAGGTGCCATG
CTCAGCGGAGATGAGGCTCTCCCATCTGTAGGGGCCGTATTAACATGCACACTCTAAAAGTGCCCTTCGTTTCTCCAGCCTCAGCTTTGT
CCCTCTCCTCCTCCACGTCAACCTGGCCAGAGGGTCTGGACGCCACAGCCAGGGCACCCCCTGCTTTGGTGGTGACTGCTAATATTGGCC
AGGCCGGCGGATCATCGTCCAGGCAGTTTCGGCAGAGAGCCTTGGGCACCAGTGACTCCCCGGTCCTCTTTATCCACTGTCCAGGAGCTG
CGGGGACTGCGCAGGGACTAGAGTACAGGGGCCGAAGAGTCACCACCGAGCTTGTGTGGGAGGAGGTGGATTCCAGCCCCCAGCCCCAGG
GCTCTGAATCGCTGCCAGCTCAGCCCCCTGCCCAGCCTGCCCCACAGCCTGAGCCCCAGCAGGCCAGAGAGCCCAGTCCTGAGGTGAGCT
GCTGTGGCCTGTGGCCCAGGCGACCCCAGCGCTCCCAGAACTGAGGCTGGCAGCCAGCCCCAGCCTCAGCCCCAACTGCGAGGCAGAGAG
ACACCAATGGGAATCCCAATGGGGAAGTCGATGCTGGTGCTTCTCACCTTCTTGGCCTTCGCCTCGTGCTGCATTGCTGCTTACCGCCCC
AGTGAGACCCTGTGCGGCGGGGAGCTGGTGGACACCCTCCAGTTCGTCTGTGGGGACCGCGGCTTCTACTTCAGCAGGCCCGCAAGCCGT
GTGAGCCGTCGCAGCCGTGGCATCGTTGAGGAGTGCTGTTTCCGCAGCTGTGACCTGGCCCTCCTGGAGACGTACTGTGCTACCCCCGCC
AAGTCCGAGAGGGACGTGTCGACCCCTCCGACCGTGCTTCCGGACAACTTCCCCAGATACCCCGTGGGCAAGTTCTTCCAATATGACACC
TGGAAGCAGTCCACCCAGCGCCTGCGCAGGGGCCTGCCTGCCCTCCTGCGTGCCCGCCGGGGTCACGTGCTCGCCAAGGAGCTCGAGGCG
TTCAGGGAGGCCAAACGTCACCGTCCCCTGATTGCTCTACCCACCCAAGACCCCGCCCACGGGGGCGCCCCCCCAGAGATGGCCAGCAAT
CGGAAGTGAGCAAAACTGCCGCAAGTCTGCAGCCCGGCGCCACCATCCTGCAGCCTCCTCCTGACCACGGACGTTTCCATCAGGTTCCAT
CCCGAAAATCTCTCGGTTCCACGTCCCCCTGGGGCTTCTCCTGACCCAGTCCCCGTGCCCCGCCTCCCCGAAACAGGCTACTCTCCTCGG
CCCCCTCCATCGGGCTGAGGAAGCACAGCAGCATCTTCAAACATGTACAAAATCGATTGGCTTTAAACACCCTTCACATACCCTCCCCCC
AAATTATCCCCAATTATCCCCACACATAAAAAATCAAAACATTAAACTAACCCCCTTCCCCCCCCCCCACAACAACCCTCTTAAAACTAA
TTGGCTTTTTAGAAACACCCCACAAAAGCTCAGAAATTGGCTTTAAAAAAAACAACCACCAAAAAAAATCAATTGGCTAAAAAAAAAAAG
TATTAAAAACGAATTGGCTGAGAAACAATTGGCAAAATAAAGGAATTTGGCACTCCCCACCCCCCTCTTTCTCTTCTCCCTTGGACTTTG
AGTCAAATTGGCCTGGACTTGAGTCCCTGAACCAGCAAAGAGAAAAGAAGGACCCCAGAAATCACAGGTGGGCACGTCGCTGCTACCGCC
ATCTCCCTTCTCACGGGAATTTTCAGGGTAAACTGGCCATCCGAAAATAGCAACAACCCAGACTGGCTCCTCACTCCCTTTTCCATCACT
AAAAATCACAGAGCAGTCAGAGGGACCCAGTAAGACCAAAGGAGGGGAGGACAGAGCATGAAAACCAAAATCCATGCAAATGAAATGTAA
TTGGCACGACCCTCACCCCCAAATCTTACATCTCAATTCCCATCCTAAAAAGCACTCATACTTTATGCATCCCCGCAGCTACACACACAC
AACACACAGCACACGCATGAACACAGCACACACACGAGCACAGCACACACACAAACGCACAGCACACACAGCACACAGATGAGCACACAG
CACACACACAAACGCACAGCACACACACGCACACACATGCACACACAGCACACAAACGCACGGCACACACACGCACACACATGCACACAC
AGCACACACACAAACGCACAGCACACACAAACGCACAGCACACACGCACACACAGCACACACACGAGCACACAGCACACAAACGCACAGC
ACACGCACACACATGCACACACAGCACACACACTAGCACACAGCACACACACAAAGACACAGCACACACATGCACACACAGCACACACAC
GCGAACACAGCACACACGAACACAGCACACACAGCACACACACAAACACAGCACACACATGCACACAGCACACGCACACACAGCACACAC
ATGAACACAGCACACAGCACACACATGCACACACAGCACACACGCATGCACAGCACACATGAACACAGCACACACACAAACACACAGCAC
ACACATGCACACACAGCACACACACTCATGCGCAGCACATACATGAACACAGCTCACAGCACACAAACACGCAGCACACACGTTGCACAC
GCAAGCACCCACCTGCACACACACATGCGCACACACACGCACACCCCCACAAAATTGGATGAAAACAATAAGCATATCTAAGCAACTACG
ATATCTGTATGGATCAGGCCAAAGTCCCGCTAAGATTCTCCAATGTTTTCATGGTCTGAGCCCCGCTCCTGTTCCCATCTCCACTGCCCC
TCGGCCCTGTCTGTGCCCTGCCTCTCAGAGGAGGGGGCTCAGATGGTGCGGCCTGAGTGTGCGGCCGGCGGCATTTGGGATACACCCGTA
GGGTGGGCGGGGTGTGTCCCAGGCCTAATTCCATCTTTCCACCATGACAGAGATGCCCTTGTGAGGCTGGCCTCCTTGGCGCCTGTCCCC
ACGGCCCCCGCAGCGTGAGCCACGATGCTCCCCATACCCCACCCATTCCCGATACACCTTACTTACTGTGTGTTGGCCCAGCCAGAGTGA
GGAAGGAGTTTGGCCACATTGGAGATGGCGGTAGCTGAGCAGACATGCCCCCACGAGTAGCCTGACTCCCTGGTGTGCTCCTGGAAGGAA
GATCTTGGGGACCCCCCCACCGGAGCACACCTAGGGATCATCTTTGCCCGTCTCCTGGGGACCCCCCAAGAAATGTGGAGTCCTCGGGGG
CCGTGCACTGATGCGGGGAGTGTGGGAAGTCTGGCGGTTGGAGGGGTGGGTGGGGGGCAGTGGGGGCTGGGCGGGGGGAGTTCTGGGGTA
GGAAGTGGTCCCGGGAGATTTTGGATGGAAAAGTCAGGAGGATTGACAGCAGACTTGCAGAATTACATAGAGAAATTAGGAACCCCCAAA
TTTCATGTCAATTGATCTATTCCCCCTCTTTGTTTCTTGGGGCATTTTTCCTTTTTTTTTTTTTTTTGTTTTTTTTTTACCCCTCCTTAG
CTTTATGCGCTCAGAAACCAAATTAAACCCCCCCCCCATGTAACAGGGGGGCAGTGACAAAAGCAAGAACGCACGAAGCCAGCCTGGAGA
CCACCACGTCCTGCCCCCCGCCATTTATCGCCCTGATTGGATTTTGTTTTTCATCTGTCCCTGTTGCTTGGGTTGAGTTGAGGGTGGAGC
CTCCTGGGGGGCACTGGCCACTGAGCCCCCTTGGAGAAGTCAGAGGGGAGTGGAGAAGGCCACTGTCCGGCCTGGCTTCTGGGGACAGTG
GCTGGTCCCCAGAAGTCCTGAGGGCGGAGGGGGGGGTTGGGCAGGGTCTCCTCAGGTGTCAGGAGGGTGCTCGGAGGCCACAGGAGGGGG
CTCCTGGCTGGCCTGAGGCTGGCCGGAGGGGAAGGGGCTAGCAGGTGTGTAAACAGAGGGTTCCATCAGGCTGGGGCAGGGTGGCCGCCT
TCCGCACACTTGAGGAACCCTCCCCTCTCCCTCGGTGACATCTTGCCCGCCCCTCAGCACCCTGCCTTGTCTCCAGGAGGTCCGAAGCTC
TGTGGGACCTCTTGGGGGCAAGGTGGGGTGAGGCCGGGGAGTAGGGAGGTCAGGCGGGTCTGAGCCCACAGAGCAGGAGAGCTGCCAGGT
CTGCCCATCGACCAGGTTGCTTGGGCCCCGGAGCCCACGGGTCTGGTGATGCCATAGCAGCCACCACCGCGGCGCCTAGGGCTGCGGCAG
GGACTCGGCCTCTGGGAGGTTTACCTCGCCCCCACTTGTGCCCCCAGCTCAGCCCCCCTGCACGCAGCCCGACTAGCAGTCTAGAGGCCT
GAGGCTTCTGGGTCCTGGTGACGGGGCTGGCATGACCCCGGGGGTCGTCCATGCCAGTCCGCCTCAGTCGCAGAGGGTCCCTCGGCAAGC
GCCCTGTGAGTGGGCCATTCGGAACATTGGACAGAAGCCCAAAGAGCCAAATTGTCACAATTGTGGAACCCACATTGGCCTGAGATCCAA
AACGCTTCGAGGCACCCCAAATTACCTGCCCATTCGTCAGGACACCCACCCACCCAGTGTTATATTCTGCCTCGCCGGAGTGGGTGTTCC
CGGGGGCACTTGCCGACCAGCCCCTTGCGTCCCCAGGTTTGCAGCTCTCCCCTGGGCCACTAACCATCCTGGCCCGGGCTGCCTGTCTGA
CCTCCGTGCCTAGTCGTGGCTCTCCATCTTGTCTCCTCCCCGTGTCCCCAATGTCTTCAGTGGGGGGCCCCCTCTTGGGTCCCCTCCTCT
GCCATCACCTGAAGACCCCCACGCCAAACACTGAATGTCACCTGTGCCTGCCGCCTCGGTCCACCTTGCGGCCCGTGTTTGACTCAACTC
AACTCCTTTAACGCTAATATTTCCGGCAAAATCCCATGCTTGGGTTTTGTCTTTAACCTTGTAACGCTTGCAATCCCAATAAAGCATTAA
AAGTCATGATGATAAAAAACCAAATGGGAGAAAAGTTGTGGGTGATGTGGCATACGACGAGGCCAAAGAGAGGGCGAGCTTCATCACTCC
TGTTCCTGGCGGCGTAGGGCCCATGACAGTTGCAATGCTCATGCAGAGCACAGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAAGCC
AGGAAAGTGGATGATTCAGTATAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATTGATATATCACGATCTTGTAAACCGAAGCC
CATTGGTAAGCTGGCTCGAGAAATTGGTCTGCTGTCTGAAGAGGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACT
AGAACGCCTGAAGCACCGGCCTGATGGGAAATACGTGGTGGTGACTGGAATAACTCCAACACCCCTGGGAGAAGGGAAAAGCACAACTAC
AATCGGGCTAGTGCAAGCCCTTGGTGCCCATCTCTACCAGAATGTCTTTGCGTGTGTGCGACAGCCTTCTCAGGGCCCCACCTTTGGAAT
AAAAGGTGGCGCTGCAGGAGGCGGCTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTCCACCTCACAGGTGACATCCATGCCATCAC
TGCAGCTAATAACCTCGTTGCTGCGGCCATTGATGCTCGGATATTTCATGAACTGACCCAGACAGACAAGGCTCTCTTTAATCGTTTGGT
GCCATCAGTAAATGGAGTGAGAAGGTTCTCTGACATCCAAATCCGAAGGTTAAAGAGACTAGGCATTGAAAAGACTGACCCTACCACACT
GACAGATGAAGAGATAAACAGATTTGCAAGATTGGACATTGATCCAGAAACCATAACTTGGCAAAGAGTGTTGGATACCAATGATAGATT
CCTGAGGAAGATCACGATTGGACAGGCTCCAACGGAGAAGGGTCACACACGGACGGCCCAGTTTGATATCTCTGTGGCCAGTGAAATTAT
GGCTGTCCTGGCTCTCACCACTTCTCTAGAAGACATGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGAGAGCCCGT
CAGTGCCGAAGATCTGGGGGTGAGTGGTGCACTGACAGTGCTTATGAAGGACGCAATCAAGCCCAATCTCATGCAGACACTGGAGGGCAC
TCCAGTGTTTGTCCATGCTGGCCCGTTTGCCAACATCGCACATGGCAATTCCTCCATCATTGCAGACCGGATCGCACTCAAGCTTGTTGG
CCCAGAAGGGTTTGTAGTGACGGAAGCAGGATTTGGAGCAGACATTGGAATGGAAAAGTTTTTTAACATCAAATGCCGGTATTCCGGCCT
CTGCCCCCACGTGGTGGTGCTTGTTGCCACTGTCAGGGCTCTCAAGATGCACGGGGGCGGCCCCACGGTCACTGCTGGACTGCCTCTTCC
CAAGGCTTACATACAGGAGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAACAAATTGAAAATGCCAGAATGTTTGGAAT
TCCAGTAGTAGTGGCCGTGAATGCATTCAAGACGGATACAGAGTCTGAGCTGGACCTCATCAGCCGCCTTTCCAGAGAACATGGGGCTTT
TGATGCCGTGAAGTGCACTCACTGGGCAGAAGGGGGCAAGGGTGCCTTAGCCCTGGCTCAGGCCGTCCAGAGAGCAGCACAAGCACCCAG
CAGCTTCCAGCTCCTTTATGACCTCAAGCTCCCAGTTGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGATGACATTGA
ATTACTTCCCGAAGCTCAACACAAAGCTGAAGTCTACACGAAGCAGGGCTTTGGGAATCTCCCCATCTGCATGGCTAAAACACACTTGTC
TTTGTCTCACAACCCAGAGCAAAAAGGTGTCCCTACAGGCTTCATTCTGCCCATTCGCGACATCCGCGCCAGCGTTGGGGCTGGTTTTCT
GTACCCCTTAGTAGGAACGATGAGCACAATGCCTGGACTCCCCACCCGGCCCTGTTTTTATGATATTGATTTGGACCCTGAAACAGAACA
GGTGAATGGATTATTCTAAACAGATCACCATCCATCTTCAAGAAGCTACTTTGAAAGTCTGGCCAGTGTCTATTCAGGCCCACTGGGAGT
TAGGAAGTATAAGTAAGCCAAGAGAAGTCAGCCCCTGCCCAGAAGATCTGAAACTAATAGTAGGAGTTTCCCCAGAAGTCATTTTCAGCC


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FusionGenePPI for IGF2_MTHFD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IGF2NOV, IGFBP7, IGFBP1, TF, IGFBP3, VTN, IDE, IGFBP6, IGFBP4, IGFBP5, BAG6, NMRK2, FAF1, PCSK4, RBPMSMTHFD1TRAF6, MCC, WRAP73, UBC, MME, HDAC5, PSMA3, FBXO25, CUL3, CUL2, CDK2, DCUN1D1, IARS2, ALDH18A1, SARS2, PRKCDBP, PPT2, ICT1, PC, SNRNP70, CDH2, MRPL49, PRPH, TMEM165, FAF2, MRPL23, SFXN1, RPL32, GAA, DBN1, SF3B3, ACSL3, HSP90AA1, HSP90AB1, VCAM1, CD81, ADRB2, FBXO6, MAT2A, RPS21, UBQLN1, RPA1, RPA2, RPA3, FUS, CUL7, CCDC8, RNF2, ESR1, CA10, ABCF2, CNN1, EIF3G, NLE1, PFKP, PHGDH, RPLP0, PAPOLA, PFKL, PRPF19, RPL35A, RPL7, SAR1A, UBA1, XPNPEP1, NTRK1, GAN, CRY1, CRY2, MCM2, MEX3C, U2AF2, CDC73, ZNF746, SLC7A6OS, DLD, DNM1L, PARK7, SOD1, TRIM25, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGF2_MTHFD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGF2_MTHFD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGF2C0004903Beckwith-Wiedemann Syndrome2CTD_human
HgeneIGF2C0015934Fetal Growth Retardation2CTD_human;HPO
HgeneIGF2C0036341Schizophrenia2PSYGENET
HgeneIGF2C0206686Adrenocortical carcinoma2CTD_human;HPO
HgeneIGF2C2239176Liver carcinoma2CTD_human;HPO
HgeneIGF2C0000786Spontaneous abortion1CTD_human
HgeneIGF2C0002395Alzheimer's Disease1CTD_human
HgeneIGF2C0002871Anemia1CTD_human
HgeneIGF2C0004153Atherosclerosis1CTD_human
HgeneIGF2C0004352Autistic Disorder1CTD_human
HgeneIGF2C0005941Bone Diseases, Developmental1CTD_human
HgeneIGF2C0009241Cognition Disorders1CTD_human
HgeneIGF2C0009375Colonic Neoplasms1CTD_human
HgeneIGF2C0009404Colorectal Neoplasms1CTD_human
HgeneIGF2C0018273Growth Disorders1CTD_human
HgeneIGF2C0019284Diaphragmatic Hernia1CTD_human
HgeneIGF2C0020224Polyhydramnios1CTD_human
HgeneIGF2C0020615Hypoglycemia1CTD_human
HgeneIGF2C0023903Liver neoplasms1CTD_human
HgeneIGF2C0025261Memory Disorders1CTD_human
HgeneIGF2C0027708Nephroblastoma1CTD_human;HPO
HgeneIGF2C0027746Nerve Degeneration1CTD_human
HgeneIGF2C0028754Obesity1CTD_human
HgeneIGF2C0030567Parkinson Disease1CTD_human
HgeneIGF2C0032045Placenta Disorders1CTD_human
HgeneIGF2C0032927Precancerous Conditions1CTD_human
HgeneIGF2C0035412Rhabdomyosarcoma1CTD_human
HgeneIGF2C0175693Russell-Silver syndrome1CTD_human
HgeneIGF2C0206624Hepatoblastoma1CTD_human;HPO
HgeneIGF2C0678807prenatal alcohol exposure1PSYGENET
HgeneIGF2C0752347Lewy Body Disease1CTD_human
TgeneMTHFD1C0027794Neural Tube Defects2CTD_human
TgeneMTHFD1C1866558Neural tube defect, folate-sensitive2CTD_human;UNIPROT
TgeneMTHFD1C0000832Abruptio Placentae1CTD_human
TgeneMTHFD1C0005586Bipolar Disorder1PSYGENET
TgeneMTHFD1C0036341Schizophrenia1PSYGENET