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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17152

FusionGeneSummary for IGF2BP2_IFITM1

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2BP2_IFITM1
Fusion gene ID: 17152
HgeneTgene
Gene symbol

IGF2BP2

IFITM1

Gene ID

10644

8519

Gene nameinsulin like growth factor 2 mRNA binding protein 2interferon induced transmembrane protein 1
SynonymsIMP-2|IMP2|VICKZ29-27|CD225|DSPA2a|IFI17|LEU13
Cytomap

3q27.2

11p15.5

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor 2 mRNA-binding protein 2IGF-II mRNA-binding protein 2IGF2 mRNA-binding protein 2VICKZ family member 2interferon-induced transmembrane protein 1dispanin subfamily A member 2ainterferon-induced protein 17interferon-inducible protein 9-27leu-13 antigen
Modification date2018052020180523
UniProtAcc

Q9Y6M1

P13164

Ensembl transtripts involved in fusion geneENST00000382199, ENST00000421047, 
ENST00000457616, ENST00000346192, 
ENST00000494906, 		ENST00000528780, 
ENST00000328221, ENST00000408968, 
ENST00000525554, 
Fusion gene scores* DoF score6 X 3 X 4=723 X 3 X 3=27
# samples 63
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IGF2BP2 [Title/Abstract] AND IFITM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFITM1

GO:0009615

response to virus

21253575|22479637

TgeneIFITM1

GO:0034341

response to interferon-gamma

21253575

TgeneIFITM1

GO:0035455

response to interferon-alpha

22479637

TgeneIFITM1

GO:0035456

response to interferon-beta

21253575

TgeneIFITM1

GO:0045071

negative regulation of viral genome replication

21253575

TgeneIFITM1

GO:0046597

negative regulation of viral entry into host cell

21253575|23358889


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-ND-A4WF-01AIGF2BP2chr3

185540941

-IFITM1chr11

314164

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000382199ENST00000528780IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000382199ENST00000328221IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000382199ENST00000408968IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-intronENST00000382199ENST00000525554IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-5UTRENST00000421047ENST00000528780IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-5UTRENST00000421047ENST00000328221IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-5UTRENST00000421047ENST00000408968IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-intronENST00000421047ENST00000525554IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000457616ENST00000528780IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000457616ENST00000328221IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000457616ENST00000408968IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-intronENST00000457616ENST00000525554IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000346192ENST00000528780IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000346192ENST00000328221IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-5UTRENST00000346192ENST00000408968IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
5CDS-intronENST00000346192ENST00000525554IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-5UTRENST00000494906ENST00000528780IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-5UTRENST00000494906ENST00000328221IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-5UTRENST00000494906ENST00000408968IGF2BP2chr3

185540941

-IFITM1chr11

314164

+
intron-intronENST00000494906ENST00000525554IGF2BP2chr3

185540941

-IFITM1chr11

314164

+

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FusionProtFeatures for IGF2BP2_IFITM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2BP2

Q9Y6M1

IFITM1

P13164

RNA-binding factor that recruits target transcripts tocytoplasmic protein-RNA complexes (mRNPs). This transcript'caging' into mRNPs allows mRNA transport and transient storage.It also modulates the rate and location at which targettranscripts encounter the translational apparatus and shields themfrom endonuclease attacks or microRNA-mediated degradation (Bysimilarity). Binds to the 5'-UTR of the insulin-like growth factor2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. {ECO:0000250,ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:9891060}. IFN-induced antiviral protein which inhibits the entryof viruses to the host cell cytoplasm, permitting endocytosis, butpreventing subsequent viral fusion and release of viral contentsinto the cytosol. Active against multiple viruses, includinginfluenza A virus, SARS coronavirus (SARS-CoV), Marburg virus(MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus(WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis Cvirus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry andSARS-CoV S protein-mediated viral entry. Also implicated in celladhesion and control of cell growth and migration. Plays a keyrole in the antiproliferative action of IFN-gamma either byinhibiting the ERK activation or by arresting cell growth in G1phase in a p53-dependent manner. Acts as a positive regulator ofosteoblast differentiation. {ECO:0000269|PubMed:16847454,ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853,ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575,ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637,ECO:0000269|PubMed:22634173}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGF2BP2_IFITM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGF2BP2_IFITM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IGF2BP2PUF60, HNRNPA1, MEPCE, CDK9, MYC, ICT1, ELAVL1, ARRB1, SIRT7, CUL3, CAND1, HNRNPD, RAB5A, PPAP2A, PA2G4, FN1, ITGA4, CBX6, CBX8, TARDBP, SAV1, WWOX, EIF2AK2, STAU1, CCDC8, IGF2BP1, OFD1, CCP110, CNTRL, FBF1, DCTN1, MCM2, ZNF746, CDC14A, ELAVL2, RBM3, CYLD, TRIM25, G3BP1IFITM1ABHD16A, CD19, CR2, CD81


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGF2BP2_IFITM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGF2BP2_IFITM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGF2BP2C0036341Schizophrenia1PSYGENET
HgeneIGF2BP2C0221765Chronic schizophrenia1PSYGENET
TgeneIFITM1C0023893Liver Cirrhosis, Experimental1CTD_human