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Fusion gene ID: 17133 |
FusionGeneSummary for IGDCC3_GLDN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGDCC3_GLDN | Fusion gene ID: 17133 | Hgene | Tgene | Gene symbol | IGDCC3 | GLDN | Gene ID | 9543 | 342035 |
| Gene name | immunoglobulin superfamily DCC subclass member 3 | gliomedin | |
| Synonyms | HsT18880|PUNC | CLOM|COLM|CRG-L2|CRGL2|LCCS11|UNC-112 | |
| Cytomap | 15q22.31 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | immunoglobulin superfamily DCC subclass member 3putative neuronal cell adhesion molecule | gliomedincollomincolmedin | |
| Modification date | 20180331 | 20180415 | |
| UniProtAcc | Q8IVU1 | Q6ZMI3 | |
| Ensembl transtripts involved in fusion gene | ENST00000327987, ENST00000559231, | ENST00000335449, ENST00000396399, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/18*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: IGDCC3 [Title/Abstract] AND GLDN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DB-5277-01A | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000327987 | ENST00000335449 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| In-frame | ENST00000327987 | ENST00000396399 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| intron-3CDS | ENST00000559231 | ENST00000335449 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| intron-3CDS | ENST00000559231 | ENST00000396399 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
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FusionProtFeatures for IGDCC3_GLDN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGDCC3 | GLDN |
| Ligand for NRCAM and NFASC/neurofascin that plays a rolein the formation and maintenance of the nodes of Ranvier onmyelinated axons. Mediates interaction between Schwann cellmicrovilli and axons via its interactions with NRCAM and NFASC.Nodes of Ranvier contain clustered sodium channels that arecrucial for the saltatory propagation of action potentials alongmyelinated axons. During development, nodes of Ranvier are formedby the fusion of two heminodes. Required for normal clustering ofsodium channels at heminodes; not required for the formation ofmature nodes with normal sodium channel clusters. Required,together with NRCAM, for maintaining NFASC and sodium channelclusters at mature nodes of Ranvier.{ECO:0000250|UniProtKB:Q8BMF8}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 36_139 | 136 | 815 | Domain | Note=Ig-like C2-type 1 |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000335449 | + | 2 | 10 | 237_264 | 144 | 552 | Compositional bias | Note=Pro-rich |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000396399 | + | 2 | 10 | 237_264 | 20 | 428 | Compositional bias | Note=Pro-rich |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000335449 | + | 2 | 10 | 196_222 | 144 | 552 | Domain | Note=Collagen-like 2 |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000335449 | + | 2 | 10 | 299_546 | 144 | 552 | Domain | Olfactomedin-like |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000396399 | + | 2 | 10 | 137_195 | 20 | 428 | Domain | Note=Collagen-like 1 |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000396399 | + | 2 | 10 | 196_222 | 20 | 428 | Domain | Note=Collagen-like 2 |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000396399 | + | 2 | 10 | 299_546 | 20 | 428 | Domain | Olfactomedin-like |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000396399 | + | 2 | 10 | 40_551 | 20 | 428 | Topological domain | Extracellular |
| Tgene | >GLDN | chr15:65667435 | chr15:51675982 | ENST00000396399 | + | 2 | 10 | 18_39 | 20 | 428 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 783_786 | 136 | 815 | Compositional bias | Note=Poly-Pro |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 140_220 | 136 | 815 | Domain | Note=Ig-like C2-type 2 |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 238_321 | 136 | 815 | Domain | Note=Ig-like C2-type 3 |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 329_416 | 136 | 815 | Domain | Note=Ig-like C2-type 4 |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 426_520 | 136 | 815 | Domain | Fibronectin type-III 1 |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 523_618 | 136 | 815 | Domain | Fibronectin type-III 2 |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 36_640 | 136 | 815 | Topological domain | Extracellular |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 662_814 | 136 | 815 | Topological domain | Cytoplasmic |
| Hgene | >IGDCC3 | chr15:65667435 | chr15:51675982 | ENST00000327987 | - | 2 | 14 | 641_661 | 136 | 815 | Transmembrane | Helical |
| Tgene | GLDN | chr15:65667435 | chr15:51675982 | ENST00000335449 | + | 2 | 10 | 137_195 | 144 | 552 | Domain | Note=Collagen-like 1 |
| Tgene | GLDN | chr15:65667435 | chr15:51675982 | ENST00000335449 | + | 2 | 10 | 1_17 | 144 | 552 | Topological domain | Cytoplasmic |
| Tgene | GLDN | chr15:65667435 | chr15:51675982 | ENST00000335449 | + | 2 | 10 | 40_551 | 144 | 552 | Topological domain | Extracellular |
| Tgene | GLDN | chr15:65667435 | chr15:51675982 | ENST00000396399 | + | 2 | 10 | 1_17 | 20 | 428 | Topological domain | Cytoplasmic |
| Tgene | GLDN | chr15:65667435 | chr15:51675982 | ENST00000335449 | + | 2 | 10 | 18_39 | 144 | 552 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for IGDCC3_GLDN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IGDCC3_ENST00000327987_chr15_65667435_-_GLDN_ENST00000335449_chr15_51675982_+_544aa MAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTL LANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIPGAAGN PGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPGETCAI PNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFIHLPYY FHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFS VVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQFLSTT >In-frame_IGDCC3_ENST00000327987_chr15_65667435_-_GLDN_ENST00000396399_chr15_51675982_+_544aa MAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTL LANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIPGAAGN PGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPGETCAI PNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFIHLPYY FHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFS VVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQFLSTT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IGDCC3_ENST00000327987_chr15_65667435_-_GLDN_ENST00000335449_chr15_51675982_+_1632nt ATGGCTGTGCAGCGCGCCGCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCC GCGCCGAGCGAGGGTCTTGGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTG CTGGACTGCAGGGTGGAGGGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTG CTGGCCAATGGGTCCTTGATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAG AACCGCTTTGGGCTGGTGGTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTG GATGGACAGCCTGGTCCTCAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAAT CCAGGGGAAAGGGGAGAAAAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGAC AAAGGAGATGTGTCCAACGACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGT CCTCCAGGGCCCCCTGGAAGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATA CCAAATGATGATACCTTGGTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGA AACCCAGTGCAAGTACTGAAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACA GAGCATTTTTCAGGCATCATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTAT TTCCATGGCTGTGGGCACGTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAG GAAACATCCCAAACTCTGAAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCT GTAGATGAAAAGGGCCTTTGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCA GTGGTGCAACACGTCAATACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAA GATATGAGGGTCACATTTGCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCC ATGTTAGCATACAACATGAGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACC >In-frame_IGDCC3_ENST00000327987_chr15_65667435_-_GLDN_ENST00000396399_chr15_51675982_+_1632nt ATGGCTGTGCAGCGCGCCGCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCC GCGCCGAGCGAGGGTCTTGGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTG CTGGACTGCAGGGTGGAGGGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTG CTGGCCAATGGGTCCTTGATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAG AACCGCTTTGGGCTGGTGGTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTG GATGGACAGCCTGGTCCTCAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAAT CCAGGGGAAAGGGGAGAAAAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGAC AAAGGAGATGTGTCCAACGACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGT CCTCCAGGGCCCCCTGGAAGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATA CCAAATGATGATACCTTGGTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGA AACCCAGTGCAAGTACTGAAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACA GAGCATTTTTCAGGCATCATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTAT TTCCATGGCTGTGGGCACGTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAG GAAACATCCCAAACTCTGAAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCT GTAGATGAAAAGGGCCTTTGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCA GTGGTGCAACACGTCAATACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAA GATATGAGGGTCACATTTGCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCC ATGTTAGCATACAACATGAGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IGDCC3_ENST00000327987_chr15_65667435_-_GLDN_ENST00000335449_chr15_51675982_+_5143nt AGCGGTGCGAGTGTGGAGCGCGCACCCCGGGCGAGGCTGACAGATCGCCCGGGTGGGTGCAAGATGGCGCAAGCGGCGCTCCCCCTGCGC CCCCCGCGCTGCTGAGCAGGCATGCGGCCCCAGTCCCCCACCGCCTGGGCTCGGCCCCGGCCGGAGCCCCAGCCCCGGCCCCGGCGCCGG CCCCGCGGGACGCTGTGAGCCGCGAGAGGCCCGGGAGCCGCGCGTCGCCGAGCCGAGCTGACCGAGAGCCCCATGGCTGTGCAGCGCGCC GCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCCGCGCCGAGCGAGGGTCTT GGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTGCTGGACTGCAGGGTGGAG GGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTGCTGGCCAATGGGTCCTTG ATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAGAACCGCTTTGGGCTGGTG GTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTGGATGGACAGCCTGGTCCT CAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAATCCAGGGGAAAGGGGAGAA AAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGACAAAGGAGATGTGTCCAAC GACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGTCCTCCAGGGCCCCCTGGA AGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATACCAAATGATGATACCTTG GTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGAAACCCAGTGCAAGTACTG AAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACAGAGCATTTTTCAGGCATC ATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTATTTCCATGGCTGTGGGCAC GTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAGGAAACATCCCAAACTCTG AAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCTGTAGATGAAAAGGGCCTT TGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCAGTGGTGCAACACGTCAAT ACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAAGATATGAGGGTCACATTT GCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCCATGTTAGCATACAACATG AGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACCTTAAATCAGTGATGTGCT GCATTCGGCTCCCTTCAGCAAATTTCAGGGGTTTTCTGGGACCAGTTCTCCCCCAACAGGAAACTTGTTTTTTTAACGTCAGCCAGATAT TTAGAAAATAACCTCAAAAGTGTTTATATGGTCAGTGAGCCCCGCTTAGTGAAATAGCAACAGATTGGAAGTTGAAATGGCTGAGATTTG GTGATCTCCCCACAGCTGGCTCTGCAAGTTACCTCTTTCTCCTTGGGCCTTAGTTTCCCCATTGGTAATCTGAATTGGCTAAGATGATTG GGGAGATTTTCTGTACCTGTAGGTAATTTGGTGATTCTTGGTGGCTGCTCTTCTCACAACTTTTATGTATCTGCTTCTGTCGTTTAGCTT TTTTAGCCACATGCTGACCAAATTTACCTTTGAGTTGATAAGTCCAGTGGCTTGAGTAGTGAATCCCTCAGTGCTGACTTATATCTTGTT CTTTGAAAAAATGCATTGACTCTTTAAGACATCTAAAGTATCACATTATCCATAATTTATTGCTTTTCTTTGCATCTGCACCTGCCACCA CAGAATAACCATTACCCTCAGCTGCTGATTGGGCAGCTCTGAGATTAGCAAAAGCCAGGGACAGCTACATGTTCAGGTTTTTTTTTTTTT TTTTTTTTCAATAAGCTATTTTTTTTCTTTTCTTATTTTAAATAGAGAGAGAGTCTTGCTATGTTTCCCAGGCTGGTCTTGAACTCCTGG GGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAATGCTGGATTACAGGCATGTGTGCCTGGCCCAGGTTTCTTAATAAAACAGAATCAT GATCTTCCAGGTTCCCCCCAGTTTCTGATCATGTTGATTTGTAGCTGTGGATCATGAACACTGAATCCTCAGATCACTCTGACTTCTTAT GCTTCTCCTGTGGATCCACTATCAAAGTACTAAATGCTGTGTAAGTAGACGTTAATCTGGCTGGAACCATGGGAAGCACTTTGCAGTGTT CAGAAGAGAGGCTCCATTTGTGGCTATTATGTAGAACTGGGCCAGAGCCAGTCCATTGCCTGTTTTTTTAAATAAGGTTTTACTGAGCAC AGCCACACTCATTTGTTTATGCAGTACGGCCTGACATTGCTTTTGCTCTGCAACAGCAGAGTCGAGTCATTGCAACAAAGAGCATATGGC CCCACAGTGCCTAAAATATTGACCAGCTACCCCTTTATGGAAAAAGATTGCTGACTCCTGATAAAGAATATAAAGTGAGCCTGATTCTTG AAAAAATCAGAACCAGAGCCTGTTTTGTTTTGTTCTAAACTAAGAAGCCGCATAGGATGTGACTTGCGTTTTGAGTAGAGGGGAAGGCTG ATAACGGCGTAAGATGAAGTGGCCCTCCACAAAGGCTGGTTAGGGGACAGTTCTTTCTCTAACATAGTTTTAAAGGATGTGATCTGGTCC CCTTGGATGCCAGGAGAGAATCCAGTTGAACTTGCTCCTAAATGCTCTTAAATATGCATATTTTCTGCCAACTCACTTCTTTAAACATCT TTCAGCCCAGCGCTGCGGCCCCGGGAAGGGCCACTGCGAATAGAGAGGAAGCTGGAAAAGTTCCTGGGGCTCTGCAGCCAGGAAGGGGAA CCAGGGCAAATCTTATGTAAAGATTTTTCAGCAACTTGTCCCAATTTGTGTGTATTCTGAAACTTTCTCTTTGGGACCAAATTCATTCTC AATGGCCCTGAGTTCAATATATTATTAACAGCAGTATTTTAAAACTTAGGGTTGAACTGGGCATGGTGGCACATAACTGCAATCCCAGCT ACTTTGGAGGCAGGGATGGGAGGATCACTTGAGGCCAGGATCTCAGGACCAGCCTAGAGAGATCCCATCTCTAAAAAATAAAATATAAGA AAATAAAACTTAGGGGATATACAGATTTAAATATTCAAATCTCCCTGCTCCCCTGAAAGTCCCCAGGCAGCTGTCAATGACTTGTTTGTT GTGTTCTCAATATGATGGCTATTTGAAACTTCACCTACTTTTCATTAGATTGGTTGTACCATGTCACCTTAGCTTTTAAAAATACTCTTT TCAGATTCACGTTCTCTAACAAAGAGTCTCATGTTCAAGATCAATATGTCTAATAAGTGCTGGTGTCCTTTTAAAGTATTTAAATATATA TGTTGCTGTTGCTGAATACAGGAGACCAGGTTAGGAATATAGTTTCATAATAATAGTACATACAATACTAATTGTATATAAGGTAGCAAC CAAAAGAGGTTGTTAATTAGCACATATTCCTTTTAGAAAAATGTTTCAGAAACCTCAGTCTTGATATCTGAGCTATCTGGGCTCCCTTAC TTGTGAGTAAGGGATCATGCTCACCACTGGAGAAGCTTACACCGGGACTTTTTTTCTTTTTTCTTTTTTTTTTGCTATGACAGAGTAATG CTAACGTAAGGACAACTGAGTTTGATCAGTGTTTAATCGCAGTGGGTAATCTTATCTGATTGTCTTTAAAAGTGAAAAGGATTAAGATTT TATTCTTTCTTGTAAACATTACTTGATTTTTTAAAGAAGTTTTGGGCTCACTGCTAAAATAGAGTATACAACTGAATGTTTTTAAGTCAA GATACTGTTTTAGGAGTTTACCCTCTCATTTATAACCAAAGTTGCTCTAAAACACTTTCCAAATATCTGCACTTCTGATGTCAGAATCAA ACCAGATAATTCTCTAATTCTTCTTTAATCTAAAGTAGATAGCTTCCCACTGGAAAGTAAACAAAACCATCCCTCCCAACCTCAAAGCTA GGCCACACTCTATTTCAAGGCATTTTCTTTCAGCTGATAAGGTGTCCTCCTGAAGCCAAGTAGGTGGTTCTGGTCTCCAAGTATCGTTAA GCACAGGTGCTATGACAGAAAAAGTTCTGGGGTGGAAGTTTTAAGATGAGGAGTTCTGATCTTAGGCATCTTAACAGTCACAAGGTGAAA AGTCAAATGAAACAGTACAATTCTTGATGAGTGAGGTGTCATCTTCCAACCACACAGAGGACGTTTTGGCTATGATCATCTGATGGCAAG TGAAGGAGAAATGAGTGATAGGGCTTTGCGTTTTCATCCAGATGCTGTGGCCCTGTGTTTCACAGCATTAAGAGCCATAATTTCCAACCT GCACAGATCCTGAACAACAAATGAATAACGATGAATGTCTTTTTGGTTGTAATTTAACAAGTCAAATAAAATAATCATTGCTGAGCACAA >In-frame_IGDCC3_ENST00000327987_chr15_65667435_-_GLDN_ENST00000396399_chr15_51675982_+_5135nt AGCGGTGCGAGTGTGGAGCGCGCACCCCGGGCGAGGCTGACAGATCGCCCGGGTGGGTGCAAGATGGCGCAAGCGGCGCTCCCCCTGCGC CCCCCGCGCTGCTGAGCAGGCATGCGGCCCCAGTCCCCCACCGCCTGGGCTCGGCCCCGGCCGGAGCCCCAGCCCCGGCCCCGGCGCCGG CCCCGCGGGACGCTGTGAGCCGCGAGAGGCCCGGGAGCCGCGCGTCGCCGAGCCGAGCTGACCGAGAGCCCCATGGCTGTGCAGCGCGCC GCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCCGCGCCGAGCGAGGGTCTT GGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTGCTGGACTGCAGGGTGGAG GGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTGCTGGCCAATGGGTCCTTG ATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAGAACCGCTTTGGGCTGGTG GTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTGGATGGACAGCCTGGTCCT CAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAATCCAGGGGAAAGGGGAGAA AAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGACAAAGGAGATGTGTCCAAC GACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGTCCTCCAGGGCCCCCTGGA AGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATACCAAATGATGATACCTTG GTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGAAACCCAGTGCAAGTACTG AAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACAGAGCATTTTTCAGGCATC ATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTATTTCCATGGCTGTGGGCAC GTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAGGAAACATCCCAAACTCTG AAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCTGTAGATGAAAAGGGCCTT TGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCAGTGGTGCAACACGTCAAT ACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAAGATATGAGGGTCACATTT GCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCCATGTTAGCATACAACATG AGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACCTTAAATCAGTGATGTGCT GCATTCGGCTCCCTTCAGCAAATTTCAGGGGTTTTCTGGGACCAGTTCTCCCCCAACAGGAAACTTGTTTTTTTAACGTCAGCCAGATAT TTAGAAAATAACCTCAAAAGTGTTTATATGGTCAGTGAGCCCCGCTTAGTGAAATAGCAACAGATTGGAAGTTGAAATGGCTGAGATTTG GTGATCTCCCCACAGCTGGCTCTGCAAGTTACCTCTTTCTCCTTGGGCCTTAGTTTCCCCATTGGTAATCTGAATTGGCTAAGATGATTG GGGAGATTTTCTGTACCTGTAGGTAATTTGGTGATTCTTGGTGGCTGCTCTTCTCACAACTTTTATGTATCTGCTTCTGTCGTTTAGCTT TTTTAGCCACATGCTGACCAAATTTACCTTTGAGTTGATAAGTCCAGTGGCTTGAGTAGTGAATCCCTCAGTGCTGACTTATATCTTGTT CTTTGAAAAAATGCATTGACTCTTTAAGACATCTAAAGTATCACATTATCCATAATTTATTGCTTTTCTTTGCATCTGCACCTGCCACCA CAGAATAACCATTACCCTCAGCTGCTGATTGGGCAGCTCTGAGATTAGCAAAAGCCAGGGACAGCTACATGTTCAGGTTTTTTTTTTTTT TTTTTTTTCAATAAGCTATTTTTTTTCTTTTCTTATTTTAAATAGAGAGAGAGTCTTGCTATGTTTCCCAGGCTGGTCTTGAACTCCTGG GGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAATGCTGGATTACAGGCATGTGTGCCTGGCCCAGGTTTCTTAATAAAACAGAATCAT GATCTTCCAGGTTCCCCCCAGTTTCTGATCATGTTGATTTGTAGCTGTGGATCATGAACACTGAATCCTCAGATCACTCTGACTTCTTAT GCTTCTCCTGTGGATCCACTATCAAAGTACTAAATGCTGTGTAAGTAGACGTTAATCTGGCTGGAACCATGGGAAGCACTTTGCAGTGTT CAGAAGAGAGGCTCCATTTGTGGCTATTATGTAGAACTGGGCCAGAGCCAGTCCATTGCCTGTTTTTTTAAATAAGGTTTTACTGAGCAC AGCCACACTCATTTGTTTATGCAGTACGGCCTGACATTGCTTTTGCTCTGCAACAGCAGAGTCGAGTCATTGCAACAAAGAGCATATGGC CCCACAGTGCCTAAAATATTGACCAGCTACCCCTTTATGGAAAAAGATTGCTGACTCCTGATAAAGAATATAAAGTGAGCCTGATTCTTG AAAAAATCAGAACCAGAGCCTGTTTTGTTTTGTTCTAAACTAAGAAGCCGCATAGGATGTGACTTGCGTTTTGAGTAGAGGGGAAGGCTG ATAACGGCGTAAGATGAAGTGGCCCTCCACAAAGGCTGGTTAGGGGACAGTTCTTTCTCTAACATAGTTTTAAAGGATGTGATCTGGTCC CCTTGGATGCCAGGAGAGAATCCAGTTGAACTTGCTCCTAAATGCTCTTAAATATGCATATTTTCTGCCAACTCACTTCTTTAAACATCT TTCAGCCCAGCGCTGCGGCCCCGGGAAGGGCCACTGCGAATAGAGAGGAAGCTGGAAAAGTTCCTGGGGCTCTGCAGCCAGGAAGGGGAA CCAGGGCAAATCTTATGTAAAGATTTTTCAGCAACTTGTCCCAATTTGTGTGTATTCTGAAACTTTCTCTTTGGGACCAAATTCATTCTC AATGGCCCTGAGTTCAATATATTATTAACAGCAGTATTTTAAAACTTAGGGTTGAACTGGGCATGGTGGCACATAACTGCAATCCCAGCT ACTTTGGAGGCAGGGATGGGAGGATCACTTGAGGCCAGGATCTCAGGACCAGCCTAGAGAGATCCCATCTCTAAAAAATAAAATATAAGA AAATAAAACTTAGGGGATATACAGATTTAAATATTCAAATCTCCCTGCTCCCCTGAAAGTCCCCAGGCAGCTGTCAATGACTTGTTTGTT GTGTTCTCAATATGATGGCTATTTGAAACTTCACCTACTTTTCATTAGATTGGTTGTACCATGTCACCTTAGCTTTTAAAAATACTCTTT TCAGATTCACGTTCTCTAACAAAGAGTCTCATGTTCAAGATCAATATGTCTAATAAGTGCTGGTGTCCTTTTAAAGTATTTAAATATATA TGTTGCTGTTGCTGAATACAGGAGACCAGGTTAGGAATATAGTTTCATAATAATAGTACATACAATACTAATTGTATATAAGGTAGCAAC CAAAAGAGGTTGTTAATTAGCACATATTCCTTTTAGAAAAATGTTTCAGAAACCTCAGTCTTGATATCTGAGCTATCTGGGCTCCCTTAC TTGTGAGTAAGGGATCATGCTCACCACTGGAGAAGCTTACACCGGGACTTTTTTTCTTTTTTCTTTTTTTTTTGCTATGACAGAGTAATG CTAACGTAAGGACAACTGAGTTTGATCAGTGTTTAATCGCAGTGGGTAATCTTATCTGATTGTCTTTAAAAGTGAAAAGGATTAAGATTT TATTCTTTCTTGTAAACATTACTTGATTTTTTAAAGAAGTTTTGGGCTCACTGCTAAAATAGAGTATACAACTGAATGTTTTTAAGTCAA GATACTGTTTTAGGAGTTTACCCTCTCATTTATAACCAAAGTTGCTCTAAAACACTTTCCAAATATCTGCACTTCTGATGTCAGAATCAA ACCAGATAATTCTCTAATTCTTCTTTAATCTAAAGTAGATAGCTTCCCACTGGAAAGTAAACAAAACCATCCCTCCCAACCTCAAAGCTA GGCCACACTCTATTTCAAGGCATTTTCTTTCAGCTGATAAGGTGTCCTCCTGAAGCCAAGTAGGTGGTTCTGGTCTCCAAGTATCGTTAA GCACAGGTGCTATGACAGAAAAAGTTCTGGGGTGGAAGTTTTAAGATGAGGAGTTCTGATCTTAGGCATCTTAACAGTCACAAGGTGAAA AGTCAAATGAAACAGTACAATTCTTGATGAGTGAGGTGTCATCTTCCAACCACACAGAGGACGTTTTGGCTATGATCATCTGATGGCAAG TGAAGGAGAAATGAGTGATAGGGCTTTGCGTTTTCATCCAGATGCTGTGGCCCTGTGTTTCACAGCATTAAGAGCCATAATTTCCAACCT GCACAGATCCTGAACAACAAATGAATAACGATGAATGTCTTTTTGGTTGTAATTTAACAAGTCAAATAAAATAATCATTGCTGAGCACAA |
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FusionGenePPI for IGDCC3_GLDN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IGDCC3 | GLDN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IGDCC3_GLDN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IGDCC3_GLDN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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