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Fusion gene ID: 17125 |
FusionGeneSummary for IFT81_GLIPR1L2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IFT81_GLIPR1L2 | Fusion gene ID: 17125 | Hgene | Tgene | Gene symbol | IFT81 | GLIPR1L2 | Gene ID | 28981 | 144321 |
| Gene name | intraflagellar transport 81 | GLIPR1 like 2 | |
| Synonyms | CDV-1|CDV-1R|CDV1|CDV1R|DV1|SRTD19 | - | |
| Cytomap | 12q24.11 | 12q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | intraflagellar transport protein 81 homologcarnitine deficiency-associated gene expressed in ventricle 1carnitine deficiency-associated protein expressed in ventricle 1 | GLIPR1-like protein 2GLI pathogenesis related 1 like 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8WYA0 | Q4G1C9 | |
| Ensembl transtripts involved in fusion gene | ENST00000552912, ENST00000242591, ENST00000361948, ENST00000549009, | ENST00000550916, ENST00000378689, ENST00000435775, ENST00000378692, ENST00000320460, ENST00000547164, ENST00000441218, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 5 X 3 X 3=45 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: IFT81 [Title/Abstract] AND GLIPR1L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A3BZ-06A | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000552912 | ENST00000550916 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-intron | ENST00000552912 | ENST00000378689 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-intron | ENST00000552912 | ENST00000435775 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000552912 | ENST00000378692 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000552912 | ENST00000320460 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000552912 | ENST00000547164 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000552912 | ENST00000441218 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| In-frame | ENST00000242591 | ENST00000550916 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-intron | ENST00000242591 | ENST00000378689 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-intron | ENST00000242591 | ENST00000435775 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000242591 | ENST00000378692 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000242591 | ENST00000320460 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000242591 | ENST00000547164 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| 5CDS-5UTR | ENST00000242591 | ENST00000441218 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-3CDS | ENST00000361948 | ENST00000550916 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-intron | ENST00000361948 | ENST00000378689 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-intron | ENST00000361948 | ENST00000435775 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000361948 | ENST00000378692 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000361948 | ENST00000320460 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000361948 | ENST00000547164 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000361948 | ENST00000441218 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-3CDS | ENST00000549009 | ENST00000550916 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-intron | ENST00000549009 | ENST00000378689 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-intron | ENST00000549009 | ENST00000435775 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000549009 | ENST00000378692 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000549009 | ENST00000320460 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000549009 | ENST00000547164 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
| intron-5UTR | ENST00000549009 | ENST00000441218 | IFT81 | chr12 | 110618376 | + | GLIPR1L2 | chr12 | 75804214 | + |
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FusionProtFeatures for IFT81_GLIPR1L2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IFT81 | GLIPR1L2 |
| Component of the intraflagellar transport (IFT) complexB: together with IFT74, forms a tubulin-binding module thatspecifically mediates transport of tubulin within the cilium.Binds tubulin via its CH (calponin-homology)-like region(PubMed:23990561). Required for ciliogenesis (PubMed:27666822,PubMed:23990561). Required for proper regulation of SHH signaling(PubMed:27666822). {ECO:0000269|PubMed:23990561,ECO:0000269|PubMed:27666822}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | IFT81 | chr12:110618376 | chr12:75804214 | ENST00000242591 | + | 12 | 19 | 132_258 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | IFT81 | chr12:110618376 | chr12:75804214 | ENST00000242591 | + | 12 | 19 | 306_389 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | IFT81 | chr12:110618376 | chr12:75804214 | ENST00000552912 | + | 12 | 19 | 132_258 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | IFT81 | chr12:110618376 | chr12:75804214 | ENST00000552912 | + | 12 | 19 | 306_389 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | IFT81 | chr12:110618376 | chr12:75804214 | ENST00000242591 | + | 12 | 19 | 2_121 | 446 | 677 | Region | Note=CH (calponin-homology)-like region |
| Hgene | IFT81 | chr12:110618376 | chr12:75804214 | ENST00000552912 | + | 12 | 19 | 2_121 | 446 | 677 | Region | Note=CH (calponin-homology)-like region |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000320460 | + | 0 | 4 | 292_343 | 78 | 254 | Compositional bias | Note=Glu-rich |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000378689 | + | 0 | 2 | 292_343 | -13 | 107 | Compositional bias | Note=Glu-rich |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000378692 | + | 1 | 7 | 292_343 | -29 | 238 | Compositional bias | Note=Glu-rich |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000435775 | + | 0 | 5 | 292_343 | 78 | 335 | Compositional bias | Note=Glu-rich |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000441218 | + | 0 | 6 | 292_343 | 13 | 280 | Compositional bias | Note=Glu-rich |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000547164 | + | 0 | 3 | 292_343 | 78 | 169 | Compositional bias | Note=Glu-rich |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000550916 | + | 0 | 6 | 292_343 | 78 | 345 | Compositional bias | Note=Glu-rich |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000378689 | + | 0 | 2 | 58_192 | -13 | 107 | Domain | Note=SCP |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000378692 | + | 1 | 7 | 58_192 | -29 | 238 | Domain | Note=SCP |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000441218 | + | 0 | 6 | 58_192 | 13 | 280 | Domain | Note=SCP |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000320460 | + | 0 | 4 | 254_274 | 78 | 254 | Transmembrane | Helical |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000378689 | + | 0 | 2 | 254_274 | -13 | 107 | Transmembrane | Helical |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000378692 | + | 1 | 7 | 254_274 | -29 | 238 | Transmembrane | Helical |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000435775 | + | 0 | 5 | 254_274 | 78 | 335 | Transmembrane | Helical |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000441218 | + | 0 | 6 | 254_274 | 13 | 280 | Transmembrane | Helical |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000547164 | + | 0 | 3 | 254_274 | 78 | 169 | Transmembrane | Helical |
| Tgene | >GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000550916 | + | 0 | 6 | 254_274 | 78 | 345 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000242591 | + | 12 | 19 | 416_456 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000242591 | + | 12 | 19 | 490_622 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000361948 | + | 1 | 12 | 132_258 | -183 | 432 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000361948 | + | 1 | 12 | 306_389 | -183 | 432 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000361948 | + | 1 | 12 | 416_456 | -183 | 432 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000361948 | + | 1 | 12 | 490_622 | -183 | 432 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000552912 | + | 12 | 19 | 416_456 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000552912 | + | 12 | 19 | 490_622 | 446 | 677 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >IFT81 | chr12:110618376 | chr12:75804214 | ENST00000361948 | + | 1 | 12 | 2_121 | -183 | 432 | Region | Note=CH (calponin-homology)-like region |
| Tgene | GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000320460 | + | 0 | 4 | 58_192 | 78 | 254 | Domain | Note=SCP |
| Tgene | GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000435775 | + | 0 | 5 | 58_192 | 78 | 335 | Domain | Note=SCP |
| Tgene | GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000547164 | + | 0 | 3 | 58_192 | 78 | 169 | Domain | Note=SCP |
| Tgene | GLIPR1L2 | chr12:110618376 | chr12:75804214 | ENST00000550916 | + | 0 | 6 | 58_192 | 78 | 345 | Domain | Note=SCP |
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FusionGeneSequence for IFT81_GLIPR1L2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IFT81_ENST00000552912_chr12_110618376_+_GLIPR1L2_ENST00000550916_chr12_75804214_+_713aa MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI KFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLTWDV ALSRTARAWGKKCLFTHNIYLQDVQMVHPKFYGIGENMWVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCA VTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRIL >In-frame_IFT81_ENST00000242591_chr12_110618376_+_GLIPR1L2_ENST00000550916_chr12_75804214_+_713aa MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI KFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLTWDV ALSRTARAWGKKCLFTHNIYLQDVQMVHPKFYGIGENMWVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCA VTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRIL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IFT81_ENST00000552912_chr12_110618376_+_GLIPR1L2_ENST00000550916_chr12_75804214_+_2139nt ATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAG CCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAG ACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTG GTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGT TTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCC TTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAA GAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGG CAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTG CAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGCAAAGCCTGAAAGTTTAATGAAGAGGCTAGAGGAGGAGATA AAATTTAATTTATATATGGTAACTGAAAAATTTCCTAAAGAATTAGAAAATAAGAAAAAGGAATTACATTTTTTACAAAAAGTAGTTTCA GAGCCAGCTATGGGCCATTCTGATCTTCTTGAACTTGAATCTAAAATAAATGAAATAAACACAGAAATTAACCAGTTGATTGAAAAGAAA ATGATGAGAAATGAGCCCATTGAAGGCAAACTCTCACTGTATAGGCAACAGGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGCTGAG GAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGATGGTACTGAA GTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGCTGAA CTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGACTTGGGATGTA GCTTTATCACGGACTGCTAGAGCATGGGGAAAAAAATGTTTGTTTACGCATAATATTTATTTACAAGATGTACAAATGGTCCATCCTAAA TTTTATGGTATTGGTGAAAATATGTGGGTCGGCCCTGAAAATGAATTTACTGCAAGTATTGCTATCAGAAGTTGGCATGCAGAGAAGAAA ATGTACAATTTTGAAAATGGCAGTTGCTCTGGAGACTGTTCTAATTATATTCAGCTTGTTTGGGACCACTCTTACAAAGTTGGTTGTGCT GTTACTCCATGTTCAAAAATTGGACATATTATACATGCAGCAATTTTCATATGCAACTATGCGCCAGGAGGAACACTGACGAGAAGACCT TATGAACCAGGAATATTTTGTACTCGATGTGGCAGACGTGACAAATGCACAGATTTTCTATGCAGTAATGCAGATCGTGACCAAGCCACA TATTACCGATTTTGGTATCCAAAATGGGAAATGCCCCGGCCAGTTGTGTGTGATCCACTGTGCACATTCATTTTATTATTGAGAATATTA TGTTTTATCCTGTGTGTCATAACTGTTTTGATAGTACAGTCTCAGTTTCCAAATATCTTGTTGGAACAACAAATGATATTTACCCCTGAG GAATCTGAAGCAGGGAATGAAGAGGAGGAAAAAGAGGAAGAGAAGAAAGAGAAAGAGGAAATGGAAATGGAAATAATGGAAATGGAGGAG >In-frame_IFT81_ENST00000242591_chr12_110618376_+_GLIPR1L2_ENST00000550916_chr12_75804214_+_2139nt ATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAG CCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAG ACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTG GTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGT TTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCC TTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAA GAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGG CAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTG CAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGCAAAGCCTGAAAGTTTAATGAAGAGGCTAGAGGAGGAGATA AAATTTAATTTATATATGGTAACTGAAAAATTTCCTAAAGAATTAGAAAATAAGAAAAAGGAATTACATTTTTTACAAAAAGTAGTTTCA GAGCCAGCTATGGGCCATTCTGATCTTCTTGAACTTGAATCTAAAATAAATGAAATAAACACAGAAATTAACCAGTTGATTGAAAAGAAA ATGATGAGAAATGAGCCCATTGAAGGCAAACTCTCACTGTATAGGCAACAGGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGCTGAG GAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGATGGTACTGAA GTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGCTGAA CTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGACTTGGGATGTA GCTTTATCACGGACTGCTAGAGCATGGGGAAAAAAATGTTTGTTTACGCATAATATTTATTTACAAGATGTACAAATGGTCCATCCTAAA TTTTATGGTATTGGTGAAAATATGTGGGTCGGCCCTGAAAATGAATTTACTGCAAGTATTGCTATCAGAAGTTGGCATGCAGAGAAGAAA ATGTACAATTTTGAAAATGGCAGTTGCTCTGGAGACTGTTCTAATTATATTCAGCTTGTTTGGGACCACTCTTACAAAGTTGGTTGTGCT GTTACTCCATGTTCAAAAATTGGACATATTATACATGCAGCAATTTTCATATGCAACTATGCGCCAGGAGGAACACTGACGAGAAGACCT TATGAACCAGGAATATTTTGTACTCGATGTGGCAGACGTGACAAATGCACAGATTTTCTATGCAGTAATGCAGATCGTGACCAAGCCACA TATTACCGATTTTGGTATCCAAAATGGGAAATGCCCCGGCCAGTTGTGTGTGATCCACTGTGCACATTCATTTTATTATTGAGAATATTA TGTTTTATCCTGTGTGTCATAACTGTTTTGATAGTACAGTCTCAGTTTCCAAATATCTTGTTGGAACAACAAATGATATTTACCCCTGAG GAATCTGAAGCAGGGAATGAAGAGGAGGAAAAAGAGGAAGAGAAGAAAGAGAAAGAGGAAATGGAAATGGAAATAATGGAAATGGAGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IFT81_ENST00000552912_chr12_110618376_+_GLIPR1L2_ENST00000550916_chr12_75804214_+_3796nt GTAACTCTACGGCCTAGCAACCGTTGCCAAGGAGCTCGACTCTGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGT TTCGTGAGGAGAATTTGAGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTT TAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCC AAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTC AGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCA GAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGT GGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTC TACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGA GACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACA GGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGC AAAGCCTGAAAGTTTAATGAAGAGGCTAGAGGAGGAGATAAAATTTAATTTATATATGGTAACTGAAAAATTTCCTAAAGAATTAGAAAA TAAGAAAAAGGAATTACATTTTTTACAAAAAGTAGTTTCAGAGCCAGCTATGGGCCATTCTGATCTTCTTGAACTTGAATCTAAAATAAA TGAAATAAACACAGAAATTAACCAGTTGATTGAAAAGAAAATGATGAGAAATGAGCCCATTGAAGGCAAACTCTCACTGTATAGGCAACA GGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGCTGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATC AGTAAAGAGAAATCAGACCCGTGAATTTGATGGTACTGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAA GAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGCTGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCA ACGTCATGAAAATATTCAACAACAACTGACTTGGGATGTAGCTTTATCACGGACTGCTAGAGCATGGGGAAAAAAATGTTTGTTTACGCA TAATATTTATTTACAAGATGTACAAATGGTCCATCCTAAATTTTATGGTATTGGTGAAAATATGTGGGTCGGCCCTGAAAATGAATTTAC TGCAAGTATTGCTATCAGAAGTTGGCATGCAGAGAAGAAAATGTACAATTTTGAAAATGGCAGTTGCTCTGGAGACTGTTCTAATTATAT TCAGCTTGTTTGGGACCACTCTTACAAAGTTGGTTGTGCTGTTACTCCATGTTCAAAAATTGGACATATTATACATGCAGCAATTTTCAT ATGCAACTATGCGCCAGGAGGAACACTGACGAGAAGACCTTATGAACCAGGAATATTTTGTACTCGATGTGGCAGACGTGACAAATGCAC AGATTTTCTATGCAGTAATGCAGATCGTGACCAAGCCACATATTACCGATTTTGGTATCCAAAATGGGAAATGCCCCGGCCAGTTGTGTG TGATCCACTGTGCACATTCATTTTATTATTGAGAATATTATGTTTTATCCTGTGTGTCATAACTGTTTTGATAGTACAGTCTCAGTTTCC AAATATCTTGTTGGAACAACAAATGATATTTACCCCTGAGGAATCTGAAGCAGGGAATGAAGAGGAGGAAAAAGAGGAAGAGAAGAAAGA GAAAGAGGAAATGGAAATGGAAATAATGGAAATGGAGGAGGAAAAAGAAGAGAGAGAGGAGGAGGAGGAGGAAACACAAAAAGAAAAGAT GGAGGAAGAGGAAAAATAAGAGTAGAAAGAGGAGGAAAAAGATGTATCACCAATATAAACCAAAAGTGTAATACAAAAAAAGACAGAAAA AAAAAAAAAGTAAAACACTGAGTTTTAACAAGAAAGAAAATATGCAAACCACCATTGGAATGTTTTTTATTCCCTTCTCTCCTATACTTA TTCAATCAATTTAAATTTGTAAAACAAAGAAACAAAAAACATGTAAGGTGGGCTCTTTGACACTAAGAACAGATAAAGACATGACAGGAA AAACACTGAAAAACATTTGACCAGTCTAATTAATCTTAAGATTTCACCATGTTATTCTAATAAAGTAGGGAATTTTCATTTTCTAAACAT GTTTCCATCTCTGTGTTTTAAATAGTAAGGTGCTTAAGATCATTCCAAGTTCATAACAACCATTGAATAAAATTTGTATTTTTTTGTTTT TACTGTTACTGTCATAGTTTTTATTGGTGGTAGTGGTATTTTCATGTGATATTAAGGTATCTAATATTATTATTTGTCTTTGTGGTTTTT GGAATAGTTTAAGTGGTACCTGTACATCCTGCTAGGATGCAAACTTATTATTTATAATTAATGTTCAATATTTCATTAAAGACTTGCTGT AATTTTCTGCCACCAAGGGCTAATAAATGCCATAATTTTAATTAGTTGTGGTAGAGGAATCTGGGTGCTTCCAAATTTATATGATAAAAT AAATAAATTTTTTAAAAACTATTAACTTGTTATTCAATAGGTATAGTAAAAGTTAACAGATTAATAAGATAACTGCTTACCACTAGTAAT ACTAATAAATGAACTAAATAAAAATACCTAGCATAGGAGATTTCTTTATCTATAAAATAAATGGATAGCACTAGATGACCACTAAGACCT CTTCCATCAATGAATATTCATGGATCAACTTTGTAAAGGAATCAATAGTAGTTGTGAAGTACACTAAGCAAACACCTGAGGGAAAAACTT GATTCCCATGAAAATATTCCTGAACTCAGCACCTTATATGGCAAAATAATAAATACCTTTTATTACTCAATTTTAAAATAGGCAAAAAGC AATGTATAATATTTTTCCAATTGCCATTCCATACTCAGCTGTCTTATTGTTGCACACTTATTAGAACTCAATGTGACTGAGATGTGAAAG GTTGATATAATTCTATTTATGACAGGGACTTAGGGAACTTATTCTAATTGAGAATCAGAGGCTTAATAAACCTGAAGGTTTAAGTGAAAG AAATGACATTGAAAGAATCACTGCATATCTGATGTTTTCAAATAAAACAATCTCTGTTTTCTGGTTTTGATAGAATATTGTGTTCTAAAG CTATATTTCTCAATGTGTGGTTCCACTGAGGGAAAGAAAAAAAAAAAAACCTAGCATAGCCAAATACCTCAAATGGTATAAATGCTATGT GTATTTACTCTGTTGTTCTTTAGTTGTATCAATATTCTGTTAAAAACCTGTTCGAAGTAGGGCAAGATGAGAATTATATTAAAAAGCCCT >In-frame_IFT81_ENST00000242591_chr12_110618376_+_GLIPR1L2_ENST00000550916_chr12_75804214_+_4172nt TGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGTTTCGTGAGGAGAATTTGAGGTAACCTCGCCAACTCGCGGTCG GAAGCTCCTCTGAACCCCGAAATAGGAGAGAGCTCCCGTCCTCTCTCGGTCCTGATGCAGCACCTCGCAAGTGGAAGGGGTCGTCGCGGT TAAGCCCCCGGATAGGGGAATCGGGCCCCTTCTGGGATTCGAGCGGATCCAGGCCGCTCCCTGGAGGGATGAACTGTCGAGGGGCCCAGG GCAGCCCCCGCTAGAGGCCCGGTCGGGTGTGGGGTCCCCTGTCCCCTGTCCCGAGCCCGGGGAGGGGGACACTATTTCTGGTACTCCCAG GAGGCTGCGGGTCGATGCTCGTGCCAGCCTGGGACCCAGGCAGCACGGTTTCTCTCCCAAATTGTGCCAGAGAACACGCACGTCCTGGTT TTCATTGTTCCCCGCCTCCTGCGACTCGTTTGTGGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTC TCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTC TGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTC TTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGC TCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTC TTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCA AGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATT TGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATC TTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCC AAGCTGCAGCAGATGCAAAGCCTGAAAGTTTAATGAAGAGGCTAGAGGAGGAGATAAAATTTAATTTATATATGGTAACTGAAAAATTTC CTAAAGAATTAGAAAATAAGAAAAAGGAATTACATTTTTTACAAAAAGTAGTTTCAGAGCCAGCTATGGGCCATTCTGATCTTCTTGAAC TTGAATCTAAAATAAATGAAATAAACACAGAAATTAACCAGTTGATTGAAAAGAAAATGATGAGAAATGAGCCCATTGAAGGCAAACTCT CACTGTATAGGCAACAGGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGCTGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCC TAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGATGGTACTGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCA ATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGCTGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTG AAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGACTTGGGATGTAGCTTTATCACGGACTGCTAGAGCATGGGGAAAAA AATGTTTGTTTACGCATAATATTTATTTACAAGATGTACAAATGGTCCATCCTAAATTTTATGGTATTGGTGAAAATATGTGGGTCGGCC CTGAAAATGAATTTACTGCAAGTATTGCTATCAGAAGTTGGCATGCAGAGAAGAAAATGTACAATTTTGAAAATGGCAGTTGCTCTGGAG ACTGTTCTAATTATATTCAGCTTGTTTGGGACCACTCTTACAAAGTTGGTTGTGCTGTTACTCCATGTTCAAAAATTGGACATATTATAC ATGCAGCAATTTTCATATGCAACTATGCGCCAGGAGGAACACTGACGAGAAGACCTTATGAACCAGGAATATTTTGTACTCGATGTGGCA GACGTGACAAATGCACAGATTTTCTATGCAGTAATGCAGATCGTGACCAAGCCACATATTACCGATTTTGGTATCCAAAATGGGAAATGC CCCGGCCAGTTGTGTGTGATCCACTGTGCACATTCATTTTATTATTGAGAATATTATGTTTTATCCTGTGTGTCATAACTGTTTTGATAG TACAGTCTCAGTTTCCAAATATCTTGTTGGAACAACAAATGATATTTACCCCTGAGGAATCTGAAGCAGGGAATGAAGAGGAGGAAAAAG AGGAAGAGAAGAAAGAGAAAGAGGAAATGGAAATGGAAATAATGGAAATGGAGGAGGAAAAAGAAGAGAGAGAGGAGGAGGAGGAGGAAA CACAAAAAGAAAAGATGGAGGAAGAGGAAAAATAAGAGTAGAAAGAGGAGGAAAAAGATGTATCACCAATATAAACCAAAAGTGTAATAC AAAAAAAGACAGAAAAAAAAAAAAAGTAAAACACTGAGTTTTAACAAGAAAGAAAATATGCAAACCACCATTGGAATGTTTTTTATTCCC TTCTCTCCTATACTTATTCAATCAATTTAAATTTGTAAAACAAAGAAACAAAAAACATGTAAGGTGGGCTCTTTGACACTAAGAACAGAT AAAGACATGACAGGAAAAACACTGAAAAACATTTGACCAGTCTAATTAATCTTAAGATTTCACCATGTTATTCTAATAAAGTAGGGAATT TTCATTTTCTAAACATGTTTCCATCTCTGTGTTTTAAATAGTAAGGTGCTTAAGATCATTCCAAGTTCATAACAACCATTGAATAAAATT TGTATTTTTTTGTTTTTACTGTTACTGTCATAGTTTTTATTGGTGGTAGTGGTATTTTCATGTGATATTAAGGTATCTAATATTATTATT TGTCTTTGTGGTTTTTGGAATAGTTTAAGTGGTACCTGTACATCCTGCTAGGATGCAAACTTATTATTTATAATTAATGTTCAATATTTC ATTAAAGACTTGCTGTAATTTTCTGCCACCAAGGGCTAATAAATGCCATAATTTTAATTAGTTGTGGTAGAGGAATCTGGGTGCTTCCAA ATTTATATGATAAAATAAATAAATTTTTTAAAAACTATTAACTTGTTATTCAATAGGTATAGTAAAAGTTAACAGATTAATAAGATAACT GCTTACCACTAGTAATACTAATAAATGAACTAAATAAAAATACCTAGCATAGGAGATTTCTTTATCTATAAAATAAATGGATAGCACTAG ATGACCACTAAGACCTCTTCCATCAATGAATATTCATGGATCAACTTTGTAAAGGAATCAATAGTAGTTGTGAAGTACACTAAGCAAACA CCTGAGGGAAAAACTTGATTCCCATGAAAATATTCCTGAACTCAGCACCTTATATGGCAAAATAATAAATACCTTTTATTACTCAATTTT AAAATAGGCAAAAAGCAATGTATAATATTTTTCCAATTGCCATTCCATACTCAGCTGTCTTATTGTTGCACACTTATTAGAACTCAATGT GACTGAGATGTGAAAGGTTGATATAATTCTATTTATGACAGGGACTTAGGGAACTTATTCTAATTGAGAATCAGAGGCTTAATAAACCTG AAGGTTTAAGTGAAAGAAATGACATTGAAAGAATCACTGCATATCTGATGTTTTCAAATAAAACAATCTCTGTTTTCTGGTTTTGATAGA ATATTGTGTTCTAAAGCTATATTTCTCAATGTGTGGTTCCACTGAGGGAAAGAAAAAAAAAAAAACCTAGCATAGCCAAATACCTCAAAT GGTATAAATGCTATGTGTATTTACTCTGTTGTTCTTTAGTTGTATCAATATTCTGTTAAAAACCTGTTCGAAGTAGGGCAAGATGAGAAT |
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FusionGenePPI for IFT81_GLIPR1L2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IFT81 | APP, IFT88, IFT57, CCDC151, ARL13B, IFT46, PRAME, IFT74, SPATA5L1, NDC80, CEP44, PCM1, LTBR, NTRK1, MED4, LCA5, OFD1, CEP128, CEP63, CNTRL, FBF1, NINL, ODF2, GLI1, UBXN10, TTC30A, TTC30B, JPH4, FGF8, RHPN1, SERPINB2, CORO6, HSPB11, IFT52, IFT27, IFT22, IFT172, TTC26, CCDC28B, IFT20, IFT80 | GLIPR1L2 | PPP1CA, ARMC8, ZZEF1, MAEA, MKLN1, RMND5A, RANBP10, RANBP9, GID4, ZMYND19, SNX11 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IFT81_GLIPR1L2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IFT81_GLIPR1L2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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