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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 171

FusionGeneSummary for ABCC6_LTA4H

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC6_LTA4H
Fusion gene ID: 171
HgeneTgene
Gene symbol

ABCC6

LTA4H

Gene ID

368

4048

Gene nameATP binding cassette subfamily C member 6leukotriene A4 hydrolase
SynonymsABC34|ARA|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|URG7-
Cytomap

16p13.11

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 6URG7 proteinATP-binding cassette, sub-family C (CFTR/MRP), member 6anthracycline resistance-associated proteinmulti-specific organic anion transporter Eleukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27
Modification date2018052320180523
UniProtAcc

O95255

P09960

Ensembl transtripts involved in fusion geneENST00000205557, ENST00000574094, 
ENST00000575728, 		ENST00000228740, 
ENST00000552789, ENST00000413268, 
ENST00000548375, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 3=108
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/108*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC6 [Title/Abstract] AND LTA4H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLTA4H

GO:0019370

leukotriene biosynthetic process

9774412|15078870

TgeneLTA4H

GO:0043171

peptide catabolic process

9774412|15078870|18804029


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-7672-01AABCC6chr16

16276269

-LTA4Hchr12

96397698

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000205557ENST00000228740ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
In-frameENST00000205557ENST00000552789ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
5CDS-intronENST00000205557ENST00000413268ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
5CDS-intronENST00000205557ENST00000548375ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-3CDSENST00000574094ENST00000228740ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-3CDSENST00000574094ENST00000552789ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-intronENST00000574094ENST00000413268ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-intronENST00000574094ENST00000548375ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-3CDSENST00000575728ENST00000228740ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-3CDSENST00000575728ENST00000552789ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-intronENST00000575728ENST00000413268ABCC6chr16

16276269

-LTA4Hchr12

96397698

-
intron-intronENST00000575728ENST00000548375ABCC6chr16

16276269

-LTA4Hchr12

96397698

-

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FusionProtFeatures for ABCC6_LTA4H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC6

O95255

LTA4H

P09960

Isoform 1: May participate directly in the activetransport of drugs into subcellular organelles or influence drugdistribution indirectly. Transports glutathione conjugates asleukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).{ECO:0000269|PubMed:11880368}. Isoform 2: Inhibits TNF-alpha-mediated apoptosis throughblocking one or more caspases. {ECO:0000269|PubMed:23912081}. Epoxide hydrolase that catalyzes the final step in thebiosynthesis of the proinflammatory mediator leukotriene B4. Hasalso aminopeptidase activity. {ECO:0000269|PubMed:11917124,ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870,ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988,ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731311_5937491504DomainABC transmembrane type-1 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731663_6707491504Nucleotide bindingATP 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731120_1317491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731150_1677491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731189_3027491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311_317491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731324_3497491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731371_4267491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731448_4507491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731472_5337491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173153_727491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731555_5757491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173194_987491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731132_1497491504TransmembraneHelical%3B Name%3D4
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731168_1887491504TransmembraneHelical%3B Name%3D5
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731303_3237491504TransmembraneHelical%3B Name%3D6
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173132_527491504TransmembraneHelical%3B Name%3D1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731350_3707491504TransmembraneHelical%3B Name%3D7
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731427_4477491504TransmembraneHelical%3B Name%3D8
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731451_4717491504TransmembraneHelical%3B Name%3D9
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731534_5547491504TransmembraneHelical%3B Name%3D10
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731576_5967491504TransmembraneHelical%3B Name%3D11
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173173_937491504TransmembraneHelical%3B Name%3D2
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173199_1197491504TransmembraneHelical%3B Name%3D3
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000228740-1519564_566510612RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000413268-018135_137-49489RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000413268-018267_272-49489RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000413268-018564_566-49489RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000552789-1519564_566486588RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311265_14997491504DomainABC transporter 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731629_8537491504DomainABC transporter 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731947_12287491504DomainABC transmembrane type-1 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121265_1499-11100DomainABC transporter 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12311_593-11100DomainABC transmembrane type-1 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12629_853-11100DomainABC transporter 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12947_1228-11100DomainABC transmembrane type-1 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311299_13067491504Nucleotide bindingATP 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121299_1306-11100Nucleotide bindingATP 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12663_670-11100Nucleotide bindingATP 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311019_10617491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311083_10837491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311105_11757491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311197_11987491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311220_15037491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731597_9397491504Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731961_9977491504Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121019_1061-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121083_1083-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121105_1175-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121197_1198-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12120_131-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121220_1503-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12150_167-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12189_302-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121_31-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12324_349-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12371_426-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12448_450-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12472_533-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1253_72-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12555_575-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12597_939-11100Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1294_98-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12961_997-11100Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311062_10827491504TransmembraneHelical%3B Name%3D14
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311084_11047491504TransmembraneHelical%3B Name%3D15
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311176_11967491504TransmembraneHelical%3B Name%3D16
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311199_12197491504TransmembraneHelical%3B Name%3D17
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731940_9607491504TransmembraneHelical%3B Name%3D12
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731998_10187491504TransmembraneHelical%3B Name%3D13
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121062_1082-11100TransmembraneHelical%3B Name%3D14
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121084_1104-11100TransmembraneHelical%3B Name%3D15
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121176_1196-11100TransmembraneHelical%3B Name%3D16
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121199_1219-11100TransmembraneHelical%3B Name%3D17
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12132_149-11100TransmembraneHelical%3B Name%3D4
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12168_188-11100TransmembraneHelical%3B Name%3D5
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12303_323-11100TransmembraneHelical%3B Name%3D6
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1232_52-11100TransmembraneHelical%3B Name%3D1
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12350_370-11100TransmembraneHelical%3B Name%3D7
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12427_447-11100TransmembraneHelical%3B Name%3D8
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12451_471-11100TransmembraneHelical%3B Name%3D9
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12534_554-11100TransmembraneHelical%3B Name%3D10
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12576_596-11100TransmembraneHelical%3B Name%3D11
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1273_93-11100TransmembraneHelical%3B Name%3D2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12940_960-11100TransmembraneHelical%3B Name%3D12
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12998_1018-11100TransmembraneHelical%3B Name%3D13
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1299_119-11100TransmembraneHelical%3B Name%3D3
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000228740-1519135_137510612RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000228740-1519267_272510612RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000552789-1519135_137486588RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000552789-1519267_272486588RegionSubstrate binding


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FusionGeneSequence for ABCC6_LTA4H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ABCC6_ENST00000205557_chr16_16276269_-_LTA4H_ENST00000228740_chr12_96397698_-_851aa
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVA
LWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAI
AFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCIT
IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
WLERVLEACALQPDVDSFPEGIHTSIGEQAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPL

>In-frame_ABCC6_ENST00000205557_chr16_16276269_-_LTA4H_ENST00000552789_chr12_96397698_-_851aa
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVA
LWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAI
AFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCIT
IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
WLERVLEACALQPDVDSFPEGIHTSIGEQAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ABCC6_ENST00000205557_chr16_16276269_-_LTA4H_ENST00000228740_chr12_96397698_-_2553nt
ATGGCCGCGCCTGCTGAGCCCTGCGCGGGGCAGGGGGTCTGGAACCAGACAGAGCCTGAACCTGCCGCCACCAGCCTGCTGAGCCTGTGC
TTCCTGAGAACAGCAGGGGTCTGGGTACCCCCCATGTACCTCTGGGTCCTTGGTCCCATCTACCTCCTCTTCATCCACCACCATGGCCGG
GGCTACCTCCGGATGTCCCCACTCTTCAAAGCCAAGATGGTGCTTGGATTCGCCCTCATAGTCCTGTGTACCTCCAGCGTGGCTGTCGCT
CTTTGGAAAATCCAACAGGGAACGCCTGAGGCCCCAGAATTCCTCATTCATCCTACTGTGTGGCTCACCACGATGAGCTTCGCAGTGTTC
CTGATTCACACCGAGAGGAAAAAGGGAGTCCAGTCATCTGGAGTGCTGTTTGGTTACTGGCTTCTCTGCTTTGTCTTGCCAGCTACCAAC
GCTGCCCAGCAGGCCTCCGGAGCGGGCTTCCAGAGCGACCCTGTCCGCCACCTGTCCACCTACCTATGCCTGTCTCTGGTGGTGGCACAG
TTTGTGCTGTCCTGCCTGGCGGATCAACCCCCCTTCTTCCCTGAAGACCCCCAGCAGTCTAACCCCTGTCCAGAGACTGGGGCAGCCTTC
CCCTCCAAAGCCACGTTCTGGTGGGTTTCTGGCCTGGTCTGGAGGGGATACAGGAGGCCACTGAGACCAAAAGACCTCTGGTCGCTTGGG
AGAGAAAACTCCTCAGAAGAACTTGTTTCCCGGCTTGAAAAGGAGTGGATGAGGAACCGCAGTGCAGCCCGGAGGCACAACAAGGCAATA
GCATTTAAAAGGAAAGGCGGCAGTGGCATGAAGGCTCCAGAGACCGAGCCCTTCCTACGGCAAGAAGGGAGCCAGTGGCGCCCACTGCTG
AAGGCCATCTGGCAGGTGTTCCATTCTACCTTCCTCCTGGGGACCCTCAGCCTCATCATCAGTGATGTCTTCAGGTTCACTGTCCCCAAG
CTGCTCAGCCTTTTCCTGGAGTTTATTGGTGATCCCAAGCCTCCAGCCTGGAAGGGCTACCTCCTCGCCGTGCTGATGTTCCTCTCAGCC
TGCCTGCAAACGCTGTTTGAGCAGCAGAACATGTACAGGCTCAAGGTGCTGCAGATGAGGTTGCGGTCGGCCATCACTGGCCTGGTGTAC
AGAAAGGTCCTGGCTCTGTCCAGCGGCTCCAGAAAGGCCAGTGCGGTGGGTGATGTGGTCAATCTGGTGTCCGTGGACGTGCAGCGGCTG
ACCGAGAGCGTCCTCTACCTCAACGGGCTGTGGCTGCCTCTCGTCTGGATCGTGGTCTGCTTCGTCTATCTCTGGCAGCTCCTGGGGCCC
TCCGCCCTCACTGCCATCGCTGTCTTCCTGAGCCTCCTCCCTCTGAATTTCTTCATCTCCAAGAAAAGGAACCACCATCAGGAGGAGCAA
ATGAGGCAGAAGGACTCACGGGCACGGCTCACCAGCTCTATCCTCAGGAACTCGAAGACCATCAAGTTCCATGGCTGGGAGGGAGCCTTT
CTGGACAGAGTCCTGGGCATCCGAGGCCAGGAGCTGGGCGCCTTGCGGACCTCCGGCCTCCTCTTCTCTGTGTCGCTGGTGTCCTTCCAA
GTGTCTACATTTCTGGTCGCACTGGTGGTGTTTGCTGTCCACACTCTGGTGGCCGAGAATGCTATGAATGCAGAGAAAGCCTTTGTGACT
CTCACAGTTCTCAACATCCTCAACAAGGCCCAGGCTTTCCTGCCCTTCTCCATCCACTCCCTCGTCCAGGCCCGGGTGTCCTTTGACCGT
CTGGTCACCTTCCTCTGCCTGGAAGAAGTTGACCCTGGTGTCGTAGACTCAAGTTCCTCTGGAAGCGCTGCCGGGAAGGATTGCATCACC
ATACACAGTGCCACCTTCGCCTGGTCCCAGGAAAGCCCTCCCTGCCTCCACAGAATAAACCTCACGGTGCCCCAGGGCTGTCTGCTGGCT
GTTGTCGGTCCAGTGGGGGCAGGGAAGTCCTCCCTGCTGTCCGCCCTCCTTGGGGAGCTGTCAAAGGTGGAGGGGTTCGTGAGCATCGAG
GGTGCTGTGGCCTACGTGCCCCAGGAGGCCTGGGTGCAGAACACCTCTGTGGTAGAGAATGTGTGCTTCGGGCAGGAGCTGGACCCACCC
TGGCTGGAGAGAGTACTAGAAGCCTGTGCCCTGCAGCCAGATGTGGACAGCTTCCCTGAGGGAATCCACACTTCAATTGGGGAGCAGGCA
CCTCTTCCATTGGGGCACATAAAGCGAATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGCTGCGG
CTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACTGAACAAGGAAGAATGAAGTTTACCCGGCCCTTA
TTCAAGGATCTTGCTGCCTTTGACAAATCCCATGATCAAGCTGTCCGAACCTACCAAGAGCACAAAGCAAGCATGCATCCCGTGACTGCA

>In-frame_ABCC6_ENST00000205557_chr16_16276269_-_LTA4H_ENST00000552789_chr12_96397698_-_2553nt
ATGGCCGCGCCTGCTGAGCCCTGCGCGGGGCAGGGGGTCTGGAACCAGACAGAGCCTGAACCTGCCGCCACCAGCCTGCTGAGCCTGTGC
TTCCTGAGAACAGCAGGGGTCTGGGTACCCCCCATGTACCTCTGGGTCCTTGGTCCCATCTACCTCCTCTTCATCCACCACCATGGCCGG
GGCTACCTCCGGATGTCCCCACTCTTCAAAGCCAAGATGGTGCTTGGATTCGCCCTCATAGTCCTGTGTACCTCCAGCGTGGCTGTCGCT
CTTTGGAAAATCCAACAGGGAACGCCTGAGGCCCCAGAATTCCTCATTCATCCTACTGTGTGGCTCACCACGATGAGCTTCGCAGTGTTC
CTGATTCACACCGAGAGGAAAAAGGGAGTCCAGTCATCTGGAGTGCTGTTTGGTTACTGGCTTCTCTGCTTTGTCTTGCCAGCTACCAAC
GCTGCCCAGCAGGCCTCCGGAGCGGGCTTCCAGAGCGACCCTGTCCGCCACCTGTCCACCTACCTATGCCTGTCTCTGGTGGTGGCACAG
TTTGTGCTGTCCTGCCTGGCGGATCAACCCCCCTTCTTCCCTGAAGACCCCCAGCAGTCTAACCCCTGTCCAGAGACTGGGGCAGCCTTC
CCCTCCAAAGCCACGTTCTGGTGGGTTTCTGGCCTGGTCTGGAGGGGATACAGGAGGCCACTGAGACCAAAAGACCTCTGGTCGCTTGGG
AGAGAAAACTCCTCAGAAGAACTTGTTTCCCGGCTTGAAAAGGAGTGGATGAGGAACCGCAGTGCAGCCCGGAGGCACAACAAGGCAATA
GCATTTAAAAGGAAAGGCGGCAGTGGCATGAAGGCTCCAGAGACCGAGCCCTTCCTACGGCAAGAAGGGAGCCAGTGGCGCCCACTGCTG
AAGGCCATCTGGCAGGTGTTCCATTCTACCTTCCTCCTGGGGACCCTCAGCCTCATCATCAGTGATGTCTTCAGGTTCACTGTCCCCAAG
CTGCTCAGCCTTTTCCTGGAGTTTATTGGTGATCCCAAGCCTCCAGCCTGGAAGGGCTACCTCCTCGCCGTGCTGATGTTCCTCTCAGCC
TGCCTGCAAACGCTGTTTGAGCAGCAGAACATGTACAGGCTCAAGGTGCTGCAGATGAGGTTGCGGTCGGCCATCACTGGCCTGGTGTAC
AGAAAGGTCCTGGCTCTGTCCAGCGGCTCCAGAAAGGCCAGTGCGGTGGGTGATGTGGTCAATCTGGTGTCCGTGGACGTGCAGCGGCTG
ACCGAGAGCGTCCTCTACCTCAACGGGCTGTGGCTGCCTCTCGTCTGGATCGTGGTCTGCTTCGTCTATCTCTGGCAGCTCCTGGGGCCC
TCCGCCCTCACTGCCATCGCTGTCTTCCTGAGCCTCCTCCCTCTGAATTTCTTCATCTCCAAGAAAAGGAACCACCATCAGGAGGAGCAA
ATGAGGCAGAAGGACTCACGGGCACGGCTCACCAGCTCTATCCTCAGGAACTCGAAGACCATCAAGTTCCATGGCTGGGAGGGAGCCTTT
CTGGACAGAGTCCTGGGCATCCGAGGCCAGGAGCTGGGCGCCTTGCGGACCTCCGGCCTCCTCTTCTCTGTGTCGCTGGTGTCCTTCCAA
GTGTCTACATTTCTGGTCGCACTGGTGGTGTTTGCTGTCCACACTCTGGTGGCCGAGAATGCTATGAATGCAGAGAAAGCCTTTGTGACT
CTCACAGTTCTCAACATCCTCAACAAGGCCCAGGCTTTCCTGCCCTTCTCCATCCACTCCCTCGTCCAGGCCCGGGTGTCCTTTGACCGT
CTGGTCACCTTCCTCTGCCTGGAAGAAGTTGACCCTGGTGTCGTAGACTCAAGTTCCTCTGGAAGCGCTGCCGGGAAGGATTGCATCACC
ATACACAGTGCCACCTTCGCCTGGTCCCAGGAAAGCCCTCCCTGCCTCCACAGAATAAACCTCACGGTGCCCCAGGGCTGTCTGCTGGCT
GTTGTCGGTCCAGTGGGGGCAGGGAAGTCCTCCCTGCTGTCCGCCCTCCTTGGGGAGCTGTCAAAGGTGGAGGGGTTCGTGAGCATCGAG
GGTGCTGTGGCCTACGTGCCCCAGGAGGCCTGGGTGCAGAACACCTCTGTGGTAGAGAATGTGTGCTTCGGGCAGGAGCTGGACCCACCC
TGGCTGGAGAGAGTACTAGAAGCCTGTGCCCTGCAGCCAGATGTGGACAGCTTCCCTGAGGGAATCCACACTTCAATTGGGGAGCAGGCA
CCTCTTCCATTGGGGCACATAAAGCGAATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGCTGCGG
CTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACTGAACAAGGAAGAATGAAGTTTACCCGGCCCTTA
TTCAAGGATCTTGCTGCCTTTGACAAATCCCATGATCAAGCTGTCCGAACCTACCAAGAGCACAAAGCAAGCATGCATCCCGTGACTGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ABCC6_ENST00000205557_chr16_16276269_-_LTA4H_ENST00000228740_chr12_96397698_-_2744nt
CGCTGGGACCCACGACGACAGAAGGCGCCGATGGCCGCGCCTGCTGAGCCCTGCGCGGGGCAGGGGGTCTGGAACCAGACAGAGCCTGAA
CCTGCCGCCACCAGCCTGCTGAGCCTGTGCTTCCTGAGAACAGCAGGGGTCTGGGTACCCCCCATGTACCTCTGGGTCCTTGGTCCCATC
TACCTCCTCTTCATCCACCACCATGGCCGGGGCTACCTCCGGATGTCCCCACTCTTCAAAGCCAAGATGGTGCTTGGATTCGCCCTCATA
GTCCTGTGTACCTCCAGCGTGGCTGTCGCTCTTTGGAAAATCCAACAGGGAACGCCTGAGGCCCCAGAATTCCTCATTCATCCTACTGTG
TGGCTCACCACGATGAGCTTCGCAGTGTTCCTGATTCACACCGAGAGGAAAAAGGGAGTCCAGTCATCTGGAGTGCTGTTTGGTTACTGG
CTTCTCTGCTTTGTCTTGCCAGCTACCAACGCTGCCCAGCAGGCCTCCGGAGCGGGCTTCCAGAGCGACCCTGTCCGCCACCTGTCCACC
TACCTATGCCTGTCTCTGGTGGTGGCACAGTTTGTGCTGTCCTGCCTGGCGGATCAACCCCCCTTCTTCCCTGAAGACCCCCAGCAGTCT
AACCCCTGTCCAGAGACTGGGGCAGCCTTCCCCTCCAAAGCCACGTTCTGGTGGGTTTCTGGCCTGGTCTGGAGGGGATACAGGAGGCCA
CTGAGACCAAAAGACCTCTGGTCGCTTGGGAGAGAAAACTCCTCAGAAGAACTTGTTTCCCGGCTTGAAAAGGAGTGGATGAGGAACCGC
AGTGCAGCCCGGAGGCACAACAAGGCAATAGCATTTAAAAGGAAAGGCGGCAGTGGCATGAAGGCTCCAGAGACCGAGCCCTTCCTACGG
CAAGAAGGGAGCCAGTGGCGCCCACTGCTGAAGGCCATCTGGCAGGTGTTCCATTCTACCTTCCTCCTGGGGACCCTCAGCCTCATCATC
AGTGATGTCTTCAGGTTCACTGTCCCCAAGCTGCTCAGCCTTTTCCTGGAGTTTATTGGTGATCCCAAGCCTCCAGCCTGGAAGGGCTAC
CTCCTCGCCGTGCTGATGTTCCTCTCAGCCTGCCTGCAAACGCTGTTTGAGCAGCAGAACATGTACAGGCTCAAGGTGCTGCAGATGAGG
TTGCGGTCGGCCATCACTGGCCTGGTGTACAGAAAGGTCCTGGCTCTGTCCAGCGGCTCCAGAAAGGCCAGTGCGGTGGGTGATGTGGTC
AATCTGGTGTCCGTGGACGTGCAGCGGCTGACCGAGAGCGTCCTCTACCTCAACGGGCTGTGGCTGCCTCTCGTCTGGATCGTGGTCTGC
TTCGTCTATCTCTGGCAGCTCCTGGGGCCCTCCGCCCTCACTGCCATCGCTGTCTTCCTGAGCCTCCTCCCTCTGAATTTCTTCATCTCC
AAGAAAAGGAACCACCATCAGGAGGAGCAAATGAGGCAGAAGGACTCACGGGCACGGCTCACCAGCTCTATCCTCAGGAACTCGAAGACC
ATCAAGTTCCATGGCTGGGAGGGAGCCTTTCTGGACAGAGTCCTGGGCATCCGAGGCCAGGAGCTGGGCGCCTTGCGGACCTCCGGCCTC
CTCTTCTCTGTGTCGCTGGTGTCCTTCCAAGTGTCTACATTTCTGGTCGCACTGGTGGTGTTTGCTGTCCACACTCTGGTGGCCGAGAAT
GCTATGAATGCAGAGAAAGCCTTTGTGACTCTCACAGTTCTCAACATCCTCAACAAGGCCCAGGCTTTCCTGCCCTTCTCCATCCACTCC
CTCGTCCAGGCCCGGGTGTCCTTTGACCGTCTGGTCACCTTCCTCTGCCTGGAAGAAGTTGACCCTGGTGTCGTAGACTCAAGTTCCTCT
GGAAGCGCTGCCGGGAAGGATTGCATCACCATACACAGTGCCACCTTCGCCTGGTCCCAGGAAAGCCCTCCCTGCCTCCACAGAATAAAC
CTCACGGTGCCCCAGGGCTGTCTGCTGGCTGTTGTCGGTCCAGTGGGGGCAGGGAAGTCCTCCCTGCTGTCCGCCCTCCTTGGGGAGCTG
TCAAAGGTGGAGGGGTTCGTGAGCATCGAGGGTGCTGTGGCCTACGTGCCCCAGGAGGCCTGGGTGCAGAACACCTCTGTGGTAGAGAAT
GTGTGCTTCGGGCAGGAGCTGGACCCACCCTGGCTGGAGAGAGTACTAGAAGCCTGTGCCCTGCAGCCAGATGTGGACAGCTTCCCTGAG
GGAATCCACACTTCAATTGGGGAGCAGGCACCTCTTCCATTGGGGCACATAAAGCGAATGCAAGAGGTGTACAACTTCAATGCCATTAAC
AATTCTGAAATACGATTCAGATGGCTGCGGCTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACTGAA
CAAGGAAGAATGAAGTTTACCCGGCCCTTATTCAAGGATCTTGCTGCCTTTGACAAATCCCATGATCAAGCTGTCCGAACCTACCAAGAG
CACAAAGCAAGCATGCATCCCGTGACTGCAATGCTGGTGGGGAAAGACTTAAAAGTGGATTAAAGACCTGCGTATTGATGATTTTAGAGA
TTTCTCTTTTTTAAATGGAATTCGTAAAGAAATATAAAACTTCAGCTCACAATTAAAACTGTCTTTTTAGTTTTGGCTTTTTATTGTTTT

>In-frame_ABCC6_ENST00000205557_chr16_16276269_-_LTA4H_ENST00000552789_chr12_96397698_-_2742nt
CGCTGGGACCCACGACGACAGAAGGCGCCGATGGCCGCGCCTGCTGAGCCCTGCGCGGGGCAGGGGGTCTGGAACCAGACAGAGCCTGAA
CCTGCCGCCACCAGCCTGCTGAGCCTGTGCTTCCTGAGAACAGCAGGGGTCTGGGTACCCCCCATGTACCTCTGGGTCCTTGGTCCCATC
TACCTCCTCTTCATCCACCACCATGGCCGGGGCTACCTCCGGATGTCCCCACTCTTCAAAGCCAAGATGGTGCTTGGATTCGCCCTCATA
GTCCTGTGTACCTCCAGCGTGGCTGTCGCTCTTTGGAAAATCCAACAGGGAACGCCTGAGGCCCCAGAATTCCTCATTCATCCTACTGTG
TGGCTCACCACGATGAGCTTCGCAGTGTTCCTGATTCACACCGAGAGGAAAAAGGGAGTCCAGTCATCTGGAGTGCTGTTTGGTTACTGG
CTTCTCTGCTTTGTCTTGCCAGCTACCAACGCTGCCCAGCAGGCCTCCGGAGCGGGCTTCCAGAGCGACCCTGTCCGCCACCTGTCCACC
TACCTATGCCTGTCTCTGGTGGTGGCACAGTTTGTGCTGTCCTGCCTGGCGGATCAACCCCCCTTCTTCCCTGAAGACCCCCAGCAGTCT
AACCCCTGTCCAGAGACTGGGGCAGCCTTCCCCTCCAAAGCCACGTTCTGGTGGGTTTCTGGCCTGGTCTGGAGGGGATACAGGAGGCCA
CTGAGACCAAAAGACCTCTGGTCGCTTGGGAGAGAAAACTCCTCAGAAGAACTTGTTTCCCGGCTTGAAAAGGAGTGGATGAGGAACCGC
AGTGCAGCCCGGAGGCACAACAAGGCAATAGCATTTAAAAGGAAAGGCGGCAGTGGCATGAAGGCTCCAGAGACCGAGCCCTTCCTACGG
CAAGAAGGGAGCCAGTGGCGCCCACTGCTGAAGGCCATCTGGCAGGTGTTCCATTCTACCTTCCTCCTGGGGACCCTCAGCCTCATCATC
AGTGATGTCTTCAGGTTCACTGTCCCCAAGCTGCTCAGCCTTTTCCTGGAGTTTATTGGTGATCCCAAGCCTCCAGCCTGGAAGGGCTAC
CTCCTCGCCGTGCTGATGTTCCTCTCAGCCTGCCTGCAAACGCTGTTTGAGCAGCAGAACATGTACAGGCTCAAGGTGCTGCAGATGAGG
TTGCGGTCGGCCATCACTGGCCTGGTGTACAGAAAGGTCCTGGCTCTGTCCAGCGGCTCCAGAAAGGCCAGTGCGGTGGGTGATGTGGTC
AATCTGGTGTCCGTGGACGTGCAGCGGCTGACCGAGAGCGTCCTCTACCTCAACGGGCTGTGGCTGCCTCTCGTCTGGATCGTGGTCTGC
TTCGTCTATCTCTGGCAGCTCCTGGGGCCCTCCGCCCTCACTGCCATCGCTGTCTTCCTGAGCCTCCTCCCTCTGAATTTCTTCATCTCC
AAGAAAAGGAACCACCATCAGGAGGAGCAAATGAGGCAGAAGGACTCACGGGCACGGCTCACCAGCTCTATCCTCAGGAACTCGAAGACC
ATCAAGTTCCATGGCTGGGAGGGAGCCTTTCTGGACAGAGTCCTGGGCATCCGAGGCCAGGAGCTGGGCGCCTTGCGGACCTCCGGCCTC
CTCTTCTCTGTGTCGCTGGTGTCCTTCCAAGTGTCTACATTTCTGGTCGCACTGGTGGTGTTTGCTGTCCACACTCTGGTGGCCGAGAAT
GCTATGAATGCAGAGAAAGCCTTTGTGACTCTCACAGTTCTCAACATCCTCAACAAGGCCCAGGCTTTCCTGCCCTTCTCCATCCACTCC
CTCGTCCAGGCCCGGGTGTCCTTTGACCGTCTGGTCACCTTCCTCTGCCTGGAAGAAGTTGACCCTGGTGTCGTAGACTCAAGTTCCTCT
GGAAGCGCTGCCGGGAAGGATTGCATCACCATACACAGTGCCACCTTCGCCTGGTCCCAGGAAAGCCCTCCCTGCCTCCACAGAATAAAC
CTCACGGTGCCCCAGGGCTGTCTGCTGGCTGTTGTCGGTCCAGTGGGGGCAGGGAAGTCCTCCCTGCTGTCCGCCCTCCTTGGGGAGCTG
TCAAAGGTGGAGGGGTTCGTGAGCATCGAGGGTGCTGTGGCCTACGTGCCCCAGGAGGCCTGGGTGCAGAACACCTCTGTGGTAGAGAAT
GTGTGCTTCGGGCAGGAGCTGGACCCACCCTGGCTGGAGAGAGTACTAGAAGCCTGTGCCCTGCAGCCAGATGTGGACAGCTTCCCTGAG
GGAATCCACACTTCAATTGGGGAGCAGGCACCTCTTCCATTGGGGCACATAAAGCGAATGCAAGAGGTGTACAACTTCAATGCCATTAAC
AATTCTGAAATACGATTCAGATGGCTGCGGCTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACTGAA
CAAGGAAGAATGAAGTTTACCCGGCCCTTATTCAAGGATCTTGCTGCCTTTGACAAATCCCATGATCAAGCTGTCCGAACCTACCAAGAG
CACAAAGCAAGCATGCATCCCGTGACTGCAATGCTGGTGGGGAAAGACTTAAAAGTGGATTAAAGACCTGCGTATTGATGATTTTAGAGA
TTTCTCTTTTTTAAATGGAATTCGTAAAGAAATATAAAACTTCAGCTCACAATTAAAACTGTCTTTTTAGTTTTGGCTTTTTATTGTTTT


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FusionGenePPI for ABCC6_LTA4H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABCC6A1BG, AK2, NR4A1, FURIN, CRYL1LTA4HGH1, MCC, TMEM62, DDA1, UBA5, HDAC5, ELAVL1, SIRT7, TINF2, SIRT1, ZNF593, ALDOA, FKBP2, GALK2, IDH1, PGM1, PRPF4, SPR, TRAP1, NAPRT, TAGLN2, NTRK1, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABCC6_LTA4H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLTA4HP09960DB01197CaptoprilLeukotriene A-4 hydrolasesmall moleculeapproved

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RelatedDiseases for ABCC6_LTA4H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC6C0033847Pseudoxanthoma Elasticum21CTD_human;ORPHANET;UNIPROT
HgeneABCC6C3276161ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY, 27UNIPROT
HgeneABCC6C0009404Colorectal Neoplasms1CTD_human
TgeneLTA4HC0004153Atherosclerosis1CTD_human
TgeneLTA4HC0011570Mental Depression1PSYGENET
TgeneLTA4HC0011581Depressive disorder1PSYGENET
TgeneLTA4HC0023893Liver Cirrhosis, Experimental1CTD_human