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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17084

FusionGeneSummary for IFNAR2_TNK2

check button Fusion gene summary
Fusion gene informationFusion gene name: IFNAR2_TNK2
Fusion gene ID: 17084
HgeneTgene
Gene symbol

IFNAR2

TNK2

Gene ID

3455

10188

Gene nameinterferon alpha and beta receptor subunit 2tyrosine kinase non receptor 2
SynonymsIFN-R|IFN-alpha-REC|IFNABR|IFNARB|IMD45ACK|ACK-1|ACK1|p21cdc42Hs
Cytomap

21q22.11

3q29

Type of geneprotein-codingprotein-coding
Descriptioninterferon alpha/beta receptor 2IFN-R-2IFN-alpha/beta receptor 2human interferon alpha/beta receptorinterferon (alpha, beta and omega) receptor 2interferon alpha binding proteininterferon receptorinterferon-alpha/beta receptor beta chaintype I intactivated CDC42 kinase 1activated Cdc42-associated kinase 1activated p21cdc42Hs kinasetyrosine kinase non-receptor protein 2
Modification date2018052320180523
UniProtAcc

P48551

Q07912

Ensembl transtripts involved in fusion geneENST00000382264, ENST00000382241, 
ENST00000404220, ENST00000342136, 
ENST00000420068, ENST00000342101, 
ENST00000413881, 
ENST00000381916, 
ENST00000333602, ENST00000428187, 
ENST00000392400, ENST00000316664, 
ENST00000468819, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IFNAR2 [Title/Abstract] AND TNK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIFNAR2

GO:0035455

response to interferon-alpha

7759950

HgeneIFNAR2

GO:0060337

type I interferon signaling pathway

7665574

TgeneTNK2

GO:0016310

phosphorylation

20333297|20979614

TgeneTNK2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10587647

TgeneTNK2

GO:2000369

regulation of clathrin-dependent endocytosis

18262180


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF926990IFNAR2chr21

34636571

-TNK2chr3

195611790

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000382264ENST00000381916IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000382264ENST00000333602IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000382264ENST00000428187IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000382264ENST00000392400IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000382264ENST00000316664IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-5UTRENST00000382264ENST00000468819IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000382241ENST00000381916IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000382241ENST00000333602IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000382241ENST00000428187IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000382241ENST00000392400IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000382241ENST00000316664IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-5UTRENST00000382241ENST00000468819IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000404220ENST00000381916IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000404220ENST00000333602IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000404220ENST00000428187IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000404220ENST00000392400IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000404220ENST00000316664IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-5UTRENST00000404220ENST00000468819IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342136ENST00000381916IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342136ENST00000333602IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342136ENST00000428187IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342136ENST00000392400IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342136ENST00000316664IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-5UTRENST00000342136ENST00000468819IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000420068ENST00000381916IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000420068ENST00000333602IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000420068ENST00000428187IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000420068ENST00000392400IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000420068ENST00000316664IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-5UTRENST00000420068ENST00000468819IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342101ENST00000381916IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342101ENST00000333602IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342101ENST00000428187IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342101ENST00000392400IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-3CDSENST00000342101ENST00000316664IFNAR2chr21

34636571

-TNK2chr3

195611790

-
3UTR-5UTRENST00000342101ENST00000468819IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000413881ENST00000381916IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000413881ENST00000333602IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000413881ENST00000428187IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000413881ENST00000392400IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-3CDSENST00000413881ENST00000316664IFNAR2chr21

34636571

-TNK2chr3

195611790

-
intron-5UTRENST00000413881ENST00000468819IFNAR2chr21

34636571

-TNK2chr3

195611790

-

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FusionProtFeatures for IFNAR2_TNK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFNAR2

P48551

TNK2

Q07912

Associates with IFNAR1 to form the type I interferonreceptor. Receptor for interferons alpha and beta. Involved inIFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569).Isoform 1 and isoform 2 are directly involved in signaltransduction due to their association with the TYR kinase, JAK1(PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is apotent inhibitor of type I IFN receptor activity (PubMed:7759950).{ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:11682488,ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:26424569,ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950,ECO:0000269|PubMed:8181059}. Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration,cell survival, cell growth and proliferation. Transducesextracellular signals to cytosolic and nuclear effectors.Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated intrafficking and clathrin-mediated endocytosis through binding toepidermal growth factor receptor (EGFR) and clathrin. Binds toboth poly- and mono-ubiquitin and regulates ligand-induceddegradation of EGFR, thereby contributing to the accumulation ofEGFR at the limiting membrane of early endosomes. Downstreameffector of CDC42 which mediates CDC42-dependent cell migrationvia phosphorylation of BCAR1. May be involved both in adultsynaptic function and plasticity and in brain development.Activates AKT1 by phosphorylating it on 'Tyr-176'. PhosphorylatesAR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment toandrogen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as aguanine nucleotide exchange factor (GEF) toward Rho familyproteins. Contributes to the control of AXL receptor levels.Confers metastatic properties on cancer cells and promotes tumorgrowth by negatively regulating tumor suppressor such as WWOX andpositively regulating pro-survival factors such as AKT1 and AR.Phosphorylates WASP (PubMed:20110370).{ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436,ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963,ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317,ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854,ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370,ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IFNAR2_TNK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IFNAR2_TNK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IFNAR2_TNK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIFNAR2P48551DB00022Peginterferon alfa-2bInterferon alpha/beta receptor 2biotechapproved
HgeneIFNAR2P48551DB00068Interferon beta-1bInterferon alpha/beta receptor 2biotechapproved
HgeneIFNAR2P48551DB00105Interferon Alfa-2b, RecombinantInterferon alpha/beta receptor 2biotechapproved
HgeneIFNAR2P48551DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 2biotechapproved|investigational
HgeneIFNAR2P48551DB00011Interferon alfa-n1Interferon alpha/beta receptor 2biotechapproved|investigational
HgeneIFNAR2P48551DB00034Interferon Alfa-2a, RecombinantInterferon alpha/beta receptor 2biotechapproved|investigational
HgeneIFNAR2P48551DB00060Interferon beta-1aInterferon alpha/beta receptor 2biotechapproved|investigational
HgeneIFNAR2P48551DB00069Interferon alfacon-1Interferon alpha/beta receptor 2biotechapproved|investigational

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RelatedDiseases for IFNAR2_TNK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNK2C0023903Liver neoplasms1CTD_human
TgeneTNK2C0032927Precancerous Conditions1CTD_human