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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17083

FusionGeneSummary for IFNAR1_USP22

check button Fusion gene summary
Fusion gene informationFusion gene name: IFNAR1_USP22
Fusion gene ID: 17083
HgeneTgene
Gene symbol

IFNAR1

USP22

Gene ID

3454

23326

Gene nameinterferon alpha and beta receptor subunit 1ubiquitin specific peptidase 22
SynonymsAVP|IFN-alpha-REC|IFNAR|IFNBR|IFRCUSP3L
Cytomap

21q22.11

17p11.2

Type of geneprotein-codingprotein-coding
Descriptioninterferon alpha/beta receptor 1CRF2-1IFN-R-1IFN-alpha/beta receptor 1alpha-type antiviral proteinbeta-type antiviral proteincytokine receptor class-II member 1cytokine receptor family 2 member 1interferon (alpha, beta and omega) receptor 1interfubiquitin carboxyl-terminal hydrolase 22deubiquitinating enzyme 22ubiquitin specific protease 22ubiquitin thioesterase 22ubiquitin thiolesterase 22ubiquitin-specific processing protease 22
Modification date2018052320180519
UniProtAcc

P17181

Q9UPT9

Ensembl transtripts involved in fusion geneENST00000416947, ENST00000493503, 
ENST00000270139, ENST00000442357, 
ENST00000261497, ENST00000537526, 
ENST00000455117, 
Fusion gene scores* DoF score4 X 4 X 2=3210 X 9 X 3=270
# samples 410
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IFNAR1 [Title/Abstract] AND USP22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIFNAR1

GO:0060337

type I interferon signaling pathway

7665574

TgeneUSP22

GO:0016574

histone ubiquitination

18469533

TgeneUSP22

GO:0016578

histone deubiquitination

18206972|18206973

TgeneUSP22

GO:0016579

protein deubiquitination

16378762


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE530994IFNAR1chr21

34727892

+USP22chr17

20904143

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000416947ENST00000261497IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-3UTRENST00000416947ENST00000537526IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-intronENST00000416947ENST00000455117IFNAR1chr21

34727892

+USP22chr17

20904143

-
intron-3UTRENST00000493503ENST00000261497IFNAR1chr21

34727892

+USP22chr17

20904143

-
intron-3UTRENST00000493503ENST00000537526IFNAR1chr21

34727892

+USP22chr17

20904143

-
intron-intronENST00000493503ENST00000455117IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-3UTRENST00000270139ENST00000261497IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-3UTRENST00000270139ENST00000537526IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-intronENST00000270139ENST00000455117IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-3UTRENST00000442357ENST00000261497IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-3UTRENST00000442357ENST00000537526IFNAR1chr21

34727892

+USP22chr17

20904143

-
3UTR-intronENST00000442357ENST00000455117IFNAR1chr21

34727892

+USP22chr17

20904143

-

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FusionProtFeatures for IFNAR1_USP22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFNAR1

P17181

USP22

Q9UPT9

Histone deubiquitinating component of the transcriptionregulatory histone acetylation (HAT) complex SAGA. Catalyzes thedeubiquitination of both histones H2A and H2B, thereby acting as acoactivator. Recruited to specific gene promoters by activatorssuch as MYC, where it is required for transcription. Required fornuclear receptor-mediated transactivation and cell cycleprogression. {ECO:0000269|PubMed:18206972,ECO:0000269|PubMed:18206973, ECO:0000269|PubMed:18469533}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IFNAR1_USP22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IFNAR1_USP22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IFNAR1_USP22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIFNAR1P17181DB00022Peginterferon alfa-2bInterferon alpha/beta receptor 1biotechapproved
HgeneIFNAR1P17181DB00068Interferon beta-1bInterferon alpha/beta receptor 1biotechapproved
HgeneIFNAR1P17181DB00105Interferon Alfa-2b, RecombinantInterferon alpha/beta receptor 1biotechapproved
HgeneIFNAR1P17181DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 1biotechapproved|investigational
HgeneIFNAR1P17181DB00011Interferon alfa-n1Interferon alpha/beta receptor 1biotechapproved|investigational
HgeneIFNAR1P17181DB00034Interferon Alfa-2a, RecombinantInterferon alpha/beta receptor 1biotechapproved|investigational
HgeneIFNAR1P17181DB00060Interferon beta-1aInterferon alpha/beta receptor 1biotechapproved|investigational
HgeneIFNAR1P17181DB00069Interferon alfacon-1Interferon alpha/beta receptor 1biotechapproved|investigational

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RelatedDiseases for IFNAR1_USP22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIFNAR1C0042769Virus Diseases1CTD_human
HgeneIFNAR1C0086132Depressive Symptoms1PSYGENET
HgeneIFNAR1C0338715Drug-induced depressive state1PSYGENET