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Fusion gene ID: 17078 |
FusionGeneSummary for IFITM2_NMI |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IFITM2_NMI | Fusion gene ID: 17078 | Hgene | Tgene | Gene symbol | IFITM2 | NMI | Gene ID | 10581 | 9111 |
| Gene name | interferon induced transmembrane protein 2 | N-myc and STAT interactor | |
| Synonyms | 1-8D|DSPA2c | - | |
| Cytomap | 11p15.5 | 2q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interferon-induced transmembrane protein 2dispanin subfamily A member 2cinterferon-inducible protein 1-8D | N-myc-interactor | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q01629 | Q13287 | |
| Ensembl transtripts involved in fusion gene | ENST00000533141, ENST00000399817, ENST00000602569, | ENST00000243346, | |
| Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 4 X 3 X 3=36 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: IFITM2 [Title/Abstract] AND NMI [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IFITM2 | GO:0009615 | response to virus | 20943977|21253575|22479637 |
| Hgene | IFITM2 | GO:0034341 | response to interferon-gamma | 21253575 |
| Hgene | IFITM2 | GO:0035455 | response to interferon-alpha | 22479637 |
| Hgene | IFITM2 | GO:0035456 | response to interferon-beta | 21253575 |
| Hgene | IFITM2 | GO:0045071 | negative regulation of viral genome replication | 21253575 |
| Hgene | IFITM2 | GO:0046597 | negative regulation of viral entry into host cell | 21253575|23358889 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB529308 | IFITM2 | chr11 | 309298 | - | NMI | chr2 | 152127296 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000533141 | ENST00000243346 | IFITM2 | chr11 | 309298 | - | NMI | chr2 | 152127296 | + |
| 3UTR-3CDS | ENST00000399817 | ENST00000243346 | IFITM2 | chr11 | 309298 | - | NMI | chr2 | 152127296 | + |
| 3UTR-3CDS | ENST00000602569 | ENST00000243346 | IFITM2 | chr11 | 309298 | - | NMI | chr2 | 152127296 | + |
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FusionProtFeatures for IFITM2_NMI |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IFITM2 | NMI |
| IFN-induced antiviral protein which inhibits the entryof viruses to the host cell cytoplasm, permitting endocytosis, butpreventing subsequent viral fusion and release of viral contentsinto the cytosol. Active against multiple viruses, includinginfluenza A virus, SARS coronavirus (SARS-CoV), Marburg virus(MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus(WNV), human immunodeficiency virus type 1 (HIV-1) and vesicularstomatitis virus (VSV). Can inhibit: influenza virus hemagglutininprotein-mediated viral entry, MARV and EBOV GP1,2-mediated viralentry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediatesapoptosis by caspase activation and in p53-independent manner.{ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371,ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977,ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575,ECO:0000269|PubMed:22479637}. | May be involved in augmenting coactivator proteinrecruitment to a group of sequence-specific transcription factors.Augments cytokine-mediated STAT transcription. Enhances CBP/p300coactivator protein recruitment to STAT1 and STAT5. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IFITM2_NMI |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IFITM2_NMI |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IFITM2_NMI |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IFITM2_NMI |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NMI | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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