FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17074

FusionGeneSummary for IFITM1_CRIM1

check button Fusion gene summary
Fusion gene informationFusion gene name: IFITM1_CRIM1
Fusion gene ID: 17074
HgeneTgene
Gene symbol

IFITM1

CRIM1

Gene ID

8519

51232

Gene nameinterferon induced transmembrane protein 1cysteine rich transmembrane BMP regulator 1
Synonyms9-27|CD225|DSPA2a|IFI17|LEU13CRIM-1|S52
Cytomap

11p15.5

2p22.2

Type of geneprotein-codingprotein-coding
Descriptioninterferon-induced transmembrane protein 1dispanin subfamily A member 2ainterferon-induced protein 17interferon-inducible protein 9-27leu-13 antigencysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52
Modification date2018052320180519
UniProtAcc

P13164

Q9NZV1

Ensembl transtripts involved in fusion geneENST00000528780, ENST00000328221, 
ENST00000408968, ENST00000525554, 
ENST00000280527, ENST00000473403, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 27
** MAII scorelog2(2/1*10)=4.32192809488736log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IFITM1 [Title/Abstract] AND CRIM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIFITM1

GO:0009615

response to virus

21253575|22479637

HgeneIFITM1

GO:0034341

response to interferon-gamma

21253575

HgeneIFITM1

GO:0035455

response to interferon-alpha

22479637

HgeneIFITM1

GO:0035456

response to interferon-beta

21253575

HgeneIFITM1

GO:0045071

negative regulation of viral genome replication

21253575

HgeneIFITM1

GO:0046597

negative regulation of viral entry into host cell

21253575|23358889


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI991482IFITM1chr11

315193

-CRIM1chr2

36686810

-
ChiTaRS3.1AI656093IFITM1chr11

315193

-CRIM1chr2

36686810

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000528780ENST00000280527IFITM1chr11

315193

-CRIM1chr2

36686810

-
3UTR-intronENST00000528780ENST00000473403IFITM1chr11

315193

-CRIM1chr2

36686810

-
3UTR-intronENST00000328221ENST00000280527IFITM1chr11

315193

-CRIM1chr2

36686810

-
3UTR-intronENST00000328221ENST00000473403IFITM1chr11

315193

-CRIM1chr2

36686810

-
3UTR-intronENST00000408968ENST00000280527IFITM1chr11

315193

-CRIM1chr2

36686810

-
3UTR-intronENST00000408968ENST00000473403IFITM1chr11

315193

-CRIM1chr2

36686810

-
intron-intronENST00000525554ENST00000280527IFITM1chr11

315193

-CRIM1chr2

36686810

-
intron-intronENST00000525554ENST00000473403IFITM1chr11

315193

-CRIM1chr2

36686810

-

Top

FusionProtFeatures for IFITM1_CRIM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFITM1

P13164

CRIM1

Q9NZV1

IFN-induced antiviral protein which inhibits the entryof viruses to the host cell cytoplasm, permitting endocytosis, butpreventing subsequent viral fusion and release of viral contentsinto the cytosol. Active against multiple viruses, includinginfluenza A virus, SARS coronavirus (SARS-CoV), Marburg virus(MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus(WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis Cvirus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry andSARS-CoV S protein-mediated viral entry. Also implicated in celladhesion and control of cell growth and migration. Plays a keyrole in the antiproliferative action of IFN-gamma either byinhibiting the ERK activation or by arresting cell growth in G1phase in a p53-dependent manner. Acts as a positive regulator ofosteoblast differentiation. {ECO:0000269|PubMed:16847454,ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853,ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575,ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637,ECO:0000269|PubMed:22634173}. May play a role in CNS development by interacting withgrowth factors implicated in motor neuron differentiation andsurvival. May play a role in capillary formation and maintenanceduring angiogenesis. Modulates BMP activity by affecting itsprocessing and delivery to the cell surface.{ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IFITM1_CRIM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IFITM1_CRIM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IFITM1_CRIM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for IFITM1_CRIM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIFITM1C0023893Liver Cirrhosis, Experimental1CTD_human