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Fusion gene ID: 17070 |
FusionGeneSummary for IFIT1_LIPA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IFIT1_LIPA | Fusion gene ID: 17070 | Hgene | Tgene | Gene symbol | IFIT1 | LIPA | Gene ID | 3434 | 10648 |
| Gene name | interferon induced protein with tetratricopeptide repeats 1 | secretoglobin family 1D member 1 | |
| Synonyms | C56|G10P1|IFI-56|IFI-56K|IFI56|IFIT-1|IFNAI1|ISG56|P56|RNM561 | LIPA|LPHA|LPNA | |
| Cytomap | 10q23.31 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interferon-induced protein with tetratricopeptide repeats 1interferon, alpha-inducible protein (MW 56kD)interferon-induced 56 kDa proteininterferon-inducible mRNA 561 | secretoglobin family 1D member 1lipophilin A (uteroglobin family member)lipophilin-Aprostatein-like lipophilin A | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P09914 | P38571 | |
| Ensembl transtripts involved in fusion gene | ENST00000371804, ENST00000546318, | ENST00000371837, ENST00000487618, ENST00000336233, ENST00000456827, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: IFIT1 [Title/Abstract] AND LIPA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IFIT1 | GO:0009615 | response to virus | 19416887 |
| Hgene | IFIT1 | GO:0019060 | intracellular transport of viral protein in host cell | 19008854 |
| Hgene | IFIT1 | GO:0032091 | negative regulation of protein binding | 19416887 |
| Hgene | IFIT1 | GO:0045070 | positive regulation of viral genome replication | 19416887 |
| Hgene | IFIT1 | GO:0050689 | negative regulation of defense response to virus by host | 19416887 |
| Hgene | IFIT1 | GO:0051097 | negative regulation of helicase activity | 19008854 |
| Hgene | IFIT1 | GO:0071357 | cellular response to type I interferon | 19008854 |
| Hgene | IFIT1 | GO:0071360 | cellular response to exogenous dsRNA | 19008854 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1506-01A | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000371804 | ENST00000371837 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| 5CDS-intron | ENST00000371804 | ENST00000487618 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| 5CDS-5UTR | ENST00000371804 | ENST00000336233 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| 5CDS-5UTR | ENST00000371804 | ENST00000456827 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| intron-intron | ENST00000546318 | ENST00000371837 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| intron-intron | ENST00000546318 | ENST00000487618 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| intron-5UTR | ENST00000546318 | ENST00000336233 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
| intron-5UTR | ENST00000546318 | ENST00000456827 | IFIT1 | chr10 | 91152474 | + | LIPA | chr10 | 91007406 | - |
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FusionProtFeatures for IFIT1_LIPA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IFIT1 | LIPA |
| Interferon-induced antiviral RNA-binding protein thatspecifically binds single-stranded RNA bearing a 5'-triphosphategroup (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs.Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5'cap and bear a 5'-triphosphate group instead, are specific fromviruses, providing a molecular signature to distinguish betweenself and non-self mRNAs by the host during viral infection.Directly binds PPP-RNA in a non-sequence-specific manner. Virusesevolved several ways to evade this restriction system such asencoding their own 2'-O-methylase for their mRNAs or by stealinghost cap containing the 2'-O-methylation (cap snatchingmechanism). Exhibits antiviral activity against several virusesincluding human papilloma and hepatitis C viruses.{ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887,ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}. | Crucial for the intracellular hydrolysis of cholesterylesters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important inmediating the effect of LDL (low density lipoprotein) uptake onsuppression of hydroxymethylglutaryl-CoA reductase and activationof endogenous cellular cholesteryl ester formation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IFIT1_LIPA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IFIT1_LIPA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IFIT1 | IFIT3, EIF3E, SAP25, ISG15, RPLP1, SNRPF, HSP90AA1, SNRPD3, IFIT1B, SNRPD1, SNRPB2, SNRPB, SNRNP70, MCCC2, PCCB, ACACA, PCCA, PC, MCCC1, PABPC4, SNRPD2, SNRPA, DCD, SNRPE, SNRPC, HSP90AB1, GRPEL1, HNRNPC, TOE1, ILF2, NCL, IGF2BP1, PABPC1, IFIT2, SNRPA1, MOV10, YBX1, S100A7, IFIT5, IFNA14, IFNA5, IFNA8, TFEB, PHACTR4, IFNA21, IFNA10, TES | LIPA | ELAVL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IFIT1_LIPA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IFIT1_LIPA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IFIT1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | IFIT1 | C0021400 | Influenza | 1 | CTD_human |
| Tgene | LIPA | C0043208 | Wolman Disease | 2 | ORPHANET;UNIPROT |
| Tgene | LIPA | C0008384 | Cholesterol Ester Storage Disease | 1 | CTD_human;ORPHANET |
| Tgene | LIPA | C0220756 | Niemann-Pick Disease, Type C | 1 | CTD_human |
| Tgene | LIPA | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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