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Fusion gene ID: 17031 |
FusionGeneSummary for IDI1_AKR1C3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IDI1_AKR1C3 | Fusion gene ID: 17031 | Hgene | Tgene | Gene symbol | IDI1 | AKR1C3 | Gene ID | 3422 | 8644 |
| Gene name | isopentenyl-diphosphate delta isomerase 1 | aldo-keto reductase family 1 member C3 | |
| Synonyms | IPP1|IPPI1 | DD3|DDX|HA1753|HAKRB|HAKRe|HSD17B5|PGFS|hluPGFS | |
| Cytomap | 10p15.3 | 10p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | isopentenyl-diphosphate Delta-isomerase 1IPP isomerase 1isopentenyl diphosphate dimethylallyl diphosphate isomerase 1isopentenyl pyrophosphate isomerase 1 | aldo-keto reductase family 1 member C33-alpha hydroxysteroid dehydrogenase, type II3-alpha-HSD type II, brainchlordecone reductase homolog HAKRbdihydrodiol dehydrogenase 3dihydrodiol dehydrogenase Xindanol dehydrogenaseprostaglandin F synthasetest | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q13907 | P42330 | |
| Ensembl transtripts involved in fusion gene | ENST00000381344, ENST00000491735, | ENST00000470862, ENST00000605149, ENST00000439082, ENST00000380554, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: IDI1 [Title/Abstract] AND AKR1C3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AKR1C3 | GO:0000060 | protein import into nucleus, translocation | 21787718 |
| Tgene | AKR1C3 | GO:0007186 | G-protein coupled receptor signaling pathway | 18508192 |
| Tgene | AKR1C3 | GO:0008284 | positive regulation of cell proliferation | 18508192|20036328 |
| Tgene | AKR1C3 | GO:0010942 | positive regulation of cell death | 21787718 |
| Tgene | AKR1C3 | GO:0016488 | farnesol catabolic process | 21187079 |
| Tgene | AKR1C3 | GO:0034614 | cellular response to reactive oxygen species | 21787718 |
| Tgene | AKR1C3 | GO:0042448 | progesterone metabolic process | 21232532 |
| Tgene | AKR1C3 | GO:0042574 | retinal metabolic process | 21851338 |
| Tgene | AKR1C3 | GO:0048385 | regulation of retinoic acid receptor signaling pathway | 21851338 |
| Tgene | AKR1C3 | GO:0051897 | positive regulation of protein kinase B signaling | 18508192 |
| Tgene | AKR1C3 | GO:0055114 | oxidation-reduction process | 16983398|19442656|21232532 |
| Tgene | AKR1C3 | GO:0071276 | cellular response to cadmium ion | 21787718 |
| Tgene | AKR1C3 | GO:0071277 | cellular response to calcium ion | 22170488 |
| Tgene | AKR1C3 | GO:0071379 | cellular response to prostaglandin stimulus | 22170488 |
| Tgene | AKR1C3 | GO:0071384 | cellular response to corticosteroid stimulus | 19336506 |
| Tgene | AKR1C3 | GO:0071395 | cellular response to jasmonic acid stimulus | 19487289 |
| Tgene | AKR1C3 | GO:0071799 | cellular response to prostaglandin D stimulus | 18508192 |
| Tgene | AKR1C3 | GO:1900053 | negative regulation of retinoic acid biosynthetic process | 21851338 |
| Tgene | AKR1C3 | GO:2000353 | positive regulation of endothelial cell apoptotic process | 19442656 |
| Tgene | AKR1C3 | GO:2000379 | positive regulation of reactive oxygen species metabolic process | 19442656 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-4B-A93V-01A | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000381344 | ENST00000470862 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| 5CDS-5UTR | ENST00000381344 | ENST00000605149 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| 5CDS-5UTR | ENST00000381344 | ENST00000439082 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| 5CDS-intron | ENST00000381344 | ENST00000380554 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| 5UTR-3UTR | ENST00000491735 | ENST00000470862 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| 5UTR-5UTR | ENST00000491735 | ENST00000605149 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| 5UTR-5UTR | ENST00000491735 | ENST00000439082 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
| 5UTR-intron | ENST00000491735 | ENST00000380554 | IDI1 | chr10 | 1094804 | - | AKR1C3 | chr10 | 5120092 | + |
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FusionProtFeatures for IDI1_AKR1C3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IDI1 | AKR1C3 |
| Catalyzes the 1,3-allylic rearrangement of thehomoallylic substrate isopentenyl (IPP) to its highlyelectrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).{ECO:0000269|PubMed:8806705}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IDI1_AKR1C3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IDI1_AKR1C3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IDI1 | BARD1, FN1, VWA8, WT1 | AKR1C3 | MAGEA11, UBE2W, ZHX1, LRIF1, AKR1C2, AKR1C4, AKR1C1, AKR1D1, SIAH2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IDI1_AKR1C3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | AKR1C3 | P42330 | DB00328 | Indomethacin | Aldo-keto reductase family 1 member C3 | small molecule | approved|investigational |
| Tgene | AKR1C3 | P42330 | DB00905 | Bimatoprost | Aldo-keto reductase family 1 member C3 | small molecule | approved|investigational |
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RelatedDiseases for IDI1_AKR1C3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | AKR1C3 | C0032460 | Polycystic Ovary Syndrome | 3 | CTD_human |
| Tgene | AKR1C3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| Tgene | AKR1C3 | C0014175 | Endometriosis | 2 | CTD_human |
| Tgene | AKR1C3 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | AKR1C3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | AKR1C3 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | AKR1C3 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | AKR1C3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | AKR1C3 | C0027661 | Neoplasms, Hormone-Dependent | 1 | CTD_human |
| Tgene | AKR1C3 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | AKR1C3 | C0036875 | Disorders of Sex Development | 1 | CTD_human |
| Tgene | AKR1C3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | AKR1C3 | C0338831 | Manic | 1 | PSYGENET |
| Tgene | AKR1C3 | C0564408 | Manic mood | 1 | PSYGENET |
| Tgene | AKR1C3 | C3658267 | Prostatic Neoplasms, Castration-Resistant | 1 | CTD_human |
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