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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17023

FusionGeneSummary for IDH2_ZNF710

check button Fusion gene summary
Fusion gene informationFusion gene name: IDH2_ZNF710
Fusion gene ID: 17023
HgeneTgene
Gene symbol

IDH2

ZNF710

Gene ID

3418

374655

Gene nameisocitrate dehydrogenase (NADP(+)) 2, mitochondrialzinc finger protein 710
SynonymsD2HGA2|ICD-M|IDH|IDHM|IDP|IDPM|mNADP-IDH-
Cytomap

15q26.1

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionisocitrate dehydrogenase [NADP], mitochondrialNADP(+)-specific ICDHisocitrate dehydrogenase 2 (NADP+), mitochondrialoxalosuccinate decarboxylasezinc finger protein 710
Modification date2018052220180523
UniProtAcc

P48735

Q8N1W2

Ensembl transtripts involved in fusion geneENST00000330062, ENST00000539790, 
ENST00000559482, ENST00000540499, 
ENST00000268154, ENST00000560908, 
Fusion gene scores* DoF score3 X 4 X 2=247 X 4 X 7=196
# samples 49
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IDH2 [Title/Abstract] AND ZNF710 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-25-1626-01AIDH2chr15

90645508

-ZNF710chr15

90610342

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000330062ENST00000268154IDH2chr15

90645508

-ZNF710chr15

90610342

+
5CDS-intronENST00000330062ENST00000560908IDH2chr15

90645508

-ZNF710chr15

90610342

+
5UTR-5UTRENST00000539790ENST00000268154IDH2chr15

90645508

-ZNF710chr15

90610342

+
5UTR-intronENST00000539790ENST00000560908IDH2chr15

90645508

-ZNF710chr15

90610342

+
5CDS-5UTRENST00000559482ENST00000268154IDH2chr15

90645508

-ZNF710chr15

90610342

+
5CDS-intronENST00000559482ENST00000560908IDH2chr15

90645508

-ZNF710chr15

90610342

+
intron-5UTRENST00000540499ENST00000268154IDH2chr15

90645508

-ZNF710chr15

90610342

+
intron-intronENST00000540499ENST00000560908IDH2chr15

90645508

-ZNF710chr15

90610342

+

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FusionProtFeatures for IDH2_ZNF710


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IDH2

P48735

ZNF710

Q8N1W2

Plays a role in intermediary metabolism and energyproduction. It may tightly associate or interact with the pyruvatedehydrogenase complex. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IDH2_ZNF710


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IDH2_ZNF710


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IDH2CDK2, HDAC1, ADRB2, PYGL, EGFR, KCMF1, IDH1, G6PD, IDH3A, IDH3B, IDH3G, NTRK1, MUS81, KBTBD7, ZNF746, SLC39A9, C1orf85, MAS1, SLC15A1, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, EIF5B, GPI, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, COQ2, SOAT1ZNF710


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IDH2_ZNF710


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IDH2_ZNF710


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIDH2C0014084Enchondromatosis2CTD_human;HPO;ORPHANET
HgeneIDH2C0079774Peripheral T-Cell Lymphoma2CTD_human
HgeneIDH2C0936248Chondroma2CTD_human
HgeneIDH2C2750850GLIOMA SUSCEPTIBILITY 12UNIPROT
HgeneIDH2C0018916Hemangioma1CTD_human
HgeneIDH2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
HgeneIDH2C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneIDH2C0023487Acute Promyelocytic Leukemia1CTD_human
HgeneIDH2C0027643Neoplasm Recurrence, Local1CTD_human
HgeneIDH2C0028945oligodendroglioma1CTD_human;ORPHANET
HgeneIDH2C0029408Degenerative polyarthritis1CTD_human
HgeneIDH2C0029456Osteoporosis1CTD_human
HgeneIDH2C0206698Cholangiocarcinoma1CTD_human
HgeneIDH2C3150909D-2-HYDROXYGLUTARIC ACIDURIA 21UNIPROT