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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17010

FusionGeneSummary for ICK_FAM83B

check button Fusion gene summary
Fusion gene informationFusion gene name: ICK_FAM83B
Fusion gene ID: 17010
HgeneTgene
Gene symbol

ICK

FAM83B

Gene ID

22858

222584

Gene nameintestinal cell kinasefamily with sequence similarity 83 member B
SynonymsECO|EJM10|LCK2|MRKC6orf143
Cytomap

6p12.1

6p12.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase ICKMAK-related kinasehICKintestinal cell (MAK-like) kinaselaryngeal cancer kinase 2serine/threonine protein kinaseprotein FAM83B
Modification date2018052320180519
UniProtAcc

Q9UPZ9

Q5T0W9

Ensembl transtripts involved in fusion geneENST00000350082, ENST00000356971, 
ENST00000306858, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 2 X 4=32
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ICK [Title/Abstract] AND FAM83B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneICK

GO:0006468

protein phosphorylation

10699974

HgeneICK

GO:0035556

intracellular signal transduction

10699974

TgeneFAM83B

GO:0007173

epidermal growth factor receptor signaling pathway

23676467


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-A5-A7WK-01AICKchr6

52883128

-FAM83Bchr6

54734985

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000350082ENST00000306858ICKchr6

52883128

-FAM83Bchr6

54734985

+
5CDS-5UTRENST00000356971ENST00000306858ICKchr6

52883128

-FAM83Bchr6

54734985

+

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FusionProtFeatures for ICK_FAM83B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ICK

Q9UPZ9

FAM83B

Q5T0W9

Required for ciliogenesis (PubMed:24797473).Phosphorylates KIF3A (By similarity). Involved in the control ofciliary length (PubMed:24853502). Regulates the ciliarylocalization of SHH pathway components as well as the localizationof IFT components at ciliary tips (By similarity). May play a keyrole in the development of multiple organ systems and particularlyin cardiac development (By similarity). Regulates intraflagellartransport (IFT) speed and negatively regulates cilium length in acAMP and mTORC1 signaling-dependent manner and this regulationrequires its kinase activity (By similarity).{ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2,ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502}. Probable proto-oncogene that functions in the epidermalgrowth factor receptor/EGFR signaling pathway. May activate boththe EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signalingcascades. {ECO:0000269|PubMed:22886302,ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ICK_FAM83B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ICK_FAM83B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ICKRPTOR, MAPK1, CDC7, MNAT1, CDK20, BAG6, APP, VCP, CD247, HSP90AA1, SMAD1, CPSF1, PSMD1, NUP188, TP53, PSMC6, LSM14B, NR0B2, MSI2, A4GALT, A4GNT, FAM217B, CENPL, MGC39584, BMP7, CDK14, CDK1, CDK16, BLM, CKS1B, DEPDC1, FCGR3B, SLC35A1, IL1R1, SMYD2, MAK, KIAA0556, IFT88, IFT172, CLUAP1FAM83BSLMAP, YWHAB, CSNK1A1, CSNK1E, CCDC8, CLEC11A, ANKRA2, CEP128, CEP135, NIN, APC, CLTB, CLTC, GAK, PFKFB2, OFD1, SEC16A, GTSE1, CDH1, POTEB3, ARC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ICK_FAM83B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ICK_FAM83B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneICKC2675227Endocrine-Cerebroosteodysplasia1CTD_human;ORPHANET;UNIPROT