FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 16994

FusionGeneSummary for IARS_TMEM165

check button Fusion gene summary
Fusion gene informationFusion gene name: IARS_TMEM165
Fusion gene ID: 16994
HgeneTgene
Gene symbol

IARS

TMEM165

Gene ID

3376

55858

Gene nameisoleucyl-tRNA synthetasetransmembrane protein 165
SynonymsGRIDHH|IARS1|ILERS|ILRS|IRS|PRO0785CDG2K|FT27|GDT1|TMPT27|TPARL
Cytomap

9q22.31

4q12

Type of geneprotein-codingprotein-coding
Descriptionisoleucine--tRNA ligase, cytoplasmicisoleucine tRNA ligase 1, cytoplasmictransmembrane protein 165TPA regulated locustransmembrane protein PT27transmembrane protein TPARL
Modification date2018052320180519
UniProtAcc

P41252

Q9HC07

Ensembl transtripts involved in fusion geneENST00000375643, ENST00000375629, 
ENST00000443024, ENST00000447699, 
ENST00000375627, ENST00000474340, 
ENST00000506198, ENST00000381334, 
ENST00000542052, ENST00000514904, 
Fusion gene scores* DoF score7 X 9 X 2=1262 X 2 X 1=4
# samples 112
** MAII scorelog2(11/126*10)=-0.195920209975257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: IARS [Title/Abstract] AND TMEM165 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIARS

GO:0006428

isoleucyl-tRNA aminoacylation

8052601

TgeneTMEM165

GO:0032472

Golgi calcium ion transport

23569283


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ711962IARSchr9

94972953

-TMEM165chr4

56292318

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000375643ENST00000506198IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-3UTRENST00000375643ENST00000381334IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375643ENST00000542052IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375643ENST00000514904IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375629ENST00000506198IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-3UTRENST00000375629ENST00000381334IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375629ENST00000542052IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375629ENST00000514904IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000443024ENST00000506198IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-3UTRENST00000443024ENST00000381334IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000443024ENST00000542052IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000443024ENST00000514904IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000447699ENST00000506198IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-3UTRENST00000447699ENST00000381334IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000447699ENST00000542052IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000447699ENST00000514904IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375627ENST00000506198IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-3UTRENST00000375627ENST00000381334IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375627ENST00000542052IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000375627ENST00000514904IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000474340ENST00000506198IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-3UTRENST00000474340ENST00000381334IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000474340ENST00000542052IARSchr9

94972953

-TMEM165chr4

56292318

-
intron-intronENST00000474340ENST00000514904IARSchr9

94972953

-TMEM165chr4

56292318

-

Top

FusionProtFeatures for IARS_TMEM165


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IARS

P41252

TMEM165

Q9HC07

Catalyzes the specific attachment of an amino acid toits cognate tRNA in a 2 step reaction: the amino acid (AA) isfirst activated by ATP to form AA-AMP and then transferred to theacceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. May function as a calcium/proton transporter involved incalcium and in lysosomal pH homeostasis. Therefore, it may play anindirect role in protein glycosylation.{ECO:0000269|PubMed:22683087, ECO:0000269|PubMed:23569283}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IARS_TMEM165


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IARS_TMEM165


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IARS_TMEM165


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for IARS_TMEM165


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMEM165C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTMEM165C3553571CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIk1ORPHANET;UNIPROT