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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16962

FusionGeneSummary for HUWE1_HUWE1

check button Fusion gene summary
Fusion gene informationFusion gene name: HUWE1_HUWE1
Fusion gene ID: 16962
HgeneTgene
Gene symbol

HUWE1

HUWE1

Gene ID

10075

10075

Gene nameHECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseHECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
SynonymsARF-BP1|HECTH9|HSPC272|Ib772|LASU1|MULE|URE-B1|UREB1ARF-BP1|HECTH9|HSPC272|Ib772|LASU1|MULE|URE-B1|UREB1
Cytomap

Xp11.22

Xp11.22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HUWE1ARF-binding protein 1BJ-HCC-24 tumor antigenHECT domain protein LASU1HECT-type E3 ubiquitin transferase HUWE1Mcl-1 ubiquitin ligase E3URE-binding protein 1homologous to E6AP carboxyl terminus homologous protein 9laE3 ubiquitin-protein ligase HUWE1ARF-binding protein 1BJ-HCC-24 tumor antigenHECT domain protein LASU1HECT-type E3 ubiquitin transferase HUWE1Mcl-1 ubiquitin ligase E3URE-binding protein 1homologous to E6AP carboxyl terminus homologous protein 9la
Modification date2018052320180523
UniProtAcc

Q7Z6Z7

Q7Z6Z7

Ensembl transtripts involved in fusion geneENST00000342160, ENST00000262854, 
ENST00000474288, ENST00000218328, 
ENST00000342160, ENST00000262854, 
ENST00000474288, ENST00000218328, 
Fusion gene scores* DoF score11 X 12 X 5=6607 X 8 X 3=168
# samples 138
** MAII scorelog2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HUWE1 [Title/Abstract] AND HUWE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHUWE1

GO:0000209

protein polyubiquitination

15989957

HgeneHUWE1

GO:0006513

protein monoubiquitination

19713937

HgeneHUWE1

GO:0016574

histone ubiquitination

15767685

TgeneHUWE1

GO:0000209

protein polyubiquitination

15989957

TgeneHUWE1

GO:0006513

protein monoubiquitination

19713937

TgeneHUWE1

GO:0016574

histone ubiquitination

15767685


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP231230HUWE1chrX

53563609

-HUWE1chrX

53576121

-
ChiTaRS3.1AW841891HUWE1chrX

53631359

+HUWE1chrX

53630604

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000342160ENST00000342160HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-3CDSENST00000342160ENST00000262854HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000342160ENST00000474288HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000342160ENST00000218328HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-3CDSENST00000262854ENST00000342160HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-3CDSENST00000262854ENST00000262854HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000262854ENST00000474288HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000262854ENST00000218328HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-3CDSENST00000474288ENST00000342160HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-3CDSENST00000474288ENST00000262854HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000474288ENST00000474288HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000474288ENST00000218328HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-3CDSENST00000218328ENST00000342160HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-3CDSENST00000218328ENST00000262854HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000218328ENST00000474288HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000218328ENST00000218328HUWE1chrX

53563609

-HUWE1chrX

53576121

-
intron-intronENST00000342160ENST00000342160HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000342160ENST00000262854HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000342160ENST00000474288HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000342160ENST00000218328HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000262854ENST00000342160HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000262854ENST00000262854HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000262854ENST00000474288HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000262854ENST00000218328HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000474288ENST00000342160HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000474288ENST00000262854HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000474288ENST00000474288HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000474288ENST00000218328HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000218328ENST00000342160HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000218328ENST00000262854HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000218328ENST00000474288HUWE1chrX

53631359

+HUWE1chrX

53630604

+
intron-intronENST00000218328ENST00000218328HUWE1chrX

53631359

+HUWE1chrX

53630604

+

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FusionProtFeatures for HUWE1_HUWE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HUWE1

Q7Z6Z7

HUWE1

Q7Z6Z7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HUWE1_HUWE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HUWE1_HUWE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HUWE1_HUWE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HUWE1_HUWE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHUWE1C2678046Mental Retardation, X-Linked, Syndromic, Turner Type1CTD_human;ORPHANET;UNIPROT
TgeneHUWE1C2678046Mental Retardation, X-Linked, Syndromic, Turner Type1CTD_human;ORPHANET;UNIPROT