|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16959 |
FusionGeneSummary for HUWE1_BICD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HUWE1_BICD1 | Fusion gene ID: 16959 | Hgene | Tgene | Gene symbol | HUWE1 | BICD1 | Gene ID | 10075 | 636 |
| Gene name | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | BICD cargo adaptor 1 | |
| Synonyms | ARF-BP1|HECTH9|HSPC272|Ib772|LASU1|MULE|URE-B1|UREB1 | BICD|bic-D 1 | |
| Cytomap | Xp11.22 | 12p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase HUWE1ARF-binding protein 1BJ-HCC-24 tumor antigenHECT domain protein LASU1HECT-type E3 ubiquitin transferase HUWE1Mcl-1 ubiquitin ligase E3URE-binding protein 1homologous to E6AP carboxyl terminus homologous protein 9la | protein bicaudal D homolog 1bicaudal D homolog 1cytoskeleton-like bicaudal D protein homolog 1 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q7Z6Z7 | Q96G01 | |
| Ensembl transtripts involved in fusion gene | ENST00000342160, ENST00000262854, ENST00000474288, ENST00000218328, | ENST00000548411, ENST00000281474, ENST00000551848, ENST00000550207, ENST00000551086, | |
| Fusion gene scores | * DoF score | 11 X 12 X 5=660 | 7 X 7 X 4=196 |
| # samples | 13 | 8 | |
| ** MAII score | log2(13/660*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HUWE1 [Title/Abstract] AND BICD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HUWE1 | GO:0000209 | protein polyubiquitination | 15989957 |
| Hgene | HUWE1 | GO:0006513 | protein monoubiquitination | 19713937 |
| Hgene | HUWE1 | GO:0016574 | histone ubiquitination | 15767685 |
| Tgene | BICD1 | GO:0033365 | protein localization to organelle | 12447383|20089649 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-A9SM-01A | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000342160 | ENST00000548411 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| Frame-shift | ENST00000342160 | ENST00000281474 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000342160 | ENST00000551848 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000342160 | ENST00000550207 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000342160 | ENST00000551086 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| Frame-shift | ENST00000262854 | ENST00000548411 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| In-frame | ENST00000262854 | ENST00000281474 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000262854 | ENST00000551848 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000262854 | ENST00000550207 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000262854 | ENST00000551086 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| intron-3CDS | ENST00000474288 | ENST00000548411 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| intron-3CDS | ENST00000474288 | ENST00000281474 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| intron-intron | ENST00000474288 | ENST00000551848 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| intron-intron | ENST00000474288 | ENST00000550207 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| intron-intron | ENST00000474288 | ENST00000551086 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| Frame-shift | ENST00000218328 | ENST00000548411 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| In-frame | ENST00000218328 | ENST00000281474 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000218328 | ENST00000551848 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000218328 | ENST00000550207 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
| 5CDS-intron | ENST00000218328 | ENST00000551086 | HUWE1 | chrX | 53651556 | - | BICD1 | chr12 | 32520604 | + |
Top |
FusionProtFeatures for HUWE1_BICD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HUWE1 | BICD1 |
| Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruitingthe dynein-dynactin motor complex. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HUWE1_BICD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HUWE1_ENST00000262854_chrX_53651556_-_BICD1_ENST00000281474_chr12_32520604_+_612aa MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLK MLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNH RKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSH SGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL >In-frame_HUWE1_ENST00000218328_chrX_53651556_-_BICD1_ENST00000281474_chr12_32520604_+_612aa MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLK MLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNH RKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSH SGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HUWE1_ENST00000262854_chrX_53651556_-_BICD1_ENST00000281474_chr12_32520604_+_1836nt ATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCTGCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAAT GATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATTGGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGC TTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCATGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAA ATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTACAGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACA ACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAATCTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGT CTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTGGCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCA GAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACTACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTC AAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATAGAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATG GAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTGTTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCAC AGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATATTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATC TTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACGGATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACA TTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATTATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCA GTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGATCCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTA TACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGTGGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGC GATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTTGACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCAT AGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTGTGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAG AGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGATGGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCC ATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGATGGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTG AAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTCCTAGATTGTCAGCAGCCTGCTGCCTCCGTACCGCCACAGTGC TCACAACTAGCCGGGAGGCAAGACTGCCCAACTGTCAGTCCTGACACAGCTCTCCCTGAGGAGCAGCCACATTCCAGCTCCCAGTGCGCC >In-frame_HUWE1_ENST00000218328_chrX_53651556_-_BICD1_ENST00000281474_chr12_32520604_+_1836nt ATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCTGCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAAT GATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATTGGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGC TTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCATGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAA ATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTACAGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACA ACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAATCTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGT CTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTGGCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCA GAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACTACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTC AAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATAGAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATG GAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTGTTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCAC AGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATATTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATC TTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACGGATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACA TTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATTATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCA GTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGATCCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTA TACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGTGGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGC GATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTTGACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCAT AGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTGTGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAG AGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGATGGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCC ATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGATGGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTG AAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTCCTAGATTGTCAGCAGCCTGCTGCCTCCGTACCGCCACAGTGC TCACAACTAGCCGGGAGGCAAGACTGCCCAACTGTCAGTCCTGACACAGCTCTCCCTGAGGAGCAGCCACATTCCAGCTCCCAGTGCGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HUWE1_ENST00000262854_chrX_53651556_-_BICD1_ENST00000281474_chr12_32520604_+_2488nt GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC CTAGATTGTCAGCAGCCTGCTGCCTCCGTACCGCCACAGTGCTCACAACTAGCCGGGAGGCAAGACTGCCCAACTGTCAGTCCTGACACA GCTCTCCCTGAGGAGCAGCCACATTCCAGCTCCCAGTGCGCCCCTCTCCACTGTCTCTCCAAGCCTCCTCACCCCTAGTCTTCATCTCCT GTGGACGAACATCTGGGGTGGAAGTTTTGTAGCCACACACAGGATACTGCCCAAGATCCAGCGGGTGTTTTCTTCTCGGTTGTTAGATGT ACAATTGGATTAATGTCCATCGTTTTGGAAGACGAGAGAAAGTTGAGAAGAACACGAAGCACAGACCCTGATGTGATAAAACATTTTGTG >In-frame_HUWE1_ENST00000218328_chrX_53651556_-_BICD1_ENST00000281474_chr12_32520604_+_2488nt GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC CTAGATTGTCAGCAGCCTGCTGCCTCCGTACCGCCACAGTGCTCACAACTAGCCGGGAGGCAAGACTGCCCAACTGTCAGTCCTGACACA GCTCTCCCTGAGGAGCAGCCACATTCCAGCTCCCAGTGCGCCCCTCTCCACTGTCTCTCCAAGCCTCCTCACCCCTAGTCTTCATCTCCT GTGGACGAACATCTGGGGTGGAAGTTTTGTAGCCACACACAGGATACTGCCCAAGATCCAGCGGGTGTTTTCTTCTCGGTTGTTAGATGT ACAATTGGATTAATGTCCATCGTTTTGGAAGACGAGAGAAAGTTGAGAAGAACACGAAGCACAGACCCTGATGTGATAAAACATTTTGTG |
Top |
FusionGenePPI for HUWE1_BICD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HUWE1 | MCL1, CDC6, USP49, USP50, USP7, VCPIP1, UBL4A, SLX1B, ATM, MYC, NR1D1, CDK5RAP3, HUWE1, USP9X, PMAIP1, CDKN2A, TP53, POLB, FAF2, UBXN1, PIAS2, CALM1, USP4, PCNA, RAD23A, SIRT7, HDAC2, HIST3H2BB, RASSF1, MFN2, HSPA4, CUL3, ABL1, UBE2L3, UBE2D1, UBE2G1, UBE2D2, UBE2D3, PRPF8, MACF1, SNRNP200, LIMCH1, TBL1X, RANGAP1, LSM4, FAP, UBC, VCP, NOS2, METTL21B, HDAC11, CLK2, MOK, FBXO6, CD2AP, FAM175B, BRCC3, SPAG9, TXNDC9, LARP7, RABEP2, BRCA1, MUTYH, DVL3, DVL1, SHFM1, EGFR, SPRTN, CEP250, SHOC2, MRAS, RAF1, MYH9, DDB1, DDIT4, UBB, SNRPD3, RPL15, RPS9, EPRS, PSMA6, ACACB, RPS3, SRSF2, RPS15A, PSMA7, CLTC, RPL13A, MDH2, COPB2, XPO1, AK2, CKB, PSMA3, HIST1H2AE, PGK1, PSMA4, HSP90B1, NUDT21, HSP90AB1, PSMD13, BLOC1S5, SF3A3, EEF2, PARP1, MCM2, PSMA1, DDX46, TPI1P1, GANAB, AHCY, RFC5, MCM4, PSMD1, EIF4A3, NACA, C16orf72, PSMB7, CSE1L, RPS24, HSP90AA1, EIF1AY, LDHA, USP15, UCHL5, ACLY, GAPDH, ANP32B, PSMA2, BUB3, CA2, PSMD14, PDIA6, DNAJA1, NCL, YWHAZ, PSMA5, IPO5, ACTN4, CANX, RPS8, PPIA, RPS7, TUFM, PSAT1P1, RPL23, ILF2, UBA1, PSMD11, DBT, SET, PSMD2, HSD17B10, EFTUD2, OAT, ALDOA, ATP5A1, RPS10, ATP5C1, PRDX4, PSMC1, KIF5B, OGT, DLG1, RPL7P32, PCMT1, TARS, PRDX6, HNRNPA2B1, SF3B3, TRIM28, HSPH1, PDHB, PSMC5, PSMD7, PSMC6, PSMD8, CAPNS1, EIF3F, DNAJA3, HNRNPU, SRSF1, DDX1, SRSF5, SLC25A5, PSMC3, HSPD1, RPL27A, SHMT2, MARS, RPL3, C1QBP, SFPQ, RPS4X, ENO1, LDHB, PSMC4, USO1, RPLP0, XRCC5, ERP29, ASNA1, OLA1, EIF4A1, HMGB1, RBBP4, IDH3A, NCKAP1, DLD, PSMD6, CTSD, RPL22, DDX21, RPL10A, ATP1A1, SLC25A6, RPL18, PSMD12, ADRM1, SSR1, NCBP1, HSPB1, NAP1L1, GET4, UFD1L, CS, PSMC2, PC, RPL5, C14orf166, SND1, SUB1, KPNA2, RPL7A, NPM1, ARF1, RPL27, DDOST, EIF3M, YWHAH, TFRC, PKM, PRMT1, PHB2, HADHB, ATP5B, RPL12, GDI2, DPM1, RPRD1B, MCM6, SF3A1, RPL8, EIF5A, ILF3, TUT1, AHSA1, IMPDH2, SSB, HNRNPH1, PCCA, COPG1, GTF2A1, EIF2S1, PDHA1, HIST2H2BE, NDUFS3, CTNNB1, PYGL, RPL13, KPNB1, DNAJC8, MCCC1, PSME1, ANXA5, TUBB4B, QARS, RPS3A, TUBB2A, TUBB, AGR2, MKL2, YWHAG, ACTR1A, MIR548AJ1, SRSF3, RPL4, RPS18, SRP14, C17orf75, PCBP2, RPS25, GPI, MTHFD2, NUDC, EEF1D, GIGYF2, RPS13, ECH1, PCCB, SNRPB, NEK9, PPP1R10, SLC25A3, YWHAE, DNAJB1, UNC45A, FAM91A1, PCBP1, CALR, HNRNPK, ALDH3A2, EIF3I, NASP, SMEK1, RPS23, PRPF19, STAT1, PHGDH, TUBA1C, PPIH, RPS14, PHB, ZBTB33, CAPZA1, RBBP7, KHSRP, STRAP, RPA2, NONO, LUC7L2, GNB2L1, PAICS, PDAP1, MCCC2, PPP1CA, PSMD3, CAPZB, CDK1, HSPA5, EIF3E, SERBP1, EEF1E1, TOX4, RPS19, RPS17, LOC389842, EPB41L3, ATG3, EEF1B2, RANP1, RTN4, WWOX, FASN, SSR4, PSME3, CSDE1, STMN1, RPS16, SNRPA1, RPP30, PAPOLA, MRE11A, MAPRE2, TCP1, CCT2, RPL6, WIPI2, PGAM5, WDR82, CCT5, LSM12, RUVBL2, CCT3, CCT4, CCT6A, EIF5, RUVBL1, CCT8, SAP30BP, CCT7, MYL6B, EIF4E2, PCNP, CRKL, TIPRL, CRK, AP3S2, MYOD1, CCDC8, FBXW11, UNK, NTRK1, GNL1, NUCKS1, U2AF2, MED4, PHAX, KRAS, IFI16, ANKRA2, RFXANK, TENC1, ZBTB17, MED20, CDC20, CPT1A, HTT, MAGEA1, NDUFS5, FURIN, PRSS1, RAD51D, VAMP2, UQCRC2, NCOA4, ELL, RBM10, MAML1, RB1CC1, CSNK2A2, EZH2, AKAP9, DNAJA2, KCTD2, NNT, WDR91, NDUFA13, LRRC16A, NCLN, KIAA1191, SLC25A19, KIF13A, SFXN3, C18orf21, KLF16, UTP23, AHNAK2, CDYL2, LSM14B, TEAD2, FOXB1, CRY1, CRY2, CDC5L, KDM3A, TBP, DPPA4, NANOG, POU5F1, PSMD4, POLL, CUL4B, H2AFX, MYCN, BAG6, KLF4, ATOH1, VHL, SCNN1A, DERL1, PREX2, GNMT, PTP4A3, WBP2, ERG, SOD1, TRIM25, TES | BICD1 | RAB6A, PLK1, DISC1, STAT3, MAPK14, NTRK1, HERC2, PCM1, CEP128, SH3BP5L, SYBU, NEFL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HUWE1_BICD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HUWE1_BICD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HUWE1 | C2678046 | Mental Retardation, X-Linked, Syndromic, Turner Type | 1 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|