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Fusion gene ID: 16938 |
FusionGeneSummary for HTN3_RIMS1 |
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Fusion gene information | Fusion gene name: HTN3_RIMS1 | Fusion gene ID: 16938 | Hgene | Tgene | Gene symbol | HTN3 | RIMS1 | Gene ID | 3347 | 22999 |
Gene name | histatin 3 | regulating synaptic membrane exocytosis 1 | |
Synonyms | HIS2|HTN2|HTN5 | CORD7|RAB3IP2|RIM|RIM1 | |
Cytomap | 4q13.3 | 6q13 | |
Type of gene | protein-coding | protein-coding | |
Description | histatin-3PBbasic histidine-rich proteinhistatin-4histatin-5histatin-6histatin-7histatin-8histatin-9histidine-rich protein 3hst | regulating synaptic membrane exocytosis protein 1RAB3-interacting protein 2rab-3-interacting protein 2rab3-interacting molecule 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P15516 | Q86UR5 | |
Ensembl transtripts involved in fusion gene | ENST00000526767, ENST00000530128, ENST00000381057, | ENST00000491071, ENST00000348717, ENST00000518273, ENST00000522291, ENST00000517960, ENST00000521978, ENST00000520567, ENST00000264839, ENST00000401910, ENST00000523963, ENST00000425662, ENST00000517827, ENST00000538414, ENST00000431478, ENST00000414192, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 4 X 2=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: HTN3 [Title/Abstract] AND RIMS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RIMS1 | GO:0065003 | protein-containing complex assembly | 11438518 |
Tgene | RIMS1 | GO:1903861 | positive regulation of dendrite extension | 23999003 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP334116 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000526767 | ENST00000491071 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000348717 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000518273 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000522291 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000517960 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000521978 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000520567 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000264839 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000401910 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000523963 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000425662 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000517827 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000538414 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000431478 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000526767 | ENST00000414192 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000491071 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000348717 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000518273 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000522291 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000517960 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000521978 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000520567 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000264839 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000401910 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000523963 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000425662 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000517827 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000538414 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000431478 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
intron-intron | ENST00000530128 | ENST00000414192 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000491071 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000348717 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000518273 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000522291 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000517960 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000521978 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000520567 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000264839 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000401910 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000523963 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000425662 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000517827 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000538414 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000431478 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
3UTR-intron | ENST00000381057 | ENST00000414192 | HTN3 | chr4 | 70902151 | + | RIMS1 | chr6 | 73101663 | + |
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FusionProtFeatures for HTN3_RIMS1 |
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Hgene | Tgene |
HTN3 | RIMS1 |
Histatins are salivary proteins that are considered tobe major precursors of the protective proteinaceous structure ontooth surfaces (enamel pellicle). In addition, histatins exhibitantibacterial and antifungal activities. His3-(20-43)-peptide(histatin-5) is especially effective against C.albicans andC.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB)from P.gingivalis. In addition, His3-(20-43)-peptide is a potentinhibitor of metalloproteinases MMP2 and MMP9.{ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HTN3_RIMS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HTN3_RIMS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HTN3_RIMS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HTN3_RIMS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RIMS1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | RIMS1 | C1863634 | Cone-Rod Dystrophy 7 | 1 | CTD_human;UNIPROT |