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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16929

FusionGeneSummary for HSPH1_DDX27

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPH1_DDX27
Fusion gene ID: 16929
HgeneTgene
Gene symbol

HSPH1

DDX27

Gene ID

10808

55661

Gene nameheat shock protein family H (Hsp110) member 1DEAD-box helicase 27
SynonymsHSP105|HSP105A|HSP105B|NY-CO-25DRS1|Drs1p|HSPC259|PP3241|RHLP|dJ686N3.1
Cytomap

13q12.3

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein 105 kDaantigen NY-CO-25heat shock 105kDa/110kDa protein 1probable ATP-dependent RNA helicase DDX27DEAD (Asp-Glu-Ala-Asp) box polypeptide 27DEAD box protein 27DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27Deficiency of ribosomal subunits protein 1 homologRNA helicase-like protein
Modification date2018052320180519
UniProtAcc

Q92598

Q96GQ7

Ensembl transtripts involved in fusion geneENST00000380406, ENST00000380405, 
ENST00000320027, ENST00000445273, 
ENST00000429785, 
ENST00000484427, 
ENST00000371764, 
Fusion gene scores* DoF score3 X 2 X 3=1835 X 5 X 20=3500
# samples 338
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(38/3500*10)=-3.20328359838874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPH1 [Title/Abstract] AND DDX27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-8010-01AHSPH1chr13

31710765

-DDX27chr20

47849303

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000380406ENST00000484427HSPH1chr13

31710765

-DDX27chr20

47849303

+
5CDS-intronENST00000380406ENST00000371764HSPH1chr13

31710765

-DDX27chr20

47849303

+
5CDS-intronENST00000380405ENST00000484427HSPH1chr13

31710765

-DDX27chr20

47849303

+
5CDS-intronENST00000380405ENST00000371764HSPH1chr13

31710765

-DDX27chr20

47849303

+
5CDS-intronENST00000320027ENST00000484427HSPH1chr13

31710765

-DDX27chr20

47849303

+
5CDS-intronENST00000320027ENST00000371764HSPH1chr13

31710765

-DDX27chr20

47849303

+
intron-intronENST00000445273ENST00000484427HSPH1chr13

31710765

-DDX27chr20

47849303

+
intron-intronENST00000445273ENST00000371764HSPH1chr13

31710765

-DDX27chr20

47849303

+
intron-intronENST00000429785ENST00000484427HSPH1chr13

31710765

-DDX27chr20

47849303

+
intron-intronENST00000429785ENST00000371764HSPH1chr13

31710765

-DDX27chr20

47849303

+

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FusionProtFeatures for HSPH1_DDX27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPH1

Q92598

DDX27

Q96GQ7

Acts as a nucleotide-exchange factor (NEF) for chaperoneproteins HSPA1A and HSPA1B, promoting the release of ADP fromHSPA1A/B thereby triggering client/substrate protein release(PubMed:24318877). Prevents the aggregation of denatured proteinsin cells under severe stress, on which the ATP levels decreasemarkedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (Bysimilarity). {ECO:0000250|UniProtKB:Q60446,ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSPH1_DDX27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSPH1_DDX27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSPH1CFL1, DYNLRB1, UBA1, PGK1, PAFAH1B3, ADD1, STK39, CHD3, TERF1, TERF2, ZBTB7B, MYC, VAV2, BLNK, CUL3, RPLP0P6, HSP90AA1, HSP90AB1, ATF2, DAB2, NOS2, METTL21A, CFTR, FBXO6, TARDBP, HECW2, HIRIP3, CARM1, CTNNA1, DPYSL2, FAF1, FARSB, HIST1H4A, HSPA4, ILK, PARVA, PLOD2, PPM1G, PUS7, SAMHD1, SEC23A, SET, UGP2, USP11, PRMT3, RANBP3, SF1, XPO7, HSPA8, HUWE1, BUB1B, TP53BP2, NF2, YAP1, RPS6KB2, ASS1, CCT2, DNAJA1, DNAJA2, DNAJA4, DNAJB1, DNAJB4, DNAJC3, HSPA2, CPS1, DNAJC17, EZR, GRPEL1, HSPA9, HSPE1, MSN, PREP, PSMB5, RDX, STIP1, TAGLN2, TAGLN3, USP39, USP7, NTRK1, CEP104, STIL, HSPA5, MCM2, U2AF2, NFATC2, ZNF207, CYLD, DLD, DNM1L, EDEM3, ESR1, BRCA1DDX27ARRB2, ARRB1, LYAR, PPP1R16A, YWHAG, SIRT7, API5, ESR1, HDAC11, TARBP2, STAU1, CUL7, OBSL1, EED, RNF2, HIST1H1A, NOL12, RPL10A, RPL14, RPL8, NIFK, NPM1, RPS8, PRR11, NTRK1, DCAF13, DDX24, EIF6, FBL, FTSJ3, KIAA0020, KRR1, NOP56, NOP58, RPL18A, RPL23, RPL31, RRP15, DKC1, PES1, RBBP6, RBM19, RBM34, RPL5, RPL9, RUVBL1, SRP68, SRP72, SSB, UTP14A, IFI16, HNRNPU, RPL10, ZNFX1, MCM5, BOP1, WDR12, SENP3, ZNF746, CDC14B, RPL37A, RPL30, MAK16, DGCR8, RPL18, WDR46, HIST1H1T, GLTSCR2, CNBP, RRP8, GPATCH4, ZC3HAV1, ZNF71, PPAN, SYNCRIP, ZNF692, HIST1H1E, NR3C1, TRIM25, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSPH1_DDX27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSPH1_DDX27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSPH1C0019693HIV Infections1CTD_human