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Fusion gene ID: 16927 |
FusionGeneSummary for HSPG2_SIAE |
Fusion gene summary |
Fusion gene information | Fusion gene name: HSPG2_SIAE | Fusion gene ID: 16927 | Hgene | Tgene | Gene symbol | HSPG2 | SIAE | Gene ID | 3339 | 54414 |
Gene name | heparan sulfate proteoglycan 2 | sialic acid acetylesterase | |
Synonyms | HSPG|PLC|PRCAN|SJA|SJS|SJS1 | AIS6|CSE-C|CSEC|LSE|YSG2 | |
Cytomap | 1p36.12 | 11q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | basement membrane-specific heparan sulfate proteoglycan core proteinendorepellin (domain V region)perlecan proteoglycan | sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P98160 | Q9HAT2 | |
Ensembl transtripts involved in fusion gene | ENST00000486901, ENST00000374695, ENST00000430507, | ENST00000263593, ENST00000545756, ENST00000525730, | |
Fusion gene scores | * DoF score | 9 X 9 X 7=567 | 32 X 5 X 12=1920 |
# samples | 10 | 36 | |
** MAII score | log2(10/567*10)=-2.5033487351675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(36/1920*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HSPG2 [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SIAE | GO:0005975 | carbohydrate metabolic process | 23308225 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-A3-3372-01A | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000486901 | ENST00000263593 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
5CDS-intron | ENST00000486901 | ENST00000545756 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
5CDS-intron | ENST00000486901 | ENST00000525730 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
In-frame | ENST00000374695 | ENST00000263593 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
5CDS-intron | ENST00000374695 | ENST00000545756 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
5CDS-intron | ENST00000374695 | ENST00000525730 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
intron-3CDS | ENST00000430507 | ENST00000263593 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
intron-intron | ENST00000430507 | ENST00000545756 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
intron-intron | ENST00000430507 | ENST00000525730 | HSPG2 | chr1 | 22148738 | - | SIAE | chr11 | 124543777 | - |
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FusionProtFeatures for HSPG2_SIAE |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
HSPG2 | SIAE |
Integral component of basement membranes. Component ofthe glomerular basement membrane (GBM), responsible for the fixednegative electrostatic membrane charge, and which provides abarrier which is both size- and charge-selective. It serves as anattachment substrate for cells. Plays essential roles invascularization. Critical for normal heart development and forregulating the vascular response to injury. Also required foravascular cartilage development. Endorepellin in an anti-angiogenic and anti-tumorpeptide that inhibits endothelial cell migration, collagen-inducedendothelial tube morphogenesis and blood vessel growth in thechorioallantoic membrane. Blocks endothelial cell adhesion tofibronectin and type I collagen. Anti-tumor agent inneovascularization. Interaction with its ligand, integrinalpha2/beta1, is required for the anti-angiogenic properties.Evokes a reduction in phosphorylation of receptor tyrosine kinasesvia alpha2/beta1 integrin-mediated activation of the tyrosinephosphatase, PTPN6. The LG3 peptide has anti-angiogenic properties thatrequire binding of calcium ions for full activity. | Catalyzes the removal of O-acetyl ester groups fromposition 9 of the parent sialic acid, N-acetylneuraminic acid. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HSPG2_SIAE |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_HSPG2_ENST00000374695_chr1_22148738_-_SIAE_ENST00000263593_chr11_124543777_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_HSPG2_ENST00000374695_chr1_22148738_-_SIAE_ENST00000263593_chr11_124543777_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_HSPG2_ENST00000374695_chr1_22148738_-_SIAE_ENST00000263593_chr11_124543777_-_19910nt GGCCGGCGAGCGGGCGGCTGCGGGCGGCGCGGAGCGGGCGGCGCGGAGCGAGCGAGCGAGAGAGCGGCGCGGGCCGGGCCATGGGGTGGC GGGCGGCGGGCGCGCTGCTGCTGGCGCTGCTGCTGCACGGGCGGCTGCTGGCGGTGACCCATGGGCTGAGGGCATACGATGGCTTGTCTC TGCCTGAGGACATAGAGACCGTCACAGCAAGCCAAATGCGCTGGACACATTCGTACCTTTCTGATGATGAGGACATGCTGGCTGACAGCA TCTCAGGAGACGACCTGGGCAGTGGGGACCTGGGCAGCGGGGACTTCCAGATGGTTTATTTCCGAGCCCTGGTGAATTTCACTCGCTCCA TCGAGTACAGCCCTCAGCTGGAGGATGCAGGCTCCAGAGAGTTCCGAGAGGTGTCCGAGGCTGTGGTAGACACGCTGGAGTCGGAGTACT TGAAAATTCCCGGAGACCAGGTTGTCAGTGTGGTGTTCATCAAGGAGCTGGATGGCTGGGTTTTTGTGGAGCTGGATGTGGGCTCGGAAG GGAATGCGGATGGGGCTCAGATTCAGGAGATGCTGCTCAGGGTCATCTCCAGCGGCTCTGTGGCCTCCTACGTCACCTCTCCCCAGGGAT TCCAGTTCCGACGCCTGGGCACAGTGCCCCAGTTCCCAAGAGCCTGCACGGAGGCCGAGTTTGCCTGCCACAGCTACAATGAGTGTGTGG CCCTGGAGTATCGCTGTGACCGGCGGCCCGACTGCAGGGACATGTCTGATGAGCTCAATTGTGAGGAGCCAGTCCTGGGTATCAGCCCCA CATTCTCTCTCCTTGTGGAGACGACATCTTTACCGCCCCGGCCAGAGACAACCATCATGCGACAGCCACCAGTCACCCACGCTCCTCAGC CCCTGCTTCCCGGTTCCGTCAGGCCCCTGCCCTGTGGGCCCCAGGAGGCCGCATGCCGCAATGGGCACTGCATCCCCAGAGACTACCTCT GCGACGGACAGGAGGACTGCGAGGACGGCAGCGATGAGCTAGACTGTGGCCCCCCGCCACCCTGTGAGCCCAACGAGTTCCCCTGCGGGA ATGGACATTGTGCCCTCAAGCTGTGGCGCTGCGATGGTGACTTTGACTGTGAGGACCGAACTGATGAAGCCAACTGCCCCACCAAGCGTC CTGAGGAAGTGTGCGGGCCCACACAGTTCCGATGCGTCTCTACCAACATGTGCATCCCAGCCAGCTTCCACTGTGACGAGGAGAGCGACT GTCCTGACCGGAGCGACGAGTTTGGCTGCATGCCCCCCCAGGTGGTGACACCTCCCCGGGAGTCCATCCAGGCTTCCCGGGGCCAGACAG TGACCTTCACCTGCGTGGCCATTGGCGTCCCCACCCCCATCATCAATTGGAGGCTCAACTGGGGCCACATCCCCTCTCATCCCAGGGTGA CAGTGACCAGCGAGGGTGGCCGTGGCACACTGATCATCCGTGATGTGAAGGAGTCAGACCAGGGTGCCTACACCTGTGAGGCCATGAACG CCCGGGGCATGGTGTTTGGCATTCCTGACGGTGTCCTTGAGCTCGTCCCACAACGAGGCCCCTGCCCTGACGGCCACTTCTACCTGGAGC ACAGCGCCGCCTGCCTGCCCTGCTTCTGCTTTGGCATCACCAGCGTGTGCCAGAGCACCCGCCGCTTCCGGGACCAGATCAGGCTGCGCT TTGACCAACCCGATGACTTCAAGGGTGTGAATGTGACAATGCCTGCGCAGCCCGGCACGCCACCCCTCTCCTCCACGCAGCTGCAGATCG ACCCATCCCTGCACGAGTTCCAGCTAGTCGACCTGTCCCGCCGCTTCCTCGTCCACGACTCCTTCTGGGCTCTGCCTGAACAGTTCCTGG GCAACAAGGTGGACTCCTATGGCGGCTCCCTGCGTTACAACGTGCGCTACGAGTTGGCCCGTGGCATGCTGGAGCCAGTGCAGCGGCCGG ACGTGGTCCTCATGGGTGCCGGGTACCGCCTCCTCTCCCGAGGCCACACACCCACCCAACCTGGTGCTCTGAACCAGCGCCAGGTCCAGT TCTCTGAGGAGCACTGGGTCCATGAGTCTGGCCGGCCGGTGCAGCGCGCGGAGCTGCTGCAGGTGCTGCAGAGCCTGGAGGCCGTGCTCA TCCAGACCGTGTACAACACCAAGATGGCCAGCGTGGGACTTAGCGACATCGCCATGGATACCACCGTCACCCATGCCACCAGCCATGGCC GTGCCCACAGTGTGGAGGAGTGCAGATGCCCCATTGGCTATTCTGGCTTGTCCTGCGAGAGCTGTGATGCCCACTTCACTCGGGTGCCTG GTGGGCCCTACCTGGGCACCTGCTCTGGTTGCAATTGCAATGGCCATGCCAGCTCCTGTGACCCTGTGTATGGCCACTGCCTGAATTGCC AGCACAACACGGAGGGGCCACAGTGCAACAAGTGCAAGGCTGGCTTCTTTGGGGACGCCATGAAGGCCACGGCCACTTCCTGCCGGCCCT GCCCTTGCCCATACATCGATGCCTCCCGCAGATTCTCAGACACTTGCTTCCTGGACACGGATGGCCAAGCCACATGTGACGCCTGTGCCC CAGGCTACACTGGCCGCCGCTGTGAGAGCTGTGCCCCCGGATACGAGGGCAACCCCATCCAGCCCGGCGGGAAGTGCAGGCCCGTCAACC AGGAGATTGTGCGCTGTGACGAGCGTGGCAGCATGGGGACCTCCGGGGAGGCCTGCCGCTGTAAGAACAATGTGGTGGGGCGCTTGTGCA ATGAATGTGCTGACGGCTCTTTCCACCTGAGTACCCGAAACCCCGATGGCTGCCTCAAGTGCTTCTGCATGGGTGTCAGTCGCCACTGCA CCAGCTCTTCATGGAGCCGTGCCCAGTTGCATGGGGCCTCTGAGGAGCCTGGTCACTTCAGCCTGACCAACGCCGCAAGCACCCACACCA CCAACGAGGGCATCTTCTCCCCCACGCCCGGGGAACTGGGATTCTCCTCCTTCCACAGACTCTTATCTGGACCCTACTTCTGGAGCCTCC CTTCACGCTTCCTGGGGGACAAGGTGACCTCCTATGGAGGAGAGCTGCGCTTCACAGTGACCCAGAGGTCCCAGCCGGGCTCCACACCCC TGCACGGGCAGCCGTTGGTGGTGCTGCAAGGTAACAACATCATCCTAGAGCACCATGTGGCCCAGGAGCCCAGCCCCGGCCAGCCCAGCA CCTTCATTGTGCCTTTCCGGGAGCAAGCATGGCAGCGGCCCGATGGGCAGCCAGCCACACGGGAGCACCTGCTGATGGCACTGGCAGGCA TCGACACCCTCCTGATCCGAGCATCCTACGCCCAGCAGCCCGCTGAGAGCAGGGTCTCTGGCATCAGCATGGACGTGGCTGTGCCCGAGG AAACCGGCCAGGACCCCGCGCTGGAAGTGGAACAGTGCTCCTGCCCACCCGGGTACCGTGGGCCGTCCTGCCAGGACTGTGACACAGGCT ACACACGCACGCCCAGTGGCCTCTACCTGGGTACCTGTGAACGCTGCAGCTGCCATGGCCACTCAGAGGCCTGCGAGCCAGAAACAGGTG CCTGCCAGGGCTGCCAGCATCACACGGAGGGCCCTCGGTGTGAGCAGTGCCAGCCAGGATACTACGGGGACGCCCAGCGGGGGACACCAC AGGACTGCCAGCTGTGCCCCTGCTACGGAGACCCTGCTGCCGGCCAGGCTGCCCACACTTGTTTTCTGGACACAGACGGCCACCCCACCT GTGATGCGTGCTCCCCAGGCCACAGTGGGCGTCACTGTGAGAGGTGCGCCCCTGGCTACTATGGCAACCCCAGCCAGGGCCAGCCATGCC AGAGAGACAGCCAGGTGCCAGGGCCCATAGGCTGCAACTGTGACCCCCAAGGCAGCGTCAGCAGCCAGTGTGATGCTGCTGGTCAGTGCC AGTGCAAGGCCCAGGTGGAAGGCCTCACTTGCAGCCACTGCCGGCCCCACCACTTCCACCTGAGTGCCAGCAACCCAGACGGCTGCCTGC CCTGCTTCTGTATGGGCATCACCCAGCAGTGCGCCAGCTCTGCCTACACACGCCACCTGATCTCCACCCACTTTGCCCCTGGGGACTTCC AAGGCTTTGCCCTGGTGAACCCACAGCGAAACAGCCGCCTGACAGGAGAATTCACTGTGGAACCCGTGCCCGAGGGTGCCCAGCTCTCTT TTGGCAACTTTGCCCAACTCGGCCATGAGTCCTTCTACTGGCAGCTGCCGGAGACATACCAGGGAGACAAGGTGGCGGCCTACGGTGGGA AGTTGCGATACACCCTCTCCTACACAGCAGGCCCACAGGGCAGCCCACTCTCTGACCCCGATGTGCAGATCACGGGCAACAACATCATGC TAGTGGCCTCCCAGCCAGCGCTGCAGGGCCCTGAGAGGAGGAGCTACGAGATCATGTTCCGAGAGGAATTCTGGCGCCGGCCCGATGGGC AGCCGGCCACACGCGAGCACCTCCTGATGGCACTGGCCGACCTGGATGAGCTCCTGATCCGGGCCACGTTCTCCTCCGTGCCGCTGGCGG CCAGCATCAGCGCAGTCAGCCTGGAGGTCGCCCAGCCGGGGCCCTCAAACAGACCCCGCGCCCTCGAGGTGGAGGAGTGCCGCTGCCCGC CAGGCTACATCGGTCTGTCCTGCCAGGACTGTGCCCCCGGCTACACGCGCACCGGGAGTGGGCTCTACCTCGGCCACTGCGAGCTATGTG AATGCAATGGCCACTCAGACCTGTGCCACCCAGAGACTGGGGCCTGCTCGCAATGCCAGCACAACGCCGCAGGGGAGTTCTGCGAGCTTT GTGCCCCTGGCTACTACGGAGATGCCACAGCCGGGACGCCTGAGGACTGCCAGCCCTGTGCCTGCCCACTGACCAACCCAGAGAACATGT TTTCCCGCACCTGTGAGAGCCTGGGAGCCGGCGGGTACCGCTGCACGGCCTGCGAACCCGGCTACACTGGCCAGTACTGTGAGCAGTGTG GCCCAGGTTACGTGGGTAACCCCAGTGTGCAAGGGGGCCAGTGCCTGCCAGAGACAAACCAAGCCCCACTGGTGGTCGAGGTCCATCCTG CTCGAAGCATAGTGCCCCAAGGTGGCTCCCACTCCCTGCGGTGTCAGGTCAGTGGGAGCCCACCCCACTACTTCTATTGGTCCCGTGAGG ATGGGCGGCCTGTGCCCAGCGGCACCCAGCAGCGACATCAAGGCTCCGAGCTCCACTTCCCCAGCGTCCAGCCCTCGGATGCTGGGGTCT ACATTTGCACCTGCCGTAATCTCCACCAATCCAATACCAGCCGGGCAGAGCTGCTGGTCACTGAGGCTCCAAGCAAGCCCATCACAGTGA CTGTGGAGGAGCAGCGGAGCCAGAGCGTGCGCCCCGGAGCTGACGTCACCTTCATCTGCACAGCCAAAAGCAAGTCCCCAGCCTATACCC TGGTGTGGACCCGCCTGCACAACGGGAAACTGCCCACCCGAGCCATGGATTTCAATGGCATCCTGACCATTCGCAACGTCCAGCTGAGTG ATGCAGGCACCTACGTGTGCACCGGCTCCAACATGTTTGCCATGGACCAGGGCACAGCCACTCTACATGTGCAGGCCTCGGGCACCTTGT CCGCCCCCGTGGTCTCCATCCATCCGCCACAGCTCACAGTGCAGCCCGGGCAACTGGCGGAGTTCCGCTGCAGCGCCACAGGGAGCCCCA CGCCCACCCTCGAGTGGACAGGGGGCCCCGGCGGCCAGCTCCCTGCGAAGGCACAAATCCACGGCGGCATCCTGCGCCTGCCAGCTGTCG AGCCCACGGATCAGGCCCAGTACTTGTGCCGAGCCCACAGCAGCGCTGGGCAGCAGGTGGCCAGGGCTGTGCTCCACGTGCATGGGGGCG GTGGGCCCAGAGTCCAAGTGAGCCCAGAGAGGACCCAGGTCCACGCAGGCCGCACCGTCAGGCTGTACTGCAGGGCTGCAGGCGTGCCTA GCGCCACCATCACCTGGAGGAAGGAAGGGGGCAGCCTCCCACCACAGGCCCGGTCAGAGCGCACAGACATCGCGACACTGCTCATCCCAG CCATCACGACTGCTGACGCCGGCTTCTACCTCTGCGTGGCCACCAGCCCTGCAGGCACTGCCCAGGCCCGGATCCAAGTGGTTGTCCTTT CAGCCTCAGATGCCAGCCCACCGCCGGTCAAGATTGAGTCCTCATCGCCTTCTGTGACAGAAGGGCAAACACTCGACCTCAACTGTGTGG TGGCAGGGTCAGCCCATGCCCAGGTCACCTGGTACAGGCGAGGGGGTAGCCTGCCTCCCCACACCCAGGTGCACGGCTCCCGTCTGCGGC TCCCCCAGGTCTCACCAGCTGATTCTGGAGAATATGTGTGCCGTGTGGAGAATGGATCGGGCCCCAAGGAGGCCTCCATTACTGTGTCTG TGCTCCACGGCACCCATTCTGGCCCCAGCTACACCCCAGTGCCCGGCAGCACCCGGCCCATCCGCATCGAGCCCTCCTCCTCACACGTGG CGGAAGGGCAGACCCTGGATCTGAACTGCGTGGTGCCCGGGCAGGCCCACGCCCAGGTCACGTGGCACAAGCGTGGGGGCAGCCTCCCTG CCCGGCACCAGACCCACGGCTCGCTGCTGCGGCTGCACCAGGTGACCCCGGCCGACTCAGGCGAGTATGTGTGCCATGTGGTGGGCACCT CCGGCCCCCTAGAGGCCTCAGTCCTGGTCACCATCGAAGCCTCTGTCATCCCTGGACCCATCCCACCTGTCAGGATCGAGTCTTCATCCT CCACAGTGGCCGAGGGCCAGACCCTGGATCTGAGCTGCGTGGTGGCAGGGCAGGCCCACGCCCAGGTCACATGGTACAAGCGTGGGGGCA GCCTCCCTGCCCGGCACCAGGTTCGTGGCTCCCGCCTGTACATCTTCCAGGCCTCACCTGCCGATGCGGGACAGTACGTCTGCCGGGCCA GCAACGGCATGGAGGCCTCCATCACGGTCACAGTAACTGGGACCCAGGGGGCCAACTTAGCCTACCCTGCCGGCAGCACCCAGCCCATCC GCATCGAGCCCTCCTCCTCGCAAGTGGCGGAAGGGCAGACCCTGGATCTGAACTGCGTGGTGCCCGGGCAGTCCCATGCCCAGGTCACGT GGCACAAGCGTGGGGGCAGCCTCCCTGTCCGGCACCAGACCCACGGCTCCCTGCTGAGACTCTACCAAGCGTCCCCCGCCGACTCGGGCG AGTACGTGTGCCGAGTGTTGGGCAGCTCCGTGCCTCTAGAGGCCTCTGTCCTGGTCACCATTGAGCCTGCGGGCTCAGTGCCTGCACTTG GGGTCACCCCCACGGTCCGGATCGAGTCATCGTCTTCGCAAGTGGCCGAGGGGCAGACCCTGGACCTGAACTGCCTCGTTGCTGGTCAGG CCCATGCCCAGGTCACGTGGCACAAGCGCGGGGGCAGCCTCCCGGCCCGGCACCAGGTGCATGGCTCGAGGCTACGCCTGCTCCAGGTGA CCCCAGCTGATTCAGGGGAGTACGTGTGCCGTGTGGTCGGCAGCTCAGGTACCCAGGAAGCCTCAGTCCTTGTCACCATCCAGCAGCGCC TTAGTGGCTCCCACTCCCAGGGTGTGGCGTACCCCGTCCGCATCGAGTCCTCCTCAGCCTCCCTGGCCAATGGACACACCCTGGACCTCA ACTGCCTGGTTGCCAGCCAGGCTCCCCACACCATCACCTGGTATAAGCGTGGAGGCAGCTTACCCAGCCGGCACCAGATCGTGGGCTCCC GGCTGCGGATCCCTCAGGTGACTCCGGCAGACTCGGGCGAGTACGTGTGTCACGTCAGTAACGGTGCAGGCTCCCGGGAGACCTCGCTCA TCGTCACCATCCAGGGCAGCGGTTCCTCCCACGTGCCCAGCGTCTCCCCACCGATCAGGATCGAGTCGTCTTCCCCCACGGTGGTGGAAG GGCAGACCTTGGATCTGAACTGCGTGGTCGCCAGGCAGCCCCAGGCTATCATCACATGGTACAAGCGTGGGGGCAGCCTTCCCTCCCGAC ACCAGACCCATGGCTCCCACCTGCGGTTGCACCAAATGTCTGTGGCTGACTCGGGCGAGTATGTGTGCCGGGCCAACAACAACATCGATG CCCTGGAGGCCTCCATCGTCATCTCCGTCTCCCCTAGCGCCGGCAGCCCCTCCGCCCCTGGCAGCTCCATGCCCATCAGAATTGAGTCAT CCTCCTCACACGTGGCCGAAGGGGAGACCCTGGATCTGAACTGCGTGGTCCCCGGGCAGGCCCATGCCCAGGTCACTTGGCACAAGCGTG GGGGCAGCCTCCCCAGTCACCATCAGACCCGCGGCTCACGGCTGCGGCTGCACCATGTGTCCCCGGCCGACTCGGGTGAATACGTGTGCC GGGTGATGGGCAGCTCTGGCCCCCTGGAGGCCTCAGTCCTGGTCACCATCGAAGCCTCTGGCTCAAGTGCTGTCCACGTCCCCGCCCCAG GTGGAGCCCCACCCATCCGCATCGAGCCCTCCTCCTCCCGAGTGGCAGAAGGGCAGACCCTGGATCTGAAGTGCGTGGTGCCCGGGCAGG CCCACGCCCAGGTCACGTGGCACAAGCGTGGAGGAAACCTCCCTGCCCGGCACCAGGTCCACGGCCCACTGCTGAGGCTGAACCAGGTGT CCCCGGCTGACTCTGGCGAGTACTCGTGCCAAGTGACCGGAAGCTCAGGCACCCTGGAGGCATCTGTCCTGGTCACAATTGAGCCCTCCA GCCCAGGACCCATTCCTGCTCCAGGACTGGCCCAGCCCATCTACATCGAGGCCTCCTCTTCACACGTGACTGAAGGGCAGACTCTGGATC TGAACTGTGTGGTGCCCGGGCAGGCCCATGCCCAGGTCACGTGGTACAAGCGCGGGGGCAGCCTCCCCGCCCGGCACCAGACCCATGGCT CCCAGCTGCGGCTCCACCTCGTCTCCCCTGCCGACTCAGGCGAGTATGTGTGTCGTGCAGCCAGCGGCCCAGGCCCTGAGCAAGAAGCCT CCTTCACAGTCACCGTCCCGCCCAGTGAGGGGTCTTCCTACCGCCTTAGGAGCCCGGTCATCTCCATCGACCCGCCCAGCAGCACCGTGC AGCAGGGCCAGGATGCCAGCTTCAAGTGCCTCATCCATGACGGGGCAGCCCCCATCAGCCTCGAGTGGAAGACCCGGAACCAGGAGCTGG AGGACAACGTCCACATCAGTCCCAATGGCTCCATCATCACCATCGTGGGCACCCGGCCCAGCAACCACGGTACCTACCGCTGCGTGGCCT CCAATGCCTACGGTGTGGCCCAGAGTGTGGTGAACCTCAGTGTGCACGGGCCCCCTACAGTGTCCGTGCTCCCCGAGGGCCCCGTGTGGG TGAAAGTGGGAAAGGCTGTCACCCTGGAGTGTGTCAGTGCCGGGGAGCCCCGCTCCTCTGCTCGTTGGACCCGGATCAGCAGCACCCCTG CCAAGTTGGAGCAGCGGACATATGGGCTCATGGACAGCCACGCGGTGCTGCAGATTTCATCAGCTAAACCATCAGATGCGGGCACTTATG TGTGCCTTGCTCAGAATGCACTAGGCACAGCACAGAAGCAGGTGGAGGTGATCGTGGACACGGGCGCCATGGCCCCAGGGGCCCCTCAGG TCCAAGCTGAAGAAGCTGAGCTGACTGTGGAGGCTGGACACACGGCCACCTTGCGCTGCTCAGCCACAGGCAGCCCCGCGCCCACCATCC ACTGGTCCAAGCTGCGTTCCCCACTGCCCTGGCAGCACCGGCTGGAAGGTGACACACTCATCATACCCCGGGTAGCCCAGCAGGACTCGG GCCAGTACATCTGCAATGCCACTAGCCCTGCTGGGCACGCTGAGGCCACCATCATCCTGCACGTGGAGAGCCCACCATATGCCACCACGG TCCCAGAGCACGCTTCGGTGCAGGCAGGGGAGACGGTGCAGCTCCAGTGCCTGGCTCACGGGACACCCCCACTCACCTTCCAGTGGAGCC GCGTGGGCAGCAGCCTTCCTGGGAGGGCGACCGCCAGGAACGAGCTGCTGCACTTTGAGCGTGCAGCCCCTGAGGACTCAGGCCGCTACC GCTGCCGGGTCACCAACAAGGTGGGCTCAGCCGAGGCCTTTGCCCAGCTGCTCGTCCAAGGCCCTCCCGGCTCTCTCCCTGCCACCTCCA TCCCAGCAGGGTCCACGCCCACCGTGCAGGTCACGCCTCAGCTAGAGACCAAGAGCATTGGGGCCAGCGTTGAGTTCCACTGTGCTGTGC CCAGCGACCGGGGTACCCAGCTCCGTTGGTTCAAGGAAGGGGGTCAGCTGCCTCCGGGTCACAGCGTGCAGGATGGGGTGCTCCGAATCC AGAACTTGGACCAGAGCTGCCAAGGGACGTATATATGCCAGGCCCATGGACCTTGGGGGAAGGCCCAGGCCAGTGCCCAGCTGGTTATCC AAGCCCTGCCCTCGGTGCTCATCAACATCCGGACCTCTGTGCAGACCGTGGTGGTTGGCCACGCCGTGGAGTTCGAATGCCTGGCACTGG GTGACCCCAAGCCTCAGGTGACATGGAGCAAAGTTGGAGGGCACCTGCGGCCAGGCATTGTGCAGAGCGGAGGTGTCGTCAGGATCGCCC ACGTAGAGCTGGCTGATGCGGGACAGTATCGCTGCACTGCCACCAACGCAGCTGGCACCACACAATCCCACGTCCTGCTGCTTGTGCAAG CCTTGCCCCAGATCTCAATGCCCCAAGAAGTCCGTGTGCCTGCTGGTTCTGCAGCTGTCTTCCCCTGCATAGCCTCAGGCTACCCCACTC CTGACATCAGCTGGAGCAAGCTGGATGGCAGCCTGCCACCTGACAGCCGCCTGGAGAACAACATGCTGATGCTGCCCTCAGTCCGACCCC AGGACGCAGGTACCTACGTCTGCACCGCCACTAACCGCCAGGGCAAGGTCAAAGCCTTTGCCCACCTGCAGGTGCCAGAGCGGGTGGTGC CCTACTTCACGCAGACCCCCTACTCCTTCCTACCGCTGCCCACCATCAAGGATGCCTACAGGAAGTTCGAGATCAAGATCACCTTCCGGC CCGACTCAGCCGATGGGATGCTGCTGTACAATGGGCAGAAGCGAGTCCCAGGGAGCCCCACCAACCTGGCCAACCGGCAGCCCGACTTCA TCTCCTTCGGCCTCGTGGGGGGAAGGCCCGAGTTCCGGTTCGATGCAGGCTCAGGCATGGCCACCATCCGCCATCCCACACCACTGGCCC TGGGCCATTTCCACACCGTGACCCTGCTGCGCAGCCTCACCCAGGGCTCCCTGATTGTGGGTGACCTGGCCCCGGTCAATGGGACCTCCC AGGGCAAGTTCCAGGGCCTGGATCTGAACGAGGAACTCTACCTGGGTGGCTATCCTGACTATGGTGCCATCCCCAAGGCGGGGCTGAGCA GCGGCTTCATAGGCTGTGTCCGGGAGCTGCGCATCCAGGGCGAGGAGATCGTCTTCCATGACCTCAACCTCACGGCGCACGGCATCTCCC ACTGCCCCACCTGTCGGGACCGGCCCTGCCAGAATGGCGGTCAGTGCCATGACTCTGAGAGCAGCAGCTACGTGTGCGTCTGCCCAGCTG GCTTCACCGGGAGCCGCTGTGAGCACTCGCAGGCCCTGCACTGCCATCCAGAGGCCTGTGGGCCCGACGCCACCTGTGTGAACCGGCCTG ACGGTCGAGGCTACACCTGCCGCTGCCACCTGGGCCGCTCGGGGTTGCGGTGTGAGGAAGGTGTGACAGTGACCACCCCCTCGCTGTCGG GTGCTGGCTCCTACCTGGCACTGCCCGCCCTCACCAACACACACCACGAGCTACGCCTGGACGTGGAGTTCAAGCCACTCGCCCCTGACG GGGTCCTGCTGTTCAGCGGGGGGAAGAGCGGGCCTGTGGAGGACTTCGTGTCCCTGGCGATGGTGGGCGGCCACCTGGAGTTCCGCTATG AGTTGGGGTCAGGGCTGGCCGTTCTGCGGAGCGCCGAGCCGCTGGCCCTGGGCCGCTGGCACCGTGTGTCTGCAGAGCGTCTCAACAAGG ACGGCAGCCTGCGGGTGAATGGTGGACGCCCTGTGCTGCGCTCCTCGCCCGGCAAGAGCCAGGGCCTCAACCTGCACACCCTGCTCTACC TGGGGGGTGTGGAGCCTTCCGTGCCACTGTCCCCGGCCACCAACATGAGCGCTCACTTCCGCGGCTGTGTGGGCGAGGTGTCAGTGAATG GCAAACGGCTGGACCTCACCTACAGTTTCCTAGGCAGCCAGGGCATCGGGCAATGCTATGATAGCTCCCCATGTGAGCGCCAGCCTTGCC AACATGGTGCCACGTGCATGCCCGCTGGCGAGTATGAGTTCCAGTGCCTGTGTCGAGATGGATTCAAAGGAGACCTGTGTGAGCACGAGG AGAACCCCTGCCAGCTCCGTGAACCCTGTCTGCATGGGGGCACCTGCCAGGGCACCCGCTGCCTCTGCCTCCCTGGCTTCTCTGGCCCAC GCTGCCAACAAGGCTCTGGACATGGCATAGCAGAGTCCGACTGGCATCTTGAAGGCAGCGGGGGCAATGATGCCCCTGGGCAGTACGGAG CCTATTTCCACGATGATGGCTTCCTCGCCTTCCCTGGCCATGTCTTCTCCAGGAGCCTGCCCGAGGTGCCCGAGACCATCGAGCTGGAGG TTCGGACCAGCACAGCCAGTGGCCTCCTGCTCTGGCAGGGTGTGGAGGTGGGAGAGGCCGGCCAAGGCAAGGACTTCATCAGCCTCGGGC TTCAAGACGGGCACCTTGTCTTCAGGTACCAGCTGGGTAGTGGGGAGGCCCGCCTGGTCTCTGAGGACCCCATCAATGACGGCGAGTGGC ACCGGGTGACAGCACTGCGGGAGGGCCGCAGAGGTTCCATCCAAGTCGACGGTGAGGAGCTGGTCAGCGGCCGGTCCCCAGGTCCCAACG TGGCAGTCAACGCCAAGGGCAGCGTCTACATCGGCGGAGCCCCTGACGTGGCCACGCTGACCGGGGGCAGATTCTCCTCAGGCATCACAG GCTGTGTCAAGAACCTGGTGCTGCACTCGGCCCGACCCGGCGCCCCGCCCCCACAGCCCCTGGACCTGCAGCACCGCGCCCAGGCCGGGG CCAACACACGCCCCTGCCCCTCGTAGGCACCTGCCTGCCCCACACGGACTCCCGGGCCACGCCCCAGCCCGACAATGTCGAGTATATTAT TATTAATATTATTATGAATTTTTGTAAGAAACCGAGGCGATGCCACGCTTTGCTGCTACCGCCCTGGGCTGGACTGGAGGTGGGCATGCC ACCCTCACACACACAGCTGGGCAAAGCCACAAGGCTGGCCAGCAAGGCAGGTTGGATGGGAGTGGGCACCTCAGAAAGTCACCAGGACTT GGGGTCAGGAACAGTGGCTGGGTGGGCCCAGAACTGCCCCCACTGTCCCCCTACCCACCGATGGAGCCCCCAGATAGAGCTGGGTGGCCT GTTTCTGCAGCCCTTGGGCAGTTCTCACTCCTAGGAGAGCCAACCTCGGCTTGTGGGCTGGTGCCCCACAGCTACCTGAGACGGGCATCG CAGGAGTCTCTGCCACCCACTCAGGATTGGGAATTGTCTTTAGTGCCGGCTGTGGAGCAAAAGGCAGCTCACCCCTGGGCAGGCGGTCCC CATCCCCACCAGCTCGTTTTTCAGCACCCCCACCCACCTCCACCCAGCCCCTGGCACCTCCTCTGGCAGACTCCCCCTCCTACCACGTCC TCCTGGCCTGCATTCCCACCCCCTCCTGCCAGCACACAGCCTGGGGTCCCTCCCTCAGGGGCTGTAAGGGAAGGCCCACCCCAACTCTTA CCAGGAGCTGCTACAGGCAGAGCCCAGCACTGATAGGGCCCCGCCCACCGGGCCCCGCCCACCCCAGGCCACATCCCCACCCATCTGGAA GTGAAGGCCCAGGGACTCCTCCAACAGACAACGGACGGACGGATGCCGCTGGTGCTCAGGAAGAGCTAGTGCCTTAGGTGGGGGAAGGCA GGACTCACGACTGAGAGAGAGAGGAGGGGGATATGACCACCCTGCCCCATCTGCAGGAGCCTGAAGATCCAGCTCAAGTGCCATCCTGCC AGTGGCCCCCAGACTGTGGGGTTGGGACGCCTGGCCTCTGTGTCCTAGAAGGGACCCTCCTGTGGTCTTTGTCTTGATTTTTCTTAATAA ACGGTGCTATCCCCGCCAAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGA GGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGAT CCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCG CTTTGCTTCATACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGT GACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGA TCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTT TGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGC GGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTC TAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCT GCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGT CCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAA TATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCAT CGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTT GTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAA TACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCG GCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCA CAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCA TCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGC TCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCAT TGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGG TCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTA GCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTG TATTGGACTAATTCTGAACTACAGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTG CCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAA AATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGT AGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAA CCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTC TGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTG CCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCT TAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGG ATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAA AGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCT ATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAA GGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATAC AATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAAT TTAAAACATTATGTGGAATTCACTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGA ATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCC AAGATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCA GTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAG TCAATCTACCCGTCCACTCCTCCACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCT AAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCAC ATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAA ATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGC TGAACCATTCACTTGACTTGAGTTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAAT AATTTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGAC ATATAGATTTTTAACAATTTTCTACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCT TAGGGTTCTTAACATGGAAGAGGATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATT CTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGA AAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGG AGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACT ACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGA TCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAG TAAAAACATTTTACACATATCTTCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAAC CAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTG TAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAA AAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTA TACAACTTATAAAAAGACTATACTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAA CACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAA TGGCAGTGCATTAACCATTCAATTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTT GGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACA GGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGA CTAACCCCCAATTATATGTGAATTTGTGTTATCATATGGTTTCAGTGTACTGAGCTAAAAAGCACATTATCTGAGGTGCAATACAAAGGT |
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FusionGenePPI for HSPG2_SIAE |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HSPG2 | FGF7, TTR, PRELP, FGFBP1, NID2, FN1, FBLN2, LAMA1, PDGFA, PDGFB, CACNA1A, ATN1, GFI1B, GRB2, FBXO6, TINAGL1, PSAT1, ADD1, TMPO, PTTG1, CCDC22, GAR1, KIF7, SKI, MCM2, ZNF408, UBC, TRIM25 | SIAE | FBXO6, PTPRK, CPE, HLA-B, ENTPD6, NPTX1, CNTNAP3, MANEAL, OAF, TMEM30A, MR1, COCH, FAM162A, GPR98, GFPT2, MOXD1, LNPEP, PLXNB2, TCTN1, POC1A, NDST2, SGSH, TENM3, ERAP1, MANBA, ITGA8, TMEM2, LAMB2, FASTKD3, CHSY3, GDF11, DDX47, TMEM131, ARSK, ARSB, MBTPS1, COL18A1, MANEA, NAAA, RPP38, NRP2, PTGFRN, PLTP, KIAA1161, DCBLD2, SEPN1, GALNT7, TGFBR3, MAN2B2, TMEM132A, GALNS, NAGLU, CTSF, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HSPG2_SIAE |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | HSPG2 | P98160 | DB00039 | Palifermin | Basement membrane-specific heparan sulfate proteoglycan core protein | biotech | approved |
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RelatedDiseases for HSPG2_SIAE |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HSPG2 | C0029422 | Osteochondrodysplasias | 2 | CTD_human;HPO |
Hgene | HSPG2 | C0036391 | Schwartz-Jampel Syndrome | 1 | ORPHANET;UNIPROT |
Hgene | HSPG2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | HSPG2 | C1857100 | Dyssegmental dysplasia | 1 | CTD_human;ORPHANET |
Tgene | SIAE | C3150797 | AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6 | 1 | UNIPROT |