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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16912

FusionGeneSummary for HSPB8_TAGLN

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPB8_TAGLN
Fusion gene ID: 16912
HgeneTgene
Gene symbol

HSPB8

TAGLN

Gene ID

26353

6876

Gene nameheat shock protein family B (small) member 8transgelin
SynonymsCMT2L|DHMN2|E2IG1|H11|HMN2|HMN2A|HSP22SM22|SM22-alpha|SMCC|TAGLN1|WS3-10
Cytomap

12q24.23

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein beta-8E2-induced gene 1 proteinalpha-crystallin C chainheat shock 22kDa protein 8heat shock 27kDa protein 8protein kinase H11small stress protein-like protein HSP22transgelin22 kDa actin-binding proteinsmooth muscle protein 22-alphatransgelin variant 2
Modification date2018051920180519
UniProtAcc

Q9UJY1

Q01995

Ensembl transtripts involved in fusion geneENST00000281938, ENST00000542496, 
ENST00000392951, ENST00000530649, 
ENST00000532870, 
Fusion gene scores* DoF score4 X 4 X 2=328 X 13 X 4=416
# samples 416
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(16/416*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPB8 [Title/Abstract] AND TAGLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAGLN

GO:0030855

epithelial cell differentiation

21492153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB962711HSPB8chr12

119616904

+TAGLNchr11

117075355

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000281938ENST00000392951HSPB8chr12

119616904

+TAGLNchr11

117075355

+
5UTR-3UTRENST00000281938ENST00000530649HSPB8chr12

119616904

+TAGLNchr11

117075355

+
5UTR-3UTRENST00000281938ENST00000532870HSPB8chr12

119616904

+TAGLNchr11

117075355

+
intron-intronENST00000542496ENST00000392951HSPB8chr12

119616904

+TAGLNchr11

117075355

+
intron-3UTRENST00000542496ENST00000530649HSPB8chr12

119616904

+TAGLNchr11

117075355

+
intron-3UTRENST00000542496ENST00000532870HSPB8chr12

119616904

+TAGLNchr11

117075355

+

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FusionProtFeatures for HSPB8_TAGLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPB8

Q9UJY1

TAGLN

Q01995

Displays temperature-dependent chaperone activity. Actin cross-linking/gelling protein (By similarity).Involved in calcium interactions and contractile properties of thecell that may contribute to replicative senescence. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSPB8_TAGLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSPB8_TAGLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSPB8_TAGLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSPB8_TAGLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSPB8C1834692NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIA2CTD_human;UNIPROT
TgeneTAGLNC0023794Lipoidosis3CTD_human
TgeneTAGLNC0009375Colonic Neoplasms1CTD_human
TgeneTAGLNC0014175Endometriosis1CTD_human
TgeneTAGLNC0022548Keloid1CTD_human
TgeneTAGLNC0279626Squamous cell carcinoma of esophagus1CTD_human