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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16884

FusionGeneSummary for HSPB11_SSBP3

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPB11_SSBP3
Fusion gene ID: 16884
HgeneTgene
Gene symbol

HSPB11

SSBP3

Gene ID

51668

23648

Gene nameheat shock protein family B (small) member 11single stranded DNA binding protein 3
SynonymsC1orf41|HSPCO34|IFT25|PP25CSDP|SSDP|SSDP1
Cytomap

1p32.3

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionintraflagellar transport protein 25 homologheat shock protein beta-11heat shock protein family B (small), member 11intraflagellar transport 25 homologplacental protein 25single-stranded DNA-binding protein 3sequence-specific single-stranded-DNA-binding protein
Modification date2018052320180523
UniProtAcc

Q9Y547

Q9BWW4

Ensembl transtripts involved in fusion geneENST00000371378, ENST00000194214, 
ENST00000371377, ENST00000489675, 
ENST00000371376, 
ENST00000326956, 
ENST00000417664, ENST00000371320, 
ENST00000371319, ENST00000357475, 
Fusion gene scores* DoF score4 X 3 X 3=3611 X 8 X 6=528
# samples 410
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/528*10)=-2.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPB11 [Title/Abstract] AND SSBP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-4366-01AHSPB11chr1

54395712

-SSBP3chr1

54708972

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000371378ENST00000326956HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371378ENST00000417664HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371378ENST00000371320HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371378ENST00000371319HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371378ENST00000357475HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000194214ENST00000326956HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000194214ENST00000417664HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000194214ENST00000371320HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000194214ENST00000371319HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000194214ENST00000357475HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371377ENST00000326956HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371377ENST00000417664HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371377ENST00000371320HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371377ENST00000371319HSPB11chr1

54395712

-SSBP3chr1

54708972

-
5CDS-5UTRENST00000371377ENST00000357475HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000489675ENST00000326956HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000489675ENST00000417664HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000489675ENST00000371320HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000489675ENST00000371319HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000489675ENST00000357475HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000371376ENST00000326956HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000371376ENST00000417664HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000371376ENST00000371320HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000371376ENST00000371319HSPB11chr1

54395712

-SSBP3chr1

54708972

-
intron-5UTRENST00000371376ENST00000357475HSPB11chr1

54395712

-SSBP3chr1

54708972

-

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FusionProtFeatures for HSPB11_SSBP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPB11

Q9Y547

SSBP3

Q9BWW4

Component of the IFT complex B required for sonichedgehog/SHH signaling. May mediate transport of SHH components:required for the export of SMO and PTCH1 receptors out of thecilium and the accumulation of GLI2 at the ciliary tip in responseto activation of the SHH pathway, suggesting it is involved in thedynamic transport of SHH signaling molecules within the cilium.Not required for ciliary assembly (By similarity). {ECO:0000250}. May be involved in transcription regulation of the alpha2(I) collagen gene where it binds to the single-strandedpolypyrimidine sequences in the promoter region. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSPB11_SSBP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSPB11_SSBP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSPB11IFT27, SEC23IP, NUP62, UBXN10, IFT52, IFT74, SMC6, TTC26, IFT81, IFT88, TTC30A, IFT20, IFT172, IFT46, TTC30B, LCA5, IFT22, IFT80SSBP3TAL1, HCLS1, LMX1B, RFC1, SUPT5H, ZNF226, ANKEF1, TRIM33, APP, EPAS1, ARNT2, LDB2, EWSR1, PIN1, YES1, LDB1, IL36RN, TBC1D23, NXT2, IDI2, SSBP2, SSBP4, DIS3, LHX1, ISL2, ISL1, LMO4, LHX9, LHX6, MDC1, CLK1, PCGF1, NANOG, LMO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSPB11_SSBP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSPB11_SSBP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource