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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1687

FusionGeneSummary for ANK3_TMPRSS15

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK3_TMPRSS15
Fusion gene ID: 1687
HgeneTgene
Gene symbol

ANK3

TMPRSS15

Gene ID

288

5651

Gene nameankyrin 3transmembrane serine protease 15
SynonymsANKYRIN-G|MRT37ENTK|PRSS7
Cytomap

10q21.2

21q21.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)enteropeptidaseenterokinase catalytic subunitprotease, serine, 7 (enterokinase)serine protease 7transmembrane protease, serine 15
Modification date2018052320180523
UniProtAcc

Q12955

P98073

Ensembl transtripts involved in fusion geneENST00000280772, ENST00000373827, 
ENST00000355288, ENST00000503366, 
ENST00000510382, ENST00000460468, 
ENST00000284885, 
Fusion gene scores* DoF score14 X 9 X 7=8822 X 2 X 2=8
# samples 152
** MAII scorelog2(15/882*10)=-2.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ANK3 [Title/Abstract] AND TMPRSS15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A12D-01AANK3chr10

61894029

-TMPRSS15chr21

19687573

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000280772ENST00000284885ANK3chr10

61894029

-TMPRSS15chr21

19687573

-
Frame-shiftENST00000373827ENST00000284885ANK3chr10

61894029

-TMPRSS15chr21

19687573

-
Frame-shiftENST00000355288ENST00000284885ANK3chr10

61894029

-TMPRSS15chr21

19687573

-
Frame-shiftENST00000503366ENST00000284885ANK3chr10

61894029

-TMPRSS15chr21

19687573

-
intron-3CDSENST00000510382ENST00000284885ANK3chr10

61894029

-TMPRSS15chr21

19687573

-
intron-3CDSENST00000460468ENST00000284885ANK3chr10

61894029

-TMPRSS15chr21

19687573

-

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FusionProtFeatures for ANK3_TMPRSS15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK3

Q12955

TMPRSS15

P98073

Responsible for initiating activation of pancreaticproteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidaseA). It catalyzes the conversion of trypsinogen to trypsin which inturn activates other proenzymes including chymotrypsinogen,procarboxypeptidases, and proelastases.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANK3_TMPRSS15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANK3_TMPRSS15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANK3KCNC1, SPTBN4, TIAM1, MAPK6, SMAD3, SMAD2, RNF2, DOK4, PALM2, C16orf70, SCN1B, SRPK2, TMEM17, KIF11, PCNA, MCM2, CDH1, CTDSPL, RAPGEF5, CHL1, MAPK8IP1, FEZ1, HIF1AN, UXS1, PWP1, NEXN, LILRB3, PROSER2, ARHGAP22, USP15, SPAG9, MCM4, MCM6, EPS15L1, IVNS1ABP, GTF3C4TMPRSS15PYCARD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANK3_TMPRSS15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANK3_TMPRSS15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANK3C0005586Bipolar Disorder7CTD_human;PSYGENET
HgeneANK3C0036341Schizophrenia3PSYGENET
HgeneANK3C0033975Psychotic Disorders2PSYGENET
HgeneANK3C0525045Mood Disorders2PSYGENET
HgeneANK3C0033300Progeria1CTD_human
HgeneANK3C0038220Status Epilepticus1CTD_human
HgeneANK3C0178417Anhedonia1PSYGENET
HgeneANK3C0349204Nonorganic psychosis1PSYGENET