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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16864

FusionGeneSummary for HSPA1B_SLC1A3

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPA1B_SLC1A3
Fusion gene ID: 16864
HgeneTgene
Gene symbol

HSPA1B

SLC1A3

Gene ID

3304

6507

Gene nameheat shock protein family A (Hsp70) member 1Bsolute carrier family 1 member 3
SynonymsHSP70-1B|HSP70-2|HSP70.2EA6|EAAT1|GLAST|GLAST1
Cytomap

6p21.33

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionheat shock 70 kDa protein 1BHSP70-1/HSP70-2HSP70.1/HSP70.2heat shock 70 kDa protein 1/2heat shock 70 kDa protein 1A/1Bheat shock 70 kDa protein 2heat shock 70kD protein 1Bheat shock 70kDa protein 1Bexcitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3
Modification date2018052320180519
UniProtAcc

P43003

Ensembl transtripts involved in fusion geneENST00000375650, ENST00000545241, 
ENST00000450744, ENST00000391548, 
ENST00000445736, ENST00000391555, 
ENST00000265113, ENST00000506725, 
ENST00000381918, 
Fusion gene scores* DoF score3 X 2 X 3=1810 X 9 X 6=540
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPA1B [Title/Abstract] AND SLC1A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSPA1B

GO:0006402

mRNA catabolic process

10205060

HgeneHSPA1B

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSPA1B

GO:0031397

negative regulation of protein ubiquitination

12150907

HgeneHSPA1B

GO:0034605

cellular response to heat

24061851

HgeneHSPA1B

GO:0042026

protein refolding

15603737|21231916

HgeneHSPA1B

GO:0046034

ATP metabolic process

23921388

HgeneHSPA1B

GO:0060548

negative regulation of cell death

12150907

HgeneHSPA1B

GO:0090084

negative regulation of inclusion body assembly

15603737|21231916

TgeneSLC1A3

GO:0015813

L-glutamate transmembrane transport

26690923

TgeneSLC1A3

GO:0051938

L-glutamate import

7521911

TgeneSLC1A3

GO:0070779

D-aspartate import across plasma membrane

7521911

TgeneSLC1A3

GO:0071805

potassium ion transmembrane transport

20477940

TgeneSLC1A3

GO:0098712

L-glutamate import across plasma membrane

26690923

TgeneSLC1A3

GO:0140009

L-aspartate import across plasma membrane

20477940

TgeneSLC1A3

GO:1902476

chloride transmembrane transport

20477940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-FG-8191-01AHSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000375650ENST00000265113HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
5CDS-intronENST00000375650ENST00000506725HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
5CDS-intronENST00000375650ENST00000381918HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-5UTRENST00000545241ENST00000265113HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000545241ENST00000506725HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000545241ENST00000381918HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-5UTRENST00000450744ENST00000265113HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000450744ENST00000506725HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000450744ENST00000381918HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-5UTRENST00000391548ENST00000265113HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000391548ENST00000506725HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000391548ENST00000381918HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-5UTRENST00000445736ENST00000265113HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000445736ENST00000506725HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000445736ENST00000381918HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-5UTRENST00000391555ENST00000265113HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000391555ENST00000506725HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+
intron-intronENST00000391555ENST00000381918HSPA1Bchr6

31798031

+SLC1A3chr5

36606541

+

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FusionProtFeatures for HSPA1B_SLC1A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPA1B

SLC1A3

P43003

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940,PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as asymporter that transports one amino acid molecule together withtwo or three Na(+) ions and one proton, in parallel with thecounter-transport of one K(+) ion (PubMed:20477940). MediatesCl(-) flux that is not coupled to amino acid transport; thisavoids the accumulation of negative charges due to aspartate andNa(+) symport (PubMed:20477940). Plays a redundant role in therapid removal of released glutamate from the synaptic cleft, whichis essential for terminating the postsynaptic action of glutamate(By similarity). {ECO:0000250|UniProtKB:P56564,ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515,ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSPA1B_SLC1A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSPA1B_SLC1A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSPA1BPGAM5, BANF1, FGFR3, DYRK2, YWHAB, YWHAZ, ELAVL1, ARRB1, ARRB2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, HSPBP1, INPPL1, CBL, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, SMURF1, CTNNB1, FMNL1, FN1, VCAM1, DAB2, PPP5C, HSP90AA1, UBL4A, ITGA4, ADRB2, PINK1, TGM2, FBXO6, TRIM25, BAG4, STUB1, STAU1, TP53, PA2G4, EZH2, RNF2, CCNI2, LRRC28, DENND2D, STIP1, TCERG1, CEP170, CNTRL, NINL, NPHP4, NEK8, EGFR, CRY1, DERL1, FLCN, FNIP1, FNIP2, KLHL34, SLC27A3, CYLD, TXNIP, UBQLN2, HDAC6SLC1A3CUL3, ZDHHC17, LGALS3, TCTN3, TMEM17, PDZK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSPA1B_SLC1A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC1A3P43003DB00142Glutamic AcidExcitatory amino acid transporter 1 {ECO:0000303|PubMed:16042756, ECO:0000303|PubMed:8647279}small moleculeapproved|nutraceutical

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RelatedDiseases for HSPA1B_SLC1A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSPA1BC0036341Schizophrenia3PSYGENET
HgeneHSPA1BC0041696Unipolar Depression3PSYGENET
HgeneHSPA1BC1269683Major Depressive Disorder3PSYGENET
HgeneHSPA1BC0004153Atherosclerosis1CTD_human
HgeneHSPA1BC0024517Single major depressive episode1PSYGENET
HgeneHSPA1BC0037274Dermatologic disorders1CTD_human
HgeneHSPA1BC0238288Muscular Dystrophy, Facioscapulohumeral1CTD_human
HgeneHSPA1BC0311375Arsenic Poisoning1CTD_human
HgeneHSPA1BC0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneHSPA1BC1458155Mammary Neoplasms1CTD_human
TgeneSLC1A3C0036341Schizophrenia4PSYGENET
TgeneSLC1A3C0004352Autistic Disorder1CTD_human
TgeneSLC1A3C0005586Bipolar Disorder1PSYGENET
TgeneSLC1A3C0014544Epilepsy1CTD_human;HPO
TgeneSLC1A3C0178417Anhedonia1PSYGENET
TgeneSLC1A3C2675211EPISODIC ATAXIA, TYPE 6 (disorder)1CTD_human;ORPHANET;UNIPROT