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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16861

FusionGeneSummary for HSPA1A_FOXP1

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPA1A_FOXP1
Fusion gene ID: 16861
HgeneTgene
Gene symbol

HSPA1A

FOXP1

Gene ID

3303

27086

Gene nameheat shock protein family A (Hsp70) member 1Aforkhead box P1
SynonymsHEL-S-103|HSP70-1|HSP70-1A|HSP70.1|HSP70I|HSP72|HSPA112CC4|HSPC215|MFH|QRF1|hFKH1B
Cytomap

6p21.33

3p13

Type of geneprotein-codingprotein-coding
Descriptionheat shock 70 kDa protein 1AHSP70-1/HSP70-2HSP70.1/HSP70.2dnaK-type molecular chaperone HSP70-1epididymis secretory protein Li 103heat shock 70 kDa protein 1heat shock 70 kDa protein 1/2heat shock 70 kDa protein 1A/1Bheat shock 70kD protein 1Aheaforkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead
Modification date2018052320180522
UniProtAcc

Q9H334

Ensembl transtripts involved in fusion geneENST00000375651, ENST00000458062, 
ENST00000608703, ENST00000430065, 
ENST00000422919, ENST00000441618, 
ENST00000449876, ENST00000433487, 
ENST00000452298, ENST00000400040, 
ENST00000383389, 
ENST00000318789, 
ENST00000475937, ENST00000493089, 
ENST00000484350, ENST00000318779, 
ENST00000491238, ENST00000498215, 
ENST00000468577, ENST00000472382, 
Fusion gene scores* DoF score2 X 2 X 1=437 X 16 X 17=10064
# samples 240
** MAII scorelog2(2/4*10)=2.32192809488736log2(40/10064*10)=-4.65306001710456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPA1A [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSPA1A

GO:0006402

mRNA catabolic process

10205060

HgeneHSPA1A

GO:0006986

response to unfolded protein

10859165

HgeneHSPA1A

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSPA1A

GO:0031397

negative regulation of protein ubiquitination

12150907

HgeneHSPA1A

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

HgeneHSPA1A

GO:0034605

cellular response to heat

24061851

HgeneHSPA1A

GO:0042026

protein refolding

15603737|21231916

HgeneHSPA1A

GO:0046034

ATP metabolic process

23921388

HgeneHSPA1A

GO:0050821

protein stabilization

21909508

HgeneHSPA1A

GO:0051131

chaperone-mediated protein complex assembly

10811660

HgeneHSPA1A

GO:0090084

negative regulation of inclusion body assembly

15603737|21231916

HgeneHSPA1A

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401

HgeneHSPA1A

GO:1901029

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

20625543

HgeneHSPA1A

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

12150907|20625543

HgeneHSPA1A

GO:1902380

positive regulation of endoribonuclease activity

20625543

TgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

TgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

TgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

TgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

TgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

TgeneFOXP1

GO:0036035

osteoclast development

18799727

TgeneFOXP1

GO:0042116

macrophage activation

18799727

TgeneFOXP1

GO:0042117

monocyte activation

18799727

TgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

TgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

TgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

TgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

TgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

TgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

TgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

TgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI826170HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000375651ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000375651ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000458062ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000608703ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000430065ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000422919ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000441618ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000449876ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000433487ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
intron-intronENST00000452298ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000400040ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000318789HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000475937HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000493089HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000484350HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000318779HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000491238HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000498215HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000468577HSPA1Achr6

3079143

-FOXP1chr3

71096093

+
3UTR-intronENST00000383389ENST00000472382HSPA1Achr6

3079143

-FOXP1chr3

71096093

+

Top

FusionProtFeatures for HSPA1A_FOXP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPA1A

FOXP1

Q9H334

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HSPA1A_FOXP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HSPA1A_FOXP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HSPA1A_FOXP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HSPA1A_FOXP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSPA1AC0036341Schizophrenia5PSYGENET
HgeneHSPA1AC0041696Unipolar Depression3PSYGENET
HgeneHSPA1AC1269683Major Depressive Disorder3PSYGENET
HgeneHSPA1AC2609414Acute kidney injury2CTD_human
HgeneHSPA1AC0013182Drug Allergy1CTD_human
HgeneHSPA1AC0023895Liver diseases1CTD_human
HgeneHSPA1AC0024517Single major depressive episode1PSYGENET
HgeneHSPA1AC0025202melanoma1CTD_human
HgeneHSPA1AC0027627Neoplasm Metastasis1CTD_human
HgeneHSPA1AC0030567Parkinson Disease1CTD_human
HgeneHSPA1AC0033578Prostatic Neoplasms1CTD_human
HgeneHSPA1AC0035126Reperfusion Injury1CTD_human
HgeneHSPA1AC0036349Paranoid Schizophrenia1PSYGENET
HgeneHSPA1AC0151744Myocardial Ischemia1CTD_human
HgeneHSPA1AC0282507Heat Stress Disorders1CTD_human
HgeneHSPA1AC0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
TgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
TgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
TgeneFOXP1C0042900Vitiligo1CTD_human
TgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
TgeneFOXP1C3495559Juvenile arthritis1CTD_human
TgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT