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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16854

FusionGeneSummary for HSPA12A_KIAA1598

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPA12A_KIAA1598
Fusion gene ID: 16854
HgeneTgene
Gene symbol

HSPA12A

KIAA1598

Gene ID

259217

57698

Gene nameheat shock protein family A (Hsp70) member 12Ashootin 1
Synonyms-KIAA1598|shootin-1
Cytomap

10q25.3

10q25.3

Type of geneprotein-codingprotein-coding
Descriptionheat shock 70 kDa protein 12Aheat shock 70kD protein 12Aheat shock 70kDa protein 12Ashootin-1shootin1
Modification date2018051920180522
UniProtAcc

O43301

Ensembl transtripts involved in fusion geneENST00000369209, ENST00000392903, 
ENST00000260777, ENST00000355371, 
ENST00000392901, ENST00000497044, 
Fusion gene scores* DoF score2 X 3 X 2=123 X 3 X 4=36
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HSPA12A [Title/Abstract] AND KIAA1598 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIAA1598

GO:2001224

positive regulation of neuron migration

23864681


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-05-4430-01AHSPA12Achr10

118501941

-KIAA1598chr10

118646077

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369209ENST00000392903HSPA12Achr10

118501941

-KIAA1598chr10

118646077

-
Frame-shiftENST00000369209ENST00000260777HSPA12Achr10

118501941

-KIAA1598chr10

118646077

-
Frame-shiftENST00000369209ENST00000355371HSPA12Achr10

118501941

-KIAA1598chr10

118646077

-
5CDS-intronENST00000369209ENST00000392901HSPA12Achr10

118501941

-KIAA1598chr10

118646077

-
5CDS-5UTRENST00000369209ENST00000497044HSPA12Achr10

118501941

-KIAA1598chr10

118646077

-

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FusionProtFeatures for HSPA12A_KIAA1598


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPA12A

O43301

KIAA1598

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSPA12A_KIAA1598


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSPA12A_KIAA1598


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSPA12ANRCAM, TMEM51, BSG, ART3, CBWD1, WBP1, CBWD2, TGOLN2, TNF, EPB41L3, TMEM17, SNW1, CDC5L, CTDSPL, PTPRG, PODXL, LAMP2, FAM174A, LAMP3, DKKL1, CCL22, MGST3, C1orf85, MISP, USP32KIAA1598IKBKG, NEDD4, LNX1, AHCYL1, UBXN1, SEC24A, UBA2, UNK, PSAT1, CAP1, FASN, HSP90B1, KCTD12, OGFR, SIRT1, TPM1, TRMT6, TPM4, ESRRG, FABP3, IGL, TFCP2, BBOX1, NME7, KIAA1598, LURAP1L, VPS29, NTRK1, MED4, CDH1, FAM167A, BCHE, NDEL1, ZCCHC17, CAV3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSPA12A_KIAA1598


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSPA12A_KIAA1598


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSPA12AC0036341Schizophrenia1PSYGENET
HgeneHSPA12AC0041696Unipolar Depression1PSYGENET
HgeneHSPA12AC0236969Substance-Related Disorders1CTD_human
HgeneHSPA12AC1269683Major Depressive Disorder1PSYGENET