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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16847

FusionGeneSummary for HSP90B1_HSP90B1

check button Fusion gene summary
Fusion gene informationFusion gene name: HSP90B1_HSP90B1
Fusion gene ID: 16847
HgeneTgene
Gene symbol

HSP90B1

HSP90B1

Gene ID

7184

7184

Gene nameheat shock protein 90 beta family member 1heat shock protein 90 beta family member 1
SynonymsECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1
Cytomap

12q23.3

12q23.3

Type of geneprotein-codingprotein-coding
Descriptionendoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1heaendoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1hea
Modification date2018052020180520
UniProtAcc

P14625

P14625

Ensembl transtripts involved in fusion geneENST00000299767, ENST00000299767, 
Fusion gene scores* DoF score8 X 11 X 6=5287 X 11 X 6=462
# samples 1312
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/462*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSP90B1 [Title/Abstract] AND HSP90B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90B1

GO:0001666

response to hypoxia

15620698

HgeneHSP90B1

GO:0031247

actin rod assembly

19000834

HgeneHSP90B1

GO:0043666

regulation of phosphoprotein phosphatase activity

19000834

HgeneHSP90B1

GO:0071318

cellular response to ATP

19000834

TgeneHSP90B1

GO:0001666

response to hypoxia

15620698

TgeneHSP90B1

GO:0031247

actin rod assembly

19000834

TgeneHSP90B1

GO:0043666

regulation of phosphoprotein phosphatase activity

19000834

TgeneHSP90B1

GO:0071318

cellular response to ATP

19000834


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG256795HSP90B1chr12

104335255

-HSP90B1chr12

104335294

+
ChiTaRS3.1BQ292081HSP90B1chr12

104336455

-HSP90B1chr12

104336314

+
ChiTaRS3.1AK025862HSP90B1chr12

104333328

+HSP90B1chr12

104331548

+
ChiTaRS3.1CV356218HSP90B1chr12

104332160

-HSP90B1chr12

104336521

-
ChiTaRS3.1N67356HSP90B1chr12

104341567

-HSP90B1chr12

104341444

+
ChiTaRS3.1W27444HSP90B1chr12

104341183

-HSP90B1chr12

104331492

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000299767ENST00000299767HSP90B1chr12

104335255

-HSP90B1chr12

104335294

+
In-frameENST00000299767ENST00000299767HSP90B1chr12

104336455

-HSP90B1chr12

104336314

+
Frame-shiftENST00000299767ENST00000299767HSP90B1chr12

104333328

+HSP90B1chr12

104331548

+
In-frameENST00000299767ENST00000299767HSP90B1chr12

104332160

-HSP90B1chr12

104336521

-
3UTR-3UTRENST00000299767ENST00000299767HSP90B1chr12

104341567

-HSP90B1chr12

104341444

+
Frame-shiftENST00000299767ENST00000299767HSP90B1chr12

104341183

-HSP90B1chr12

104331492

+

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FusionProtFeatures for HSP90B1_HSP90B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90B1

P14625

HSP90B1

P14625

Molecular chaperone that functions in the processing andtransport of secreted proteins. When associated with CNPY3,required for proper folding of Toll-like receptors (Bysimilarity). Functions in endoplasmic reticulum associateddegradation (ERAD). Has ATPase activity. {ECO:0000250,ECO:0000269|PubMed:18264092}. Molecular chaperone that functions in the processing andtransport of secreted proteins. When associated with CNPY3,required for proper folding of Toll-like receptors (Bysimilarity). Functions in endoplasmic reticulum associateddegradation (ERAD). Has ATPase activity. {ECO:0000250,ECO:0000269|PubMed:18264092}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSP90B1_HSP90B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSP90B1_HSP90B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSP90B1_HSP90B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHSP90B1P14625DB00615RifabutinEndoplasminsmall moleculeapproved|investigational
TgeneHSP90B1P14625DB00615RifabutinEndoplasminsmall moleculeapproved|investigational

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RelatedDiseases for HSP90B1_HSP90B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSP90B1C0005586Bipolar Disorder3PSYGENET
HgeneHSP90B1C0033578Prostatic Neoplasms1CTD_human
TgeneHSP90B1C0005586Bipolar Disorder3PSYGENET
TgeneHSP90B1C0033578Prostatic Neoplasms1CTD_human