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Fusion gene ID: 16845 |
FusionGeneSummary for HSP90B1_APP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HSP90B1_APP | Fusion gene ID: 16845 | Hgene | Tgene | Gene symbol | HSP90B1 | APP | Gene ID | 7184 | 351 |
| Gene name | heat shock protein 90 beta family member 1 | amyloid beta precursor protein | |
| Synonyms | ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1 | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 | |
| Cytomap | 12q23.3 | 21q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1hea | amyloid-beta A4 proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteincereb | |
| Modification date | 20180520 | 20180527 | |
| UniProtAcc | P14625 | P05067 | |
| Ensembl transtripts involved in fusion gene | ENST00000299767, | ENST00000346798, ENST00000354192, ENST00000348990, ENST00000357903, ENST00000358918, ENST00000359726, ENST00000448388, ENST00000440126, ENST00000439274, ENST00000474136, | |
| Fusion gene scores | * DoF score | 8 X 11 X 6=528 | 16 X 17 X 6=1632 |
| # samples | 13 | 20 | |
| ** MAII score | log2(13/528*10)=-2.02202630633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1632*10)=-3.02856915219677 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HSP90B1 [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HSP90B1 | GO:0001666 | response to hypoxia | 15620698 |
| Hgene | HSP90B1 | GO:0031247 | actin rod assembly | 19000834 |
| Hgene | HSP90B1 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 19000834 |
| Hgene | HSP90B1 | GO:0071318 | cellular response to ATP | 19000834 |
| Tgene | APP | GO:0001934 | positive regulation of protein phosphorylation | 11404397 |
| Tgene | APP | GO:0008285 | negative regulation of cell proliferation | 22944668 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU607969 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000299767 | ENST00000346798 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-3UTR | ENST00000299767 | ENST00000354192 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-3UTR | ENST00000299767 | ENST00000348990 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-3UTR | ENST00000299767 | ENST00000357903 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-3UTR | ENST00000299767 | ENST00000358918 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-3UTR | ENST00000299767 | ENST00000359726 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-intron | ENST00000299767 | ENST00000448388 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-intron | ENST00000299767 | ENST00000440126 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-intron | ENST00000299767 | ENST00000439274 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
| 5CDS-intron | ENST00000299767 | ENST00000474136 | HSP90B1 | chr12 | 104341140 | - | APP | chr21 | 27253243 | - |
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FusionProtFeatures for HSP90B1_APP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HSP90B1 | APP |
| Molecular chaperone that functions in the processing andtransport of secreted proteins. When associated with CNPY3,required for proper folding of Toll-like receptors (Bysimilarity). Functions in endoplasmic reticulum associateddegradation (ERAD). Has ATPase activity. {ECO:0000250,ECO:0000269|PubMed:18264092}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HSP90B1_APP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HSP90B1_APP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HSP90B1_APP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HSP90B1 | P14625 | DB00615 | Rifabutin | Endoplasmin | small molecule | approved|investigational |
| Tgene | APP | P05067 | DB06782 | Dimercaprol | Amyloid-beta A4 protein | small molecule | approved |
| Tgene | APP | P05067 | DB09148 | Florbetaben (18F) | Amyloid-beta A4 protein | small molecule | approved |
| Tgene | APP | P05067 | DB00746 | Deferoxamine | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Tgene | APP | P05067 | DB01370 | Aluminium | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Tgene | APP | P05067 | DB01593 | Zinc | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Tgene | APP | P05067 | DB09149 | Florbetapir (18F) | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Tgene | APP | P05067 | DB09151 | Flutemetamol (18F) | Amyloid-beta A4 protein | small molecule | approved|investigational |
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RelatedDiseases for HSP90B1_APP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HSP90B1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Hgene | HSP90B1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | APP | C0002395 | Alzheimer's Disease | 55 | CTD_human;HPO;ORPHANET;UNIPROT |
| Tgene | APP | C0025261 | Memory Disorders | 12 | CTD_human |
| Tgene | APP | C0027746 | Nerve Degeneration | 11 | CTD_human |
| Tgene | APP | C0023186 | Learning Disorders | 6 | CTD_human |
| Tgene | APP | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | APP | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | APP | C2751536 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED | 5 | ORPHANET;UNIPROT |
| Tgene | APP | C0009241 | Cognition Disorders | 4 | CTD_human |
| Tgene | APP | C0522224 | Paralysed | 4 | CTD_human |
| Tgene | APP | C0524851 | Neurodegenerative Disorders | 2 | CTD_human |
| Tgene | APP | C0600467 | Neurogenic Inflammation | 2 | CTD_human |
| Tgene | APP | C2931672 | Cerebral hemorrhage with amyloidosis, hereditary, Dutch type | 2 | CTD_human;ORPHANET |
| Tgene | APP | C0002622 | Amnesia | 1 | CTD_human |
| Tgene | APP | C0002726 | Amyloidosis | 1 | CTD_human |
| Tgene | APP | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Tgene | APP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | APP | C0006111 | Brain Diseases | 1 | CTD_human |
| Tgene | APP | C0011573 | Endogenous depression | 1 | PSYGENET |
| Tgene | APP | C0016667 | Fragile X Syndrome | 1 | CTD_human |
| Tgene | APP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | APP | C0027540 | Necrosis | 1 | CTD_human |
| Tgene | APP | C0037928 | Spinal Cord Diseases | 1 | CTD_human |
| Tgene | APP | C0038002 | Splenomegaly | 1 | CTD_human |
| Tgene | APP | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | APP | C0085220 | Cerebral Amyloid Angiopathy | 1 | CTD_human;HPO |
| Tgene | APP | C0231341 | Premature aging syndrome | 1 | CTD_human |
| Tgene | APP | C0338656 | Impaired cognition | 1 | CTD_human |
| Tgene | APP | C0497327 | Dementia | 1 | CTD_human;HPO |
| Tgene | APP | C2936349 | Plaque, Amyloid | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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