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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 1683

FusionGeneSummary for ANK3_MCU

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK3_MCU
Fusion gene ID: 1683
HgeneTgene
Gene symbol

ANK3

MCU

Gene ID

288

90550

Gene nameankyrin 3mitochondrial calcium uniporter
SynonymsANKYRIN-G|MRT37C10orf42|CCDC109A|HsMCU
Cytomap

10q21.2

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)calcium uniporter protein, mitochondrialcoiled-coil domain-containing protein 109A
Modification date2018052320180523
UniProtAcc

Q12955

Q8NE86

Ensembl transtripts involved in fusion geneENST00000280772, ENST00000373827, 
ENST00000355288, ENST00000503366, 
ENST00000510382, ENST00000460468, 
ENST00000373053, ENST00000357157, 
ENST00000536019, ENST00000605416, 
Fusion gene scores* DoF score14 X 9 X 7=8825 X 1 X 4=20
# samples 154
** MAII scorelog2(15/882*10)=-2.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/20*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANK3 [Title/Abstract] AND MCU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMCU

GO:0006851

mitochondrial calcium ion transmembrane transport

21685888|24560927

TgeneMCU

GO:0019722

calcium-mediated signaling

21685886|21685888

TgeneMCU

GO:0036444

calcium import into the mitochondrion

22925203

TgeneMCU

GO:0051259

protein complex oligomerization

21685886

TgeneMCU

GO:0051561

positive regulation of mitochondrial calcium ion concentration

21685888|24560927


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-NF-A5CP-01AANK3chr10

62374944

-MCUchr10

74594117

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000280772ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000280772ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000280772ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000280772ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
In-frameENST00000373827ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
In-frameENST00000373827ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
In-frameENST00000373827ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
5CDS-intronENST00000373827ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000355288ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000355288ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000355288ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000355288ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000503366ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000503366ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000503366ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000503366ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-3CDSENST00000510382ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-3CDSENST00000510382ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-3CDSENST00000510382ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-intronENST00000510382ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000460468ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000460468ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000460468ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000460468ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+

Top

FusionProtFeatures for ANK3_MCU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK3

Q12955

MCU

Q8NE86

Mitochondrial inner membrane calcium uniporter thatmediates calcium uptake into mitochondria (PubMed:21685888,PubMed:21685886, PubMed:23101630, PubMed:22904319,PubMed:23178883, PubMed:22829870, PubMed:22822213,PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutesthe pore-forming and calcium-conducting subunit of the uniportercomplex (uniplex) (PubMed:23755363). Activity is regulated byMICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1increases MCU activity (PubMed:24560927, PubMed:26903221).Mitochondrial calcium homeostasis plays key roles in cellularphysiology and regulates cell bioenergetics, cytoplasmic calciumsignals and activation of cell death pathways. Involved inbuffering the amplitude of systolic calcium rises incardiomyocytes (PubMed:22822213). While dispensable for baselinehomeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight'response during acute stress: acts by mediating a rapid increaseof mitochondrial calcium in pacemaker cells (PubMed:25603276).participates in mitochondrial permeability transition duringischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulatingmitochondrial calcium uptake (PubMed:22904319, PubMed:22829870).Mitochondrial calcium uptake in skeletal muscle cells is involvedin muscle size in adults (By similarity). Regulates synapticvesicle endocytosis kinetics in central nerve terminal (Bysimilarity). Involved in antigen processing and presentation (Bysimilarity). {ECO:0000250|UniProtKB:Q3UMR5,ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888,ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870,ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630,ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:23755363,ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927,ECO:0000269|PubMed:25603276, ECO:0000269|PubMed:26341627,ECO:0000269|PubMed:26903221}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANK3_MCU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000373053_chr10_74594117_+_334aa
MASSASSSPAGTEDSAPAQGGFGSDYSRSSRKVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSV
GVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLN
KERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQE

>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000357157_chr10_74594117_+_313aa
MASSASSSPAGTEDSAPAQGGFGSDYSRSSRKVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSV
GVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRVEMGFCHVGQNGFELLTSSYLPASASQSAEIIA
VRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKK

>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000536019_chr10_74594117_+_334aa
MASSASSSPAGTEDSAPAQGGFGSDYSRSSRKVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSV
GVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLN
KERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000373053_chr10_74594117_+_1002nt
ATGGCCTCCTCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCT
AGAAAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTT
TATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTT
GGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCA
ACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTA
AGTCATGAAAATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAAC
AAGGAAAGGGAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCT
GAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATAT
TCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAA
TATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAAT
CAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGT

>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000357157_chr10_74594117_+_939nt
ATGGCCTCCTCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCT
AGAAAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTT
TATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTT
GGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCA
ACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGTAGAGATG
GGGTTTTGCCATGTTGGCCAGAATGGTTTTGAACTCCTGACCTCAAGTTATCTACCTGCCTCAGCCTCCCAAAGTGCCGAGATTATAGCC
GTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATT
TTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTAT
GCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAG
TCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAA

>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000536019_chr10_74594117_+_1002nt
ATGGCCTCCTCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCT
AGAAAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTT
TATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTT
GGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCA
ACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTA
AGTCATGAAAATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAAC
AAGGAAAGGGAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCT
GAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATAT
TCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAA
TATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAAT
CAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000373053_chr10_74594117_+_3045nt
ACAGCAGGAGGAGGATAGGCCGCGCTGGGCGGGCGTCGCGGGGCCGCGCTTGGTGTTCCTGAGCCGCGGCCGAACTTTTTCCCAAGAAGT
CCCACGTTTGGAGGCCCGAGGAGCGGGACGGGGAGGAGAGACTGGAGTTCCTGGAAGGAGCAGCAGCAGCAGCCCCACAACATGGCCTCC
TCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCTAGAAAGGTA
CACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAAT
GGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTT
TTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATA
GACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAA
AATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGG
GAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGG
ACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGAC
ATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTAT
CCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAG
GATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGAT
TGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGT
GGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCA
TTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGA
GAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCA
CTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCT
AAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCT
ACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCT
TAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTT
TTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAA
ATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCAT
TTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTC
ATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGT
GCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAA
AGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAA
TATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCAT
CCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACC
CAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGAC
GGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATT
TATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGC
AAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAA

>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000357157_chr10_74594117_+_2982nt
ACAGCAGGAGGAGGATAGGCCGCGCTGGGCGGGCGTCGCGGGGCCGCGCTTGGTGTTCCTGAGCCGCGGCCGAACTTTTTCCCAAGAAGT
CCCACGTTTGGAGGCCCGAGGAGCGGGACGGGGAGGAGAGACTGGAGTTCCTGGAAGGAGCAGCAGCAGCAGCCCCACAACATGGCCTCC
TCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCTAGAAAGGTA
CACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAAT
GGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTT
TTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATA
GACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGTAGAGATGGGGTTTTGC
CATGTTGGCCAGAATGGTTTTGAACTCCTGACCTCAAGTTATCTACCTGCCTCAGCCTCCCAAAGTGCCGAGATTATAGCCGTACGAATT
GAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGG
CTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTT
GTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTT
GACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTG
CCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGC
ATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAG
GGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGG
ATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCA
GCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTAAATAAATATAC
TAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTC
CTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAACTTATAACTGTT
TAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCA
ACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATACTTATCTATTG
ATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATT
GGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATG
GGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGT
AAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCT
ATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATGACATCTGCGCT
TGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTG
ATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTAT
GAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCC
TGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCAC
CCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTT
AAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAA
ATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATGTATAAAAAGCAATGTACCTTCTGGAACAATAAATACTTAT

>In-frame_ANK3_ENST00000373827_chr10_62374944_-_MCU_ENST00000536019_chr10_74594117_+_3043nt
ACAGCAGGAGGAGGATAGGCCGCGCTGGGCGGGCGTCGCGGGGCCGCGCTTGGTGTTCCTGAGCCGCGGCCGAACTTTTTCCCAAGAAGT
CCCACGTTTGGAGGCCCGAGGAGCGGGACGGGGAGGAGAGACTGGAGTTCCTGGAAGGAGCAGCAGCAGCAGCCCCACAACATGGCCTCC
TCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCTAGAAAGGTA
CACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAAT
GGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTT
TTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATA
GACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAA
AATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGG
GAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGG
ACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGAC
ATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTAT
CCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAG
GATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGAT
TGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGT
GGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCA
TTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGA
GAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCA
CTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCT
AAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCT
ACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCT
TAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTT
TTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAA
ATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCAT
TTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTC
ATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGT
GCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAA
AGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAA
TATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCAT
CCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACC
CAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGAC
GGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATT
TATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGC
AAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAA


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FusionGenePPI for ANK3_MCU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANK3KCNC1, SPTBN4, TIAM1, MAPK6, SMAD3, SMAD2, RNF2, DOK4, PALM2, C16orf70, SCN1B, SRPK2, TMEM17, KIF11, PCNA, MCM2, CDH1, CTDSPL, RAPGEF5, CHL1, MAPK8IP1, FEZ1, HIF1AN, UXS1, PWP1, NEXN, LILRB3, PROSER2, ARHGAP22, USP15, SPAG9, MCM4, MCM6, EPS15L1, IVNS1ABP, GTF3C4MCUICT1, ELAVL1, ABCC1, SLC38A2, SLC1A5, ERLIN2, COLEC10, GNAI2, NYX, NDUFA9, MYC, RAB7A, VAPA, GOLT1B, ZNF526, NDUFA4, ASPH, TOR1AIP2, EDEM2, SLC5A8, APLNR, SLC22A6, IRGC, PDCD1, SLC15A1, ARMC6, IL13RA2, SMDT1, EIF2B1, EIF2B2, EIF2B4, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANK3_MCU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANK3_MCU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANK3C0005586Bipolar Disorder7CTD_human;PSYGENET
HgeneANK3C0036341Schizophrenia3PSYGENET
HgeneANK3C0033975Psychotic Disorders2PSYGENET
HgeneANK3C0525045Mood Disorders2PSYGENET
HgeneANK3C0033300Progeria1CTD_human
HgeneANK3C0038220Status Epilepticus1CTD_human
HgeneANK3C0178417Anhedonia1PSYGENET
HgeneANK3C0349204Nonorganic psychosis1PSYGENET