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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16827

FusionGeneSummary for HSP90AA1_CCDC91

check button Fusion gene summary
Fusion gene informationFusion gene name: HSP90AA1_CCDC91
Fusion gene ID: 16827
HgeneTgene
Gene symbol

HSP90AA1

CCDC91

Gene ID

3320

55297

Gene nameheat shock protein 90 alpha family class A member 1coiled-coil domain containing 91
SynonymsEL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2HSD8|p56
Cytomap

14q32.31

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shockcoiled-coil domain-containing protein 91GGA-binding partnerp56 accessory protein
Modification date2018052720180523
UniProtAcc

P07900

Q7Z6B0

Ensembl transtripts involved in fusion geneENST00000216281, ENST00000334701, 
ENST00000441629, ENST00000558600, 
ENST00000539107, ENST00000545336, 
ENST00000381256, ENST00000381259, 
ENST00000540401, ENST00000306172, 
Fusion gene scores* DoF score15 X 16 X 3=7206 X 5 X 5=150
# samples 176
** MAII scorelog2(17/720*10)=-2.08246216019197
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSP90AA1 [Title/Abstract] AND CCDC91 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90AA1

GO:0001934

positive regulation of protein phosphorylation

19363271

HgeneHSP90AA1

GO:0007004

telomere maintenance via telomerase

10197982

HgeneHSP90AA1

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSP90AA1

GO:0032273

positive regulation of protein polymerization

19363271

HgeneHSP90AA1

GO:0045040

protein import into mitochondrial outer membrane

15644312

HgeneHSP90AA1

GO:0051131

chaperone-mediated protein complex assembly

15644312

HgeneHSP90AA1

GO:0051973

positive regulation of telomerase activity

10197982

HgeneHSP90AA1

GO:1902949

positive regulation of tau-protein kinase activity

19363271

HgeneHSP90AA1

GO:1905323

telomerase holoenzyme complex assembly

10197982


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ318634HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000216281ENST00000539107HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000216281ENST00000545336HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000216281ENST00000381256HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000216281ENST00000381259HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000216281ENST00000540401HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000216281ENST00000306172HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000334701ENST00000539107HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000334701ENST00000545336HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000334701ENST00000381256HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000334701ENST00000381259HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000334701ENST00000540401HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000334701ENST00000306172HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000441629ENST00000539107HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000441629ENST00000545336HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000441629ENST00000381256HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000441629ENST00000381259HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000441629ENST00000540401HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000441629ENST00000306172HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000558600ENST00000539107HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000558600ENST00000545336HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000558600ENST00000381256HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3CDSENST00000558600ENST00000381259HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000558600ENST00000540401HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+
intron-3UTRENST00000558600ENST00000306172HSP90AA1chr14

102551149

-CCDC91chr12

28603291

+

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FusionProtFeatures for HSP90AA1_CCDC91


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90AA1

P07900

CCDC91

Q7Z6B0

Molecular chaperone that promotes the maturation,structural maintenance and proper regulation of specific targetproteins involved for instance in cell cycle control and signaltransduction. Undergoes a functional cycle that is linked to itsATPase activity which is essential for its chaperone activity.This cycle probably induces conformational changes in the clientproteins, thereby causing their activation. Interacts dynamicallywith various co-chaperones that modulate its substraterecognition, ATPase cycle and chaperone function (PubMed:11274138,PubMed:15577939, PubMed:15937123, PubMed:27353360,PubMed:29127155). Engages with a range of client protein classesvia its interaction with various co-chaperone proteins orcomplexes, that act as adapters, simultaneously able to interactwith the specific client and the central chaperone itself(PubMed:29127155). Recruitment of ATP and co-chaperone followed byclient protein forms a functional chaperone. After the completionof the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformationand finally, ADP is released from HSP90 which acquires an openconformation for the next cycle (PubMed:27295069,PubMed:26991466). Apart from its chaperone activity, it also playsa role in the regulation of the transcription machinery. HSP90 andits co-chaperones modulate transcription at least at threedifferent levels (PubMed:25973397). In the first place, they alterthe steady-state levels of certain transcription factors inresponse to various physiological cues(PubMed:25973397). Second,they modulate the activity of certain epigenetic modifiers, suchas histone deacetylases or DNA methyl transferases, and therebyrespond to the change in the environment (PubMed:25973397). Third,they participate in the eviction of histones from the promoterregion of certain genes and thereby turn on gene expression(PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) andmediates LPS-induced inflammatory response, including TNFsecretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).{ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205,ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123,ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27353360,ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397,ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}. Involved in the regulation of membrane traffic throughthe trans-Golgi network (TGN). Functions in close cooperation withthe GGAs in the sorting of hydrolases to lysosomes.{ECO:0000269|PubMed:17596511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSP90AA1_CCDC91


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSP90AA1_CCDC91


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSP90AA1_CCDC91


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHSP90AA1P07900DB00615RifabutinHeat shock protein HSP 90-alphasmall moleculeapproved|investigational
HgeneHSP90AA1P07900DB00716NedocromilHeat shock protein HSP 90-alphasmall moleculeapproved|investigational

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RelatedDiseases for HSP90AA1_CCDC91


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSP90AA1C0009178Cocaine withdrawal1PSYGENET
HgeneHSP90AA1C0011616Contact Dermatitis1CTD_human
HgeneHSP90AA1C0019693HIV Infections1CTD_human
HgeneHSP90AA1C0027627Neoplasm Metastasis1CTD_human
HgeneHSP90AA1C0041696Unipolar Depression1PSYGENET
HgeneHSP90AA1C0206180Ki-1+ Anaplastic Large Cell Lymphoma1CTD_human
HgeneHSP90AA1C0525045Mood Disorders1PSYGENET
HgeneHSP90AA1C1269683Major Depressive Disorder1PSYGENET
HgeneHSP90AA1C1458155Mammary Neoplasms1CTD_human
TgeneCCDC91C0236969Substance-Related Disorders1CTD_human