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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16816

FusionGeneSummary for HSDL2_TEX10

check button Fusion gene summary
Fusion gene informationFusion gene name: HSDL2_TEX10
Fusion gene ID: 16816
HgeneTgene
Gene symbol

HSDL2

TEX10

Gene ID

84263

54881

Gene namehydroxysteroid dehydrogenase like 2testis expressed 10
SynonymsC9orf99|SDR13C1Ipi1|bA208F1.2
Cytomap

9q32

9q31.1

Type of geneprotein-codingprotein-coding
Descriptionhydroxysteroid dehydrogenase-like protein 2short chain dehydrogenase/reductase family 13C member 1testis-expressed protein 10testis expressed gene 10testis-expressed sequence 10 protein
Modification date2018051920180523
UniProtAcc

Q6YN16

Q9NXF1

Ensembl transtripts involved in fusion geneENST00000398805, ENST00000398803, 
ENST00000488101, ENST00000262542, 
ENST00000539114, 		ENST00000535814, 
ENST00000374902, ENST00000477648, 
ENST00000537512, 
Fusion gene scores* DoF score2 X 1 X 2=42 X 1 X 2=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: HSDL2 [Title/Abstract] AND TEX10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-TS-A8AY-01AHSDL2chr9

115142460

+TEX10chr9

103111654

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000398805ENST00000535814HSDL2chr9

115142460

+TEX10chr9

103111654

-
5CDS-5UTRENST00000398805ENST00000374902HSDL2chr9

115142460

+TEX10chr9

103111654

-
5CDS-intronENST00000398805ENST00000477648HSDL2chr9

115142460

+TEX10chr9

103111654

-
5CDS-intronENST00000398805ENST00000537512HSDL2chr9

115142460

+TEX10chr9

103111654

-
Frame-shiftENST00000398803ENST00000535814HSDL2chr9

115142460

+TEX10chr9

103111654

-
5CDS-5UTRENST00000398803ENST00000374902HSDL2chr9

115142460

+TEX10chr9

103111654

-
5CDS-intronENST00000398803ENST00000477648HSDL2chr9

115142460

+TEX10chr9

103111654

-
5CDS-intronENST00000398803ENST00000537512HSDL2chr9

115142460

+TEX10chr9

103111654

-
3UTR-3CDSENST00000488101ENST00000535814HSDL2chr9

115142460

+TEX10chr9

103111654

-
3UTR-5UTRENST00000488101ENST00000374902HSDL2chr9

115142460

+TEX10chr9

103111654

-
3UTR-intronENST00000488101ENST00000477648HSDL2chr9

115142460

+TEX10chr9

103111654

-
3UTR-intronENST00000488101ENST00000537512HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-3CDSENST00000262542ENST00000535814HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-5UTRENST00000262542ENST00000374902HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-intronENST00000262542ENST00000477648HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-intronENST00000262542ENST00000537512HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-3CDSENST00000539114ENST00000535814HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-5UTRENST00000539114ENST00000374902HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-intronENST00000539114ENST00000477648HSDL2chr9

115142460

+TEX10chr9

103111654

-
5UTR-intronENST00000539114ENST00000537512HSDL2chr9

115142460

+TEX10chr9

103111654

-

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FusionProtFeatures for HSDL2_TEX10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSDL2

Q6YN16

TEX10

Q9NXF1

Has apparently no steroid dehydrogenase activity.{ECO:0000269|PubMed:19703561}. Functions as a component of the Five Friends ofMethylated CHTOP (5FMC) complex; the 5FMC complex is recruited toZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 andsubsequent transactivation of ZNF148 target genes(PubMed:22872859). Component of the PELP1 complex involved in thenucleolar steps of 28S rRNA maturation and the subsequentnucleoplasmic transit of the pre-60S ribosomal subunit(PubMed:21326211). {ECO:0000269|PubMed:21326211,ECO:0000269|PubMed:22872859}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSDL2_TEX10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSDL2_TEX10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSDL2PEX5, ADRB2, FBXO6, PARK2, DLD, NDUFA8, SF1, TAGLN2, TRAP1, KRAS, TCTN3, CNTRL, NPHP1, RPGRIP1L, HDAC1, COQ9, PPM1A, MIPEP, HERC2, F2RL1, NEURL4, NIPSNAP3A, DNAJC9, XRCC4, DNPEP, KIF3A, DLST, PDHA1TEX10USP42, SLX4, SIRT7, LAS1L, MDN1, PTPN12, PELP1, SOX2, RPA3, RPA2, RPA1, CUL7, OBSL1, RNF2, SUMO2, RPL13, NPM1, RPS2, WDR18, HIST1H2BA, NTRK1, GNL3, NOL9, SENP3, IFI16, HERC2, RPL10, KIF2C, FOXQ1, CDC14B, DUSP5, TNFRSF13B, PHF19, MECP2, NEUROG3, HIST1H1E, RBM4, H2AFY2, ZBTB48, PDGFB, RSBN1, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSDL2_TEX10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSDL2_TEX10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSDL2C0023903Liver neoplasms1CTD_human