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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1679

FusionGeneSummary for ANK3_CCDC106

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK3_CCDC106
Fusion gene ID: 1679
HgeneTgene
Gene symbol

ANK3

CCDC106

Gene ID

288

29903

Gene nameankyrin 3coiled-coil domain containing 106
SynonymsANKYRIN-G|MRT37HSU79303|ZNF581
Cytomap

10q21.2

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)coiled-coil domain-containing protein 106protein predicted by clone 23882
Modification date2018052320180522
UniProtAcc

Q12955

Q9BWC9

Ensembl transtripts involved in fusion geneENST00000280772, ENST00000373827, 
ENST00000355288, ENST00000503366, 
ENST00000510382, ENST00000460468, 
ENST00000308964, ENST00000586790, 
ENST00000591578, ENST00000588740, 
ENST00000591241, 
Fusion gene scores* DoF score14 X 9 X 7=8823 X 3 X 2=18
# samples 153
** MAII scorelog2(15/882*10)=-2.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANK3 [Title/Abstract] AND CCDC106 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX107511ANK3chr10

61844520

-CCDC106chr19

56164472

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000280772ENST00000308964ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000280772ENST00000586790ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000280772ENST00000591578ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000280772ENST00000588740ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-intronENST00000280772ENST00000591241ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000373827ENST00000308964ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000373827ENST00000586790ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000373827ENST00000591578ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000373827ENST00000588740ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-intronENST00000373827ENST00000591241ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000355288ENST00000308964ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000355288ENST00000586790ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000355288ENST00000591578ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000355288ENST00000588740ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-intronENST00000355288ENST00000591241ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000503366ENST00000308964ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000503366ENST00000586790ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000503366ENST00000591578ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000503366ENST00000588740ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-intronENST00000503366ENST00000591241ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000510382ENST00000308964ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000510382ENST00000586790ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000510382ENST00000591578ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000510382ENST00000588740ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-intronENST00000510382ENST00000591241ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000460468ENST00000308964ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000460468ENST00000586790ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000460468ENST00000591578ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-3UTRENST00000460468ENST00000588740ANK3chr10

61844520

-CCDC106chr19

56164472

+
intron-intronENST00000460468ENST00000591241ANK3chr10

61844520

-CCDC106chr19

56164472

+

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FusionProtFeatures for ANK3_CCDC106


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK3

Q12955

CCDC106

Q9BWC9

Promotes the degradation of p53/TP53 protein andinhibits its transactivity. {ECO:0000269|PubMed:20159018}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANK3_CCDC106


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANK3_CCDC106


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANK3_CCDC106


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ANK3_CCDC106


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANK3C0005586Bipolar Disorder7CTD_human;PSYGENET
HgeneANK3C0036341Schizophrenia3PSYGENET
HgeneANK3C0033975Psychotic Disorders2PSYGENET
HgeneANK3C0525045Mood Disorders2PSYGENET
HgeneANK3C0033300Progeria1CTD_human
HgeneANK3C0038220Status Epilepticus1CTD_human
HgeneANK3C0178417Anhedonia1PSYGENET
HgeneANK3C0349204Nonorganic psychosis1PSYGENET