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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16787

FusionGeneSummary for HS3ST4_FEN1

check button Fusion gene summary
Fusion gene informationFusion gene name: HS3ST4_FEN1
Fusion gene ID: 16787
HgeneTgene
Gene symbol

HS3ST4

FEN1

Gene ID

9951

2237

Gene nameheparan sulfate-glucosamine 3-sulfotransferase 4flap structure-specific endonuclease 1
Synonyms3-OST-4|30ST4|3OST4|h3-OST-4FEN-1|MF1|RAD2
Cytomap

16p12.1

11q12.2

Type of geneprotein-codingprotein-coding
Descriptionheparan sulfate glucosamine 3-O-sulfotransferase 4heparan sulfate (glucosamine) 3-O-sulfotransferase 4heparan sulfate 3-O-sulfotransferase 4heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4flap endonuclease 1DNase IVmaturation factor-1
Modification date2018032920180523
UniProtAcc

Q9Y661

P39748

Ensembl transtripts involved in fusion geneENST00000331351, ENST00000475436, 
ENST00000305885, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: HS3ST4 [Title/Abstract] AND FEN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFEN1

GO:0043137

DNA replication, removal of RNA primer

18995831

TgeneFEN1

GO:0090305

nucleic acid phosphodiester bond hydrolysis

18499658


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC019599HS3ST4chr16

26043662

+FEN1chr11

61563094

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000331351ENST00000305885HS3ST4chr16

26043662

+FEN1chr11

61563094

+
intron-3CDSENST00000475436ENST00000305885HS3ST4chr16

26043662

+FEN1chr11

61563094

+

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FusionProtFeatures for HS3ST4_FEN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HS3ST4

Q9Y661

FEN1

P39748

Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid uniton heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (Bysimilarity). {ECO:0000250}. Structure-specific nuclease with 5'-flap endonucleaseand 5'-3' exonuclease activities involved in DNA replication andrepair. During DNA replication, cleaves the 5'-overhanging flapstructure that is generated by displacement synthesis when DNApolymerase encounters the 5'-end of a downstream Okazaki fragment.It enters the flap from the 5'-end and then tracks to cleave theflap base, leaving a nick for ligation. Also involved in the longpatch base excision repair (LP-BER) pathway, by cleaving withinthe apurinic/apyrimidinic (AP) site-terminated flap. Acts as agenome stabilization factor that prevents flaps from equilibratinginto structurs that lead to duplications and deletions. Alsopossesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved inreplication and repair of rDNA and in repairing mitochondrial DNA.{ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741,ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037,ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:7961795,ECO:0000269|PubMed:8621570}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HS3ST4_FEN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HS3ST4_FEN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HS3ST4_FEN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFEN1P39748DB01592IronFlap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}small moleculeapproved

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RelatedDiseases for HS3ST4_FEN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHS3ST4C0236733Amphetamine-Related Disorders1CTD_human
TgeneFEN1C0009404Colorectal Neoplasms1CTD_human