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Fusion gene ID: 16758 |
FusionGeneSummary for HPS4_UBE2L3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: HPS4_UBE2L3 | Fusion gene ID: 16758 | Hgene | Tgene | Gene symbol | HPS4 | UBE2L3 | Gene ID | 89781 | 7332 |
Gene name | HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 | ubiquitin conjugating enzyme E2 L3 | |
Synonyms | BLOC3S2|LE | E2-F1|L-UBC|UBCH7|UbcM4 | |
Cytomap | 22q12.1 | 22q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | Hermansky-Pudlak syndrome 4 proteinlight-ear protein homolog | ubiquitin-conjugating enzyme E2 L3E2 ubiquitin-conjugating enzyme L3ubiquitin carrier protein L3ubiquitin conjugating enzyme E2L 3ubiquitin-conjugating enzyme E2-F1ubiquitin-conjugating enzyme UBCH7ubiquitin-protein ligase L3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NQG7 | P68036 | |
Ensembl transtripts involved in fusion gene | ENST00000398141, ENST00000398145, ENST00000402105, ENST00000336873, ENST00000493455, | ENST00000458578, ENST00000342192, ENST00000545681, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 8 X 4 X 4=128 |
# samples | 3 | 9 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/128*10)=-0.508146903670325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HPS4 [Title/Abstract] AND UBE2L3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HPS4 | GO:0006605 | protein targeting | 12663659 |
Hgene | HPS4 | GO:0007040 | lysosome organization | 12663659 |
Hgene | HPS4 | GO:1903232 | melanosome assembly | 23084991 |
Tgene | UBE2L3 | GO:0000209 | protein polyubiquitination | 10888878|14765125 |
Tgene | UBE2L3 | GO:0006355 | regulation of transcription, DNA-templated | 17003263 |
Tgene | UBE2L3 | GO:0016567 | protein ubiquitination | 9990509|21532592 |
Tgene | UBE2L3 | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
Tgene | UBE2L3 | GO:0071385 | cellular response to glucocorticoid stimulus | 17003263 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-XV-A9W2-01A | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000398141 | ENST00000458578 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
In-frame | ENST00000398141 | ENST00000342192 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
5CDS-intron | ENST00000398141 | ENST00000545681 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
Frame-shift | ENST00000398145 | ENST00000458578 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
Frame-shift | ENST00000398145 | ENST00000342192 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
5CDS-intron | ENST00000398145 | ENST00000545681 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
In-frame | ENST00000402105 | ENST00000458578 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
In-frame | ENST00000402105 | ENST00000342192 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
5CDS-intron | ENST00000402105 | ENST00000545681 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
In-frame | ENST00000336873 | ENST00000458578 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
In-frame | ENST00000336873 | ENST00000342192 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
5CDS-intron | ENST00000336873 | ENST00000545681 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
5UTR-3CDS | ENST00000493455 | ENST00000458578 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
5UTR-3CDS | ENST00000493455 | ENST00000342192 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
5UTR-intron | ENST00000493455 | ENST00000545681 | HPS4 | chr22 | 26859883 | - | UBE2L3 | chr22 | 21947150 | + |
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FusionProtFeatures for HPS4_UBE2L3 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
HPS4 | UBE2L3 |
Component of the BLOC-3 complex, a complex that acts asa guanine exchange factor (GEF) for RAB32 and RAB38, promotes theexchange of GDP to GTP, converting them from an inactive GDP-boundform into an active GTP-bound form. The BLOC-3 complex plays animportant role in the control of melanin production and melanosomebiogenesis and promotes the membrane localization of RAB32 andRAB38 (PubMed:23084991). {ECO:0000269|PubMed:23084991}. | Ubiquitin-conjugating enzyme E2 that specifically actswith HECT-type and RBR family E3 ubiquitin-protein ligases. Doesnot function with most RING-containing E3 ubiquitin-proteinligases because it lacks intrinsic E3-independent reactivity withlysine: in contrast, it has activity with the RBR family E3enzymes, such as PRKN and ARIH1, that function like function likeRING-HECT hybrids. Accepts ubiquitin from the E1 complex andcatalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-11'-linked polyubiquitination. Involved in theselective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression throughthe cell cycle. Regulates nuclear hormone receptorstranscriptional activity. May play a role in myelopoiesis.{ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689,ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090,ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:21532592}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HPS4_UBE2L3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_HPS4_ENST00000398141_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_730aa MAPLCSLARWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDSPPTLVRLRKLKFAIKVDGDYLWVLG CAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARILQTCQR SPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGKWMLWSFKNRVTHQNPNGAALPPNVQIIPVFVTKEEAIS LHEFPVEQMTRSLASPAGLQDGSAQHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARG EVLGLSSSLGKELVFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDTAISSLRPPSAPEMLTQH GAQEQLEDHPGHSSQAPIPRADPLPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISS RLTPAESCMGLVRMNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEI NFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTK >In-frame_HPS4_ENST00000398141_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_730aa MAPLCSLARWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDSPPTLVRLRKLKFAIKVDGDYLWVLG CAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARILQTCQR SPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGKWMLWSFKNRVTHQNPNGAALPPNVQIIPVFVTKEEAIS LHEFPVEQMTRSLASPAGLQDGSAQHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARG EVLGLSSSLGKELVFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDTAISSLRPPSAPEMLTQH GAQEQLEDHPGHSSQAPIPRADPLPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISS RLTPAESCMGLVRMNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEI NFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTK >In-frame_HPS4_ENST00000402105_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_712aa MAPLCSLARWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDSPPTLVRLRKLKFAIKVDGDYLWVLG CAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARILQTCQR SPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGAALPPNVQIIPVFVTKEEAISLHEFPVEQMTRSLASPAG LQDGSAQHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSLGKELVFLQE ELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHSSQAPI PRADPLPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISSRLTPAESCMGLVRMNLYT HCVKGLVLSLLAEEPLLGDSAAIEEVELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTK >In-frame_HPS4_ENST00000402105_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_712aa MAPLCSLARWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDSPPTLVRLRKLKFAIKVDGDYLWVLG CAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARILQTCQR SPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGAALPPNVQIIPVFVTKEEAISLHEFPVEQMTRSLASPAG LQDGSAQHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSLGKELVFLQE ELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHSSQAPI PRADPLPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISSRLTPAESCMGLVRMNLYT HCVKGLVLSLLAEEPLLGDSAAIEEVELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTK >In-frame_HPS4_ENST00000336873_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_717aa MATSTSTEAKSASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDSPPTLVRLRKLKFAIKVDGDY LWVLGCAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARIL QTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGAALPPNVQIIPVFVTKEEAISLHEFPVEQMTRSL ASPAGLQDGSAQHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSLGKEL VFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHS SQAPIPRADPLPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISSRLTPAESCMGLVR MNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKI >In-frame_HPS4_ENST00000336873_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_717aa MATSTSTEAKSASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDSPPTLVRLRKLKFAIKVDGDY LWVLGCAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARIL QTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGAALPPNVQIIPVFVTKEEAISLHEFPVEQMTRSL ASPAGLQDGSAQHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSLGKEL VFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHS SQAPIPRADPLPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISSRLTPAESCMGLVR MNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKI |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_HPS4_ENST00000398141_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_2190nt ATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCT GGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCT GACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGC TGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTA GCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAG ATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGC TCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTT CACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAAAATGGATGTTATGGAGCTTCAAGAAT CGAGTTACCCACCAGAACCCTAATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGT CTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGT GGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCT TGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGT GAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCT CAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGC GCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCAT GGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGG CCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTC TGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCC AGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCT GAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATC CAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATC AACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTC TGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCC CAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAG >In-frame_HPS4_ENST00000398141_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_2190nt ATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCT GGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCT GACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGC TGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTA GCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAG ATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGC TCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTT CACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAAAATGGATGTTATGGAGCTTCAAGAAT CGAGTTACCCACCAGAACCCTAATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGT CTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGT GGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCT TGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGT GAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCT CAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGC GCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCAT GGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGG CCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTC TGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCC AGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCT GAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATC CAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATC AACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTC TGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCC CAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAG >In-frame_HPS4_ENST00000402105_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_2136nt ATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCT GGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCT GACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGC TGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTA GCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAG ATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGC TCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTT CACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCGGCATTGCCCCCGAATGTCCAGATT ATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGA CTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCC TGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGC ATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAA GAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCA GATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTG CGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATT CCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACG GGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGT CAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACT CACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAA ATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAAC CCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAG ATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAA GTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGT >In-frame_HPS4_ENST00000402105_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_2136nt ATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCT GGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCT GACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGC TGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTA GCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAG ATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGC TCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTT CACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCGGCATTGCCCCCGAATGTCCAGATT ATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGA CTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCC TGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGC ATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAA GAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCA GATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTG CGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATT CCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACG GGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGT CAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACT CACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAA ATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAAC CCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAG ATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAA GTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGT >In-frame_HPS4_ENST00000336873_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_2151nt ATGGCCACCTCTACCTCCACAGAGGCAAAGTCAGCCTCGTGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGC GATCCAACAAGAGCTGGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTT GTCCGCTGTGTTTCTGACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTAC CTTTGGGTGCTGGGCTGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAAT GGACCTGTTTCCCTAGCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACC AGTGATCTGCATAAGATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTG CAGACCTGCCAGCGCTCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACC GCCAAGGTCCTGCTTCACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCGGCATTGCCC CCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTA GCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCAT GTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGC CATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTA GTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTA CATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACA GCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGC AGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGA AACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCA GGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGG ATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAA GTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTT ATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATC ACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCA ACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAA >In-frame_HPS4_ENST00000336873_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_2151nt ATGGCCACCTCTACCTCCACAGAGGCAAAGTCAGCCTCGTGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGC GATCCAACAAGAGCTGGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTT GTCCGCTGTGTTTCTGACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTAC CTTTGGGTGCTGGGCTGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAAT GGACCTGTTTCCCTAGCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACC AGTGATCTGCATAAGATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTG CAGACCTGCCAGCGCTCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACC GCCAAGGTCCTGCTTCACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCGGCATTGCCC CCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTA GCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCAT GTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGC CATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTA GTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTA CATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACA GCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGC AGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGA AACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCA GGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGG ATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAA GTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTT ATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATC ACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCA ACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_HPS4_ENST00000398141_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_2773nt ATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCT GGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCT GACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGC TGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTA GCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAG ATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGC TCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTT CACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAAAATGGATGTTATGGAGCTTCAAGAAT CGAGTTACCCACCAGAACCCTAATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGT CTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGT GGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCT TGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGT GAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCT CAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGC GCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCAT GGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGG CCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTC TGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCC AGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCT GAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATC CAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATC AACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTC TGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCC CAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAG AAATATGGGGAAAAGCGACCTGTGGACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGACA CCCCGCAAAGCAGGACTCTGTGGAAATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAACTTTCTACAGTTTTCTTAAT CAAAAGTGGTCTAGGTAACCTGTAAAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGTTTTAAAAATCACTGCTTCAA TCTACTTCAAAAGAATGGTGTTTCTTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCCATAAGGTTTAAAAAAAAGGA AAAAAAACGGTTGTGGTTCCCTTTCTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTTTCACTTACTTACTTCCCCAG ACCCCGGGCTCGCCTCCACAAAGGAGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGTGGCACTGTTGCCCAGTGTGG >In-frame_HPS4_ENST00000398141_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_4555nt ATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCT GGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCT GACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGC TGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTA GCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAG ATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGC TCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTT CACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAAAATGGATGTTATGGAGCTTCAAGAAT CGAGTTACCCACCAGAACCCTAATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGT CTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGT GGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCT TGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGT GAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCT CAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGC GCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCAT GGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGG CCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTC TGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCC AGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCT GAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATC CAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATC AACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTC TGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCC CAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAG AAATATGGGGAAAAGCGACCTGTGGACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGACA CCCCGCAAAGCAGGACTCTGTGGAAATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAACTTTCTACAGTTTTCTTAAT CAAAAGTGGTCTAGGTAACCTGTAAAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGTTTTAAAAATCACTGCTTCAA TCTACTTCAAAAGAATGGTGTTTCTTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCCATAAGGTTTAAAAAAAAGGA AAAAAAACGGTTGTGGTTCCCTTTCTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTTTCACTTACTTACTTCCCCAG ACCCCGGGCTCGCCTCCACAAAGGAGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGTGGCACTGTTGCCCAGTGTGG GAGTTGGTTTAAATTCTCCTGACTCCAGTTTATAACATCCTTTTAAAAAATTTAAAAACAAACAGCCACACCCCTCCTCCAGTCCTTCTC CTCAGTTCTTGTGTGAAACTCCAGCTGATGTTACCACAGTAACATCAGTTAATTGGGCAAGCCCTGATGTCAGTGTGTGTAACTGACCTC TGGCCTGGCCTGCACAGAGAAGCCCTATAATCACAGGTCTGTGGTGGCCCCGAAATGGGGGGCCTGCTAGTCAGGAGGATGCTGTGCACA CTGTGTGTGATGAATCTCGCCAGAAAGGCTCCTGAGGTCCCAGGTTGGCACTTCTCCCTGCAGCCATTGTAGAAGATCTGCTGGTCCTTG CAGGCAAAGCTACAGCCAGAATGTCCGTTTGAAACTCCTAGCTCATCTGTCACCGAGCTTCATCCGAATGTGCCACGGAGCTTGCTCTCC ACTTCCTCCGTGCAGTGGCCCTGCCACAGCCCTCCCTCGGCACACTTTGACCCTTTGTAGGATTGGAATTAGCAGGACTCGGCTATTTAA AGCACCAGTCTGGGGTCGCCTGGGCCCCTGCTGACCCCCTCCTCCAGAGCAGCCAGCCCAGCCCGGGAACAAGACGGACTTCCTCTCCCT TCGGACTCACAGCCTTTGCAGAGTCAAGCTCCACTTGAAGCTCACTCAGTAATATCCTTTCAATGTGTTTTATATTGTTTTGACTGCCTT TTTTTGTAGAAATAAAAATTGACCTTAGAATTTATCGTCAGATAAACTTGTAAAGATTTGAATATTAATGTCTTTTCAAGGCAAATGGGA TTGTCCCCGCACTAGTAGAGAATCCATGTCGCTCTGACACCCCAAGGAAGCCGACGATCCAAATGCCGTGTGTCACCAACCCCGCTTCTG CCACTGGCGGCTTCCCTTCTTGGCTCTTGGGGGGGACTAGATCCTGTGGAGAAGATGACTTAAACTTTGCTTTTTGTTTTAATTTTAATT CTATAACTTGAGATCTTTCCGGGGCCTACAGGCGTGTAAGACAGCTTGGTCTGGTCTGTGCAGAAGTGGGGAGTGATGGGCAGGTTCGGC AGCCTAACATTGTTCAGGCGCATGGCCCCTGCGGTGTGTACACGAACTCGGCTTCTTTTGTCCTAGGTACGCCAAGGGCAGGTTTCTGGA GACTCCCTTGTGCCCGGGATGGCAAGGGCACCGGGCTGGCGTTTCCACATCTGTCTTCATTAGCAGAAAAGTGATGATGGATTTTATTTC ACTCACACTCCAGTTTGTAATAAAATGCCAAATTCTGTCAGCTATCCAAACAAGCCACCATTTGTTCTTGTTGCTTCTCTGGATCCAGAA ATGTTGCCATTCTTGGAAACTGTCCCATTGCTTCGTATTTCTGCCAACGTAGCTCTGCCTGCCTGTCAACCCCTCACTGCACTCTGCTCA TCACGGGAGGATACCTGTGTGCCGGCAGCCCCTCAGGGACTCTCAGCCCTGGCACTGGCACCCCAGGGTTGGCCCCGTCAGCAGAGGCTT GGCTTTCGAGCCAGTGGGTGTCTCTCCTTTGGGCCTGGGCGGCTTGCTCCTGCCAGCCATGCCTTCAGGGTAGGCTCTGAGCAAGCTGGC GAACAGCCCTGGCTGCTCCAAAACCAAAAAGCTGGGTCCTCTGGAGGAGGGGCGAGCTGTGGAGCAGCCACCCACTGCTGCCCCAAGCTC ACTCAGGAATTCACACCCGCCTGGTTTCTTGAAGTGTGCTGGGTCCTTCCCTCTGCTCCCTACTCCCCACCACGGCAGAGAATAGGCTTT >In-frame_HPS4_ENST00000402105_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_3019nt AGACCATGTGGTTGTATAGTTAAGGTTCAGTGTTTCAAATAAGAGCAGTCATTGTGGGCGCCTCGTTTTTTTTTCTAGCTACTCGTGTCT TCTCCGGCAGATGGTCTAACGGCTGGATAGAGGCATATTTTTAGTTTGAATTTCCTGCGCTTACAGAATGGTTTTATCTAATTTGTAGCT ACTGGGGTTCTTTATTCTCTGGGGCCACCTGAAGGCTTTCAAACACAGTAATAAGCCCTCCTCGGGCTGGGAAACAGGAAGCTGTGTTTT AAATGCCGTGATCACTGGATTAAAGGAAACATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAG GTAAAGGAAGAAGGCGATCCAACAAGAGCTGGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGA CAGATTGCTGGAGTTGTCCGCTGTGTTTCTGACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAA GTTGATGGAGATTACCTTTGGGTGCTGGGCTGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTC TTTAATTTTTACAATGGACCTGTTTCCCTAGCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAA ATTCTGAAAAACACCAGTGATCTGCATAAGATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAG GCAGCCCGCATTCTGCAGACCTGCCAGCGCTCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTC CCGCCCTCCCTCACCGCCAAGGTCCTGCTTCACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACAT GGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAG ATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAA AACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAAC GGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCC CTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGT CATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACG CCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGAC CATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGAT CCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGT CTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGC ATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGC GCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTG ACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTC AAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAA AACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCT GACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTG GACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGACACCCCGCAAAGCAGGACTCTGTGGA AATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAACTTTCTACAGTTTTCTTAATCAAAAGTGGTCTAGGTAACCTGTA AAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGTTTTAAAAATCACTGCTTCAATCTACTTCAAAAGAATGGTGTTTC TTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCCATAAGGTTTAAAAAAAAGGAAAAAAAACGGTTGTGGTTCCCTTT CTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTTTCACTTACTTACTTCCCCAGACCCCGGGCTCGCCTCCACAAAGG AGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGTGGCACTGTTGCCCAGTGTGGGAGTTGGTTTAAATTCTCCTGACT >In-frame_HPS4_ENST00000402105_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_4801nt AGACCATGTGGTTGTATAGTTAAGGTTCAGTGTTTCAAATAAGAGCAGTCATTGTGGGCGCCTCGTTTTTTTTTCTAGCTACTCGTGTCT TCTCCGGCAGATGGTCTAACGGCTGGATAGAGGCATATTTTTAGTTTGAATTTCCTGCGCTTACAGAATGGTTTTATCTAATTTGTAGCT ACTGGGGTTCTTTATTCTCTGGGGCCACCTGAAGGCTTTCAAACACAGTAATAAGCCCTCCTCGGGCTGGGAAACAGGAAGCTGTGTTTT AAATGCCGTGATCACTGGATTAAAGGAAACATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAG GTAAAGGAAGAAGGCGATCCAACAAGAGCTGGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGA CAGATTGCTGGAGTTGTCCGCTGTGTTTCTGACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAA GTTGATGGAGATTACCTTTGGGTGCTGGGCTGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTC TTTAATTTTTACAATGGACCTGTTTCCCTAGCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAA ATTCTGAAAAACACCAGTGATCTGCATAAGATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAG GCAGCCCGCATTCTGCAGACCTGCCAGCGCTCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTC CCGCCCTCCCTCACCGCCAAGGTCCTGCTTCACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACAT GGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAG ATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAA AACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAAC GGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCC CTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGT CATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACG CCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGAC CATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGAT CCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGT CTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGC ATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGC GCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTG ACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTC AAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAA AACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCT GACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTG GACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGACACCCCGCAAAGCAGGACTCTGTGGA AATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAACTTTCTACAGTTTTCTTAATCAAAAGTGGTCTAGGTAACCTGTA AAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGTTTTAAAAATCACTGCTTCAATCTACTTCAAAAGAATGGTGTTTC TTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCCATAAGGTTTAAAAAAAAGGAAAAAAAACGGTTGTGGTTCCCTTT CTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTTTCACTTACTTACTTCCCCAGACCCCGGGCTCGCCTCCACAAAGG AGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGTGGCACTGTTGCCCAGTGTGGGAGTTGGTTTAAATTCTCCTGACT CCAGTTTATAACATCCTTTTAAAAAATTTAAAAACAAACAGCCACACCCCTCCTCCAGTCCTTCTCCTCAGTTCTTGTGTGAAACTCCAG CTGATGTTACCACAGTAACATCAGTTAATTGGGCAAGCCCTGATGTCAGTGTGTGTAACTGACCTCTGGCCTGGCCTGCACAGAGAAGCC CTATAATCACAGGTCTGTGGTGGCCCCGAAATGGGGGGCCTGCTAGTCAGGAGGATGCTGTGCACACTGTGTGTGATGAATCTCGCCAGA AAGGCTCCTGAGGTCCCAGGTTGGCACTTCTCCCTGCAGCCATTGTAGAAGATCTGCTGGTCCTTGCAGGCAAAGCTACAGCCAGAATGT CCGTTTGAAACTCCTAGCTCATCTGTCACCGAGCTTCATCCGAATGTGCCACGGAGCTTGCTCTCCACTTCCTCCGTGCAGTGGCCCTGC CACAGCCCTCCCTCGGCACACTTTGACCCTTTGTAGGATTGGAATTAGCAGGACTCGGCTATTTAAAGCACCAGTCTGGGGTCGCCTGGG CCCCTGCTGACCCCCTCCTCCAGAGCAGCCAGCCCAGCCCGGGAACAAGACGGACTTCCTCTCCCTTCGGACTCACAGCCTTTGCAGAGT CAAGCTCCACTTGAAGCTCACTCAGTAATATCCTTTCAATGTGTTTTATATTGTTTTGACTGCCTTTTTTTGTAGAAATAAAAATTGACC TTAGAATTTATCGTCAGATAAACTTGTAAAGATTTGAATATTAATGTCTTTTCAAGGCAAATGGGATTGTCCCCGCACTAGTAGAGAATC CATGTCGCTCTGACACCCCAAGGAAGCCGACGATCCAAATGCCGTGTGTCACCAACCCCGCTTCTGCCACTGGCGGCTTCCCTTCTTGGC TCTTGGGGGGGACTAGATCCTGTGGAGAAGATGACTTAAACTTTGCTTTTTGTTTTAATTTTAATTCTATAACTTGAGATCTTTCCGGGG CCTACAGGCGTGTAAGACAGCTTGGTCTGGTCTGTGCAGAAGTGGGGAGTGATGGGCAGGTTCGGCAGCCTAACATTGTTCAGGCGCATG GCCCCTGCGGTGTGTACACGAACTCGGCTTCTTTTGTCCTAGGTACGCCAAGGGCAGGTTTCTGGAGACTCCCTTGTGCCCGGGATGGCA AGGGCACCGGGCTGGCGTTTCCACATCTGTCTTCATTAGCAGAAAAGTGATGATGGATTTTATTTCACTCACACTCCAGTTTGTAATAAA ATGCCAAATTCTGTCAGCTATCCAAACAAGCCACCATTTGTTCTTGTTGCTTCTCTGGATCCAGAAATGTTGCCATTCTTGGAAACTGTC CCATTGCTTCGTATTTCTGCCAACGTAGCTCTGCCTGCCTGTCAACCCCTCACTGCACTCTGCTCATCACGGGAGGATACCTGTGTGCCG GCAGCCCCTCAGGGACTCTCAGCCCTGGCACTGGCACCCCAGGGTTGGCCCCGTCAGCAGAGGCTTGGCTTTCGAGCCAGTGGGTGTCTC TCCTTTGGGCCTGGGCGGCTTGCTCCTGCCAGCCATGCCTTCAGGGTAGGCTCTGAGCAAGCTGGCGAACAGCCCTGGCTGCTCCAAAAC CAAAAAGCTGGGTCCTCTGGAGGAGGGGCGAGCTGTGGAGCAGCCACCCACTGCTGCCCCAAGCTCACTCAGGAATTCACACCCGCCTGG TTTCTTGAAGTGTGCTGGGTCCTTCCCTCTGCTCCCTACTCCCCACCACGGCAGAGAATAGGCTTTCTAAGATGCTGCGATCCCGTTCTG >In-frame_HPS4_ENST00000336873_chr22_26859883_-_UBE2L3_ENST00000458578_chr22_21947150_+_3243nt GTGACCTAAGGCCTCTCTGCCGCGCGCGCAGAGCCAAGGCACTGATGTTTGAACTGGAAACTTCAAAACGTTTAATAAGAGTCTTCAGGA TGGGTTTGAACTAGACAAGCTAGAAATTTCTTTAGAACACCAGCTCTAGCATGCATCTCCCACTTTTGGCTTTCCTGGAGAGGAGCTTGA AGAGGTGGTTCTGCAGACAGCCACAGTGATACTTAGGAAACCAGAGGAATGGATTTGACTTTTCTGCTAGGATTCTCTGTTATAGTTTCT CCCTGAGTTGTAAGAGGCATGGAAATATACATGAAACTGAAGAACCTGCAAGGAAGGGAAGTGGAACTTTCCATGCTGAGTGAAAACTAA CCAAGTGGCAGTTGTGACTGAAAACACTGAAACCTACCACGTCCAGATTCACTGGATTGGGGGATAGAGGAACGGTCACAGCTAGGGAGA AAGAAGTGATACCGGAAAAGAAAACCTAAATGAAGAGAATGAGGATGACTGCACAGTAGATGGCCACCTCTACCTCCACAGAGGCAAAGT CAGCCTCGTGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCTGGCATTTGTTACTTTT ATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCTGACATTTCTGACTCTC CTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGCTGTGCTGTGGAGCTCC CTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTAGCTTATGAGAACTGTT CTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAGATTTTCAATTCCCTCT GGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGCTCGCCTCACATTCTCG CTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTTCACCGAACAGCACCTC AGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGA CCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAG CCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATC CCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGAC TGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTG AAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTT ACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTC CTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTC TCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGG ATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCT CTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGC TGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGA TGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGG GAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACA TCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCA TAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGA ATGCTGAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACC CCGTGCAGTGCATTCAGACACCCCGCAAAGCAGGACTCTGTGGAAATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAA CTTTCTACAGTTTTCTTAATCAAAAGTGGTCTAGGTAACCTGTAAAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGT TTTAAAAATCACTGCTTCAATCTACTTCAAAAGAATGGTGTTTCTTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCC ATAAGGTTTAAAAAAAAGGAAAAAAAACGGTTGTGGTTCCCTTTCTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTT TCACTTACTTACTTCCCCAGACCCCGGGCTCGCCTCCACAAAGGAGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGT GGCACTGTTGCCCAGTGTGGGAGTTGGTTTAAATTCTCCTGACTCCAGTTTATAACATCCTTTTAAAAAATTTAAAAACAAACAGCCACA >In-frame_HPS4_ENST00000336873_chr22_26859883_-_UBE2L3_ENST00000342192_chr22_21947150_+_5025nt GTGACCTAAGGCCTCTCTGCCGCGCGCGCAGAGCCAAGGCACTGATGTTTGAACTGGAAACTTCAAAACGTTTAATAAGAGTCTTCAGGA TGGGTTTGAACTAGACAAGCTAGAAATTTCTTTAGAACACCAGCTCTAGCATGCATCTCCCACTTTTGGCTTTCCTGGAGAGGAGCTTGA AGAGGTGGTTCTGCAGACAGCCACAGTGATACTTAGGAAACCAGAGGAATGGATTTGACTTTTCTGCTAGGATTCTCTGTTATAGTTTCT CCCTGAGTTGTAAGAGGCATGGAAATATACATGAAACTGAAGAACCTGCAAGGAAGGGAAGTGGAACTTTCCATGCTGAGTGAAAACTAA CCAAGTGGCAGTTGTGACTGAAAACACTGAAACCTACCACGTCCAGATTCACTGGATTGGGGGATAGAGGAACGGTCACAGCTAGGGAGA AAGAAGTGATACCGGAAAAGAAAACCTAAATGAAGAGAATGAGGATGACTGCACAGTAGATGGCCACCTCTACCTCCACAGAGGCAAAGT CAGCCTCGTGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCTGGCATTTGTTACTTTT ATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCTGACATTTCTGACTCTC CTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGCTGTGCTGTGGAGCTCC CTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTAGCTTATGAGAACTGTT CTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAGATTTTCAATTCCCTCT GGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGCTCGCCTCACATTCTCG CTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTTCACCGAACAGCACCTC AGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGA CCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAG CCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATC CCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGAC TGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTG AAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTT ACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTC CTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTC TCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGG ATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCT CTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGC TGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGGAGCTTGAAGAAATCCGCAAATGTGGGA TGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGG GAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACA TCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCA TAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGA ATGCTGAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACC CCGTGCAGTGCATTCAGACACCCCGCAAAGCAGGACTCTGTGGAAATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAA CTTTCTACAGTTTTCTTAATCAAAAGTGGTCTAGGTAACCTGTAAAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGT TTTAAAAATCACTGCTTCAATCTACTTCAAAAGAATGGTGTTTCTTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCC ATAAGGTTTAAAAAAAAGGAAAAAAAACGGTTGTGGTTCCCTTTCTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTT TCACTTACTTACTTCCCCAGACCCCGGGCTCGCCTCCACAAAGGAGAAAAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGT GGCACTGTTGCCCAGTGTGGGAGTTGGTTTAAATTCTCCTGACTCCAGTTTATAACATCCTTTTAAAAAATTTAAAAACAAACAGCCACA CCCCTCCTCCAGTCCTTCTCCTCAGTTCTTGTGTGAAACTCCAGCTGATGTTACCACAGTAACATCAGTTAATTGGGCAAGCCCTGATGT CAGTGTGTGTAACTGACCTCTGGCCTGGCCTGCACAGAGAAGCCCTATAATCACAGGTCTGTGGTGGCCCCGAAATGGGGGGCCTGCTAG TCAGGAGGATGCTGTGCACACTGTGTGTGATGAATCTCGCCAGAAAGGCTCCTGAGGTCCCAGGTTGGCACTTCTCCCTGCAGCCATTGT AGAAGATCTGCTGGTCCTTGCAGGCAAAGCTACAGCCAGAATGTCCGTTTGAAACTCCTAGCTCATCTGTCACCGAGCTTCATCCGAATG TGCCACGGAGCTTGCTCTCCACTTCCTCCGTGCAGTGGCCCTGCCACAGCCCTCCCTCGGCACACTTTGACCCTTTGTAGGATTGGAATT AGCAGGACTCGGCTATTTAAAGCACCAGTCTGGGGTCGCCTGGGCCCCTGCTGACCCCCTCCTCCAGAGCAGCCAGCCCAGCCCGGGAAC AAGACGGACTTCCTCTCCCTTCGGACTCACAGCCTTTGCAGAGTCAAGCTCCACTTGAAGCTCACTCAGTAATATCCTTTCAATGTGTTT TATATTGTTTTGACTGCCTTTTTTTGTAGAAATAAAAATTGACCTTAGAATTTATCGTCAGATAAACTTGTAAAGATTTGAATATTAATG TCTTTTCAAGGCAAATGGGATTGTCCCCGCACTAGTAGAGAATCCATGTCGCTCTGACACCCCAAGGAAGCCGACGATCCAAATGCCGTG TGTCACCAACCCCGCTTCTGCCACTGGCGGCTTCCCTTCTTGGCTCTTGGGGGGGACTAGATCCTGTGGAGAAGATGACTTAAACTTTGC TTTTTGTTTTAATTTTAATTCTATAACTTGAGATCTTTCCGGGGCCTACAGGCGTGTAAGACAGCTTGGTCTGGTCTGTGCAGAAGTGGG GAGTGATGGGCAGGTTCGGCAGCCTAACATTGTTCAGGCGCATGGCCCCTGCGGTGTGTACACGAACTCGGCTTCTTTTGTCCTAGGTAC GCCAAGGGCAGGTTTCTGGAGACTCCCTTGTGCCCGGGATGGCAAGGGCACCGGGCTGGCGTTTCCACATCTGTCTTCATTAGCAGAAAA GTGATGATGGATTTTATTTCACTCACACTCCAGTTTGTAATAAAATGCCAAATTCTGTCAGCTATCCAAACAAGCCACCATTTGTTCTTG TTGCTTCTCTGGATCCAGAAATGTTGCCATTCTTGGAAACTGTCCCATTGCTTCGTATTTCTGCCAACGTAGCTCTGCCTGCCTGTCAAC CCCTCACTGCACTCTGCTCATCACGGGAGGATACCTGTGTGCCGGCAGCCCCTCAGGGACTCTCAGCCCTGGCACTGGCACCCCAGGGTT GGCCCCGTCAGCAGAGGCTTGGCTTTCGAGCCAGTGGGTGTCTCTCCTTTGGGCCTGGGCGGCTTGCTCCTGCCAGCCATGCCTTCAGGG TAGGCTCTGAGCAAGCTGGCGAACAGCCCTGGCTGCTCCAAAACCAAAAAGCTGGGTCCTCTGGAGGAGGGGCGAGCTGTGGAGCAGCCA CCCACTGCTGCCCCAAGCTCACTCAGGAATTCACACCCGCCTGGTTTCTTGAAGTGTGCTGGGTCCTTCCCTCTGCTCCCTACTCCCCAC |
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FusionGenePPI for HPS4_UBE2L3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HPS4 | RAC1 | UBE2L3 | UBOX5, AURKA, BRCA1, RNF216, EIF4E2, ARIH1, PTEN, NEDD4, UBE3A, ARIH2, CUL9, CBL, RNF19A, POLR2A, SMURF2, ITCH, WWP2, UBASH3A, RNF125, RNF144B, RNF113B, RNF144A, RBCK1, TRAF7, DTX3, CBLC, MID1, MKRN3, TRIM39, RNF19B, BIRC2, BIRC3, XIAP, PARK2, MYC, MAPK6, ATXN3, ELAVL1, NFKBIA, FOS, NCOA1, UBA1, RELA, SMAD7, RNF103, NR3C1, HACE1, HUWE1, TRIM28, PJA1, TRAF6, NEDD4L, TRIM21, MDM2, STUB1, FBXO2, RNF2, UBE3C, HERC3, TRIP12, WWP1, UBE2D2, AHCYL1, NDUFA7, USP9X, USP34, ZPR1, C12orf5, UBE2B, USP26, SRPRB, UBXN7, TSNAXIP1, UBE2V2, SF1, MRPL53, YAP1, UCHL3, VDAC2, PSMD2, SUGP1, PSMA5, UBE4B, UBXN1, LIG4, FN1, CCNB1IP1, RBX1, AICDA, HSPA4, BAG3, MAP1LC3B, CACNA1B, UBR5, SMURF1, UBA6, UBC, UBE2L3, MUL1, TP53BP1, UBA7, RNF20, HECW2, RNF31, HSPE1, RAB10, SNX12, SNX3, ACAT2, DAZAP1, HEBP1, MDH2, MMACHC, MSI2, PCK2, PIR, PITPNA, PTRHD1, SOD1, UBE2A, UFM1, NDFIP1, AREL1, CACNA1A, RC3H1, HECW1, MCM2, OTUB1, HERC4, HERC6, DUSP4, DUSP8, DNM1L, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HPS4_UBE2L3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HPS4_UBE2L3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HPS4 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | UBE2L3 | C0524909 | Hepatitis B, Chronic | 1 | CTD_human |