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Fusion gene ID: 16748 |
FusionGeneSummary for HPRT1_CTPS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HPRT1_CTPS2 | Fusion gene ID: 16748 | Hgene | Tgene | Gene symbol | HPRT1 | CTPS2 | Gene ID | 3251 | 56474 |
| Gene name | hypoxanthine phosphoribosyltransferase 1 | CTP synthase 2 | |
| Synonyms | HGPRT|HPRT | - | |
| Cytomap | Xq26.2-q26.3 | Xp22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hypoxanthine-guanine phosphoribosyltransferaseHGPRTasehypoxanthine-guanine phosphoribosyltransferase 1testicular tissue protein Li 89 | CTP synthase 2CTP synthase IICTP synthetase type 2UTP-ammonia ligase 2cytidine 5'-triphosphate synthetase 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P00492 | Q9NRF8 | |
| Ensembl transtripts involved in fusion gene | ENST00000298556, ENST00000462974, | ENST00000443824, ENST00000359276, ENST00000380241, ENST00000483053, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 2=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HPRT1 [Title/Abstract] AND CTPS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HPRT1 | GO:0006178 | guanine salvage | 19527031 |
| Hgene | HPRT1 | GO:0043103 | hypoxanthine salvage | 19527031 |
| Hgene | HPRT1 | GO:0046038 | GMP catabolic process | 19527031 |
| Hgene | HPRT1 | GO:0046040 | IMP metabolic process | 19527031 |
| Hgene | HPRT1 | GO:0051289 | protein homotetramerization | 9521733 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A24W-01A | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000298556 | ENST00000443824 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| In-frame | ENST00000298556 | ENST00000359276 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| In-frame | ENST00000298556 | ENST00000380241 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| 5CDS-intron | ENST00000298556 | ENST00000483053 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| 3UTR-3CDS | ENST00000462974 | ENST00000443824 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| 3UTR-3CDS | ENST00000462974 | ENST00000359276 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| 3UTR-3CDS | ENST00000462974 | ENST00000380241 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
| 3UTR-intron | ENST00000462974 | ENST00000483053 | HPRT1 | chrX | 133609394 | + | CTPS2 | chrX | 16657366 | - |
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FusionProtFeatures for HPRT1_CTPS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HPRT1 | CTPS2 |
| Converts guanine to guanosine monophosphate, andhypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto thepurine. Plays a central role in the generation of purinenucleotides through the purine salvage pathway. | Catalyzes the ATP-dependent amination of UTP to CTP witheither L-glutamine or ammonia as the source of nitrogen.Constitutes the rate-limiting enzyme in the synthesis of cytosinenucleotides. {ECO:0000269|PubMed:10899599,ECO:0000269|PubMed:16179339}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HPRT1 | chrX:133609394 | chrX:16657366 | ENST00000298556 | + | 3 | 9 | 134_142 | 106 | 219 | Nucleotide binding | GMP |
| Hgene | >HPRT1 | chrX:133609394 | chrX:16657366 | ENST00000298556 | + | 3 | 9 | 186_188 | 106 | 219 | Nucleotide binding | GMP |
| Tgene | CTPS2 | chrX:133609394 | chrX:16657366 | ENST00000359276 | - | 12 | 19 | 300_554 | 432 | 939 | Domain | Glutamine amidotransferase type-1 |
| Tgene | CTPS2 | chrX:133609394 | chrX:16657366 | ENST00000380241 | - | 12 | 19 | 300_554 | 432 | 974 | Domain | Glutamine amidotransferase type-1 |
| Tgene | CTPS2 | chrX:133609394 | chrX:16657366 | ENST00000443824 | - | 12 | 19 | 300_554 | 432 | 911 | Domain | Glutamine amidotransferase type-1 |
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FusionGeneSequence for HPRT1_CTPS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000443824_chrX_16657366_-_261aa MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSD RSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDG >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000359276_chrX_16657366_-_261aa MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSD RSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDG >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000380241_chrX_16657366_-_261aa MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSD RSIPMTVDFIRLKSYCVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000443824_chrX_16657366_-_783nt ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAG GATTTGGAAAGGGTGTTTATTCCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGAT AGATCCATTCCTATGACTGTAGATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGA ACAATGAGACTGGGAATAAGAAGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAA AGACACAGACATCGGTTCGAGGTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGA GACAGGATGGAAATCATTGAACTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCT TCCCCTCCGTATCTGGGGCTGTTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGA >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000359276_chrX_16657366_-_783nt ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAG GATTTGGAAAGGGTGTTTATTCCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGAT AGATCCATTCCTATGACTGTAGATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGA ACAATGAGACTGGGAATAAGAAGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAA AGACACAGACATCGGTTCGAGGTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGA GACAGGATGGAAATCATTGAACTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCT TCCCCTCCGTATCTGGGGCTGTTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGA >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000380241_chrX_16657366_-_783nt ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAG GATTTGGAAAGGGTGTTTATTCCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGAT AGATCCATTCCTATGACTGTAGATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGA ACAATGAGACTGGGAATAAGAAGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAA AGACACAGACATCGGTTCGAGGTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGA GACAGGATGGAAATCATTGAACTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCT TCCCCTCCGTATCTGGGGCTGTTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000443824_chrX_16657366_-_2756nt CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA TTGCAGAGTGTCCCATCTTGGGAGGGAATGCTGAATAATTAATTGATTTACAGCCTTGTTGCCGCTGGCCAGACCACCAGGTGGCCCATT ACTCGAGATGATCATCACAACCAGATGATGCTAACCTATATCCTCTACCCTTCGCGTGCTTTGTCTGGGAAGTCTTTTGGCCCCATGTCA GTTTCTATTGCATTGAGAGCCCAAGAGCCCCTGGTCAGTCAGGCTTCCATTTAGCATGGCGTTTGCAAGGTTTACCCATGTTGTAGCATG >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000359276_chrX_16657366_-_2453nt CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA >In-frame_HPRT1_ENST00000298556_chrX_133609394_+_CTPS2_ENST00000380241_chrX_16657366_-_2453nt CTGCTTCTCCTCAGCTTCAGGCGGCTGCGACGAGCCCTCAGGCGAACCTCTCGGCTTTCCCGCGCGGCGCCGCCTCTTGCTGCGCCTCCG CCTCCTCCTCTGCTCCGCCACCGGCTTCCTCCTCCTGAGCAGTCAGCCCGCGCGCCGGCCGGCTCCGTTATGGCGACCCGCAGCCCTGGC GTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATT CCTCATGGACTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTG CTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTA GATTTTATCAGACTGAAGAGCTATTGTGTGATTGATATGCCCGAGCACAACCCTGGCAATTTGGGAGGAACAATGAGACTGGGAATAAGA AGAACTGTTTTCAAAACTGAAAATTCAATATTAAGGAAACTTTATGGTGATGTTCCTTTTATAGAAGAAAGACACAGACATCGGTTCGAG GTAAACCCTAACCTGATCAAACAATTTGAGCAGAATGACTTAAGTTTTGTAGGTCAGGATGTTGATGGAGACAGGATGGAAATCATTGAA CTGGCAAATCATCCTTATTTTGTTGGTGTCCAGTTCCATCCTGAGTTTTCTTCTAGGCCGATGAAGCCTTCCCCTCCGTATCTGGGGCTG TTACTTGCAGCAACTGGGAACCTGAATGCCTACTTGCAACAGGGTTGCAAACTGTCTTCCAGTGATAGATACAGTGATGCCAGTGATGAC AGCTTTTCAGAGCCAAGGATAGCTGAGTTGGAAATAAGCTGAAATGAATACATGACTGGGAATAATGGGGACTGCCTGTGAGGCCTCTGA AATAATTGAAGGCAAGATGAAGGAACTATCTGAAGAAATCACTACACTCTTAGAGAATCCCTCTGTTCTCCAGCAAACATGGGATGTAAA GCCTCACAGGGAATCTGATAATACATACTTCTGTCAACCAGAACCAGAGGGGTAGTTTTCTTTTCCCTCCAGAGGCAGCCTTTGGTACTT AAAATATCTGTAGCTGATTAAATTTTTCCCAACAACCTCACTGGGGAGAAAGTGTGTTCATGTTTTGTCCAGCGGATCAGGATGTTAGGA TGACGAGCAAGAGTCCAGGTCACTGTGCCTTTGCTGTGTTGTATGGAAAGGATGGCAGGGAACATGCTGTAAGTAATTTTGAGTAAGAAA ATGAGTCACTGTGTTACCTGGAACTCAGCCACAGATTTGTGTGTGGTCCAAGATCATTGCAGTTTCTCACCCTGTTTATTTCCTGGTAAA AGTAAAATTGAATAGGTCCAAGACTTGGGGGTGGCAAGTAAGGCTTTGCCTCAGGCACAAAATTTAAGGGGGCTCCAAAAAACTCAGGAA TCAAGATCAGCAATACAGTCTGAGTATCCCTTATGTGAAATGCTTGGGGCTAGAAGTGTTTTGAATTTCAGATTTTGGAATATTTGCATA TACATGCGATATCTTGGGGATGAGACTCAAGACTAAACATGAAATTCATTTATGCTTCATATACACCTTATATACATAGCCTAAAGGTAA TTTGATACAATATTTTAAATAATTTTGTGCATGAAACAAAGTTTCGACTGCATTTTGACTGTGATTTCTGGCATGAGATCAGTTATGGAA TTTTCCACTTCTAGCGTCATGTTGGCATTCAGAAATTTTGAAATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACCTGTATA TATATTTTTTAATCGACGTGAAATTCACGTAACATAGAATTAACCATTTTGAAGTGAACAATTTGGTTGCATTCACTGATGTTGAGCAAC CACCACCTTTAACTATTTCCAAAACATTTTCATCACTCCAAAATAAATGCCTGTACACACTAGCAGTCACTCCCTATCTTCCCCTCCACC TGTCCGCTGGCAACCACTGATCTCCTTTTTATTTCTGTGGCTTTTTCTATTCTGGATATTTCATATAAGTGGAATTACACAATATATGTG GTCTTTTGTGTCTGGCTTCTTCTGAGACAGTAGGAAGGGGGGCTTGGCTTTGGCTCACCCCCACTAGAGCATTTTTTCATGCATTCCCAC TGATCACAAAACCCATACTACTACCTCATTGACACCATACCTGCTAACCTCGAGGCTTTAGTCATACAAAGAAAATGGCCTTTCTGTATT GTTCTTCTGTGCTCTCATAATGCTTAACCATGTCTTTTACTTAAACAATTCCAGGAACTGGCCTTAGGAGATCCAAATAGGGAACCAAGA |
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FusionGenePPI for HPRT1_CTPS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HPRT1 | WDYHV1, PRTFDC1, EIF1B, MCC, HUS1, FANCA, CUL3, CUL5, APRT, FAT3, ANXA6, EIF6, GOT1, PPID, SNCA, MTAP, NME1-NME2, PSAT1, PTGES3, FUS, HPRT1, SDCBP, ISCU, CUL7, PPAT, EWSR1, MCM2, PPA1, NANS, UBE2N, GPI, ANXA5, PA2G4, DLD, DNM1L, HSD17B10 | CTPS2 | CTPS2, SPG21, OTUD5, CTBP2, FGFR1, RPL23A, RPL37A, DHPS, EHD1, EHD4, GTF2I, KTN1, METTL1, NUCB1, PRKDC, WARS, HSF1, LRSAM1, MTMR2, PLIN3, RNF2, COL9A1, SLAMF1, ENPP6, NTRK1, XPO1, NASP, SNX3, ATOH1, TIGD3, CTPS1, SUGP1, MTNR1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HPRT1_CTPS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HPRT1 | P00492 | DB00993 | Azathioprine | Hypoxanthine-guanine phosphoribosyltransferase | small molecule | approved |
| Hgene | HPRT1 | P00492 | DB01033 | Mercaptopurine | Hypoxanthine-guanine phosphoribosyltransferase | small molecule | approved |
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RelatedDiseases for HPRT1_CTPS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HPRT1 | C0268117 | Gout, HPRT-Related | 15 | CTD_human;ORPHANET;UNIPROT |
| Hgene | HPRT1 | C0023374 | Lesch-Nyhan Syndrome | 13 | CTD_human;ORPHANET;UNIPROT |
| Hgene | HPRT1 | C0740394 | Hyperuricemia | 1 | CTD_human |
| Hgene | HPRT1 | C1959897 | Alcohol consumption during pregnancy | 1 | PSYGENET |
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