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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16732

FusionGeneSummary for HP1BP3_PINK1

check button Fusion gene summary
Fusion gene informationFusion gene name: HP1BP3_PINK1
Fusion gene ID: 16732
HgeneTgene
Gene symbol

HP1BP3

PINK1

Gene ID

50809

65018

Gene nameheterochromatin protein 1 binding protein 3PTEN induced putative kinase 1
SynonymsHP1-BP74|HP1BP74BRPK|PARK6
Cytomap

1p36.12

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionheterochromatin protein 1-binding protein 3serine/threonine-protein kinase PINK1, mitochondrialPTEN-induced putative kinase protein 1protein kinase BRPK
Modification date2018051920180523
UniProtAcc

Q5SSJ5

Q9BXM7

Ensembl transtripts involved in fusion geneENST00000312239, ENST00000487117, 
ENST00000375000, ENST00000375003, 
ENST00000321556, ENST00000492302, 
Fusion gene scores* DoF score8 X 6 X 7=3363 X 5 X 2=30
# samples 85
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HP1BP3 [Title/Abstract] AND PINK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHP1BP3

GO:0071456

cellular response to hypoxia

25100860

TgenePINK1

GO:0001934

positive regulation of protein phosphorylation

25244949

TgenePINK1

GO:0002082

regulation of oxidative phosphorylation

20871098

TgenePINK1

GO:0006468

protein phosphorylation

14607334|21177249|25527291

TgenePINK1

GO:0018105

peptidyl-serine phosphorylation

17579517|19880420

TgenePINK1

GO:0031396

regulation of protein ubiquitination

19880420

TgenePINK1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

21177249

TgenePINK1

GO:0035556

intracellular signal transduction

14607334

TgenePINK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19880420

TgenePINK1

GO:0043254

regulation of protein complex assembly

19880420

TgenePINK1

GO:1903202

negative regulation of oxidative stress-induced cell death

16632486

TgenePINK1

GO:1903214

regulation of protein targeting to mitochondrion

25244949

TgenePINK1

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

21177249

TgenePINK1

GO:1903751

negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

17579517

TgenePINK1

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

15087508


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A8DV-01AHP1BP3chr1

21103090

-PINK1chr1

20970983

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000312239ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
5CDS-3UTRENST00000312239ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3CDSENST00000487117ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3UTRENST00000487117ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+
In-frameENST00000375000ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
5CDS-3UTRENST00000375000ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3CDSENST00000375003ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3UTRENST00000375003ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+

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FusionProtFeatures for HP1BP3_PINK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HP1BP3

Q5SSJ5

PINK1

Q9BXM7

Protects against mitochondrial dysfunction duringcellular stress by phosphorylating mitochondrial proteins.Involved in the clearance of damaged mitochondria via selectiveautophagy (mitophagy) by mediating activation and translocation ofPRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105,PubMed:19966284, PubMed:20404107, PubMed:20798600,PubMed:23620051, PubMed:23754282, PubMed:23933751,PubMed:24660806, PubMed:24751536, PubMed:24784582,PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctionaldepolarized mitochondria through the phosphorylation of MFN2(PubMed:23620051). Activates PRKN in 2 steps: (1) by mediatingphosphorylation at 'Ser-65' of PRKN and (2) mediatingphosphorylation of ubiquitin, converting PRKN to its fully-activeform (PubMed:24660806, PubMed:24751536, PubMed:24784582,PubMed:25527291). Required for ubiquinone reduction bymitochondrial complex I by mediating phosphorylation of complex Isubunit NDUFA10 (By similarity). {ECO:0000250|UniProtKB:Q99MQ3,ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508,ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284,ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20798600,ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282,ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806,ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582,ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413454_553116554Compositional biasNote=Lys-rich
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45454_553116134Compositional biasNote=Lys-rich
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19454_553-501402Compositional biasNote=Lys-rich
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413157_232116554DomainH15 1
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413255_330116554DomainH15 2
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413337_413116554DomainH15 3
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45157_232116134DomainH15 1
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45255_330116134DomainH15 2
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45337_413116134DomainH15 3
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19157_232-501402DomainH15 1
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19255_330-501402DomainH15 2
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19337_413-501402DomainH15 3
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413255_259116554MotifPxVxL motif
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45255_259116134MotifPxVxL motif
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19255_259-501402MotifPxVxL motif
TgenePINK1chr1:21103090chr1:20970983ENST00000321556+28156_511258582DomainProtein kinase
TgenePINK1chr1:21103090chr1:20970983ENST00000321556+28162_170258582Nucleotide bindingATP
TgenePINK1chr1:21103090chr1:20970983ENST00000321556+28111_581258582Topological domainCytoplasmic
TgenePINK1chr1:21103090chr1:20970983ENST00000321556+2878_93258582Topological domainMitochondrial intermembrane
TgenePINK1chr1:21103090chr1:20970983ENST00000321556+2894_110258582TransmembraneHelical


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FusionGeneSequence for HP1BP3_PINK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HP1BP3_ENST00000312239_chr1_21103090_-_PINK1_ENST00000321556_chr1_20970983_+_440aa
MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATS
SEAEQPKGEPENEEKEENKSSEETKKEKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYP
CTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGC
LMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARV

>In-frame_HP1BP3_ENST00000375000_chr1_21103090_-_PINK1_ENST00000321556_chr1_20970983_+_323aa
KIQERSQATSPSPQHHPGSPRLHLFRAAAARGPGRLPXCAALTPPPXRPGPWPDAVPRYEELSLYPAPVPLCEHTQPPPRRHDAAAAAGR
RGPSGSTGHRAQRPEIRQHPCGAGPRRLPLAGDRRFWLLPGXXEHRPAVALQQLVRGSGRKRLSDGPRGVHGPSWPQGSDXLQQGXCLGS
GSHRLXNLRACQSLLRPGQGPPXKPQLPRGSATCTARVSASRRETVGEGTAPARGQQETICPSSRKCASSKPLGXTYSSPEESEVRQDGW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HP1BP3_ENST00000312239_chr1_21103090_-_PINK1_ENST00000321556_chr1_20970983_+_1320nt
ATGGCGACTGATACGTCTCAAGGTGAACTCGTCCATCCTAAGGCACTCCCACTTATAGTAGGAGCTCAGCTGATCCACGCGGACAAGTTA
GGTGAGAAGGTAGAAGATAGCACCATGCCGATTCGTCGAACTGTGAATTCTACCCGGGAAACTCCTCCCAAAAGCAAGCTTGCTGAAGGG
GAGGAAGAAAAGCCAGAACCAGACATAAGTTCAGAGGAATCTGTCTCCACTGTAGAAGAACAAGAGAATGAAACTCCACCTGCTACTTCG
AGTGAGGCAGAGCAGCCAAAGGGGGAACCTGAGAATGAAGAGAAGGAAGAAAATAAGTCTTCTGAGGAAACCAAAAAGGAAAAATCCAAG
AGAGGTCCCAAGCAACTAGCCCCTCACCCCAACATCATCCGGGTTCTCCGCGCCTTCACCTCTTCCGTGCCGCTGCTGCCAGGGGCCCTG
GTCGACTACCCTGATGTGCTGCCCTCACGCCTCCACCCTGAAGGCCTGGGCCATGGCCGGACGCTGTTCCTCGTTATGAAGAACTATCCC
TGTACCCTGCGCCAGTACCTTTGTGTGAACACACCCAGCCCCCGCCTCGCCGCCATGATGCTGCTGCAGCTGCTGGAAGGCGTGGACCAT
CTGGTTCAACAGGGCATCGCGCACAGAGACCTGAAATCCGACAACATCCTTGTGGAGCTGGACCCAGACGGCTGCCCCTGGCTGGTGATC
GCAGATTTTGGCTGCTGCCTGGCTGATGAGAGCATCGGCCTGCAGTTGCCCTTCAGCAGCTGGTACGTGGATCGGGGCGGAAACGGCTGT
CTGATGGCCCCAGAGGTGTCCACGGCCCGTCCTGGCCCCAGGGCAGTGATTGACTACAGCAAGGCTGATGCCTGGGCAGTGGGAGCCATC
GCCTATGAAATCTTCGGGCTTGTCAATCCCTTCTACGGCCAGGGCAAGGCCCACCTTGAAAGCCGCAGCTACCAAGAGGCTCAGCTACCT
GCACTGCCCGAGTCAGTGCCTCCAGACGTGAGACAGTTGGTGAGGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATCTGCCCGAGTA
GCCGCAAATGTGCTTCATCTAAGCCTCTGGGGTGAACATATTCTAGCCCTGAAGAATCTGAAGTTAGACAAGATGGTTGGCTGGCTCCTC
CAACAATCGGCCGCCACTTTGTTGGCCAACAGGCTCACAGAGAAGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCTGGCTAACCTG

>In-frame_HP1BP3_ENST00000375000_chr1_21103090_-_PINK1_ENST00000321556_chr1_20970983_+_970nt
AAAATCCAAGAGAGGTCCCAAGCAACTAGCCCCTCACCCCAACATCATCCGGGTTCTCCGCGCCTTCACCTCTTCCGTGCCGCTGCTGCC
AGGGGCCCTGGTCGACTACCCTGATGTGCTGCCCTCACGCCTCCACCCTGAAGGCCTGGGCCATGGCCGGACGCTGTTCCTCGTTATGAA
GAACTATCCCTGTACCCTGCGCCAGTACCTTTGTGTGAACACACCCAGCCCCCGCCTCGCCGCCATGATGCTGCTGCAGCTGCTGGAAGG
CGTGGACCATCTGGTTCAACAGGGCATCGCGCACAGAGACCTGAAATCCGACAACATCCTTGTGGAGCTGGACCCAGACGGCTGCCCCTG
GCTGGTGATCGCAGATTTTGGCTGCTGCCTGGCTGATGAGAGCATCGGCCTGCAGTTGCCCTTCAGCAGCTGGTACGTGGATCGGGGCGG
AAACGGCTGTCTGATGGCCCCAGAGGTGTCCACGGCCCGTCCTGGCCCCAGGGCAGTGATTGACTACAGCAAGGCTGATGCCTGGGCAGT
GGGAGCCATCGCCTATGAAATCTTCGGGCTTGTCAATCCCTTCTACGGCCAGGGCAAGGCCCACCTTGAAAGCCGCAGCTACCAAGAGGC
TCAGCTACCTGCACTGCCCGAGTCAGTGCCTCCAGACGTGAGACAGTTGGTGAGGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATC
TGCCCGAGTAGCCGCAAATGTGCTTCATCTAAGCCTCTGGGGTGAACATATTCTAGCCCTGAAGAATCTGAAGTTAGACAAGATGGTTGG
CTGGCTCCTCCAACAATCGGCCGCCACTTTGTTGGCCAACAGGCTCACAGAGAAGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_HP1BP3_ENST00000312239_chr1_21103090_-_PINK1_ENST00000321556_chr1_20970983_+_2280nt
GTTCTCCGCCCCCGCCGCCGCCATTACGGAGCTCCCAGTGGTTGATTCTTCACCACACTGAAACCATTAGGAAAAATCCTTGTGGTTAAC
AGCAGAGGCTTCAGAGTGTAACCTGTACTCGGGCCTAGAAATTATTTAAAATGGCGACTGATACGTCTCAAGGTGAACTCGTCCATCCTA
AGGCACTCCCACTTATAGTAGGAGCTCAGCTGATCCACGCGGACAAGTTAGGTGAGAAGGTAGAAGATAGCACCATGCCGATTCGTCGAA
CTGTGAATTCTACCCGGGAAACTCCTCCCAAAAGCAAGCTTGCTGAAGGGGAGGAAGAAAAGCCAGAACCAGACATAAGTTCAGAGGAAT
CTGTCTCCACTGTAGAAGAACAAGAGAATGAAACTCCACCTGCTACTTCGAGTGAGGCAGAGCAGCCAAAGGGGGAACCTGAGAATGAAG
AGAAGGAAGAAAATAAGTCTTCTGAGGAAACCAAAAAGGAAAAATCCAAGAGAGGTCCCAAGCAACTAGCCCCTCACCCCAACATCATCC
GGGTTCTCCGCGCCTTCACCTCTTCCGTGCCGCTGCTGCCAGGGGCCCTGGTCGACTACCCTGATGTGCTGCCCTCACGCCTCCACCCTG
AAGGCCTGGGCCATGGCCGGACGCTGTTCCTCGTTATGAAGAACTATCCCTGTACCCTGCGCCAGTACCTTTGTGTGAACACACCCAGCC
CCCGCCTCGCCGCCATGATGCTGCTGCAGCTGCTGGAAGGCGTGGACCATCTGGTTCAACAGGGCATCGCGCACAGAGACCTGAAATCCG
ACAACATCCTTGTGGAGCTGGACCCAGACGGCTGCCCCTGGCTGGTGATCGCAGATTTTGGCTGCTGCCTGGCTGATGAGAGCATCGGCC
TGCAGTTGCCCTTCAGCAGCTGGTACGTGGATCGGGGCGGAAACGGCTGTCTGATGGCCCCAGAGGTGTCCACGGCCCGTCCTGGCCCCA
GGGCAGTGATTGACTACAGCAAGGCTGATGCCTGGGCAGTGGGAGCCATCGCCTATGAAATCTTCGGGCTTGTCAATCCCTTCTACGGCC
AGGGCAAGGCCCACCTTGAAAGCCGCAGCTACCAAGAGGCTCAGCTACCTGCACTGCCCGAGTCAGTGCCTCCAGACGTGAGACAGTTGG
TGAGGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATCTGCCCGAGTAGCCGCAAATGTGCTTCATCTAAGCCTCTGGGGTGAACATA
TTCTAGCCCTGAAGAATCTGAAGTTAGACAAGATGGTTGGCTGGCTCCTCCAACAATCGGCCGCCACTTTGTTGGCCAACAGGCTCACAG
AGAAGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCTGGCTAACCTGGAGTGTGAAACGCTCTGCCAGGCAGCCCTCCTCCTCTGCT
CATGGAGGGCAGCCCTGTGATGTCCCTGCATGGAGCTGGTGAATTACTAAAAGAACATGGCATCCTCTGTGTCGTGATGGTCTGTGAATG
GTGAGGGTGGGAGTCAGGAGACAAGACAGCGCAGAGAGGGCTGGTTAGCCGGAAAAGGCCTCGGGCTTGGCAAATGGAAGAACTTGAGTG
AGAGTTCAGTCTGCAGTCCTCTGCTCACAGACATCTGAAAAGTGAATGGCCAAGCTGGTCTAGTAGATGAGGCTGGACTGAGGAGGGGTA
GGCCTGCATCCACAGAGAGGATCCAGGCCAAGGCACTGGCTGTCAGTGGCAGAGTTTGGCTGTGACCTTTGCCCCTAACACGAGGAACTC
GTTTGAAGGGGGCAGCGTAGCATGTCTGATTTGCCACCTGGATGAAGGCAGACATCAACATGGGTCAGCACGTTCAGTTACGGGAGTGGG
AAATTACATGAGGCCTGGGCCTCTGCGTTCCCAAGCTGTGCGTTCTGGACCAGCTACTGAATTATTAATCTCACTTAGCGAAAGTGACGG
ATGAGCAGTAAGTAAGTAAGTGTGGGGATTTAAACTTGAGGGTTTCCCTCCTGACTAGCCTCTCTTACAGGAATTGTGAAATATTAAATG
CAAATTTACAACTGCAGATGACGTATGTGCCTTGAACTGAATATTTGGCTTTAAGAATGATTCTTATACTCTGAAGGTGAGAATATTTTG
TGGGCAGGTATCAACATTGGGGAAGAGATTTCATGTCTAACTAACTAACTTTATACATGATTTTTAGGAAGCTATTGCCTAAATCAGCGT

>In-frame_HP1BP3_ENST00000375000_chr1_21103090_-_PINK1_ENST00000321556_chr1_20970983_+_2367nt
GCGGAGCGCCGAGGCTCGCGTTCCGCCGCTGCTTCCGTCGCCGGGGCGGGCGCCGCGGTGTCCCTGCCGAGCGTGAGCCCCGAACTGTCA
CCGCGCCGAGCCCCAGCCTCATCCGTCGGTGTCCGCGGTTGATTCTTCACCACACTGAAACCATTAGGAAAAATCCTTGTGGTTAACAGC
AGAGGCTTCAGAGTGTAACCTGTACTCGGGCCTAGAAATTATTTAAAATGGCGACTGATACGTCTCAAGGTGAACTCGTCCATCCTAAGG
CACTCCCACTTATAGTAGGAGCTCAGCTGATCCACGCGGACAAGTTAGGTGAGAAGGTAGAAGATAGCACCATGCCGATTCGTCGAACTG
TGAATTCTACCCGGGAAACTCCTCCCAAAAGCAAGCTTGCTGAAGGGGAGGAAGAAAAGCCAGAACCAGACATAAGTTCAGAGGAATCTG
TCTCCACTGTAGAAGAACAAGAGAATGAAACTCCACCTGCTACTTCGAGTGAGGCAGAGCAGCCAAAGGGGGAACCTGAGAATGAAGAGA
AGGAAGAAAATAAGTCTTCTGAGGAAACCAAAAAGGAAAAATCCAAGAGAGGTCCCAAGCAACTAGCCCCTCACCCCAACATCATCCGGG
TTCTCCGCGCCTTCACCTCTTCCGTGCCGCTGCTGCCAGGGGCCCTGGTCGACTACCCTGATGTGCTGCCCTCACGCCTCCACCCTGAAG
GCCTGGGCCATGGCCGGACGCTGTTCCTCGTTATGAAGAACTATCCCTGTACCCTGCGCCAGTACCTTTGTGTGAACACACCCAGCCCCC
GCCTCGCCGCCATGATGCTGCTGCAGCTGCTGGAAGGCGTGGACCATCTGGTTCAACAGGGCATCGCGCACAGAGACCTGAAATCCGACA
ACATCCTTGTGGAGCTGGACCCAGACGGCTGCCCCTGGCTGGTGATCGCAGATTTTGGCTGCTGCCTGGCTGATGAGAGCATCGGCCTGC
AGTTGCCCTTCAGCAGCTGGTACGTGGATCGGGGCGGAAACGGCTGTCTGATGGCCCCAGAGGTGTCCACGGCCCGTCCTGGCCCCAGGG
CAGTGATTGACTACAGCAAGGCTGATGCCTGGGCAGTGGGAGCCATCGCCTATGAAATCTTCGGGCTTGTCAATCCCTTCTACGGCCAGG
GCAAGGCCCACCTTGAAAGCCGCAGCTACCAAGAGGCTCAGCTACCTGCACTGCCCGAGTCAGTGCCTCCAGACGTGAGACAGTTGGTGA
GGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATCTGCCCGAGTAGCCGCAAATGTGCTTCATCTAAGCCTCTGGGGTGAACATATTC
TAGCCCTGAAGAATCTGAAGTTAGACAAGATGGTTGGCTGGCTCCTCCAACAATCGGCCGCCACTTTGTTGGCCAACAGGCTCACAGAGA
AGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCTGGCTAACCTGGAGTGTGAAACGCTCTGCCAGGCAGCCCTCCTCCTCTGCTCAT
GGAGGGCAGCCCTGTGATGTCCCTGCATGGAGCTGGTGAATTACTAAAAGAACATGGCATCCTCTGTGTCGTGATGGTCTGTGAATGGTG
AGGGTGGGAGTCAGGAGACAAGACAGCGCAGAGAGGGCTGGTTAGCCGGAAAAGGCCTCGGGCTTGGCAAATGGAAGAACTTGAGTGAGA
GTTCAGTCTGCAGTCCTCTGCTCACAGACATCTGAAAAGTGAATGGCCAAGCTGGTCTAGTAGATGAGGCTGGACTGAGGAGGGGTAGGC
CTGCATCCACAGAGAGGATCCAGGCCAAGGCACTGGCTGTCAGTGGCAGAGTTTGGCTGTGACCTTTGCCCCTAACACGAGGAACTCGTT
TGAAGGGGGCAGCGTAGCATGTCTGATTTGCCACCTGGATGAAGGCAGACATCAACATGGGTCAGCACGTTCAGTTACGGGAGTGGGAAA
TTACATGAGGCCTGGGCCTCTGCGTTCCCAAGCTGTGCGTTCTGGACCAGCTACTGAATTATTAATCTCACTTAGCGAAAGTGACGGATG
AGCAGTAAGTAAGTAAGTGTGGGGATTTAAACTTGAGGGTTTCCCTCCTGACTAGCCTCTCTTACAGGAATTGTGAAATATTAAATGCAA
ATTTACAACTGCAGATGACGTATGTGCCTTGAACTGAATATTTGGCTTTAAGAATGATTCTTATACTCTGAAGGTGAGAATATTTTGTGG
GCAGGTATCAACATTGGGGAAGAGATTTCATGTCTAACTAACTAACTTTATACATGATTTTTAGGAAGCTATTGCCTAAATCAGCGTCAA


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FusionGenePPI for HP1BP3_PINK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HP1BP3HDGF, SIRT7, CUL3, CUL5, CUL1, CAND1, APP, LMNB1, PCDHA2, NOP16, TMPO, LAMP2, RPS24, SON, ZNF326, KRT3, RSL1D1, RRP7A, UTP14A, SURF4, RPL5, NFIA, NXF1, FTSJ3, TPBG, TRA2A, IMMT, NOP2, RPS14, SRSF7, VTN, ZC3H18, RBM14, BARD1, PAXIP1, HSP90AA1, ITGA4, LMNA, FBXO25, RIOK2, LIN28A, TARBP2, ZNF346, CEP250, MEOX2, SHMT2, CUL7, OBSL1, SUZ12, EED, RNF2, BMI1, SUMO2, HIST1H1A, RPL14, NPM1, RPS8, PRR11, NTRK1, SCARNA22, IFI16, XPO1, HNRNPU, RPL10, NIPSNAP1, HMG20A, C17orf85, IPO7, DDI2, NUSAP1, ZC3HAV1, RPL30, IPO8, SART3, KPNB1, WDR46, DLST, PDHA1, VDAC1, TRIM25, BRCA1PINK1PARK2, PTEN, PINK1, MAP1B, PRKDC, IRS4, KIF11, PSMD1, PSMD2, HSP90AA1, HSPA4, TUBA1A, TUBB, CDC37, PSMC6, PGAM5, PARL, SNCAIP, MAP1LC3A, HSP90AB1, SNCA, MARK2, PARK7, RHOT1, HTRA2, TOMM20, TOMM40, TOMM70A, TOMM22, RICTOR, MAPKAP1, AKT1, UBE2M, COPS8, TRAF6, MAP3K7, TOLLIP, IRAK1, VIM, SARM1, HSPA1A, HSPA1B, RB1CC1, FBXO7, BAG2, CRLS1, UBC, BCL2L1, BCL2L2, MCL1, RHOT2, IMMT, NAE1, TGM2, KRAS, HSH2D, SOCS4, APPL2, STAT3, HSD17B10, DNM1L, BAG5, BNIP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HP1BP3_PINK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHP1BP3Q5SSJ5DB11638ArtenimolHeterochromatin protein 1-binding protein 3small moleculeapproved|investigational

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RelatedDiseases for HP1BP3_PINK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHP1BP3C0221074Depression, Postpartum1PSYGENET
TgenePINK1C1853833Parkinson Disease 6, Autosomal Recessive Early-Onset17CTD_human;UNIPROT
TgenePINK1C0030567Parkinson Disease5CTD_human
TgenePINK1C0242422Parkinsonian Disorders4CTD_human
TgenePINK1C0036341Schizophrenia3PSYGENET
TgenePINK1C0027746Nerve Degeneration1CTD_human
TgenePINK1C0027819Neuroblastoma1CTD_human
TgenePINK1C0041696Unipolar Depression1PSYGENET
TgenePINK1C1269683Major Depressive Disorder1PSYGENET