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Fusion gene ID: 16713 |
FusionGeneSummary for HOXC10_WIBG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HOXC10_WIBG | Fusion gene ID: 16713 | Hgene | Tgene | Gene symbol | HOXC10 | WIBG | Gene ID | 3226 | 84305 |
| Gene name | homeobox C10 | PYM homolog 1, exon junction complex associated factor | |
| Synonyms | HOX3I | PYM|WIBG | |
| Cytomap | 12q13.13 | 12q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeobox protein Hox-C10homeo box C10homeobox protein Hox-3Ihomeoprotein C10 | partner of Y14 and magoprotein wibg homologwithin bgcn homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NYD6 | ||
| Ensembl transtripts involved in fusion gene | ENST00000303460, ENST00000511575, | ENST00000408946, ENST00000398213, ENST00000302533, ENST00000557259, ENST00000547925, ENST00000454792, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 1 X 2=6 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/6*10)=1.73696559416621 | |
| Context | PubMed: HOXC10 [Title/Abstract] AND WIBG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HOXC10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10835276 |
| Tgene | WIBG | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 19410547 |
| Tgene | WIBG | GO:0045727 | positive regulation of translation | 18026120 |
| Tgene | WIBG | GO:1903259 | exon-exon junction complex disassembly | 19410547 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-19-2624-01A | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000303460 | ENST00000408946 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| In-frame | ENST00000303460 | ENST00000398213 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| 5CDS-5UTR | ENST00000303460 | ENST00000302533 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| 5CDS-5UTR | ENST00000303460 | ENST00000557259 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| 5CDS-5UTR | ENST00000303460 | ENST00000547925 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| 5CDS-intron | ENST00000303460 | ENST00000454792 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| intron-3CDS | ENST00000511575 | ENST00000408946 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| intron-3CDS | ENST00000511575 | ENST00000398213 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| intron-5UTR | ENST00000511575 | ENST00000302533 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| intron-5UTR | ENST00000511575 | ENST00000557259 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| intron-5UTR | ENST00000511575 | ENST00000547925 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
| intron-intron | ENST00000511575 | ENST00000454792 | HOXC10 | chr12 | 54379794 | + | WIBG | chr12 | 56297264 | - |
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FusionProtFeatures for HOXC10_WIBG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HOXC10 | WIBG |
| Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >WIBG | chr12:54379794 | chr12:56297264 | ENST00000398213 | - | 0 | 3 | 145_204 | 11 | 204 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >WIBG | chr12:54379794 | chr12:56297264 | ENST00000398213 | - | 0 | 3 | 82_116 | 11 | 204 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >WIBG | chr12:54379794 | chr12:56297264 | ENST00000408946 | - | 0 | 3 | 145_204 | 12 | 205 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >WIBG | chr12:54379794 | chr12:56297264 | ENST00000408946 | - | 0 | 3 | 82_116 | 12 | 205 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >WIBG | chr12:54379794 | chr12:56297264 | ENST00000398213 | - | 0 | 3 | 152_204 | 11 | 204 | Region | Note=eIF2A-like |
| Tgene | >WIBG | chr12:54379794 | chr12:56297264 | ENST00000408946 | - | 0 | 3 | 152_204 | 12 | 205 | Region | Note=eIF2A-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HOXC10 | chr12:54379794 | chr12:56297264 | ENST00000303460 | + | 1 | 2 | 268_327 | 250 | 343 | DNA binding | Homeobox |
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FusionGeneSequence for HOXC10_WIBG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HOXC10_ENST00000303460_chr12_54379794_+_WIBG_ENST00000408946_chr12_56297264_-_443aa MTCPRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGSSPSLALNTYPSYLSQLDSWGDPKAAYRLEQ PVGRPLSSCSYPPSVKEENVCCMYSAEKRAKSGPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQRASL NPRAEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEKERAKAADSSPDTSDNEAKGKYIASTQRPDGTWRKQRRV KEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATAPVTPSRPEGGEPGLSKTAKRNLKRKEKRRQQQEKGEAEALSRTLDKVSLEETA >In-frame_HOXC10_ENST00000303460_chr12_54379794_+_WIBG_ENST00000398213_chr12_56297264_-_443aa MTCPRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGSSPSLALNTYPSYLSQLDSWGDPKAAYRLEQ PVGRPLSSCSYPPSVKEENVCCMYSAEKRAKSGPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQRASL NPRAEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEKERAKAADSSPDTSDNEAKGKYIASTQRPDGTWRKQRRV KEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATAPVTPSRPEGGEPGLSKTAKRNLKRKEKRRQQQEKGEAEALSRTLDKVSLEETA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HOXC10_ENST00000303460_chr12_54379794_+_WIBG_ENST00000408946_chr12_56297264_-_1329nt ATGACATGCCCTCGCAATGTAACTCCGAACTCGTACGCGGAGCCCTTGGCTGCGCCCGGCGGAGGAGAGCGCTATAGCCGGAGCGCAGGC ATGTATATGCAGTCTGGGAGTGACTTCAATTGCGGGGTGATGAGGGGCTGCGGGCTCGCGCCCTCGCTCTCCAAGAGGGACGAGGGCAGC AGCCCCAGCCTCGCCCTCAACACCTATCCGTCCTACCTCTCGCAGCTGGACTCCTGGGGCGACCCCAAAGCCGCCTATCGCCTGGAACAA CCTGTTGGCAGGCCGCTGTCCTCCTGCTCCTACCCACCTAGTGTCAAGGAGGAGAATGTCTGCTGCATGTACAGCGCAGAGAAGCGGGCG AAAAGTGGCCCCGAGGCAGCTCTCTACTCCCACCCCTTGCCGGAGTCCTGCCTTGGGGAGCACGAGGTACCCGTGCCCAGCTACTACCGC GCCAGCCCGAGCTACTCCGCGCTGGACAAGACGCCCCACTGTTCTGGGGCCAACGACTTCGAAGCCCCTTTCGAGCAGCGGGCCAGTCTC AACCCGCGCGCCGAACATCTGGAATCGCCTCAGCTGGGGGGCAAAGTGAGTTTCCCTGAGACCCCCAAGTCCGACAGCCAGACCCCCAGC CCCAATGAAATCAAGACGGAGCAGAGCCTGGCGGGCCCTAAAGGGAGCCCCTCGGAGAGCGAAAAGGAGAGGGCCAAAGCTGCCGACTCC AGCCCAGACACCTCGGATAACGAAGCGAAAGGCAAGTATATCGCGTCAACACAGCGACCTGACGGGACCTGGCGCAAGCAGCGGAGGGTG AAAGAAGGATATGTGCCCCAGGAGGAGGTCCCAGTATATGAAAACAAGTATGTGAAGTTTTTCAAGAGTAAACCAGAGTTGCCCCCAGGG CTAAGCCCTGAGGCCACTGCTCCTGTCACCCCATCCAGGCCTGAAGGTGGTGAACCAGGCCTCTCCAAGACAGCCAAACGTAACCTGAAG CGAAAGGAGAAGAGGCGGCAGCAGCAAGAGAAAGGAGAGGCAGAGGCCTTGAGCAGGACTCTTGATAAGGTGTCCCTGGAAGAGACAGCC CAACTCCCCAGTGCTCCACAGGGCTCTCGGGCAGCCCCCACAGCTGCATCTGACCAGCCTGACTCAGCTGCCACCACTGAGAAAGCCAAG AAGATAAAGAACCTAAAGAAGAAACTCCGGCAGGTGGAAGAGCTGCAGCAGCGGATCCAGGCTGGGGAAGTCAGCCAGCCTAGCAAAGAG >In-frame_HOXC10_ENST00000303460_chr12_54379794_+_WIBG_ENST00000398213_chr12_56297264_-_1329nt ATGACATGCCCTCGCAATGTAACTCCGAACTCGTACGCGGAGCCCTTGGCTGCGCCCGGCGGAGGAGAGCGCTATAGCCGGAGCGCAGGC ATGTATATGCAGTCTGGGAGTGACTTCAATTGCGGGGTGATGAGGGGCTGCGGGCTCGCGCCCTCGCTCTCCAAGAGGGACGAGGGCAGC AGCCCCAGCCTCGCCCTCAACACCTATCCGTCCTACCTCTCGCAGCTGGACTCCTGGGGCGACCCCAAAGCCGCCTATCGCCTGGAACAA CCTGTTGGCAGGCCGCTGTCCTCCTGCTCCTACCCACCTAGTGTCAAGGAGGAGAATGTCTGCTGCATGTACAGCGCAGAGAAGCGGGCG AAAAGTGGCCCCGAGGCAGCTCTCTACTCCCACCCCTTGCCGGAGTCCTGCCTTGGGGAGCACGAGGTACCCGTGCCCAGCTACTACCGC GCCAGCCCGAGCTACTCCGCGCTGGACAAGACGCCCCACTGTTCTGGGGCCAACGACTTCGAAGCCCCTTTCGAGCAGCGGGCCAGTCTC AACCCGCGCGCCGAACATCTGGAATCGCCTCAGCTGGGGGGCAAAGTGAGTTTCCCTGAGACCCCCAAGTCCGACAGCCAGACCCCCAGC CCCAATGAAATCAAGACGGAGCAGAGCCTGGCGGGCCCTAAAGGGAGCCCCTCGGAGAGCGAAAAGGAGAGGGCCAAAGCTGCCGACTCC AGCCCAGACACCTCGGATAACGAAGCGAAAGGCAAGTATATCGCGTCAACACAGCGACCTGACGGGACCTGGCGCAAGCAGCGGAGGGTG AAAGAAGGATATGTGCCCCAGGAGGAGGTCCCAGTATATGAAAACAAGTATGTGAAGTTTTTCAAGAGTAAACCAGAGTTGCCCCCAGGG CTAAGCCCTGAGGCCACTGCTCCTGTCACCCCATCCAGGCCTGAAGGTGGTGAACCAGGCCTCTCCAAGACAGCCAAACGTAACCTGAAG CGAAAGGAGAAGAGGCGGCAGCAGCAAGAGAAAGGAGAGGCAGAGGCCTTGAGCAGGACTCTTGATAAGGTGTCCCTGGAAGAGACAGCC CAACTCCCCAGTGCTCCACAGGGCTCTCGGGCAGCCCCCACAGCTGCATCTGACCAGCCTGACTCAGCTGCCACCACTGAGAAAGCCAAG AAGATAAAGAACCTAAAGAAGAAACTCCGGCAGGTGGAAGAGCTGCAGCAGCGGATCCAGGCTGGGGAAGTCAGCCAGCCTAGCAAAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HOXC10_ENST00000303460_chr12_54379794_+_WIBG_ENST00000408946_chr12_56297264_-_1862nt TCCCGGATGGGGAAAAAAAAAGATGTCAGCTCCTCCGCTGTAGTATTGCTCCTTAAAAACCCCTCTCTCTGAAAATGACATGCCCTCGCA ATGTAACTCCGAACTCGTACGCGGAGCCCTTGGCTGCGCCCGGCGGAGGAGAGCGCTATAGCCGGAGCGCAGGCATGTATATGCAGTCTG GGAGTGACTTCAATTGCGGGGTGATGAGGGGCTGCGGGCTCGCGCCCTCGCTCTCCAAGAGGGACGAGGGCAGCAGCCCCAGCCTCGCCC TCAACACCTATCCGTCCTACCTCTCGCAGCTGGACTCCTGGGGCGACCCCAAAGCCGCCTATCGCCTGGAACAACCTGTTGGCAGGCCGC TGTCCTCCTGCTCCTACCCACCTAGTGTCAAGGAGGAGAATGTCTGCTGCATGTACAGCGCAGAGAAGCGGGCGAAAAGTGGCCCCGAGG CAGCTCTCTACTCCCACCCCTTGCCGGAGTCCTGCCTTGGGGAGCACGAGGTACCCGTGCCCAGCTACTACCGCGCCAGCCCGAGCTACT CCGCGCTGGACAAGACGCCCCACTGTTCTGGGGCCAACGACTTCGAAGCCCCTTTCGAGCAGCGGGCCAGTCTCAACCCGCGCGCCGAAC ATCTGGAATCGCCTCAGCTGGGGGGCAAAGTGAGTTTCCCTGAGACCCCCAAGTCCGACAGCCAGACCCCCAGCCCCAATGAAATCAAGA CGGAGCAGAGCCTGGCGGGCCCTAAAGGGAGCCCCTCGGAGAGCGAAAAGGAGAGGGCCAAAGCTGCCGACTCCAGCCCAGACACCTCGG ATAACGAAGCGAAAGGCAAGTATATCGCGTCAACACAGCGACCTGACGGGACCTGGCGCAAGCAGCGGAGGGTGAAAGAAGGATATGTGC CCCAGGAGGAGGTCCCAGTATATGAAAACAAGTATGTGAAGTTTTTCAAGAGTAAACCAGAGTTGCCCCCAGGGCTAAGCCCTGAGGCCA CTGCTCCTGTCACCCCATCCAGGCCTGAAGGTGGTGAACCAGGCCTCTCCAAGACAGCCAAACGTAACCTGAAGCGAAAGGAGAAGAGGC GGCAGCAGCAAGAGAAAGGAGAGGCAGAGGCCTTGAGCAGGACTCTTGATAAGGTGTCCCTGGAAGAGACAGCCCAACTCCCCAGTGCTC CACAGGGCTCTCGGGCAGCCCCCACAGCTGCATCTGACCAGCCTGACTCAGCTGCCACCACTGAGAAAGCCAAGAAGATAAAGAACCTAA AGAAGAAACTCCGGCAGGTGGAAGAGCTGCAGCAGCGGATCCAGGCTGGGGAAGTCAGCCAGCCTAGCAAAGAGCAGCTAGAAAAGCTAG CAAGGAGGAGGGCGCTAGAAGAGGAGTTAGAGGACTTGGAGTTAGGCCTCTGAGGCCTTTGGGGAATAGGGAATGGACTGCAGAACAAAC CGTGGGGCTCTCTGGGGTCTGGGGGAATACGGGCAACAGCAGTCAGGAGGGGTACCCCCCATACTGGCTTACTTCCACCTCCTGCGGCCC AGCTCTGTCCTCCAGAGCCTAGCGTCTCCCTCAATCCTTCCCTTTTCTTCCCAACTTCTACTTTTTGGACTTTCCCCCTCCCATTCCCAG TGTTCAAAATCTCAGTGACTACCCCAGGTACCTTTGCTGCTGATTTGGGTGTCTTGTTTAAAAGAAAATCAGGTGGGTGGGAATCTCTTG GAGAACTGAGGCTGAGGGTAGAGGGAGTATGCCCAAGTCTTGGAGTCTTGGTTCCTGTTCGCGGTGTTTATGGGTTATTTCCCTCTCCAT >In-frame_HOXC10_ENST00000303460_chr12_54379794_+_WIBG_ENST00000398213_chr12_56297264_-_1861nt TCCCGGATGGGGAAAAAAAAAGATGTCAGCTCCTCCGCTGTAGTATTGCTCCTTAAAAACCCCTCTCTCTGAAAATGACATGCCCTCGCA ATGTAACTCCGAACTCGTACGCGGAGCCCTTGGCTGCGCCCGGCGGAGGAGAGCGCTATAGCCGGAGCGCAGGCATGTATATGCAGTCTG GGAGTGACTTCAATTGCGGGGTGATGAGGGGCTGCGGGCTCGCGCCCTCGCTCTCCAAGAGGGACGAGGGCAGCAGCCCCAGCCTCGCCC TCAACACCTATCCGTCCTACCTCTCGCAGCTGGACTCCTGGGGCGACCCCAAAGCCGCCTATCGCCTGGAACAACCTGTTGGCAGGCCGC TGTCCTCCTGCTCCTACCCACCTAGTGTCAAGGAGGAGAATGTCTGCTGCATGTACAGCGCAGAGAAGCGGGCGAAAAGTGGCCCCGAGG CAGCTCTCTACTCCCACCCCTTGCCGGAGTCCTGCCTTGGGGAGCACGAGGTACCCGTGCCCAGCTACTACCGCGCCAGCCCGAGCTACT CCGCGCTGGACAAGACGCCCCACTGTTCTGGGGCCAACGACTTCGAAGCCCCTTTCGAGCAGCGGGCCAGTCTCAACCCGCGCGCCGAAC ATCTGGAATCGCCTCAGCTGGGGGGCAAAGTGAGTTTCCCTGAGACCCCCAAGTCCGACAGCCAGACCCCCAGCCCCAATGAAATCAAGA CGGAGCAGAGCCTGGCGGGCCCTAAAGGGAGCCCCTCGGAGAGCGAAAAGGAGAGGGCCAAAGCTGCCGACTCCAGCCCAGACACCTCGG ATAACGAAGCGAAAGGCAAGTATATCGCGTCAACACAGCGACCTGACGGGACCTGGCGCAAGCAGCGGAGGGTGAAAGAAGGATATGTGC CCCAGGAGGAGGTCCCAGTATATGAAAACAAGTATGTGAAGTTTTTCAAGAGTAAACCAGAGTTGCCCCCAGGGCTAAGCCCTGAGGCCA CTGCTCCTGTCACCCCATCCAGGCCTGAAGGTGGTGAACCAGGCCTCTCCAAGACAGCCAAACGTAACCTGAAGCGAAAGGAGAAGAGGC GGCAGCAGCAAGAGAAAGGAGAGGCAGAGGCCTTGAGCAGGACTCTTGATAAGGTGTCCCTGGAAGAGACAGCCCAACTCCCCAGTGCTC CACAGGGCTCTCGGGCAGCCCCCACAGCTGCATCTGACCAGCCTGACTCAGCTGCCACCACTGAGAAAGCCAAGAAGATAAAGAACCTAA AGAAGAAACTCCGGCAGGTGGAAGAGCTGCAGCAGCGGATCCAGGCTGGGGAAGTCAGCCAGCCTAGCAAAGAGCAGCTAGAAAAGCTAG CAAGGAGGAGGGCGCTAGAAGAGGAGTTAGAGGACTTGGAGTTAGGCCTCTGAGGCCTTTGGGGAATAGGGAATGGACTGCAGAACAAAC CGTGGGGCTCTCTGGGGTCTGGGGGAATACGGGCAACAGCAGTCAGGAGGGGTACCCCCCATACTGGCTTACTTCCACCTCCTGCGGCCC AGCTCTGTCCTCCAGAGCCTAGCGTCTCCCTCAATCCTTCCCTTTTCTTCCCAACTTCTACTTTTTGGACTTTCCCCCTCCCATTCCCAG TGTTCAAAATCTCAGTGACTACCCCAGGTACCTTTGCTGCTGATTTGGGTGTCTTGTTTAAAAGAAAATCAGGTGGGTGGGAATCTCTTG GAGAACTGAGGCTGAGGGTAGAGGGAGTATGCCCAAGTCTTGGAGTCTTGGTTCCTGTTCGCGGTGTTTATGGGTTATTTCCCTCTCCAT |
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FusionGenePPI for HOXC10_WIBG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HOXC10 | CWC27, YWHAG, NUP205, EGFR, NXF1, ESR1, SNX15, TRMU, MAPK14, MAPK9, TRIM25 | WIBG | NEDD4L, NEDD4, ISG15, POT1, PRNP, APP, UPF3B, ACIN1, DEK, RNPS1, SRRM2, TOE1, DDX39B, VRK1, MAGOH, TARDBP, FAU, PNO1, RPS14, RPS15A, RPS16, RPS25, RPS3A, RPS3, RPS6, RPS8, RPS9, TSR1, BYSL, KCMF1, RPS10, RPS12, RPS13, RPS18, RPS19, RPS2, RPS20, RPS23, RPS24, RPS26, RPS27, RPS27L, RPS28, RPS29, RPS4X, RPS5, RPS7, UBQLN1, ZNF503, RTN4IP1, MOV10, NXF1, MAST3, SRPK1, NELFE, DNTTIP1, EIF2S3, RBM8A, XPO1, AKAP1, EMC2, MAGOHB, NELFA, MAD2L1BP, CASC3, CDKN2C, DCAF5, MAD2L1, FGB, GTF2E2, CDA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HOXC10_WIBG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HOXC10_WIBG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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