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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16704

FusionGeneSummary for HOXB3_PTPRA

check button Fusion gene summary
Fusion gene informationFusion gene name: HOXB3_PTPRA
Fusion gene ID: 16704
HgeneTgene
Gene symbol

HOXB3

PTPRA

Gene ID

3213

5786

Gene namehomeobox B3protein tyrosine phosphatase, receptor type A
SynonymsHOX2|HOX2G|Hox-2.7HEPTP|HLPR|HPTPA|HPTPalpha|LRP|PTPA|PTPRL2|R-PTP-alpha|RPTPA
Cytomap

17q21.32

20p13

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Hox-B3homeo box 2Ghomeobox protein Hox-2.7homeobox protein Hox-2Greceptor-type tyrosine-protein phosphatase alphaLeukocyte common antigen-related peptide (protein tyrosine phosphate)PTPLCA-related phosphatasePTPase-alphaprotein tyrosine phosphatase, receptor type, alpha polypeptideprotein-tyrosine phosphatase alph
Modification date2018052320180527
UniProtAcc

P14651

P18433

Ensembl transtripts involved in fusion geneENST00000472863, ENST00000498678, 
ENST00000460160, ENST00000476342, 
ENST00000552000, ENST00000470495, 
ENST00000311626, ENST00000490677, 
ENST00000485909, ENST00000489475, 
ENST00000465120, 
ENST00000380393, 
ENST00000216877, ENST00000358719, 
ENST00000399903, ENST00000425918, 
ENST00000318266, ENST00000356147, 
Fusion gene scores* DoF score9 X 5 X 6=2703 X 3 X 1=9
# samples 93
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HOXB3 [Title/Abstract] AND PTPRA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHOXB3

GO:0045944

positive regulation of transcription by RNA polymerase II

9556594


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA748390HOXB3chr17

46667485

-PTPRAchr20

2903853

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000472863ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000472863ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000472863ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000472863ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000472863ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000472863ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000472863ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000498678ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000498678ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000498678ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000498678ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000498678ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000498678ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000498678ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000460160ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000460160ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000460160ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000460160ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000460160ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000460160ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000460160ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000476342ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000476342ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000476342ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000476342ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000476342ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000476342ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
5UTR-5UTRENST00000476342ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000552000ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000552000ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000552000ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000552000ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000552000ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000552000ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000552000ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000470495ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000470495ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000470495ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000470495ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000470495ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000470495ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000470495ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000311626ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000311626ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000311626ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000311626ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000311626ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000311626ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000311626ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000490677ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000490677ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000490677ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000490677ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000490677ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000490677ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000490677ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000485909ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000485909ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000485909ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000485909ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000485909ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000485909ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000485909ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000489475ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000489475ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000489475ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000489475ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000489475ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000489475ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000489475ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000465120ENST00000380393HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000465120ENST00000216877HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000465120ENST00000358719HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000465120ENST00000399903HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000465120ENST00000425918HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000465120ENST00000318266HOXB3chr17

46667485

-PTPRAchr20

2903853

+
intron-5UTRENST00000465120ENST00000356147HOXB3chr17

46667485

-PTPRAchr20

2903853

+

Top

FusionProtFeatures for HOXB3_PTPRA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOXB3

P14651

PTPRA

P18433

Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HOXB3_PTPRA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HOXB3_PTPRA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HOXB3_PTPRA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HOXB3_PTPRA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHOXB3C0019284Diaphragmatic Hernia1CTD_human
TgenePTPRAC0036341Schizophrenia2PSYGENET
TgenePTPRAC0151744Myocardial Ischemia1CTD_human