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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 167

FusionGeneSummary for ABCC5_SPRR4

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC5_SPRR4
Fusion gene ID: 167
HgeneTgene
Gene symbol

ABCC5

SPRR4

Gene ID

10057

163778

Gene nameATP binding cassette subfamily C member 5small proline rich protein 4
SynonymsABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11-
Cytomap

3q27.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter Csmall proline-rich protein 4
Modification date2018052320180523
UniProtAcc

O15440

Q96PI1

Ensembl transtripts involved in fusion geneENST00000334444, ENST00000265586, 
ENST00000492216, ENST00000427120, 
ENST00000392579, ENST00000382494, 
ENST00000446941, 
ENST00000328051, 
Fusion gene scores* DoF score8 X 6 X 4=1922 X 1 X 2=4
# samples 72
** MAII scorelog2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: ABCC5 [Title/Abstract] AND SPRR4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1ZQ-06AABCC5chr3

183645118

-SPRR4chr1

152944347

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334444ENST00000328051ABCC5chr3

183645118

-SPRR4chr1

152944347

+
5CDS-5UTRENST00000265586ENST00000328051ABCC5chr3

183645118

-SPRR4chr1

152944347

+
intron-5UTRENST00000492216ENST00000328051ABCC5chr3

183645118

-SPRR4chr1

152944347

+
intron-5UTRENST00000427120ENST00000328051ABCC5chr3

183645118

-SPRR4chr1

152944347

+
intron-5UTRENST00000392579ENST00000328051ABCC5chr3

183645118

-SPRR4chr1

152944347

+
intron-5UTRENST00000382494ENST00000328051ABCC5chr3

183645118

-SPRR4chr1

152944347

+
intron-5UTRENST00000446941ENST00000328051ABCC5chr3

183645118

-SPRR4chr1

152944347

+

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FusionProtFeatures for ABCC5_SPRR4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC5

O15440

SPRR4

Q96PI1

Cross-linked envelope protein of keratinocytes. Involvedin UV-induced cornification.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABCC5_SPRR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABCC5_SPRR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABCC5SMC2, SERPINA3, AK2, RBP5, SHMT2, MOV10, NXF1, TMEM17, NUPL1, TRDN, SCN3BSPRR4APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABCC5_SPRR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABCC5_SPRR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC5C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC5C0009404Colorectal Neoplasms1CTD_human
HgeneABCC5C0023893Liver Cirrhosis, Experimental1CTD_human