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Fusion gene ID: 16679 |
FusionGeneSummary for HOOK3_IKBKB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HOOK3_IKBKB | Fusion gene ID: 16679 | Hgene | Tgene | Gene symbol | HOOK3 | IKBKB | Gene ID | 84376 | 3551 |
| Gene name | hook microtubule tethering protein 3 | inhibitor of nuclear factor kappa B kinase subunit beta | |
| Synonyms | HK3 | IKK-beta|IKK2|IKKB|IMD15|NFKBIKB | |
| Cytomap | 8p11.21 | 8p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein Hook homolog 3h-hook3hHK3hook homolog 3 | inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betaIKK-Binhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase beta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86VS8 | O14920 | |
| Ensembl transtripts involved in fusion gene | ENST00000307602, ENST00000524839, | ENST00000520810, ENST00000416505, ENST00000519735, ENST00000520835, ENST00000379708, ENST00000518983, ENST00000522147, ENST00000522785, | |
| Fusion gene scores | * DoF score | 11 X 10 X 6=660 | 8 X 7 X 3=168 |
| # samples | 15 | 10 | |
| ** MAII score | log2(15/660*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HOOK3 [Title/Abstract] AND IKBKB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IKBKB | GO:0006468 | protein phosphorylation | 15084260|20434986 |
| Tgene | IKBKB | GO:0018105 | peptidyl-serine phosphorylation | 21399639 |
| Tgene | IKBKB | GO:0042325 | regulation of phosphorylation | 26212789 |
| Tgene | IKBKB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055|23453807 |
| Tgene | IKBKB | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15790681 |
| Tgene | IKBKB | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0D1-01A | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000307602 | ENST00000520810 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| In-frame | ENST00000307602 | ENST00000416505 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| In-frame | ENST00000307602 | ENST00000519735 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| In-frame | ENST00000307602 | ENST00000520835 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| 5CDS-intron | ENST00000307602 | ENST00000379708 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| 5CDS-intron | ENST00000307602 | ENST00000518983 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| 5CDS-intron | ENST00000307602 | ENST00000522147 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| 5CDS-intron | ENST00000307602 | ENST00000522785 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-3CDS | ENST00000524839 | ENST00000520810 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-3CDS | ENST00000524839 | ENST00000416505 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-3CDS | ENST00000524839 | ENST00000519735 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-3CDS | ENST00000524839 | ENST00000520835 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-intron | ENST00000524839 | ENST00000379708 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-intron | ENST00000524839 | ENST00000518983 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-intron | ENST00000524839 | ENST00000522147 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
| intron-intron | ENST00000524839 | ENST00000522785 | HOOK3 | chr8 | 42798588 | + | IKBKB | chr8 | 42162705 | + |
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FusionProtFeatures for HOOK3_IKBKB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HOOK3 | IKBKB |
| Probably serves as a target for the spiC protein fromSalmonella typhimurium, which inactivates it, leading to a strongalteration in cellular trafficking (By similarity). Component ofthe FTS/Hook/FHIP complex (FHF complex). The FHF complex mayfunction to promote vesicle trafficking and/or fusion via thehomotypic vesicular protein sorting complex (the HOPS complex).May regulate clearance of endocytosed receptors such as MSR1.Participates in defining the architecture and localization of theGolgi complex. Acts as an adapter protein linking the dynein motorcomplex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence ofdynactin. Facilitates the interaction between dynein and dynactinand activates dynein processivity (the ability to move along amicrotubule for a long distance without falling off the track)(PubMed:25035494). {ECO:0000250|UniProtKB:Q8BUK6,ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231,ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494}. | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimulisuch as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. Acts as part of the canonicalIKK complex in the conventional pathway of NF-kappa-B activationand phosphorylates inhibitors of NF-kappa-B on 2 critical serineresidues. These modifications allow polyubiquitination of theinhibitors and subsequent degradation by the proteasome. In turn,free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response,growth control, or protection against apoptosis. In addition tothe NF-kappa-B inhibitors, phosphorylates several other componentsof the signaling pathway including NEMO/IKBKG, NF-kappa-B subunitsRELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE.IKK-related kinase phosphorylations may prevent the overproductionof inflammatory mediators since they exert a negative regulationon canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor.Also phosphorylates other substrates including NCOA3, BCL10 andIRS1. Within the nucleus, acts as an adapter protein for NFKBIAdegradation in UV-induced NF-kappa-B activation.{ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:15084260,ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809,ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986,ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HOOK3 | chr8:42798588 | chr8:42162705 | ENST00000307602 | + | 5 | 22 | 10_126 | 133 | 719 | Domain | Calponin-homology (CH) |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000416505 | + | 3 | 21 | 458_479 | 70 | 698 | Region | Note=Leucine-zipper |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000416505 | + | 3 | 21 | 737_742 | 70 | 698 | Region | Note=NEMO-binding |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000519735 | + | 4 | 9 | 458_479 | 129 | 257 | Region | Note=Leucine-zipper |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000519735 | + | 4 | 9 | 737_742 | 129 | 257 | Region | Note=NEMO-binding |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520810 | + | 4 | 22 | 458_479 | 129 | 757 | Region | Note=Leucine-zipper |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520810 | + | 4 | 22 | 737_742 | 129 | 757 | Region | Note=NEMO-binding |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520835 | + | 3 | 21 | 458_479 | 127 | 755 | Region | Note=Leucine-zipper |
| Tgene | >IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520835 | + | 3 | 21 | 737_742 | 127 | 755 | Region | Note=NEMO-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HOOK3 | chr8:42798588 | chr8:42162705 | ENST00000307602 | + | 5 | 22 | 167_433 | 133 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >HOOK3 | chr8:42798588 | chr8:42162705 | ENST00000307602 | + | 5 | 22 | 462_667 | 133 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >HOOK3 | chr8:42798588 | chr8:42162705 | ENST00000307602 | + | 5 | 22 | 553_718 | 133 | 719 | Region | Note=Required for association with Golgi |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000416505 | + | 3 | 21 | 15_300 | 70 | 698 | Domain | Protein kinase |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000519735 | + | 4 | 9 | 15_300 | 129 | 257 | Domain | Protein kinase |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520810 | + | 4 | 22 | 15_300 | 129 | 757 | Domain | Protein kinase |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520835 | + | 3 | 21 | 15_300 | 127 | 755 | Domain | Protein kinase |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000416505 | + | 3 | 21 | 21_29 | 70 | 698 | Nucleotide binding | ATP |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000519735 | + | 4 | 9 | 21_29 | 129 | 257 | Nucleotide binding | ATP |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520810 | + | 4 | 22 | 21_29 | 129 | 757 | Nucleotide binding | ATP |
| Tgene | IKBKB | chr8:42798588 | chr8:42162705 | ENST00000520835 | + | 3 | 21 | 21_29 | 127 | 755 | Nucleotide binding | ATP |
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FusionGeneSequence for HOOK3_IKBKB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000520810_chr8_42162705_+_761aa MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEI LGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG SLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLN SVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQE AGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNR LQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVER MMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELL PKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLC >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000416505_chr8_42162705_+_761aa MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEI LGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG SLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLN SVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQE AGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNR LQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVER MMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELL PKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLC >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000519735_chr8_42162705_+_261aa MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEI LGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000520835_chr8_42162705_+_761aa MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEI LGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG SLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLN SVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQE AGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNR LQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVER MMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELL PKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000520810_chr8_42162705_+_2283nt ATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTAATGTGGATGCACCATGCCAG ACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTGATGAAAATTGGCTAAACAGA ATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCTTGGATTATAATCATGAGATT TTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAGAGCTTGGAAGGATGCTTCAG CTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACAGAATCATCCATCGGGATCTA AAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATGCCAAGGAGCTGGATCAGGGC AGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACACAGTGACCGTCGACTACTGG AGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGCAGTGGCATTCAAAAGTGCGG CAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTACCCTACCCCAATAATCTTAAC AGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCACGGATCCCACGTATGGGCCC AATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGGGCACCATCCACACCTACCCT GTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGGACCAGGAGCTGCTGCAGGAA GCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCCACACATTGGACATGGATCTT GTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTGTCAGCTGTATCCTTCAAGAG CCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCCTGAAGGAAGATTGCAACCGG CTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGAATTCCATGGCTTCCATGTCT CAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGCAAACCGAGTTTGGGATCACA TCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAGTGAAACTCCTGGTAGAACGG ATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGCTGGACGACCTAGAGGAGCAA GCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAATGGTACGGCTGCTGCTTCAG GCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGCAGAAGGCGCTGGAACTGTTG CCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGCGGCAGAAGGAGCTCTGGAAT CTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTCGACTTAGCCAGCCTGGGCAG CTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGGCTGAAGCACATAACCTCTGC ACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGAGCTGGTTACAGACGGAAGAA >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000416505_chr8_42162705_+_2283nt ATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTAATGTGGATGCACCATGCCAG ACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTGATGAAAATTGGCTAAACAGA ATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCTTGGATTATAATCATGAGATT TTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAGAGCTTGGAAGGATGCTTCAG CTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACAGAATCATCCATCGGGATCTA AAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATGCCAAGGAGCTGGATCAGGGC AGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACACAGTGACCGTCGACTACTGG AGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGCAGTGGCATTCAAAAGTGCGG CAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTACCCTACCCCAATAATCTTAAC AGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCACGGATCCCACGTATGGGCCC AATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGGGCACCATCCACACCTACCCT GTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGGACCAGGAGCTGCTGCAGGAA GCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCCACACATTGGACATGGATCTT GTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTGTCAGCTGTATCCTTCAAGAG CCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCCTGAAGGAAGATTGCAACCGG CTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGAATTCCATGGCTTCCATGTCT CAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGCAAACCGAGTTTGGGATCACA TCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAGTGAAACTCCTGGTAGAACGG ATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGCTGGACGACCTAGAGGAGCAA GCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAATGGTACGGCTGCTGCTTCAG GCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGCAGAAGGCGCTGGAACTGTTG CCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGCGGCAGAAGGAGCTCTGGAAT CTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTCGACTTAGCCAGCCTGGGCAG CTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGGCTGAAGCACATAACCTCTGC ACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGAGCTGGTTACAGACGGAAGAA >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000519735_chr8_42162705_+_783nt ATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTAATGTGGATGCACCATGCCAG ACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTGATGAAAATTGGCTAAACAGA ATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCTTGGATTATAATCATGAGATT TTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAGAGCTTGGAAGGATGCTTCAG CTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACAGAATCATCCATCGGGATCTA AAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATGCCAAGGAGCTGGATCAGGGC AGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACACAGTGACCGTCGACTACTGG AGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGCAGTGCGTAAGAATGTGGCCG >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000520835_chr8_42162705_+_2283nt ATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTAATGTGGATGCACCATGCCAG ACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTGATGAAAATTGGCTAAACAGA ATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCTTGGATTATAATCATGAGATT TTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAGAGCTTGGAAGGATGCTTCAG CTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACAGAATCATCCATCGGGATCTA AAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATGCCAAGGAGCTGGATCAGGGC AGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACACAGTGACCGTCGACTACTGG AGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGCAGTGGCATTCAAAAGTGCGG CAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTACCCTACCCCAATAATCTTAAC AGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCACGGATCCCACGTATGGGCCC AATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGGGCACCATCCACACCTACCCT GTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGGACCAGGAGCTGCTGCAGGAA GCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCCACACATTGGACATGGATCTT GTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTGTCAGCTGTATCCTTCAAGAG CCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCCTGAAGGAAGATTGCAACCGG CTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGAATTCCATGGCTTCCATGTCT CAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGCAAACCGAGTTTGGGATCACA TCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAGTGAAACTCCTGGTAGAACGG ATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGCTGGACGACCTAGAGGAGCAA GCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAATGGTACGGCTGCTGCTTCAG GCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGCAGAAGGCGCTGGAACTGTTG CCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGCGGCAGAAGGAGCTCTGGAAT CTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTCGACTTAGCCAGCCTGGGCAG CTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGGCTGAAGCACATAACCTCTGC ACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGAGCTGGTTACAGACGGAAGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000520810_chr8_42162705_+_3112nt CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC AGTGGCATTCAAAAGTGCGGCAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTAC CCTACCCCAATAATCTTAACAGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCA CGGATCCCACGTATGGGCCCAATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGG GCACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGG ACCAGGAGCTGCTGCAGGAAGCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCC ACACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTG TCAGCTGTATCCTTCAAGAGCCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCC TGAAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGA ATTCCATGGCTTCCATGTCTCAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGC AAACCGAGTTTGGGATCACATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAG TGAAACTCCTGGTAGAACGGATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGC TGGACGACCTAGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAA TGGTACGGCTGCTGCTTCAGGCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGC AGAAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGC GGCAGAAGGAGCTCTGGAATCTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTC GACTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGG CTGAAGCACATAACCTCTGCACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGA GCTGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGATGTGGGGGGACTCGACCCCCTGACATGGGGCAGCCCA TAGCAGGCCTTGTGCAGTGGGGGGACTCGACCCCCTGACATGGGGCTGCCTGGAGCAGGCCGCGTGACGTGGGGCTGCCTGGCCGCGGCT CTCACATGGTGGTTCCTGCTGCACTGATGGCCCAGGGGTCTCTGGTATCCAGATGGAGCTCTCGCTTCCTCAGCAGCTGTGACTTTCACC CAGGACCCAGGACGCAGCCCTCCGTGGGCACTGCCGGCGCCTTGTCTGCACACTGGAGGTCCTCCATTACAGAGGCCCAGCGCACATCGC TGGCCCCACAAACGTTCAGGGGTACAGCCATGGCAGCTCCTTCCTCTGCCGTGAGAAAAGTGCTTGGAGTACGGTTTGCCACACACGTGA CTGGACAGTGTCCAATTCAAATCTTTCAGGGCAGAGTCCGAGCAGCGCTTGGTGACAGCCTGTCCTCTCCTGCTCTCCAAAGGCCCTGCT CCCTGTCCTCTCTCACTTTACAGCTTGTGTTTCTTCTGGATTCAGCTTCTCCTAAACAGACAGTTTAATTATAGTTGCGGCCTGGCCCCA >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000416505_chr8_42162705_+_2636nt CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC AGTGGCATTCAAAAGTGCGGCAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTAC CCTACCCCAATAATCTTAACAGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCA CGGATCCCACGTATGGGCCCAATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGG GCACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGG ACCAGGAGCTGCTGCAGGAAGCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCC ACACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTG TCAGCTGTATCCTTCAAGAGCCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCC TGAAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGA ATTCCATGGCTTCCATGTCTCAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGC AAACCGAGTTTGGGATCACATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAG TGAAACTCCTGGTAGAACGGATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGC TGGACGACCTAGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAA TGGTACGGCTGCTGCTTCAGGCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGC AGAAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGC GGCAGAAGGAGCTCTGGAATCTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTC GACTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGG CTGAAGCACATAACCTCTGCACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGA GCTGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGATGTGGGGGGACTCGACCCCCTGACATGGGGCAGCCCA TAGCAGGCCTTGTGCAGTGGGGGGACTCGACCCCCTGACATGGGGCTGCCTGGAGCAGGCCGCGTGACGTGGGGCTGCCTGGCCGCGGCT >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000519735_chr8_42162705_+_1208nt CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC AGTGCGTAAGAATGTGGCCGGGTACAGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCAGTTGAGGCCAGC AGTTCCAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAACCCTAGCCAGGTGTGGTGGCGGGCGCCTGTAATCCCAGCT ACTCGGAAGGCTGAGGTGGGAGAATTGCTTAAACCCAGGAGGCAGAGGTCGCATCACTGCAATCCAGCCTGGGCGACAGAGTGAGACTCT >In-frame_HOOK3_ENST00000307602_chr8_42798588_+_IKBKB_ENST00000520835_chr8_42162705_+_2568nt CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC AGTGGCATTCAAAAGTGCGGCAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTAC CCTACCCCAATAATCTTAACAGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCA CGGATCCCACGTATGGGCCCAATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGG GCACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGG ACCAGGAGCTGCTGCAGGAAGCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCC ACACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTG TCAGCTGTATCCTTCAAGAGCCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCC TGAAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGA ATTCCATGGCTTCCATGTCTCAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGC AAACCGAGTTTGGGATCACATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAG TGAAACTCCTGGTAGAACGGATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGC TGGACGACCTAGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAA TGGTACGGCTGCTGCTTCAGGCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGC AGAAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGC GGCAGAAGGAGCTCTGGAATCTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTC GACTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGG CTGAAGCACATAACCTCTGCACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGA GCTGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGATGTGGGGGGACTCGACCCCCTGACATGGGGCAGCCCA |
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FusionGenePPI for HOOK3_IKBKB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HOOK3 | CUL3, AKTIP, HOOK1, HOOK2, HOOK3, FAM160A2, VPS16, VPS41, SCFD1, CCDC8, ZC4H2, COMTD1, TNFSF13B, IFT57, FNTB, MRE11A, NTRK1, SSX2IP, CEP63, DUSP3, FAM160A1, MTMR4, SYCE3, RALBP1, CDC16, NCAPH2, KLHL10, KLHL20 | IKBKB | TRPC4AP, PPM1B, NFKB1, BTRC, MAP3K13, PRDX3, IRS1, PRKCQ, CHUK, IKBKG, CDC37, PRKDC, TNFRSF1A, TRAF2, CTNNB1, IRAK1, NFKBIA, FANCA, MAP3K11, EIF2AK2, CASP8, NCOA3, IKBKAP, TNFAIP3, MAP3K14, TRAF3IP2, NFKBIB, IKBKB, MAP3K1, MAP3K7, CUEDC2, PPP1CA, PPP1R15A, RELA, AKT1, TNF, PRKCA, PRKCI, PRKCD, DUSP1, TP53, KEAP1, CUL3, HTT, COPS3, COPS4, COPS5, COPS7A, CUL1, JUN, ERC1, TRIM21, HNRNPU, TRIM40, FKBP4, FKBP5, PYGL, CSNK2B, MAPK14, NLRX1, PLK1, MUC1, TP63, HOMER3, IKBKE, NEDD4L, RIPK1, PELI1, TRAF6, USP4, BRAP, BCL10, TNIP2, SRC, PPP2R3C, NLRP2, HSP90AA1, EGLN3, TRIM27, TP73, TRAPPC9, FAF1, PPP2CA, MEOX2, CDKN2A, TRAF1, FOXO3, STAP2, CSF2RA, CSF2RB, TSC1, CREBBP, NAA20, BCL2, DPP4, TAB1, PRKCE, HSPB1, PYCARD, NLRC5, TAB2, AURKA, TPX2, NGFR, SASH1, TFAP2C, FLNC, ROCK1, MTOR, RPTOR, RICTOR, PPARG, SHARPIN, DHCR24, RAN, SLC25A13, SLC25A22, CD40, MAVS, BIRC3, HSP90AB1, CLTC, PRKCB, STK26, COMMD7, MACROD1, LATS2, GLI1, ITCH, USP18, TWIST1, SMN1, KLHL21, TAB3, PSG1, UBC, MALT1, HIF1A, EPAS1, TNIK, IFIT5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HOOK3_IKBKB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | IKBKB | O14920 | DB00244 | Mesalazine | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved |
| Tgene | IKBKB | O14920 | DB00795 | Sulfasalazine | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved |
| Tgene | IKBKB | O14920 | DB00995 | Auranofin | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|investigational |
| Tgene | IKBKB | O14920 | DB01169 | Arsenic trioxide | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|investigational |
| Tgene | IKBKB | O14920 | DB06151 | Acetylcysteine | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|investigational |
| Tgene | IKBKB | O14920 | DB00945 | Acetylsalicylic acid | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|vet_approved |
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RelatedDiseases for HOOK3_IKBKB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HOOK3 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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