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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16662

FusionGeneSummary for HOMER2_HOMER2

check button Fusion gene summary
Fusion gene informationFusion gene name: HOMER2_HOMER2
Fusion gene ID: 16662
HgeneTgene
Gene symbol

HOMER2

HOMER2

Gene ID

9455

9455

Gene namehomer scaffold protein 2homer scaffold protein 2
SynonymsACPD|CPD|DFNA68|HOMER-2|VESL-2ACPD|CPD|DFNA68|HOMER-2|VESL-2
Cytomap

15q25.2

15q25.2

Type of geneprotein-codingprotein-coding
Descriptionhomer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2homer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2
Modification date2018052320180523
UniProtAcc

Q9NSB8

Q9NSB8

Ensembl transtripts involved in fusion geneENST00000450735, ENST00000304231, 
ENST00000399166, ENST00000426485, 
ENST00000500334, 		ENST00000450735, 
ENST00000304231, ENST00000399166, 
ENST00000426485, ENST00000500334, 
Fusion gene scores* DoF score3 X 2 X 2=125 X 3 X 3=45
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HOMER2 [Title/Abstract] AND HOMER2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE159788HOMER2chr15

83646178

+HOMER2chr15

83642326

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000450735ENST00000450735HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000450735ENST00000304231HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000450735ENST00000399166HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000450735ENST00000426485HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000450735ENST00000500334HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000304231ENST00000450735HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000304231ENST00000304231HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000304231ENST00000399166HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000304231ENST00000426485HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000304231ENST00000500334HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000399166ENST00000450735HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000399166ENST00000304231HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000399166ENST00000399166HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000399166ENST00000426485HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000399166ENST00000500334HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000426485ENST00000450735HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000426485ENST00000304231HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000426485ENST00000399166HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000426485ENST00000426485HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000426485ENST00000500334HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000500334ENST00000450735HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000500334ENST00000304231HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000500334ENST00000399166HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000500334ENST00000426485HOMER2chr15

83646178

+HOMER2chr15

83642326

-
intron-intronENST00000500334ENST00000500334HOMER2chr15

83646178

+HOMER2chr15

83642326

-

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FusionProtFeatures for HOMER2_HOMER2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOMER2

Q9NSB8

HOMER2

Q9NSB8

Postsynaptic density scaffolding protein. Binds andcross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1,RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 withER-associated ITPR1 receptors, it aids the coupling of surfacereceptors to intracellular calcium release. May also couple GRM1to PI3 kinase through its interaction with AGAP2. Isoforms can bedifferently regulated and may play an important role inmaintaining the plasticity at glutamatergic synapses(PubMed:9808459). Required for normal hearing (PubMed:25816005).Negatively regulates T cell activation through negative regulationof IL2 expression by inhibiting calcineurin-NFAT pathwayactivation through interaction with NFATC2 (PubMed:18218901).{ECO:0000269|PubMed:18218901, ECO:0000269|PubMed:25816005,ECO:0000269|PubMed:9808459}. Postsynaptic density scaffolding protein. Binds andcross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1,RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 withER-associated ITPR1 receptors, it aids the coupling of surfacereceptors to intracellular calcium release. May also couple GRM1to PI3 kinase through its interaction with AGAP2. Isoforms can bedifferently regulated and may play an important role inmaintaining the plasticity at glutamatergic synapses(PubMed:9808459). Required for normal hearing (PubMed:25816005).Negatively regulates T cell activation through negative regulationof IL2 expression by inhibiting calcineurin-NFAT pathwayactivation through interaction with NFATC2 (PubMed:18218901).{ECO:0000269|PubMed:18218901, ECO:0000269|PubMed:25816005,ECO:0000269|PubMed:9808459}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HOMER2_HOMER2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HOMER2_HOMER2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HOMER2_HOMER2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HOMER2_HOMER2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHOMER2C0036341Schizophrenia1PSYGENET
HgeneHOMER2C0236736Cocaine-Related Disorders1CTD_human
HgeneHOMER2C4225240DEAFNESS, AUTOSOMAL DOMINANT 681UNIPROT
TgeneHOMER2C0036341Schizophrenia1PSYGENET
TgeneHOMER2C0236736Cocaine-Related Disorders1CTD_human
TgeneHOMER2C4225240DEAFNESS, AUTOSOMAL DOMINANT 681UNIPROT