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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16659

FusionGeneSummary for HOMER1_EFNB3

check button Fusion gene summary
Fusion gene informationFusion gene name: HOMER1_EFNB3
Fusion gene ID: 16659
HgeneTgene
Gene symbol

HOMER1

EFNB3

Gene ID

9456

1949

Gene namehomer scaffold protein 1ephrin B3
SynonymsHOMER|HOMER1A|HOMER1B|HOMER1C|SYN47|Ves-1EFL6|EPLG8|LERK8
Cytomap

5q14.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionhomer protein homolog 1homer homolog 1homer scaffolding protein 1homer, neuronal immediate early gene, 1homer-1ephrin-B3EPH-related receptor transmembrane ligand ELK-L3eph-related receptor tyrosine kinase ligand 8
Modification date2018052320180523
UniProtAcc

Q86YM7

Q15768

Ensembl transtripts involved in fusion geneENST00000334082, ENST00000535690, 
ENST00000508576, ENST00000282260, 
ENST00000226091, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 1=4
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: HOMER1 [Title/Abstract] AND EFNB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHOMER1

GO:0051592

response to calcium ion

14505576

TgeneEFNB3

GO:0048013

ephrin receptor signaling pathway

8808709


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF935692HOMER1chr5

78808692

-EFNB3chr17

7613903

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000334082ENST00000226091HOMER1chr5

78808692

-EFNB3chr17

7613903

+
intron-3UTRENST00000535690ENST00000226091HOMER1chr5

78808692

-EFNB3chr17

7613903

+
intron-3UTRENST00000508576ENST00000226091HOMER1chr5

78808692

-EFNB3chr17

7613903

+
intron-3UTRENST00000282260ENST00000226091HOMER1chr5

78808692

-EFNB3chr17

7613903

+

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FusionProtFeatures for HOMER1_EFNB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOMER1

Q86YM7

EFNB3

Q15768

Postsynaptic density scaffolding protein. Binds andcross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1,RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 withER-associated ITPR1 receptors, it aids the coupling of surfacereceptors to intracellular calcium release. May also couple GRM1to PI3 kinase through its interaction with AGAP2. Isoform 1regulates the trafficking and surface expression of GRM5. Isoform3 acts as a natural dominant negative, in dynamic competition withconstitutively expressed isoform 1 to regulate synapticmetabotropic glutamate function. Isoform 3, may be involved in thestructural changes that occur at synapses during long-lastingneuronal plasticity and development. Forms a high-order complexwith SHANK1, which in turn is necessary for the structural andfunctional integrity of dendritic spines (By similarity).{ECO:0000250|UniProtKB:Q9Z214}. Cell surface transmembrane ligand for Eph receptors, afamily of receptor tyrosine kinases which are crucial formigration, repulsion and adhesion during neuronal, vascular andepithelial development. Binds promiscuously Eph receptors residingon adjacent cells, leading to contact-dependent bidirectionalsignaling into neighboring cells. The signaling pathway downstreamof the receptor is referred to as forward signaling while thesignaling pathway downstream of the ephrin ligand is referred toas reverse signaling. May play a pivotal role in forebrainfunction. Binds to, and induce the collapse of, commissuralaxons/growth cones in vitro. May play a role in constraining theorientation of longitudinally projecting axons (By similarity).{ECO:0000250}. (Microbial infection) Acts as a receptor for nipah virusand hendra virus. {ECO:0000269|PubMed:16477309,ECO:0000269|PubMed:17376907}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HOMER1_EFNB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HOMER1_EFNB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HOMER1_EFNB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HOMER1_EFNB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHOMER1C0036341Schizophrenia4PSYGENET
HgeneHOMER1C0011570Mental Depression3PSYGENET
HgeneHOMER1C0011581Depressive disorder3PSYGENET
HgeneHOMER1C0236736Cocaine-Related Disorders2CTD_human
HgeneHOMER1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneHOMER1C0013386Dyskinesia, Drug-Induced1CTD_human
HgeneHOMER1C0018524Hallucinations1CTD_human
HgeneHOMER1C0041696Unipolar Depression1PSYGENET
HgeneHOMER1C0041755Adverse reaction to drug1CTD_human
HgeneHOMER1C0237123Alcohol or Other Drugs use1PSYGENET
HgeneHOMER1C1269683Major Depressive Disorder1PSYGENET