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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16647

FusionGeneSummary for HNRNPUL2_TNFAIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPUL2_TNFAIP1
Fusion gene ID: 16647
HgeneTgene
Gene symbol

HNRNPUL2

TNFAIP1

Gene ID

221092

7126

Gene nameheterogeneous nuclear ribonucleoprotein U like 2TNF alpha induced protein 1
SynonymsHNRPUL2|SAF-A2B12|B61|BTBD34|EDP1|hBACURD2
Cytomap

11q12.3

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein U-like protein 2scaffold-attachment factor A2BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2BTB/POZ domain-containing protein TNFAIP1tumor necrosis factor, alpha induced protein 1tumor necrosis factor, alpha-induced protein 1 (endothelial)
Modification date2018051920180522
UniProtAcc

Q1KMD3

Q13829

Ensembl transtripts involved in fusion geneENST00000301785, ENST00000544907, 
ENST00000226225, ENST00000583213, 
Fusion gene scores* DoF score6 X 6 X 3=1083 X 3 X 2=18
# samples 73
** MAII scorelog2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HNRNPUL2 [Title/Abstract] AND TNFAIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNFAIP1

GO:0016567

protein ubiquitination

19782033

TgeneTNFAIP1

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

19782033


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI570637HNRNPUL2chr11

62482282

+TNFAIP1chr17

26669308

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000301785ENST00000544907HNRNPUL2chr11

62482282

+TNFAIP1chr17

26669308

-
intron-3CDSENST00000301785ENST00000226225HNRNPUL2chr11

62482282

+TNFAIP1chr17

26669308

-
intron-3UTRENST00000301785ENST00000583213HNRNPUL2chr11

62482282

+TNFAIP1chr17

26669308

-

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FusionProtFeatures for HNRNPUL2_TNFAIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPUL2

Q1KMD3

TNFAIP1

Q13829

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex involved in regulation ofcytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligasecomplex mediates the ubiquitination of RHOA, leading to itsdegradation by the proteasome, thereby regulating the actincytoskeleton and cell migration. Its interaction with RHOB mayregulate apoptosis. May enhance the PCNA-dependent DNA polymerasedelta activity. {ECO:0000269|PubMed:19637314,ECO:0000269|PubMed:19782033}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPUL2_TNFAIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPUL2_TNFAIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPUL2_TNFAIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPUL2_TNFAIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNFAIP1C0011881Diabetic Nephropathy1CTD_human