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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1664

FusionGeneSummary for ANGPTL4_CLCN3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANGPTL4_CLCN3
Fusion gene ID: 1664
HgeneTgene
Gene symbol

ANGPTL4

CLCN3

Gene ID

51129

1182

Gene nameangiopoietin like 4chloride voltage-gated channel 3
SynonymsARP4|FIAF|HARP|HFARP|NL2|PGAR|TGQTL|UNQ171|pp1158CLC3|ClC-3
Cytomap

19p13.2

4q33

Type of geneprotein-codingprotein-coding
Descriptionangiopoietin-related protein 4PPARG angiopoietin related proteinfasting-induced adipose factorhepatic angiopoietin-related proteinhepatic fibrinogen/angiopoietin-related proteinperoxisome proliferator-activated receptor (PPAR) gamma induced angiopoieH(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3
Modification date2018051920180523
UniProtAcc

Q9BY76

P51790

Ensembl transtripts involved in fusion geneENST00000301455, ENST00000541807, 
ENST00000393962, 
ENST00000513761, 
ENST00000347613, ENST00000360642, 
ENST00000504131, ENST00000506924, 
Fusion gene scores* DoF score2 X 2 X 2=836 X 4 X 19=2736
# samples 239
** MAII scorelog2(2/8*10)=1.32192809488736log2(39/2736*10)=-2.81052220113629
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANGPTL4 [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANGPTL4

GO:0043066

negative regulation of apoptotic process

10698685

HgeneANGPTL4

GO:0051005

negative regulation of lipoprotein lipase activity

19542565

TgeneCLCN3

GO:1902476

chloride transmembrane transport

11274166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-80-5608-01AANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000301455ENST00000513761ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000347613ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000360642ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000504131ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000506924ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000513761ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000347613ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000360642ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000504131ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000506924ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000513761ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000347613ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000360642ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000504131ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000506924ANGPTL4chr19

8439257

+CLCN3chr4

170623929

+

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FusionProtFeatures for ANGPTL4_CLCN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANGPTL4

Q9BY76

CLCN3

P51790

Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANGPTL4_CLCN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANGPTL4_CLCN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANGPTL4SMARCA4, ACTB, KAT5, MYC, AURKA, BRMS1, CASP8, CDKN2A, CDKN2C, ESR1, FBXW7, FGFR4, TGFB1, WDR47, NMT2, PM20D2, AASDHPPT, NMT1, ITIH2, ARMC8, DNAJB4CLCN3CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANGPTL4_CLCN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANGPTL4_CLCN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANGPTL4C0024232Lymphatic Metastasis1CTD_human
HgeneANGPTL4C0027626Neoplasm Invasiveness1CTD_human
HgeneANGPTL4C0027627Neoplasm Metastasis1CTD_human
HgeneANGPTL4C0242339Dyslipidemias1CTD_human
HgeneANGPTL4C1458155Mammary Neoplasms1CTD_human
HgeneANGPTL4C1956346Coronary Artery Disease1CTD_human
TgeneCLCN3C0017638Glioma1CTD_human
TgeneCLCN3C0038356Stomach Neoplasms1CTD_human
TgeneCLCN3C2931822Nasopharyngeal carcinoma1CTD_human