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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 16636

FusionGeneSummary for HNRNPUL1_DAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPUL1_DAB1
Fusion gene ID: 16636
HgeneTgene
Gene symbol

HNRNPUL1

DAB1

Gene ID

11100

115209

Gene nameheterogeneous nuclear ribonucleoprotein U like 1OMA1 zinc metallopeptidase
SynonymsE1B-AP5|E1BAP5|HNRPUL12010001O09Rik|DAB1|MPRP-1|MPRP1|YKR087C|ZMPOMA1|peptidase
Cytomap

19q13.2

1p32.2-p32.1

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5metalloendopeptidase OMA1, mitochondrialOMA1 homolog, zinc metallopeptidaseOMA1 zinc metallopeptidase homologmetalloprotease-related protein 1overlapping activity with M-AAA proteaseoverlapping with the m-AAA protease 1 homologzinc metallopeptidase
Modification date2018052220180519
UniProtAcc

Q9BUJ2

O75553

Ensembl transtripts involved in fusion geneENST00000352456, ENST00000595018, 
ENST00000392006, ENST00000378215, 
ENST00000602130, ENST00000593587, 
ENST00000263367, ENST00000594207, 
ENST00000485760, ENST00000371236, 
ENST00000371234, ENST00000420954, 
ENST00000439789, ENST00000414851, 
ENST00000371231, ENST00000371230, 
Fusion gene scores* DoF score13 X 8 X 8=83210 X 7 X 7=490
# samples 1310
** MAII scorelog2(13/832*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/490*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPUL1 [Title/Abstract] AND DAB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-ZN-A9VP-01AHNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
TCGALDMESOTCGA-ZN-A9VP-01AHNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000352456ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000352456ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000352456ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000352456ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000352456ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000352456ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000352456ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000352456ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000595018ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000595018ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000595018ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000595018ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000595018ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000595018ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000595018ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000595018ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-5UTRENST00000392006ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000392006ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-5UTRENST00000392006ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000392006ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000392006ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000392006ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000392006ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000392006ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000378215ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000378215ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000378215ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000378215ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000378215ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000378215ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000378215ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000378215ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-5UTRENST00000602130ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000602130ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-5UTRENST00000602130ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000602130ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000602130ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000602130ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000602130ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5CDS-intronENST00000602130ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000593587ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000593587ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000593587ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000593587ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000593587ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000593587ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000593587ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000593587ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000263367ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000263367ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000263367ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000263367ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000263367ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000263367ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000263367ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000263367ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000594207ENST00000485760HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000594207ENST00000371236HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-5UTRENST00000594207ENST00000371234HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000594207ENST00000420954HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000594207ENST00000439789HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000594207ENST00000414851HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000594207ENST00000371231HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
intron-intronENST00000594207ENST00000371230HNRNPUL1chr19

41770598

+DAB1chr1

58349834

-
5UTR-intronENST00000352456ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000352456ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000352456ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000352456ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000352456ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000352456ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000352456ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000352456ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
5UTR-intronENST00000595018ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000392006ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000378215ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000602130ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000593587ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000263367ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000485760HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000371236HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000371234HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000420954HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000439789HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000414851HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000371231HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-
intron-intronENST00000594207ENST00000371230HNRNPUL1chr19

41768487

+DAB1chr1

58436537

-

Top

FusionProtFeatures for HNRNPUL1_DAB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPUL1

Q9BUJ2

DAB1

O75553


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HNRNPUL1_DAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HNRNPUL1_DAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPUL1POLR1E, CNBP, BRD7, C14orf1, MED31, CRMP1, PRPF40A, PRMT1, PRMT2, MEPCE, TLX3, ATM, ATRIP, RPA1, RPA2, PCM1, ELAVL1, SF3A2, SIRT7, TSG101, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, NXF1, HNRNPH1, HNRNPF, RBMX, EEF1A1, HNRNPA0, ILF2, HNRNPDL, HSPA5, RAB11B, ATP6V1H, DES, HNRNPH3, ZMPSTE24, TMEM179B, HNRNPUL2, EPB41L1, DBN1, ECH1, SAMM50, BARD1, SNRPC, SNRPB2, SF3B4, SF1, SRSF9, RBM22, PPIL1, ZNF207, HNRNPUL1, RBM4, SMN1, HNRNPH2, RAE1, NUP98, IL7R, BAG3, EP300, EWSR1, TGM2, GIT2, PIAS4, TARDBP, ITCH, NEDD4, APEX1, OSGEP, PEG10, TES, SERPINE2, RPA3, WWOX, ERG, IVNS1ABP, SMN2, TP53BP2, DZIP3, SORBS3, WWP2, ROPN1, VPS37C, RBM4B, MAPK1IP1L, CUL7, OBSL1, EED, RNF2, HNRNPA1, FBXW11, NTRK1, PDCD6, SAFB, SAFB2, TMED2, DMRTB1, MATR3, SYNCRIP, DGCR8, PCIF1, MCM2, SENP3, CFAP20, CYLD, CD2BP2, COX15, FOXA1, TRIM25, G3BP1, UBE2A, BRCA1DAB1APLP1, SIAH1, LRP2, LRP1, LDLR, VLDLR, LRP8, MYO6, APP, APLP2, CDK5, SH3KBP1, SOCS1, SOCS3, ERBB2, ERBB3, INPP5D, RBFOX1, CDK6, MBNL1, ROR2, PIN1, SNRPB, TCEA2, HYAL3, BHLHE40, PPIG, MAGED1, DAZAP2, SERF2, SIRPB1, ARID5A, CLASRP, POGZ, FAM168A, RBFOX2, ZBTB32, VENTX, TOLLIP, USP53, ZCCHC10, WDYHV1, STRBP, MBNL3, SMAP2, HMBOX1, FAM103A1, RHOXF2, LNX1, ZC3H10, C1orf94, NAF1, HNRNPLL, ZNF488, PRR20A, CIART, TMTC3, TCEANC, LGALS9B, KRTAP8-1, KRTAP19-5, KRTAP19-7, LGALS9C, SOCS6, SOCS7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPUL1_DAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPUL1_DAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDAB1C0004352Autistic Disorder1CTD_human