|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16625 |
FusionGeneSummary for HNRNPM_SLC25A23 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPM_SLC25A23 | Fusion gene ID: 16625 | Hgene | Tgene | Gene symbol | HNRNPM | SLC25A23 | Gene ID | 4670 | 79085 |
| Gene name | heterogeneous nuclear ribonucleoprotein M | solute carrier family 25 member 23 | |
| Synonyms | CEAR|HNRNPM4|HNRPM|HNRPM4|HTGR1|NAGR1|hnRNP M | APC2|MCSC2|SCaMC-3 | |
| Cytomap | 19p13.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein MCEA receptorN-acetylglucosamine receptor 1heterogenous nuclear ribonucleoprotein M4hnRNA-binding protein M4 | calcium-binding mitochondrial carrier protein SCaMC-3mitochondrial ATP-Mg/Pi carrier protein 2mitochondrial Ca(2+)-dependent solute carrier protein 2mitochondrial Ca2+-dependent solute carrier protein 2short calcium-binding mitochondrial carrier 3sma | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P52272 | Q9BV35 | |
| Ensembl transtripts involved in fusion gene | ENST00000348943, ENST00000325495, ENST00000602219, | ENST00000601760, ENST00000301454, ENST00000414491, ENST00000334510, | |
| Fusion gene scores | * DoF score | 12 X 10 X 8=960 | 2 X 2 X 2=8 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/960*10)=-2.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: HNRNPM [Title/Abstract] AND SLC25A23 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-75-5125-01A | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000348943 | ENST00000601760 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| 5CDS-intron | ENST00000348943 | ENST00000301454 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| 5CDS-intron | ENST00000348943 | ENST00000414491 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| 5CDS-intron | ENST00000348943 | ENST00000334510 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| 5CDS-intron | ENST00000325495 | ENST00000601760 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| 5CDS-intron | ENST00000325495 | ENST00000301454 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| 5CDS-intron | ENST00000325495 | ENST00000414491 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| 5CDS-intron | ENST00000325495 | ENST00000334510 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| intron-intron | ENST00000602219 | ENST00000601760 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| intron-intron | ENST00000602219 | ENST00000301454 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| intron-intron | ENST00000602219 | ENST00000414491 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
| intron-intron | ENST00000602219 | ENST00000334510 | HNRNPM | chr19 | 8509995 | + | SLC25A23 | chr19 | 6438545 | - |
Top |
FusionProtFeatures for HNRNPM_SLC25A23 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPM | SLC25A23 |
| Pre-mRNA binding protein in vivo, binds avidly topoly(G) and poly(U) RNA homopolymers in vitro. Involved insplicing. Acts as a receptor for carcinoembryonic antigen inKupffer cells, may initiate a series of signaling events leadingto tyrosine phosphorylation of proteins and induction of IL-1alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. | Calcium-dependent mitochondrial solute carrier.Mitochondrial solute carriers shuttle metabolites, nucleotides,and cofactors through the mitochondrial inner membrane(PubMed:15123600). May act as a ATP-Mg/Pi exchanger that mediatesthe transport of Mg-ATP in exchange for phosphate, catalyzing thenet uptake or efflux of adenine nucleotides into or from themitochondria (PubMed:15123600). Acts as a regulator ofmitochondrial calcium uptake via interaction with MCU and MICU1(PubMed:24430870). {ECO:0000269|PubMed:15123600,ECO:0000269|PubMed:24430870}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HNRNPM_SLC25A23 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HNRNPM_SLC25A23 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HNRNPM | PRRC2A, RBM4B, LMO3, TCERG1, GSTK1, PHLDA3, RFXANK, PTP4A3, TSC22D1, JUN, LYST, HNRNPA1, HNRNPH1, APC, SRRM1, SRRM2, TOPORS, MORF4L1, MORF4L2, MRGBP, DOT1L, NPM1, TADA2A, UBC, NOP56, VHL, SMARCAD1, ARRB1, ARRB2, ERG, KIAA0368, NFX1, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, PRAME, FBXO6, RBM8A, U2AF2, PRPF6, EFTUD2, NHP2L1, SNRPD1, RBMX, SF3B3, SF3A1, SNRPA1, SF3B1, U2AF1, HNRNPC, SNRPD3, SRSF1, HNRNPF, ALYREF, HNRNPR, HNRNPK, PRPF8, RNPS1, SRSF5, SRSF3, SYNCRIP, SFPQ, NONO, RBM25, HNRNPA0, HNRNPL, RPL10A, RPS6, RPL7, RALY, RPS24, RPS8, RPL11, RPL23A, RPS23, RPL7A, RPL12, DDX5, RPL31, RPS13, RPL6, RPL14, RPS15A, RPS16, RPLP0, DDX1, RPL18, RPL5, RPS11, TOP1, RPS7, RPS2, RPS14, PRPF19, RPL10, RPL19, RPL23, HNRNPDL, RPL18A, RPL30, RPL22, PUF60, RPS26, SRRT, RPS4X, PRPF40A, RPSA, RPS21, PRPF3, RPS5, RPS28, RPS25, RBM14, SND1, RANBP2, MRPL37, KRT16, STOM, MBD3, UQCR10, SLC25A24, SUPT16H, RPLP0P6, RRBP1, VTN, RCC1, RRS1, ZNF326, PCDHA2, LMNA, SMC3, SON, TRA2A, RAB31, RTN4, SMARCA5, LMNB1, MRPL55, MYH10, RAP1A, SSR1, FLNB, THRAP3, RRP7A, SEPT2, MRPS28, TOR1AIP1, SAMM50, TOMM70A, RCC2, ADAR, DHODH, MRPL23, MRPS9, TIMM9, MTA2, GTF3C1, ESR1, MAGOH, EIF4A3, FN1, VCAM1, ZNF207, RBM4, WDR77, MAP1LC3A, UBL4A, ITGA4, CTNNB1, AICDA, PAN2, CD81, IGSF8, LMO2, STAT3, SRPK2, CLK2, SRPK3, TARDBP, PARK2, ABCF1, RTCB, DHX9, EIF2B2, EIF2B3, FLII, IGF2BP3, NMT1, PSMB8, RFC4, RPL26L1, RPL27, MRE11A, RPA1, RPA2, RPA3, CDC37, IVNS1ABP, STAU1, MDM2, HAUS1, CEP250, TP53, AKAP9, GMCL1P1, TEKT4, ENO1, SHMT2, MOV10, NXF1, UBE2I, EED, ERLIN2, UBAC2, ABL1, ILK, MAST3, SRPK1, PLRG1, CDC5L, RPS6KB2, NTRK1, LRRC59, UQCRC2, SFN, SCARNA22, B9D2, XPO1, HNRNPH2, MATR3, SEC16A, MYEF2, GAN, SKI, CRY2, MCM2, SNW1, CRBN, C11orf30, ZNF746, CYLD, SMARCB1, BRCA1, RNF168, MTF1 | SLC25A23 | ELAVL1, CUL3, TARDBP, APPBP2, NRG1, SLC25A25, IL13RA2, SYP, CD79B, PDCD1, SLC22A6, SLC2A12, AIFM1, APLNR, VSIG4, TMEM108, SLC5A8, LRP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HNRNPM_SLC25A23 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HNRNPM_SLC25A23 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|