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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16623

FusionGeneSummary for HNRNPM_PC

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPM_PC
Fusion gene ID: 16623
HgeneTgene
Gene symbol

HNRNPM

PC

Gene ID

4670

5420

Gene nameheterogeneous nuclear ribonucleoprotein Mpodocalyxin like
SynonymsCEAR|HNRNPM4|HNRPM|HNRPM4|HTGR1|NAGR1|hnRNP MGp200|PC|PCLP|PCLP-1
Cytomap

19p13.2

7q32.3

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein MCEA receptorN-acetylglucosamine receptor 1heterogenous nuclear ribonucleoprotein M4hnRNA-binding protein M4podocalyxinGCTM-2 antigenpodocalyxin-like protein 1
Modification date2018052320180527
UniProtAcc

P52272

P11498

Ensembl transtripts involved in fusion geneENST00000348943, ENST00000325495, 
ENST00000602219, 
ENST00000393958, 
ENST00000393960, ENST00000355677, 
ENST00000524491, ENST00000529047, 
ENST00000393955, ENST00000528224, 
Fusion gene scores* DoF score12 X 10 X 8=9609 X 5 X 7=315
# samples 139
** MAII scorelog2(13/960*10)=-2.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPM [Title/Abstract] AND PC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePC

GO:0030335

positive regulation of cell migration

18456258

TgenePC

GO:0033634

positive regulation of cell-cell adhesion mediated by integrin

18456258


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-IQ-7631-01AHNRNPMchr19

8509995

+PCchr11

66721907

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000348943ENST00000393958HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-5UTRENST00000348943ENST00000393960HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000348943ENST00000355677HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000348943ENST00000524491HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000348943ENST00000529047HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000348943ENST00000393955HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000348943ENST00000528224HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000325495ENST00000393958HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-5UTRENST00000325495ENST00000393960HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000325495ENST00000355677HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000325495ENST00000524491HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000325495ENST00000529047HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000325495ENST00000393955HNRNPMchr19

8509995

+PCchr11

66721907

-
5CDS-intronENST00000325495ENST00000528224HNRNPMchr19

8509995

+PCchr11

66721907

-
intron-intronENST00000602219ENST00000393958HNRNPMchr19

8509995

+PCchr11

66721907

-
intron-5UTRENST00000602219ENST00000393960HNRNPMchr19

8509995

+PCchr11

66721907

-
intron-intronENST00000602219ENST00000355677HNRNPMchr19

8509995

+PCchr11

66721907

-
intron-intronENST00000602219ENST00000524491HNRNPMchr19

8509995

+PCchr11

66721907

-
intron-intronENST00000602219ENST00000529047HNRNPMchr19

8509995

+PCchr11

66721907

-
intron-intronENST00000602219ENST00000393955HNRNPMchr19

8509995

+PCchr11

66721907

-
intron-intronENST00000602219ENST00000528224HNRNPMchr19

8509995

+PCchr11

66721907

-

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FusionProtFeatures for HNRNPM_PC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPM

P52272

PC

P11498

Pre-mRNA binding protein in vivo, binds avidly topoly(G) and poly(U) RNA homopolymers in vitro. Involved insplicing. Acts as a receptor for carcinoembryonic antigen inKupffer cells, may initiate a series of signaling events leadingto tyrosine phosphorylation of proteins and induction of IL-1alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. Pyruvate carboxylase catalyzes a 2-step reaction,involving the ATP-dependent carboxylation of the covalentlyattached biotin in the first step and the transfer of the carboxylgroup to pyruvate in the second. Catalyzes in a tissue specificmanner, the initial reactions of glucose (liver, kidney) and lipid(adipose tissue, liver, brain) synthesis from pyruvate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPM_PC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPM_PC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPMPRRC2A, RBM4B, LMO3, TCERG1, GSTK1, PHLDA3, RFXANK, PTP4A3, TSC22D1, JUN, LYST, HNRNPA1, HNRNPH1, APC, SRRM1, SRRM2, TOPORS, MORF4L1, MORF4L2, MRGBP, DOT1L, NPM1, TADA2A, UBC, NOP56, VHL, SMARCAD1, ARRB1, ARRB2, ERG, KIAA0368, NFX1, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, PRAME, FBXO6, RBM8A, U2AF2, PRPF6, EFTUD2, NHP2L1, SNRPD1, RBMX, SF3B3, SF3A1, SNRPA1, SF3B1, U2AF1, HNRNPC, SNRPD3, SRSF1, HNRNPF, ALYREF, HNRNPR, HNRNPK, PRPF8, RNPS1, SRSF5, SRSF3, SYNCRIP, SFPQ, NONO, RBM25, HNRNPA0, HNRNPL, RPL10A, RPS6, RPL7, RALY, RPS24, RPS8, RPL11, RPL23A, RPS23, RPL7A, RPL12, DDX5, RPL31, RPS13, RPL6, RPL14, RPS15A, RPS16, RPLP0, DDX1, RPL18, RPL5, RPS11, TOP1, RPS7, RPS2, RPS14, PRPF19, RPL10, RPL19, RPL23, HNRNPDL, RPL18A, RPL30, RPL22, PUF60, RPS26, SRRT, RPS4X, PRPF40A, RPSA, RPS21, PRPF3, RPS5, RPS28, RPS25, RBM14, SND1, RANBP2, MRPL37, KRT16, STOM, MBD3, UQCR10, SLC25A24, SUPT16H, RPLP0P6, RRBP1, VTN, RCC1, RRS1, ZNF326, PCDHA2, LMNA, SMC3, SON, TRA2A, RAB31, RTN4, SMARCA5, LMNB1, MRPL55, MYH10, RAP1A, SSR1, FLNB, THRAP3, RRP7A, SEPT2, MRPS28, TOR1AIP1, SAMM50, TOMM70A, RCC2, ADAR, DHODH, MRPL23, MRPS9, TIMM9, MTA2, GTF3C1, ESR1, MAGOH, EIF4A3, FN1, VCAM1, ZNF207, RBM4, WDR77, MAP1LC3A, UBL4A, ITGA4, CTNNB1, AICDA, PAN2, CD81, IGSF8, LMO2, STAT3, SRPK2, CLK2, SRPK3, TARDBP, PARK2, ABCF1, RTCB, DHX9, EIF2B2, EIF2B3, FLII, IGF2BP3, NMT1, PSMB8, RFC4, RPL26L1, RPL27, MRE11A, RPA1, RPA2, RPA3, CDC37, IVNS1ABP, STAU1, MDM2, HAUS1, CEP250, TP53, AKAP9, GMCL1P1, TEKT4, ENO1, SHMT2, MOV10, NXF1, UBE2I, EED, ERLIN2, UBAC2, ABL1, ILK, MAST3, SRPK1, PLRG1, CDC5L, RPS6KB2, NTRK1, LRRC59, UQCRC2, SFN, SCARNA22, B9D2, XPO1, HNRNPH2, MATR3, SEC16A, MYEF2, GAN, SKI, CRY2, MCM2, SNW1, CRBN, C11orf30, ZNF746, CYLD, SMARCB1, BRCA1, RNF168, MTF1PCMDH2, GOT1, NPM1, UBE2N, ILF2, ILF3, MTHFD1, CDH2, RPS3A, NACA, PPT2, PRKCDBP, TUFM, IFIT1, ADRB2, HECW2, HUWE1, EGFR, TSHR, KLK5, DTWD2, ANTXR1, DNASE2B, CBWD1, PSG1, THBS3, CAD, CCT6A, COPB1, CYP27A1, FASN, KPNA4, ATP1A1, CANX, CCT3, GNB2, PPP2R1A, RPN1, RPN2, SLC25A3, PFAS, UQCRC2, NTRK1, PTEN, ERBB2, XRCC3, RAB7A, DYNLL1, WWP2, ZNF746, PTPN9, STRAP, DEFA5, ASS1, HSD3B2, BPNT1, SLAMF1, LRP1, TPSB2, YBEY, EPHA7, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPM_PC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePCP11498DB00121BiotinPyruvate carboxylase, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for HNRNPM_PC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePCC0006413Burkitt Lymphoma1CTD_human
TgenePCC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePCC0034341Pyruvate Carboxylase Deficiency Disease1CTD_human;UNIPROT