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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16588

FusionGeneSummary for HNRNPH2_TMEM27

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPH2_TMEM27
Fusion gene ID: 16588
HgeneTgene
Gene symbol

HNRNPH2

TMEM27

Gene ID

3188

Gene nameheterogeneous nuclear ribonucleoprotein H2
SynonymsFTP3|HNRPH'|HNRPH2|MRXSB|NRPH2|hnRNPH'
Cytomap

Xq22.1

Type of geneprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein H2FTP-3heterogeneous nuclear ribonucleoprotein H-primeheterogeneous nuclear ribonucleoprotein H2 (H')hnRNP H'hnRNP H2
Modification date20180522
UniProtAcc

P55795

Q9HBJ8

Ensembl transtripts involved in fusion geneENST00000316594, ENST00000380342, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: HNRNPH2 [Title/Abstract] AND TMEM27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5740-01AHNRNPH2chrX

100667512

+TMEM27chrX

15657879

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000316594ENST00000380342HNRNPH2chrX

100667512

+TMEM27chrX

15657879

-

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FusionProtFeatures for HNRNPH2_TMEM27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPH2

P55795

TMEM27

Q9HBJ8

This protein is a component of the heterogeneous nuclearribonucleoprotein (hnRNP) complexes which provide the substratefor the processing events that pre-mRNAs undergo before becomingfunctional, translatable mRNAs in the cytoplasm. Binds poly(RG). Regulator of SNARE complex function. Stimulator of betacell replication. {ECO:0000269|PubMed:16330323}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPH2_TMEM27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPH2_TMEM27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPH2HNRNPH1, MEPCE, GPN1, HDAC5, VHL, RAD21, MBNL1, ARRB2, HNRNPA1, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, HNRNPDL, MAX, SERPINH1, CIRBP, CNN2, C19orf25, MAGOH, EIF4A3, SMURF1, VCP, FN1, SNRPC, RBM10, SF1, RBM39, ILF3, HNRNPA0, PRPF8, PRPF31, PQBP1, WDR83, DDX5, HNRNPUL1, RBM4, HNRNPH2, GNB2L1, QKI, RBFOX2, UBL4A, SRPK2, FBXO6, PRMT6, HSPA5, UBASH3B, STAU1, TEKT1, MSI2, CUL7, OBSL1, EED, FBXW11, HSPB1, CLIC4, CRKL, DLD, GMFB, HIBCH, HNRNPA1L2, HNRNPA2B1, HNRNPA3, IARS2, ISYNA1, LGMN, MCM3, PLOD1, YARS, PDCD6, LYST, DDX1, HNRNPD, HNRNPF, MATR3, HNRNPH3, HNRNPK, MOV10, HNRNPM, PLOD2, PRCP, PYCR1, TNK1, PLOD3, APOBEC3B, SYNCRIP, FASTK, FAM120A, TARDBP, RUSC1, EPC2, RBMX, PKN3, ZSWIM5, QSER1, NUDT16L1, MAK16, HNRNPUL2, RBM12B, CRY1, MCM2, ESR1, ERBB3, ESRRB, NANOG, CYLD, FOXA1, G3BP1, BRCA1TMEM27RBM18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPH2_TMEM27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPH2_TMEM27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource